SIMILAR PATTERNS OF AMINO ACIDS FOR 1LIN_A_TFPA155_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLN A  33
PHE A 137
MET A  67
ALA A  68
 None
 1.00A 1linA-1c1dA:
undetectable		 1linA-1c1dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckr HEAT SHOCK SUBSTRATE
BINDING DOMAIN OF
HSC-70

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 GLU A 520
MET A 408
MET A 447
ALA A 446
 None
 1.30A 1linA-1ckrA:
undetectable		 1linA-1ckrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLN A 127
GLU A 126
MET A  12
ALA A  13
 None
 1.31A 1linA-1f0kA:
undetectable		 1linA-1f0kA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		4 GLN A 229
GLU A 232
PHE A 145
MET A 159
 None
 1.25A 1linA-1hg2A:
undetectable		 1linA-1hg2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsl HISTIDINE-BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		4 GLN A 118
GLU A 123
PHE A  83
ALA A  54
 None
 1.21A 1linA-1hslA:
undetectable		 1linA-1hslA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLN A 301
GLU A  27
MET A 506
ALA A 504
 None
 1.35A 1linA-1kv9A:
undetectable		 1linA-1kv9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 MET A 225
PHE A 176
MET A  33
ALA A  32
 None
 1.23A 1linA-1otwA:
0.0		 1linA-1otwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u05 ORF, CONSERVED
HYPOTHETICAL PROTEIN

(Shigella
flexneri) 		PF02578
(Cu-oxidase_4) 		4 GLU A  49
MET A   1
PHE A 225
ALA A  57
 None
 1.32A 1linA-1u05A:
undetectable		 1linA-1u05A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 239
MET A 301
MET A 402
ALA A 398
 None
 1.27A 1linA-1ulzA:
0.0		 1linA-1ulzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		4 GLU A 247
MET A 237
PHE A 167
ALA A 328
 None
 1.22A 1linA-1umfA:
undetectable		 1linA-1umfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhz ADP COMPOUNDS
HYDROLASE NUDE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 MET A 115
PHE A 164
MET A  51
ALA A  49
 None
 1.22A 1linA-1vhzA:
undetectable		 1linA-1vhzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 GLU A 131
PHE A 106
MET A 189
ALA A 187
 None
MLY  A 107 ( 4.8A)
None
None
 1.25A 1linA-1vk1A:
undetectable		 1linA-1vk1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLN A 409
MET A 435
PHE A 252
ALA A 426
 None
 1.31A 1linA-1wveA:
undetectable		 1linA-1wveA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		4 GLN A 615
GLU A 480
PHE A 555
ALA A 608
 None
 0.99A 1linA-1x9sA:
undetectable		 1linA-1x9sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		4 MET A  36
PHE A 195
MET A 219
ALA A 222
 None
 1.35A 1linA-1xe4A:
undetectable		 1linA-1xe4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd7 2-KETO
ACID:FERREDOXIN
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF01855
(POR_N) 		4 GLN A  61
PHE A 163
MET A  48
ALA A  49
 None
 1.08A 1linA-1yd7A:
undetectable		 1linA-1yd7A:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bl0 MAJOR PLASMODIAL
MYOSIN HEAVY CHAIN
MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF00612
(IQ)
PF13833
(EF-hand_8) 		4 GLN C  16
GLU C  19
MET C  80
ALA A 819
 None
 0.92A 1linA-2bl0C:
11.0		 1linA-2bl0C:
44.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l NONSPECIFIC
LIPID-TRANSFER
PROTEIN

