SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQT_A_ACTA1869_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 172
HIS A 144
ARG A 200
GLU A 168
None
ZN  A 350 (-3.3A)
None
ZN  A 350 (-2.2A)
0.90A 1lqtA-1bqbA:
1.6
1lqtA-1bqbA:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e1k ADRENODOXIN
REDUCTASE


(Bos taurus)
PF07992
(Pyr_redox_2)
4 ASP A  54
HIS A  55
ARG A 162
GLU A 212
None
FAD  A 801 ( 4.9A)
None
None
0.39A 1lqtA-1e1kA:
50.3
1lqtA-1e1kA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E


(Cellvibrio
japonicus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
4 ASP A 472
HIS A 473
ARG A 151
GLU A 430
None
1.36A 1lqtA-1gqjA:
3.2
1lqtA-1gqjA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lqt FPRA

(Mycobacterium
tuberculosis)
PF07992
(Pyr_redox_2)
4 ASP A  56
HIS A  57
ARG A 164
GLU A 214
ACT  A1869 (-3.7A)
ACT  A1869 (-3.7A)
None
ACT  A1869 (-2.6A)
0.01A 1lqtA-1lqtA:
66.0
1lqtA-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npc NEUTRAL PROTEASE

(Bacillus cereus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 171
HIS A 143
ARG A 204
GLU A 167
None
ZN  A 323 ( 3.3A)
None
ZN  A 323 ( 2.0A)
0.92A 1lqtA-1npcA:
0.0
1lqtA-1npcA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
4 ASP A 527
HIS A 530
ARG A 470
GLU A 283
None
1.27A 1lqtA-1nylA:
1.0
1lqtA-1nylA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2f CYTOLETHAL
DISTENDING TOXIN C


(Aggregatibacter
actinomycetemcomitans)
PF03498
(CDtoxinA)
4 ASP C 143
HIS C 139
ARG C 145
GLU C 147
None
1.05A 1lqtA-2f2fC:
undetectable
1lqtA-2f2fC:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iie INTEGRATION HOST
FACTOR


(Escherichia
coli)
PF00216
(Bac_DNA_binding)
4 ASP A  66
HIS A  18
ARG A  65
GLU A  69
None
1.41A 1lqtA-2iieA:
undetectable
1lqtA-2iieA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus)
PF05059
(Orbi_VP4)
4 ASP A 408
HIS A 133
ARG A 406
GLU A 131
None
1.02A 1lqtA-2jh9A:
2.4
1lqtA-2jh9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug)
4 ASP A 814
HIS A 280
ARG A 812
GLU A 282
PO4  A   9 ( 4.9A)
PO4  A  10 ( 3.5A)
PO4  A   4 ( 2.6A)
PO4  A  10 (-3.0A)
1.18A 1lqtA-2o5pA:
undetectable
1lqtA-2o5pA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep)
4 ASP A 190
HIS A 162
ARG A 227
GLU A 186
None
ZN  A1342 (-3.4A)
None
ZN  A1342 (-2.4A)
0.94A 1lqtA-2vqxA:
undetectable
1lqtA-2vqxA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis)
PF00995
(Sec1)
4 ASP A 402
HIS A 237
ARG A 405
GLU A 368
None
1.20A 1lqtA-2xheA:
undetectable
1lqtA-2xheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY


(Geobacter
sulfurreducens)
PF01435
(Peptidase_M48)
4 ASP A 166
HIS A 106
ARG A 214
GLU A 162
None
ZN  A 301 (-3.2A)
None
ZN  A 301 (-2.2A)
0.83A 1lqtA-3c37A:
undetectable
1lqtA-3c37A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 168
HIS A 140
ARG A 198
GLU A 164
None
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.6A)
ZN  A 302 ( 2.2A)
0.98A 1lqtA-3dbkA:
undetectable
1lqtA-3dbkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1


