SIMILAR PATTERNS OF AMINO ACIDS FOR 1LIN_A_TFPA156

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE


(Thermococcus
litoralis)
PF01470
(Peptidase_C15)
5 ILE A 166
ILE A 198
GLU A 199
VAL A 202
ILE A  66
None
1.47A 1linA-1a2zA:
undetectable
1linA-1a2zA:
24.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1avs TROPONIN C

(Gallus gallus)
PF13833
(EF-hand_8)
6 ILE A  37
LEU A  42
ILE A  62
VAL A  65
ILE A  73
MET A  81
None
0.87A 1linA-1avsA:
13.5
1linA-1avsA:
51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avw TRYPSIN INHIBITOR

(Glycine max)
PF00197
(Kunitz_legume)
5 ILE B 558
LEU B 573
ILE B 567
GLU B 569
VAL B 503
None
1.26A 1linA-1avwB:
undetectable
1linA-1avwB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus)
PF00248
(Aldo_ket_red)
5 ILE A  74
LEU A  99
ILE A  58
VAL A  31
ILE A  42
None
1.40A 1linA-1c9wA:
undetectable
1linA-1c9wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckv PROTEIN (PROTEIN B)

(Escherichia
coli)
PF02406
(MmoB_DmpM)
5 ILE A  48
ILE A  79
GLU A  71
VAL A  70
ILE A  52
None
1.44A 1linA-1ckvA:
undetectable
1linA-1ckvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22)
PF09251
(PhageP22-tail)
5 ILE A 516
LEU A 501
ILE A 526
VAL A 530
ILE A 535
None
1.47A 1linA-1clwA:
undetectable
1linA-1clwA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE


(Pseudomonas
aeruginosa)
PF00753
(Lactamase_B)
5 ILE A  47
ILE A 130
GLU A 131
VAL A 132
ILE A  74
None
1.20A 1linA-1ddkA:
undetectable
1linA-1ddkA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE


(Arabidopsis
thaliana)
PF00709
(Adenylsucc_synt)
5 ILE A 431
LEU A 350
ILE A 433
VAL A 403
ILE A 441
None
0.94A 1linA-1dj2A:
undetectable
1linA-1dj2A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE


(Bacillus
subtilis)
PF14562
(Endonuc_BglI)
5 ILE A 214
LEU A 237
ILE A  42
GLU A  40
VAL A  41
None
1.39A 1linA-1dmuA:
undetectable
1linA-1dmuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 LEU A 353
ILE A 374
GLU A 377
VAL A 378
ILE A 332
None
1.17A 1linA-1e1tA:
undetectable
1linA-1e1tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE


(Lactobacillus
pentosus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 262
LEU A 134
ILE A 258
VAL A 272
ILE A 293
None
1.48A 1linA-1ez4A:
undetectable
1linA-1ez4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 217
ILE A 241
GLU A 244
VAL A 301
ILE A 311
None
1.36A 1linA-1fnoA:
undetectable
1linA-1fnoA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Escherichia
coli)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 ILE A 292
LEU A 286
ILE A 303
VAL A 315
ILE A 309
ILE  A 292 ( 0.7A)
LEU  A 286 ( 0.6A)
ILE  A 303 ( 0.7A)
VAL  A 315 ( 0.6A)
ILE  A 309 ( 0.7A)
1.35A 1linA-1fxjA:
undetectable
1linA-1fxjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 ILE A 263
LEU A 265
GLU A  37
VAL A  33
ILE A 282
None
1.46A 1linA-1g68A:
undetectable
1linA-1g68A:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1


(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE A  27
LEU A  32
MET A  51
GLU A  54
MET A  71
None
0.66A 1linA-1ggzA:
14.9
1linA-1ggzA:
84.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8a MYB TRANSFORMING
PROTEIN


(Avian
myeloblastosis
virus)
PF00249
(Myb_DNA-binding)
5 ILE C 154
LEU C 172
ILE C 169
VAL C 181
ILE C 155
None
1.39A 1linA-1h8aC:
undetectable
1linA-1h8aC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hci ALPHA-ACTININ 2

(Homo sapiens)
PF00435
(Spectrin)
5 ILE A 591
LEU A 510
ILE A 514
GLU A 581
ILE A 586
None
1.14A 1linA-1hciA:
undetectable
1linA-1hciA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669