(Homo sapiens) 		PF02036
(SCP2) 		4 GLN B 116
PHE B  55
MET B 104
ALA B 102
 None
 0.91A 1linA-2c0lB:
undetectable		 1linA-2c0lB:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		4 GLU A 291
PHE A 103
MET A 115
ALA A 117
 None
 1.30A 1linA-2csnA:
undetectable		 1linA-2csnA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 245
PHE A 421
MET A 414
ALA A 410
 None
 1.33A 1linA-2dzdA:
undetectable		 1linA-2dzdA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 GLU A  56
MET A 121
MET A 132
ALA A 130
 None
 1.13A 1linA-2h1yA:
undetectable		 1linA-2h1yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLU A 785
PHE A 805
MET A 237
ALA A 482
 None
 1.28A 1linA-2ivfA:
undetectable		 1linA-2ivfA:
10.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1

(Saccharomyces
cerevisiae;
synthetic
construct) 		PF13499
(EF-hand_7) 		4 GLN A  83
GLU A  87
PHE A  19
MET A  72
 None
 1.35A 1linA-2lhiA:
15.1		 1linA-2lhiA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntj ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 GLN A 100
PHE A 149
MET A 199
ALA A 201
 None
P1H  A 300 (-3.5A)
None
None
 1.25A 1linA-2ntjA:
undetectable		 1linA-2ntjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLN B1146
MET B1153
MET B1074
ALA B1162
 None
 1.25A 1linA-2o8eB:
undetectable		 1linA-2o8eB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 MET B1074
MET B1156
MET B1153
ALA B1154
 None
 1.35A 1linA-2o8eB:
undetectable		 1linA-2o8eB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A 258
PHE A 365
MET A 403
ALA A 401
 DTT  A 901 ( 3.8A)
None
None
None
 1.28A 1linA-2panA:
undetectable		 1linA-2panA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		4 GLU A 200
MET A 203
PHE A 296
ALA A 188
 None
 1.36A 1linA-2q9gA:
undetectable		 1linA-2q9gA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 248
PHE A 426
MET A 419
ALA A 415
 None
 1.33A 1linA-2qf7A:
undetectable		 1linA-2qf7A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLU A 239
MET A 302
PHE A 410
ALA A 399
 None
 1.30A 1linA-2vpqA:
undetectable		 1linA-2vpqA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLU A 271
MET A 250
PHE A  74
ALA A 193
 None
 1.35A 1linA-2vr2A:
undetectable		 1linA-2vr2A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC

(Legionella
pneumophila) 		PF06314
(ADC) 		4 GLU A  98
MET A  61
PHE A 123
ALA A 250
 None
None
LCK  A 125 ( 4.1A)
None
 1.02A 1linA-3c8wA:
undetectable		 1linA-3c8wA:
15.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLN A 311
GLU A 314
MET A 375
ALA A 376
 None
 1.27A 1linA-3evrA:
18.7		 1linA-3evrA:
38.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLN A 311
GLU A 314
MET A 375
PHE A 395
 None
 0.58A 1linA-3evrA:
18.7		 1linA-3evrA:
38.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLN A 311
GLU A 314
MET A 375
PHE A 444
 None
 1.09A 1linA-3evrA:
18.7		 1linA-3evrA:
38.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLN A 311
MET A 375
PHE A 395
MET A 448
 None
 1.15A 1linA-3evrA:
18.7		 1linA-3evrA:
38.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 GLN A  68
GLU A  69
PHE A 434
ALA A  38
 None
 1.23A 1linA-3fcrA:
undetectable		 1linA-3fcrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 MET A 260
PHE A 301
MET A 293
ALA A 289
 None
 1.21A 1linA-3gayA:
undetectable		 1linA-3gayA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 MET A 392
PHE A  35
MET A 151
ALA A 153
 None
 1.29A 1linA-3ifeA:
undetectable		 1linA-3ifeA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		4 GLN C 179
GLU C 180
MET C 173
PHE Z  80
 None
 1.35A 1linA-3j7aC:
undetectable		 1linA-3j7aC:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S7,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL

(Bos taurus) 		PF00177
(Ribosomal_S7)
PF00380
(Ribosomal_S9) 		4 GLN I 308
GLU I 311
MET G 111
ALA G 107
 G  A 811 ( 4.4A)
None
None
U  A 719 ( 4.2A)
 1.21A 1linA-3jd5I:
undetectable		 1linA-3jd5I:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLU A 122
PHE A 532
MET A 368
ALA A 371
 None
 1.27A 1linA-3k0sA:
undetectable		 1linA-3k0sA:
13.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 PHE A  36
MET A  88
MET A  89
ALA A  91
 None
 0.82A 1linA-3kf9A:
19.6		 1linA-3kf9A:
56.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqa HEAVY CHAIN OF ANTI
HIV FAB FROM HUMAN
21C ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H  64
MET H  81
MET H  70
ALA H  79
 None
 1.09A 1linA-3lqaH:
undetectable		 1linA-3lqaH:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 GLU A 345
PHE A 461
MET A1016
ALA A1014
 None
 1.16A 1linA-3ne5A:
0.9		 1linA-3ne5A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 GLU A 334
MET A 341
PHE A 157
ALA A 282
 None
 1.21A 1linA-3nixA:
undetectable		 1linA-3nixA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnq N-TERMINAL DOMAIN OF
MOLONEY MURINE
LEUKEMIA VIRUS
INTEGRASE

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 GLN A  48
GLU A  52
MET A  45
MET A  81
 None
 1.35A 1linA-3nnqA:
undetectable		 1linA-3nnqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orw PHOSPHOTRIESTERASE

(Geobacillus
kaustophilus) 		PF02126
(PTE) 		4 GLN A 180
GLU A 103
MET A 236
ALA A 239
 None
 1.35A 1linA-3orwA:
undetectable		 1linA-3orwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		4 GLU A 266
MET A 204
MET A 203
ALA A 202
 None
 1.18A 1linA-3r9wA:
undetectable		 1linA-3r9wA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLN A 123
GLU A 122
MET A   8
ALA A   9
 None
 1.28A 1linA-3s2uA:
undetectable		 1linA-3s2uA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 197
PHE A 258
MET A 228
ALA A 226
 None
 1.30A 1linA-3sqwA:
undetectable		 1linA-3sqwA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 GLN A   5
PHE A 166
MET A  43
ALA A  45
 None
 1.26A 1linA-3tc1A:
undetectable		 1linA-3tc1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)

(Borreliella
burgdorferi) 		PF04069
(OpuAC) 		4 GLN A 110
GLU A 217
PHE A  98
ALA A 144
 None
None
None
BET  A 310 ( 4.0A)
 1.37A 1linA-3tmgA:
undetectable		 1linA-3tmgA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLN A 301
PHE A 367
MET A 333
ALA A 334
 SO4  A 715 (-4.2A)
ATP  A 701 (-3.6A)
None
SO4  A 715 ( 4.5A)
 1.33A 1linA-3w1gA:
undetectable		 1linA-3w1gA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 GLU A 475
PHE A 234
MET A 345
ALA A 347
 None
 1.24A 1linA-3wfzA:
undetectable		 1linA-3wfzA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evf GIARDIN SUBUNIT
ALPHA-1

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 GLU A 124
PHE A  95
MET A 144
ALA A 145
 None
 1.33A 1linA-4evfA:
undetectable		 1linA-4evfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 GLN A  25
PHE A 197
MET A  41
ALA A  39
 None
 1.28A 1linA-4gtnA:
undetectable		 1linA-4gtnA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 GLN A 261
GLU A 193
PHE A 364
ALA A 343
 GLN  A 261 (-0.6A)
GLU  A 193 ( 0.5A)
PHE  A 364 ( 1.3A)
ALA  A 343 ( 0.0A)
 1.36A 1linA-4hneA:
undetectable		 1linA-4hneA:
16.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLN A 311
GLU A 314
MET A 375
PHE A 395
 None
 0.79A 1linA-4i2yA:
18.4		 1linA-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 GLN A 311
MET A 375
PHE A 395
MET A 448
 None
 1.06A 1linA-4i2yA:
18.4		 1linA-4i2yA:
65.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 GLN A  42
GLU A  50
PHE A 123
ALA A  21
 GOL  A 302 (-4.0A)
GOL  A 302 (-2.8A)
None
None
 1.36A 1linA-4jb3A:
undetectable		 1linA-4jb3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLN A 297
GLU A 322
PHE A 141
ALA A 196
 None
 1.26A 1linA-4jhmA:
undetectable		 1linA-4jhmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 4 GLN A 171
MET A 143
MET A 140
ALA A 141
 None
 1.20A 1linA-4jw1A:
undetectable		 1linA-4jw1A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leu PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT3G46870

