SIMILAR PATTERNS OF AMINO ACIDS FOR 1LQT_A_ACTA1869_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqb | PROTEIN (AUREOLYSIN) (Staphylococcusaureus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 172HIS A 144ARG A 200GLU A 168 | None ZN A 350 (-3.3A)None ZN A 350 (-2.2A) | 0.90A | 1lqtA-1bqbA:1.6 | 1lqtA-1bqbA:21.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1e1k | ADRENODOXINREDUCTASE (Bos taurus) |
PF07992(Pyr_redox_2) | 4 | ASP A 54HIS A 55ARG A 162GLU A 212 | NoneFAD A 801 ( 4.9A)NoneNone | 0.39A | 1lqtA-1e1kA:50.3 | 1lqtA-1e1kA:40.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqj | ALPHA-D-GLUCURONIDASE (Cellvibriojaponicus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 4 | ASP A 472HIS A 473ARG A 151GLU A 430 | None | 1.36A | 1lqtA-1gqjA:3.2 | 1lqtA-1gqjA:23.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lqt | FPRA (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 4 | ASP A 56HIS A 57ARG A 164GLU A 214 | ACT A1869 (-3.7A)ACT A1869 (-3.7A)NoneACT A1869 (-2.6A) | 0.01A | 1lqtA-1lqtA:66.0 | 1lqtA-1lqtA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1npc | NEUTRAL PROTEASE (Bacillus cereus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 171HIS A 143ARG A 204GLU A 167 | None ZN A 323 ( 3.3A)None ZN A 323 ( 2.0A) | 0.92A | 1lqtA-1npcA:0.0 | 1lqtA-1npcA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nyl | GLUTAMINYL-TRNASYNTHETASE (Escherichiacoli) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 4 | ASP A 527HIS A 530ARG A 470GLU A 283 | None | 1.27A | 1lqtA-1nylA:1.0 | 1lqtA-1nylA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2f | CYTOLETHALDISTENDING TOXIN C (Aggregatibacteractinomycetemcomitans) |
PF03498(CDtoxinA) | 4 | ASP C 143HIS C 139ARG C 145GLU C 147 | None | 1.05A | 1lqtA-2f2fC:undetectable | 1lqtA-2f2fC:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iie | INTEGRATION HOSTFACTOR (Escherichiacoli) |
PF00216(Bac_DNA_binding) | 4 | ASP A 66HIS A 18ARG A 65GLU A 69 | None | 1.41A | 1lqtA-2iieA:undetectable | 1lqtA-2iieA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jh9 | VP4 CORE PROTEIN (Bluetonguevirus) |
PF05059(Orbi_VP4) | 4 | ASP A 408HIS A 133ARG A 406GLU A 131 | None | 1.02A | 1lqtA-2jh9A:2.4 | 1lqtA-2jh9A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | ASP A 814HIS A 280ARG A 812GLU A 282 | PO4 A 9 ( 4.9A)PO4 A 10 ( 3.5A)PO4 A 4 ( 2.6A)PO4 A 10 (-3.0A) | 1.18A | 1lqtA-2o5pA:undetectable | 1lqtA-2o5pA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vqx | METALLOPROTEINASE (Serratiaproteamaculans) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C)PF16485(PLN_propep) | 4 | ASP A 190HIS A 162ARG A 227GLU A 186 | None ZN A1342 (-3.4A)None ZN A1342 (-2.4A) | 0.94A | 1lqtA-2vqxA:undetectable | 1lqtA-2vqxA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhe | UNC18 (Monosigabrevicollis) |
PF00995(Sec1) | 4 | ASP A 402HIS A 237ARG A 405GLU A 368 | None | 1.20A | 1lqtA-2xheA:undetectable | 1lqtA-2xheA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c37 | PEPTIDASE, M48FAMILY (Geobactersulfurreducens) |
PF01435(Peptidase_M48) | 4 | ASP A 166HIS A 106ARG A 214GLU A 162 | None ZN A 301 (-3.2A)None ZN A 301 (-2.2A) | 0.83A | 1lqtA-3c37A:undetectable | 1lqtA-3c37A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbk | ELASTASE (Pseudomonasaeruginosa) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 168HIS A 140ARG A 198GLU A 164 | None ZN A 302 ( 3.2A)RDF A2001 (-2.6A) ZN A 302 ( 2.2A) | 0.98A | 1lqtA-3dbkA:undetectable | 1lqtA-3dbkA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwb | ENDOTHELIN-CONVERTING ENZYME 1 (Homo sapiens) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | ASP A 671HIS A 607ARG A 738GLU A 667 | None ZN A 771 ( 3.4A)RDF