(Methanocaldococcus
jannaschii)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ILE A  94
LEU A  65
ILE A 126
VAL A 128
ILE A 105
None
1.38A 1linA-1hv8A:
undetectable
1linA-1hv8A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus)
PF14622
(Ribonucleas_3_3)
5 ILE A  95
ILE A 104
GLU A  40
VAL A 108
ILE A  93
None
1.35A 1linA-1i4sA:
undetectable
1linA-1i4sA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is7 GTP CYCLOHYDROLASE I

(Rattus
norvegicus)
PF01227
(GTP_cyclohydroI)
5 ILE A 162
LEU A 159
ILE A 145
VAL A 143
ILE A 180
None
1.34A 1linA-1is7A:
undetectable
1linA-1is7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642


(Pyrococcus
horikoshii)
PF00795
(CN_hydrolase)
5 ILE A 193
ILE A 235
GLU A 234
VAL A 233
ILE A 212
None
1.13A 1linA-1j31A:
undetectable
1linA-1j31A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum)
PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ)
5 LEU A 825
ILE A 810
GLU A 813
VAL A 815
ILE A 807
None
1.45A 1linA-1k32A:
undetectable
1linA-1k32A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98


(Homo sapiens)
PF04096
(Nucleoporin2)
5 ILE A 750
ILE A 777
GLU A 781
VAL A 782
ILE A 758
None
1.35A 1linA-1ko6A:
undetectable
1linA-1ko6A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1laj CAPSID PROTEIN

(Tomato aspermy
virus)
PF00760
(Cucumo_coat)
5 LEU A  90
ILE A 202
VAL A 107
ILE A 204
MET A 169
None
1.35A 1linA-1lajA:
undetectable
1linA-1lajA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE


(Pyrococcus
horikoshii)
PF06026
(Rib_5-P_isom_A)
5 ILE A 200
ILE A 138
GLU A 139
VAL A 140
ILE A 148
None
1.33A 1linA-1lk5A:
undetectable
1linA-1lk5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkt TAILSPIKE PROTEIN

(Salmonella
virus P22)
PF09008
(Head_binding)
5 ILE A  61
LEU A  65
ILE A  82
VAL A  80
ILE A  51
None
1.32A 1linA-1lktA:
undetectable
1linA-1lktA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli)
PF00004
(AAA)
5 ILE A 256
LEU A 192
VAL A 296
ILE A 253
MET A 285
None
1.37A 1linA-1lv7A:
undetectable
1linA-1lv7A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF02548
(Pantoate_transf)
5 LEU A  42
ILE A 212
GLU A 181
VAL A 179
ILE A 200
KPL  A 265 (-4.9A)
KPL  A 265 ( 4.0A)
KPL  A 265 (-3.0A)
None
None
1.38A 1linA-1m3uA:
undetectable
1linA-1m3uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE


(Methanosarcina
barkeri)
PF01913
(FTR)
PF02741
(FTR_C)
5 ILE A 265
ILE A   8
GLU A   2
VAL A   6
ILE A 277
None
1.42A 1linA-1m5sA:
undetectable
1linA-1m5sA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM


(Caenorhabditis
elegans)
PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like)
5 ILE A  88
LEU A 104
MET A 136
VAL A  70
ILE A 119
None
1.45A 1linA-1mg7A:
undetectable
1linA-1mg7A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A


(Escherichia
coli)
PF00248
(Aldo_ket_red)
5 ILE A 217
ILE A 258
GLU A 257
VAL A 202
ILE A 203
None
1.45A 1linA-1mzrA:
undetectable
1linA-1mzrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN


(Oligotropha
carboxidovorans)
PF00111
(Fer2)
PF01799
(Fer2_2)
5 ILE A  10
LEU A  35
ILE A  29
VAL A  52
ILE A  74
None
1.43A 1linA-1n60A:
undetectable
1linA-1n60A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o1c SKELETAL MUSCLE
MYOSIN II REGULATORY
LIGHT CHAIN


(Gallus gallus)
PF13833
(EF-hand_8)
5 ILE B  42
LEU B  47
MET B  67
ILE B  75
MET B  83
None
1.28A 1linA-1o1cB:
10.3
1linA-1o1cB:
36.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus)
PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N)
5 ILE X 139
ILE X 130
GLU X 163
VAL X 162
ILE X 149
None
1.48A 1linA-1ogoX:
undetectable
1linA-1ogoX:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqp CALTRACTIN