(Arabidopsis
thaliana) 		PF13041
(PPR_2) 		4 MET A 145
PHE A 103
MET A 110
ALA A 112
 None
 1.22A 1linA-4leuA:
undetectable		 1linA-4leuA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 GLN A 177
GLU A 214
PHE A 295
ALA A 151
 GCU  A 401 ( 3.4A)
None
None
GCU  A 401 (-3.6A)
 1.32A 1linA-4n91A:
undetectable		 1linA-4n91A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		4 GLU A 432
PHE A 327
MET A 345
ALA A 344
 None
 1.24A 1linA-4nscA:
2.2		 1linA-4nscA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 4 GLN A 330
GLU A 326
MET A 283
ALA A 284
 None
 1.31A 1linA-4nuzA:
undetectable		 1linA-4nuzA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		4 GLU A 346
PHE A 297
MET A 176
ALA A 174
 None
 1.04A 1linA-4o8vA:
undetectable		 1linA-4o8vA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph6 3-DEHYDROQUINATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF01487
(DHquinase_I) 		4 GLN A 151
GLU A 152
MET A 191
PHE A 118
 None
 1.08A 1linA-4ph6A:
undetectable		 1linA-4ph6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 GLN A 859
GLU A 856
MET A 939
ALA A 937
 None
 1.35A 1linA-4q0wA:
undetectable		 1linA-4q0wA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU A1951
MET A1938
PHE A1833
ALA A1281
 None
 1.34A 1linA-4r7yA:
0.4		 1linA-4r7yA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 197
PHE A 258
MET A 228
ALA A 226
 None
 1.34A 1linA-4tz0A:
undetectable		 1linA-4tz0A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA

(Escherichia
virus T4;
Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		4 GLN A 257
GLU A 189
PHE A 362
ALA A 341
 ATP  A1201 (-3.1A)
None
None
None
 1.30A 1linA-4wtvA:
undetectable		 1linA-4wtvA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 GLN A 311
GLU A 307
MET A 338
ALA A 336
 None
 1.29A 1linA-4xf5A:
undetectable		 1linA-4xf5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLN A 564
PHE A 807
MET A 438
ALA A 436
 None
 0.96A 1linA-4xvmA:
undetectable		 1linA-4xvmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLN A2431
PHE A2923
MET A2824
ALA A2823
 None
 1.26A 1linA-4z37A:
undetectable		 1linA-4z37A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 GLN K 393
GLU K 391
MET K 400
ALA K 398
 None
 1.29A 1linA-5anbK:
undetectable		 1linA-5anbK:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		4 GLU A1147
PHE A1240
MET A1196
ALA A1200
 None
 1.37A 1linA-5b16A:
undetectable		 1linA-5b16A:
9.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN

(Homo sapiens;
Staphylococcus
aureus) 		PF02216
(B)
PF13499
(EF-hand_7) 		4 PHE A1020
MET A1072
MET A1073
ALA A1074
 None
 1.31A 1linA-5cocA:
13.2		 1linA-5cocA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4w PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 MET A 276
PHE A 351
MET A 301
ALA A 313
 None
 1.34A 1linA-5d4wA:
undetectable		 1linA-5d4wA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE GAMMA
CHAIN
ZETA INHIBITOR
PROTEIN