A 817 (-3.0A) ZN A 771 ( 2.1A) | 1.13A | 1lqtA-3dwbA:undetectable | 1lqtA-3dwbA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdc | MULTICOPPER OXIDASE (Arthrobactersp. FB24) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ASP A 49HIS A 90ARG A 35GLU A 47 | None | 1.41A | 1lqtA-3gdcA:undetectable | 1lqtA-3gdcA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqx | SECRETEDMETALLOPROTEASEMCP02 (Pseudoalteromonassp. SM9913) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 373HIS A 345ARG A 403GLU A 369 | None ZN A 1 (-3.2A)None ZN A 1 (-2.3A) | 0.85A | 1lqtA-3nqxA:0.9 | 1lqtA-3nqxA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4z | GLYCOSYL HYDROLASEFAMILY 32, NTERMINAL (Saccharophagusdegradans) |
PF04616(Glyco_hydro_43) | 4 | ASP A 282HIS A 264ARG A 235GLU A 224 | NoneGLA A 375 (-4.0A)GLA A 375 (-2.8A)GLA A 375 (-2.9A) | 1.30A | 1lqtA-3r4zA:undetectable | 1lqtA-3r4zA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuk | ENDOPEPTIDASE,PEPTIDASE FAMILY M13 (Mycobacteriumtuberculosis) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | ASP A 564HIS A 493ARG A 628GLU A 560 | None ZN A1664 ( 3.4A)RDF A1665 (-2.6A) ZN A1664 ( 2.3A) | 0.97A | 1lqtA-3zukA:undetectable | 1lqtA-3zukA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | ASP A1182HIS A1245ARG A1180GLU A1243 | None | 1.30A | 1lqtA-3zyvA:undetectable | 1lqtA-3zyvA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ak5 | ANHYDRO-ALPHA-L-GALACTOSIDASE (Bacteroidesplebeius) |
PF04616(Glyco_hydro_43) | 4 | ASP A 320HIS A 302ARG A 273GLU A 262 | None | 1.33A | 1lqtA-4ak5A:undetectable | 1lqtA-4ak5A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b52 | BACILLOLYSIN (Paenibacilluspolymyxa) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 163HIS A 135ARG A 191GLU A 159 | None ZN A 401 ( 3.2A)RDF A 501 (-2.7A) ZN A 401 ( 1.9A) | 0.97A | 1lqtA-4b52A:undetectable | 1lqtA-4b52A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwv | PHOSPHOADENOSINE-PHOSPHOSULPHATEREDUCTASE (Physcomitrellapatens) |
PF01507(PAPS_reduct) | 4 | ASP A 227HIS A 228ARG A 225GLU A 299 | None | 1.48A | 1lqtA-4bwvA:2.5 | 1lqtA-4bwvA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cca | SYNTAXIN-BINDINGPROTEIN 2 (Homo sapiens) |
PF00995(Sec1) | 4 | ASP A 402HIS A 245ARG A 405GLU A 368 | None | 1.27A | 1lqtA-4ccaA:undetectable | 1lqtA-4ccaA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqd | NIKO PROTEIN (Streptomycestendae) |
PF00275(EPSP_synthase) | 4 | ASP A 451HIS A 19ARG A 453GLU A 17 | None | 1.07A | 1lqtA-4fqdA:undetectable | 1lqtA-4fqdA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjh | PHOSPHOMANNOMUTASE (Brucellamelitensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | ASP A 214HIS A 105ARG A 445GLU A 443 | NoneSEP A 104 (-3.7A)G6Q A 544 (-4.0A)None | 1.13A | 1lqtA-4hjhA:undetectable | 1lqtA-4hjhA:25.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxx | METHIONINEAMINOPEPTIDASE 1 (Homo sapiens) |
PF00557(Peptidase_M24) | 4 | ASP A 160HIS A 390ARG A 383GLU A 243 | None | 1.26A | 1lqtA-4hxxA:undetectable | 1lqtA-4hxxA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4il3 | STE24P (Saccharomycesmikatae) |
PF01435(Peptidase_M48)PF16491(Peptidase_M48_N) | 4 | ASP A 394HIS A 297ARG A 440GLU A 390 | None ZN A 501 (-3.2A)None ZN A 501 (-1.7A) | 0.85A | 1lqtA-4il3A:undetectable | 1lqtA-4il3A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu6 | METHIONINEAMINOPEPTIDASE 1 (Homo sapiens) |
PF00557(Peptidase_M24) | 4 | ASP A 160HIS A 390ARG A 383GLU A 243 | None | 1.25A | 1lqtA-4iu6A:undetectable | 1lqtA-4iu6A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuw | NEUTRALENDOPEPTIDASE (Lactobacillusrhamnosus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | ASP A 541HIS A 477ARG A 596GLU A 537 | None ZN A 701 ( 3.2A)CIT A 702 (-3.0A) ZN A 701 ( 2.2A) | 1.00A | 1lqtA-4iuwA:undetectable | 1lqtA-4iuwA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jeu | SYNTAXIN-BINDINGPROTEIN 1 (Rattusnorvegicus) |