(Chlamydomonas
reinhardtii)
PF13499
(EF-hand_7)
5 ILE A 118
LEU A 123
MET A 142
ILE A 143
ILE A 154
None
0.88A 1linA-1oqpA:
12.1
1linA-1oqpA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D


(Escherichia
coli)
PF00849
(PseudoU_synth_2)
5 ILE A  86
LEU A  84
ILE A  96
VAL A 148
ILE A  94
None
1.44A 1linA-1przA:
undetectable
1linA-1przA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Zymomonas
mobilis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 MET A 312
ILE A 315
GLU A 313
ILE A 223
MET A 325
None
1.36A 1linA-1r0lA:
undetectable
1linA-1r0lA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE


(Fervidobacterium
pennivorans)
PF00082
(Peptidase_S8)
5 ILE A  89
ILE A  42
GLU A 101
VAL A  44
ILE A  55
None
1.40A 1linA-1r6vA:
undetectable
1linA-1r6vA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sko MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1 INTERACTING
PROTEIN 1


(Homo sapiens)
PF08923
(MAPKK1_Int)
5 ILE A  34
LEU A  10
ILE A  23
GLU A 108
VAL A  91
None
1.28A 1linA-1skoA:
undetectable
1linA-1skoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spx SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5L265)


(Caenorhabditis
elegans)
PF13561
(adh_short_C2)
5 ILE A 146
ILE A 239
GLU A 237
VAL A 238
ILE A 190
None
1.28A 1linA-1spxA:
undetectable
1linA-1spxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE


(Bacillus
anthracis)
PF00809
(Pterin_bind)
5 ILE A  98
ILE A 100
GLU A  79
VAL A  83
ILE A  87
None
1.41A 1linA-1twwA:
undetectable
1linA-1twwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3


(Bos taurus)
PF00022
(Actin)
5 ILE A 195
ILE A 296
GLU A 298
VAL A 299
ILE A 193
None
1.28A 1linA-1u2vA:
undetectable
1linA-1u2vA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE


(Sulfurisphaera
tokodaii)
PF01048
(PNP_UDP_1)
5 ILE A  13
ILE A 248
GLU A 246
VAL A 247
ILE A  89
None
1.44A 1linA-1v4nA:
undetectable
1linA-1v4nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9d DIAPHANOUS PROTEIN
HOMOLOG 1


(Mus musculus)
PF02181
(FH2)
5 ILE A 874
ILE A 861
GLU A 863
VAL A 864
ILE A 923
None
1.14A 1linA-1v9dA:
undetectable
1linA-1v9dA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1veu MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1 INTERACTING
PROTEIN 1


(Mus musculus)
PF08923
(MAPKK1_Int)
5 ILE A  33
LEU A   9
ILE A  22
GLU A 107
VAL A  90
None
1.33A 1linA-1veuA:
undetectable
1linA-1veuA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima)
PF05343
(Peptidase_M42)
5 ILE A 299
LEU A 324
ILE A 260
GLU A 262
ILE A 246
ILE  A 299 ( 0.7A)
LEU  A 324 ( 0.6A)
ILE  A 260 ( 0.7A)
GLU  A 262 ( 0.6A)
ILE  A 246 ( 0.7A)
1.45A 1linA-1vhoA:
undetectable
1linA-1vhoA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965)
5 ILE A 296
ILE A 203
GLU A 200
VAL A 205
ILE A 235
CL  A 813 ( 4.7A)
None
None
None
None
1.44A 1linA-1w7cA:
undetectable
1linA-1w7cA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wba WINGED BEAN ALBUMIN
1


(Psophocarpus
tetragonolobus)
PF00197
(Kunitz_legume)
5 ILE A  59
LEU A  78
ILE A  72
GLU A  74
VAL A   5
None
1.34A 1linA-1wbaA:
undetectable
1linA-1wbaA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES


(Homo sapiens)
PF13833
(EF-hand_8)
5 ILE A  36
LEU A  41
MET A  60
ILE A  61
GLU A  63
None
None
TFP  A 202 ( 4.0A)
None
None
0.45A 1linA-1wrkA:
11.1
1linA-1wrkA:
60.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES


(Homo sapiens)
PF13833
(EF-hand_8)
5 LEU A  41
MET A  60
ILE A  61
GLU A  63
VAL A  64
None
TFP  A 202 ( 4.0A)
None
None
None
0.41A 1linA-1wrkA:
11.1
1linA-1wrkA:
60.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1


(Homo sapiens)
PF03127
(GAT)
5 ILE A 280
LEU A 266
ILE A 218
GLU A 220
VAL A 221
None
1.27A 1linA-1x79A:
undetectable
1linA-1x79A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xbf CLOSTRIDIUM
ACETOBUTYLICUM
Q97KL0


(Clostridium
acetobutylicum)
PF01894
(UPF0047)
5 ILE A  51
LEU A 108
ILE A  99
VAL A  24
ILE A 114
None
1.48A 1linA-1xbfA:
undetectable
1linA-1xbfA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgh METHIONYL-TRNA
FORMYLTRANSFERASE


(Ruminiclostridium
thermocellum)
PF00551
(Formyl_trans_N)
5 ILE A 136
LEU A 120
MET A  75
ILE A 100
ILE A 137
None
None
None
UNX  A 244 ( 4.6A)
UNX  A 238 ( 4.0A)
1.38A 1linA-1zghA:
undetectable
1linA-1zghA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE B 100
LEU B 105
MET B 124
ILE B 125
GLU B 127
None
0.96A 1linA-1zotB:
13.0
1linA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE B 100
LEU B 105
MET B 124
ILE B 125
MET B 144
None
0.60A 1linA-1zotB:
13.0
1linA-1zotB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ILE A 350
LEU A 324
ILE A 326
VAL A 335
ILE A 367
None
1.45A 1linA-1zu4A:
undetectable
1linA-1zu4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 ILE A  66
LEU A 207
ILE A 194
GLU A 192
VAL A 193
None
1.24A 1linA-2akpA:
undetectable
1linA-2akpA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 ILE A  72
LEU A  76
ILE A   5
VAL A  21
ILE A  68
None
1.01A 1linA-2akzA:
undetectable
1linA-2akzA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]


(Ogataea angusta)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
5 LEU A 121
MET A 125
ILE A 124
GLU A 126
ILE A 119
None
1.33A 1linA-2biiA:
undetectable
1linA-2biiA:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN


(Physarum
polycephalum)
PF13833
(EF-hand_8)
5 ILE C  35
LEU C  40
MET C  59
GLU C  62
ILE C  71
None
0.98A 1linA-2bl0C:
11.0
1linA-2bl0C:
44.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN


(Physarum
polycephalum)
PF13833
(EF-hand_8)
5 ILE C  35
LEU C  40
MET C  59
ILE C  71
MET C  79
None
1.16A 1linA-2bl0C:
11.0
1linA-2bl0C:
44.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea)
PF00246
(Peptidase_M14)
5 ILE A  50
LEU A 107
ILE A  83
VAL A  87
ILE A  25
None
1.19A 1linA-2c1cA:
undetectable
1linA-2c1cA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1


(Homo sapiens)
no annotation 5 ILE A  65
LEU A  70
ILE A  90
GLU A  92
VAL A  93
None
0.78A 1linA-2d58A:
9.5
1linA-2d58A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1


(Homo sapiens)
no annotation 5 ILE A  65
LEU A  70
ILE A  90
VAL A  93
MET A 109
None
0.39A 1linA-2d58A:
9.5
1linA-2d58A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgx KIAA0430 PROTEIN

(Homo sapiens)
PF00076
(RRM_1)
5 ILE A 622
LEU A 571
ILE A 562
VAL A 559
ILE A 627
None
1.35A 1linA-2dgxA:
undetectable
1linA-2dgxA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG


(Aquifex
aeolicus)
PF01434
(Peptidase_M41)
5 ILE A 522
LEU A 543
ILE A 547
GLU A 550
VAL A 508
None
1.31A 1linA-2di4A:
undetectable
1linA-2di4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE


(Archaeoglobus
fulgidus)
PF05889
(SepSecS)
5 ILE A 366
ILE A 313
GLU A 308
VAL A 309
ILE A 367
None
1.28A 1linA-2e7jA:
undetectable
1linA-2e7jA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN


(Sulfurisphaera
tokodaii)
PF05694
(SBP56)
5 ILE A 152
LEU A 169
ILE A 108
GLU A 130
VAL A 131
None
1.38A 1linA-2eceA:
undetectable
1linA-2eceA:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN


(Bos taurus)
PF13499
(EF-hand_7)
7 ILE A  27
LEU A  32
MET A  51
ILE A  52
GLU A  54
VAL A  55
ILE A  63
None
0.93A 1linA-2f2pA:
12.6
1linA-2f2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE


(Methanopyrus
kandleri)
PF01913
(FTR)
PF02741
(FTR_C)
5 ILE A 264
ILE A   8
GLU A   2
VAL A   6
ILE A 276
None
1.37A 1linA-2fhkA:
undetectable
1linA-2fhkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsn HYPOTHETICAL PROTEIN
TA0583


(Thermoplasma
acidophilum)
no annotation 5 ILE A 297
LEU A 280
ILE A 175
VAL A 184
ILE A 266
None
1.32A 1linA-2fsnA:
undetectable
1linA-2fsnA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ggm CENTRIN-2

(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE A 121
LEU A 126
MET A 145
ILE A 146
GLU A 148
None
0.75A 1linA-2ggmA:
13.2
1linA-2ggmA:
45.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 ILE A 289
LEU A 283
ILE A 300
VAL A 312
ILE A 306
None
1.45A 1linA-2ggqA:
undetectable
1linA-2ggqA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN


(Salmonella
enterica)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  57
LEU A  60
MET A  97
ILE A 100
ILE A  28
None
1.38A 1linA-2gl5A:
undetectable
1linA-2gl5A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ILE A 305
LEU A 330
ILE A 291
GLU A 322
ILE A 399
None
1.47A 1linA-2gp6A:
undetectable
1linA-2gp6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
5 LEU A 463
ILE A 447
VAL A 440
ILE A 449
MET A 409
None
1.26A 1linA-2hj0A:
undetectable
1linA-2hj0A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5p GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1


(Kluyveromyces
marxianus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE O 161
LEU O 307
ILE O 157
VAL O 259
ILE O 160
None
1.42A 1linA-2i5pO:
undetectable
1linA-2i5pO:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN


(Staphylococcus
aureus)
PF00005
(ABC_tran)
5 ILE A 214
LEU A 232
ILE A 207
GLU A 205
ILE A  32
None
0.99A 1linA-2ihyA:
undetectable
1linA-2ihyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE


(Bacillus sp.
snu-7)
no annotation 5 ILE A 100
LEU A 120
ILE A  82
VAL A 113
ILE A  78
None
1.35A 1linA-2invA:
undetectable
1linA-2invA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Caldanaerobacter
subterraneus)
PF13407
(Peripla_BP_4)
5 ILE A 202
LEU A 178
ILE A 184
VAL A 187
ILE A 210
None
1.47A 1linA-2ioyA:
undetectable
1linA-2ioyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens)
PF00248
(Aldo_ket_red)
5 ILE A  74
LEU A  99
ILE A  58
VAL A  31
ILE A  42
None
1.45A 1linA-2is7A:
undetectable
1linA-2is7A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D


(Escherichia
coli)
PF00849
(PseudoU_synth_2)
PF01479
(S4)
5 ILE A  86
LEU A  84
ILE A  96
VAL A 148
ILE A  94
None
BCT  A 804 (-4.2A)
None
None
None
1.47A 1linA-2istA:
undetectable
1linA-2istA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j22 FUCOLECTIN-RELATED
PROTEIN


(Streptococcus
pneumoniae)
PF00754
(F5_F8_type_C)
5 ILE A  92
LEU A  74
ILE A  76
GLU A 142
ILE A 129
None
None
None
CA  A1150 (-3.5A)
None
1.26A 1linA-2j22A:
undetectable
1linA-2j22A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE


(Escherichia
coli)
PF00692
(dUTPase)
5 LEU A 107
ILE A 135
GLU A  95
VAL A  97
ILE A 127
None
YYY  A1175 (-4.6A)
None
None
YYY  A1175 ( 4.2A)
1.30A 1linA-2j4hA:
undetectable
1linA-2j4hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE


(Acanthamoeba
polyphaga
mimivirus)
PF00579
(tRNA-synt_1b)
5 ILE A  45
ILE A 307
GLU A 238
VAL A 241
ILE A 232
ILE  A  45 ( 0.7A)
ILE  A 307 ( 0.7A)
GLU  A 238 ( 0.6A)
VAL  A 241 ( 0.6A)
ILE  A 232 ( 0.7A)
1.45A 1linA-2j5bA:
undetectable
1linA-2j5bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2


(Homo sapiens)
no annotation 5 ILE B  67
LEU B  72
MET B  88
ILE B  92
ILE B 103
None
1.42A 1linA-2jjzB:
8.8
1linA-2jjzB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2


(Homo sapiens)
no annotation 8 ILE B  67
LEU B  72
MET B  91
ILE B  92
GLU B  94
VAL B  95
ILE B 103
MET B 111
None
0.75A 1linA-2jjzB:
8.8
1linA-2jjzB:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max)
PF13499
(EF-hand_7)
5 ILE A  27
LEU A  32
ILE A  52
ILE A  63
MET A  72
None
0.81A 1linA-2l1wA:
11.5
1linA-2l1wA:
77.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max)
PF13499
(EF-hand_7)
5 ILE A 100
LEU A 105
MET A 124
ILE A 125
MET A 144
None
1.00A 1linA-2l1wA:
11.5
1linA-2l1wA:
77.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1


(Saccharomyces
cerevisiae;
synthetic
construct)
PF13499
(EF-hand_7)
5 ILE A 100
LEU A 105
MET A 124
GLU A 127
VAL A 128
None
0.97A 1linA-2lhiA:
15.1
1linA-2lhiA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lle CHEMOTAXIS PROTEIN
CHEY, IMIDAZOLE
GLYCEROL PHOSPHATE
SYNTHASE SUBUNIT
HISF CHIMERA


(Thermotoga
maritima)
PF00072
(Response_reg)
PF00977
(His_biosynth)
5 ILE A 177
LEU A 149
MET A 165
ILE A 166
GLU A 164
None
1.05A 1linA-2lleA:
undetectable
1linA-2lleA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lmv CALMODULIN-RELATED
PROTEIN 97A


(Drosophila
melanogaster)
PF13499
(EF-hand_7)
5 ILE A 100
LEU A 105
ILE A 125
GLU A 127
ILE A 136
None
0.60A 1linA-2lmvA:
10.6
1linA-2lmvA:
66.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lmv CALMODULIN-RELATED
PROTEIN 97A


(Drosophila
melanogaster)
PF13499
(EF-hand_7)
5 ILE A 100
LEU A 105
MET A 124
ILE A 125
GLU A 127
None
1.00A 1linA-2lmvA:
10.6
1linA-2lmvA:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2u OR358

(synthetic
construct)
no annotation 5 ILE A  37
LEU A  39
MET A  50
VAL A  54
ILE A   6
None
1.37A 1linA-2n2uA:
undetectable
1linA-2n2uA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID


(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE A  27
ILE A  52
VAL A  55
ILE A  63
MET A  71
None
1.05A 1linA-2n6aA:
13.3
1linA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID


(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE A  52
GLU A  54
VAL A  55
ILE A  63
MET A  71
None
1.12A 1linA-2n6aA:
13.3
1linA-2n6aA:
83.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID


(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE A 100
LEU A 105
MET A 124
ILE A 125
MET A 144
None
1.23A 1linA-2n6aA:
13.3
1linA-2n6aA:
83.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ns0 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii)
PF11625
(DUF3253)
5 ILE A  25
ILE A  12
GLU A  58
VAL A  59
ILE A  79
None
1.27A 1linA-2ns0A:
undetectable
1linA-2ns0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvm FDXN ELEMENT
EXCISION CONTROLLING
FACTOR XISI


(Trichormus
variabilis)
PF08869
(XisI)
5 ILE A  82
LEU A  75
ILE A  84
VAL A  94
ILE A 107
None
1.29A 1linA-2nvmA:
undetectable
1linA-2nvmA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obh CENTRIN-2

(Homo sapiens)
PF13499
(EF-hand_7)
5 ILE A 121
LEU A 126
MET A 145
ILE A 146
GLU A 148
None
0.96A 1linA-2obhA:
12.9
1linA-2obhA:
52.08