(Paracoccus
denitrificans) 		PF00231
(ATP-synt)
PF07345
(DUF1476) 		4 GLN G 242
GLU G 241
MET G  24
PHE Z  14
 None
 0.95A 1linA-5dn6G:
undetectable		 1linA-5dn6G:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		4 GLN A 236
PHE A 258
MET A 209
ALA A  75
 None
 1.28A 1linA-5f8vA:
undetectable		 1linA-5f8vA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF00625
(Guanylate_kin)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		4 GLN A 372
MET A 367
MET C 292
ALA C 296
 None
 1.07A 1linA-5gjvA:
undetectable		 1linA-5gjvA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 GLN B1344
PHE B1377
MET B1336
ALA B1337
 None
 1.17A 1linA-5hb4B:
undetectable		 1linA-5hb4B:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j74 SCFV AM2.2

(Homo sapiens) 		PF07686
(V-set) 		4 GLU A  10
PHE A  64
MET A  81
ALA A  79
 None
 1.30A 1linA-5j74A:
undetectable		 1linA-5j74A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k52 ALDEHYDE
DECARBONYLASE

(Limnothrix sp.
KNUA012) 		PF11266
(Ald_deCOase) 		4 GLN A 110
GLU A 115
MET A  59
ALA A  57
 None
OCD  A 500 (-3.5A)
None
None
 1.23A 1linA-5k52A:
undetectable		 1linA-5k52A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 GLN A 365
GLU A 368
MET A 565
ALA A 233
 None
 1.37A 1linA-5lc8A:
undetectable		 1linA-5lc8A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdm GLYCOPROTEIN

(Chandipura
vesiculovirus) 		no annotation 4 GLN E 245
GLU E  39
PHE E 230
ALA E 198
 None
 1.12A 1linA-5mdmE:
undetectable		 1linA-5mdmE:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF08638
(Med14)
PF10156
(Med17) 		4 GLN A 479
GLU A 482
PHE W 441
ALA A 441
 None
 1.02A 1linA-5n9jA:
undetectable		 1linA-5n9jA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 4 GLU A  40
PHE A 143
MET A 118
ALA A 120
 None
 1.34A 1linA-5o7gA:
undetectable		 1linA-5o7gA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 4 GLN B 183
GLU B 185
MET B 170
PHE B 424
 None
 1.21A 1linA-5oetB:
undetectable		 1linA-5oetB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 GLU A 349
PHE A 284
MET A 336
ALA A 338
 None
 1.34A 1linA-5ukgA:
16.5		 1linA-5ukgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 GLN A1077
PHE A 635
MET A 919
ALA A 921
 None
 1.08A 1linA-5yimA:
undetectable		 1linA-5yimA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n PGV19 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 PHE D  63
MET D  80
MET D  69
ALA D  78
 None
 1.25A 1linA-6b0nD:
undetectable		 1linA-6b0nD:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 4 GLN A 255
GLU A 251
PHE A 177
ALA A 290
 None
 1.37A 1linA-6blgA:
undetectable		 1linA-6blgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 GLN A 427
GLU A 237
PHE A 534
ALA A 502
 None
 1.37A 1linA-6es9A:
undetectable		 1linA-6es9A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 GLN A 196
GLU A 153
MET A 100
ALA A 105
 None
 1.33A 1linA-6etzA:
undetectable		 1linA-6etzA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 GLN A 344
MET A  43
PHE A 257
MET A  51
 C3H  A 514 (-2.8A)
None
None
None
 1.28A 1linA-6exsA:
undetectable		 1linA-6exsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 4 GLN A 151
GLU A  68
PHE A  25
MET A 121
 None
 1.01A 1linA-6eyyA:
undetectable		 1linA-6eyyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 4 GLU A 116
MET A  84
PHE A  14
ALA A 163
 None
None
GDN  A 301 ( 4.9A)
None
 1.23A 1linA-6f4fA:
undetectable		 1linA-6f4fA:
18.79