PF00995(Sec1) | 4 | ASP A 403HIS A 245ARG A 406GLU A 369 | None | 1.27A | 1lqtA-4jeuA:undetectable | 1lqtA-4jeuA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k90 | EXTRACELLULARMETALLOPROTEINASEMEP (Aspergillusfumigatus) |
PF02128(Peptidase_M36) | 4 | ASP A 463HIS A 429ARG A 495GLU A 459 | None ZN A 701 (-3.2A)MLA A 704 (-2.7A) ZN A 701 (-2.2A) | 1.03A | 1lqtA-4k90A:1.8 | 1lqtA-4k90A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pbv | NT-3 GROWTH FACTORRECEPTOR (Gallus gallus) |
PF00047(ig)PF13855(LRR_8)PF16920(TPKR_C2) | 4 | ASP A 133HIS A 84ARG A 111GLU A 86 | None | 1.38A | 1lqtA-4pbvA:undetectable | 1lqtA-4pbvA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Drosophilamelanogaster) |
PF07034(ORC3_N) | 4 | ASP C 382HIS C 350ARG C 357GLU C 354 | None | 1.42A | 1lqtA-4xgcC:undetectable | 1lqtA-4xgcC:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yai | CALPHA-DEHYDROGENASE (Sphingobium sp.SYK-6) |
PF00106(adh_short) | 4 | ASP A 40HIS A 41ARG A 38GLU A 197 | NoneNAI A 500 (-3.9A)NoneNone | 1.45A | 1lqtA-4yaiA:5.8 | 1lqtA-4yaiA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr5 | NEPRILYSIN (Oryctolaguscuniculus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 4 | ASP A 651HIS A 584ARG A 718GLU A 647 | None ZN A 801 ( 3.3A)RDF A 802 (-2.7A) ZN A 801 ( 2.2A) | 1.07A | 1lqtA-4zr5A:undetectable | 1lqtA-4zr5A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3y | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 170HIS A 142ARG A 203GLU A 166 | None ZN A1317 (-3.2A)VAL A1322 (-2.6A) ZN A1317 (-2.3A) | 0.90A | 1lqtA-5a3yA:1.1 | 1lqtA-5a3yA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epg | ALDEHYDE OXIDASE (Homo sapiens) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | ASP A1186HIS A1249ARG A1184GLU A1247 | None | 1.01A | 1lqtA-5epgA:undetectable | 1lqtA-5epgA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxn | THERMOLYSIN (Bacillusthermoproteolyticus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASP A 170HIS A 142ARG A 203GLU A 166 | None ZN A1317 (-3.2A)VAL A1318 (-2.6A) ZN A1317 (-2.2A) | 0.90A | 1lqtA-5fxnA:undetectable | 1lqtA-5fxnA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6f | 3-DEOXY-D-ARABINO-HEPTULOSONATE7-PHOSPHATESYNTHASE, CHORISMATEMUTASE-ISOZYME 3 (Geobacillus sp.GHH01) |
PF00793(DAHP_synth_1)PF01817(CM_2) | 4 | ASP A 293HIS A 296ARG A 150GLU A 322 | None MN A 401 ( 3.5A)None MN A 401 (-1.9A) | 1.45A | 1lqtA-5j6fA:1.5 | 1lqtA-5j6fA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5syt | CAAX PRENYL PROTEASE1 HOMOLOG (Homo sapiens) |
PF01435(Peptidase_M48)PF16491(Peptidase_M48_N) | 4 | ASP A 419HIS A 335ARG A 465GLU A 415 | None ZN A 517 (-3.2A)None ZN A 517 (-2.1A) | 0.87A | 1lqtA-5sytA:undetectable | 1lqtA-5sytA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ta9 | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
PF04616(Glyco_hydro_43) | 4 | ASP A 320HIS A 302ARG A 273GLU A 262 | NoneGAL A 501 (-3.9A)GAL A 501 (-2.8A)GAL A 501 (-2.7A) | 1.36A | 1lqtA-5ta9A:undetectable | 1lqtA-5ta9A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2i | GLYCOSYLASPARAGINASE (Elizabethkingiameningoseptica) |
PF01112(Asparaginase_2) | 4 | ASP A 58HIS A 178ARG A 62GLU A 83 | None | 1.29A | 1lqtA-5v2iA:undetectable | 1lqtA-5v2iA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfl | CATENIN ALPHA-2 (Mus musculus) |
no annotation | 4 | ASP A 386HIS A 516ARG A 324GLU A 519 | None | 1.49A | 1lqtA-5xflA:undetectable | 1lqtA-5xflA:undetectable |