(Homo sapiens)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
4 ASP A 671
HIS A 607
ARG A 738
GLU A 667
None
ZN  A 771 ( 3.4A)
RDF  A 817 (-3.0A)
ZN  A 771 ( 2.1A)
1.13A 1lqtA-3dwbA:
undetectable
1lqtA-3dwbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 ASP A  49
HIS A  90
ARG A  35
GLU A  47
None
1.41A 1lqtA-3gdcA:
undetectable
1lqtA-3gdcA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02


(Pseudoalteromonas
sp. SM9913)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 373
HIS A 345
ARG A 403
GLU A 369
None
ZN  A   1 (-3.2A)
None
ZN  A   1 (-2.3A)
0.85A 1lqtA-3nqxA:
0.9
1lqtA-3nqxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4z GLYCOSYL HYDROLASE
FAMILY 32, N
TERMINAL


(Saccharophagus
degradans)
PF04616
(Glyco_hydro_43)
4 ASP A 282
HIS A 264
ARG A 235
GLU A 224
None
GLA  A 375 (-4.0A)
GLA  A 375 (-2.8A)
GLA  A 375 (-2.9A)
1.30A 1lqtA-3r4zA:
undetectable
1lqtA-3r4zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13


(Mycobacterium
tuberculosis)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
4 ASP A 564
HIS A 493
ARG A 628
GLU A 560
None
ZN  A1664 ( 3.4A)
RDF  A1665 (-2.6A)
ZN  A1664 ( 2.3A)
0.97A 1lqtA-3zukA:
undetectable
1lqtA-3zukA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 ASP A1182
HIS A1245
ARG A1180
GLU A1243
None
1.30A 1lqtA-3zyvA:
undetectable
1lqtA-3zyvA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE


(Bacteroides
plebeius)
PF04616
(Glyco_hydro_43)
4 ASP A 320
HIS A 302
ARG A 273
GLU A 262
None
1.33A 1lqtA-4ak5A:
undetectable
1lqtA-4ak5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 163
HIS A 135
ARG A 191
GLU A 159
None
ZN  A 401 ( 3.2A)
RDF  A 501 (-2.7A)
ZN  A 401 ( 1.9A)
0.97A 1lqtA-4b52A:
undetectable
1lqtA-4b52A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE


(Physcomitrella
patens)
PF01507
(PAPS_reduct)
4 ASP A 227
HIS A 228
ARG A 225
GLU A 299
None
1.48A 1lqtA-4bwvA:
2.5
1lqtA-4bwvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cca SYNTAXIN-BINDING
PROTEIN 2


(Homo sapiens)
PF00995
(Sec1)
4 ASP A 402
HIS A 245
ARG A 405
GLU A 368
None
1.27A 1lqtA-4ccaA:
undetectable
1lqtA-4ccaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae)
PF00275
(EPSP_synthase)
4 ASP A 451
HIS A  19
ARG A 453
GLU A  17
None
1.07A 1lqtA-4fqdA:
undetectable
1lqtA-4fqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 ASP A 214
HIS A 105
ARG A 445
GLU A 443
None
SEP  A 104 (-3.7A)
G6Q  A 544 (-4.0A)
None
1.13A 1lqtA-4hjhA:
undetectable
1lqtA-4hjhA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1


(Homo sapiens)
PF00557
(Peptidase_M24)
4 ASP A 160
HIS A 390
ARG A 383
GLU A 243
None
1.26A 1lqtA-4hxxA:
undetectable
1lqtA-4hxxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae)
PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N)
4 ASP A 394
HIS A 297
ARG A 440
GLU A 390
None
ZN  A 501 (-3.2A)
None
ZN  A 501 (-1.7A)
0.85A 1lqtA-4il3A:
undetectable
1lqtA-4il3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1


(Homo sapiens)
PF00557
(Peptidase_M24)
4 ASP A 160
HIS A 390
ARG A 383
GLU A 243
None
1.25A 1lqtA-4iu6A:
undetectable
1lqtA-4iu6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE


(Lactobacillus
rhamnosus)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
4 ASP A 541
HIS A 477
ARG A 596
GLU A 537
None
ZN  A 701 ( 3.2A)
CIT  A 702 (-3.0A)
ZN  A 701 ( 2.2A)
1.00A 1lqtA-4iuwA:
undetectable
1lqtA-4iuwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1


(Rattus
norvegicus)
PF00995
(Sec1)
4 ASP A 403
HIS A 245
ARG A 406
GLU A 369
None
1.27A 1lqtA-4jeuA:
undetectable
1lqtA-4jeuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP


(Aspergillus
fumigatus)
PF02128
(Peptidase_M36)
4 ASP A 463
HIS A 429
ARG A 495
GLU A 459
None
ZN  A 701 (-3.2A)
MLA  A 704 (-2.7A)
ZN  A 701 (-2.2A)
1.03A 1lqtA-4k90A:
1.8
1lqtA-4k90A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR


(Gallus gallus)
PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2)
4 ASP A 133
HIS A  84
ARG A 111
GLU A  86
None
1.38A 1lqtA-4pbvA:
undetectable
1lqtA-4pbvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Drosophila
melanogaster)
PF07034
(ORC3_N)
4 ASP C 382
HIS C 350
ARG C 357
GLU C 354
None
1.42A 1lqtA-4xgcC:
undetectable
1lqtA-4xgcC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE


(Sphingobium sp.
SYK-6)
PF00106
(adh_short)
4 ASP A  40
HIS A  41
ARG A  38
GLU A 197
None
NAI  A 500 (-3.9A)
None
None
1.45A 1lqtA-4yaiA:
5.8
1lqtA-4yaiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus)
PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N)
4 ASP A 651
HIS A 584
ARG A 718
GLU A 647
None
ZN  A 801 ( 3.3A)
RDF  A 802 (-2.7A)
ZN  A 801 ( 2.2A)
1.07A 1lqtA-4zr5A:
undetectable
1lqtA-4zr5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 170
HIS A 142
ARG A 203
GLU A 166
None
ZN  A1317 (-3.2A)
VAL  A1322 (-2.6A)
ZN  A1317 (-2.3A)
0.90A 1lqtA-5a3yA:
1.1
1lqtA-5a3yA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 ASP A1186
HIS A1249
ARG A1184
GLU A1247
None
1.01A 1lqtA-5epgA:
undetectable
1lqtA-5epgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASP A 170
HIS A 142
ARG A 203
GLU A 166
None
ZN  A1317 (-3.2A)
VAL  A1318 (-2.6A)
ZN  A1317 (-2.2A)
0.90A 1lqtA-5fxnA:
undetectable
1lqtA-5fxnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3


(Geobacillus sp.
GHH01)
PF00793
(DAHP_synth_1)
PF01817
(CM_2)
4 ASP A 293
HIS A 296
ARG A 150
GLU A 322
None
MN  A 401 ( 3.5A)
None
MN  A 401 (-1.9A)
1.45A 1lqtA-5j6fA:
1.5
1lqtA-5j6fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG


(Homo sapiens)
PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N)
4 ASP A 419
HIS A 335
ARG A 465
GLU A 415
None
ZN  A 517 (-3.2A)
None
ZN  A 517 (-2.1A)
0.87A 1lqtA-5sytA:
undetectable
1lqtA-5sytA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
PF04616
(Glyco_hydro_43)
4 ASP A 320
HIS A 302
ARG A 273
GLU A 262
None
GAL  A 501 (-3.9A)
GAL  A 501 (-2.8A)
GAL  A 501 (-2.7A)
1.36A 1lqtA-5ta9A:
undetectable
1lqtA-5ta9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica)
PF01112
(Asparaginase_2)
4 ASP A  58
HIS A 178
ARG A  62
GLU A  83
None
1.29A 1lqtA-5v2iA:
undetectable
1lqtA-5v2iA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus)
no annotation 4 ASP A 386
HIS A 516
ARG A 324
GLU A 519
None
1.49A 1lqtA-5xflA:
undetectable
1lqtA-5xflA:
undetectable