SIMILAR PATTERNS OF AMINO ACIDS FOR 1LIN_A_TFPA154_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)

(Pyrococcus
woesei) 		PF00382
(TFIIB) 		4 LEU B1166
GLU B1132
LEU B1136
GLU B1139
 None
 1.00A 1linA-1aisB:
undetectable		 1linA-1aisB:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 MET A 504
GLU A 573
LEU A 575
GLU A 605
 None
 1.06A 1linA-1cygA:
undetectable		 1linA-1cygA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 GLU A 314
LEU A 248
MET A 291
MET A 338
 None
 1.09A 1linA-1ek2A:
undetectable		 1linA-1ek2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi6 EH DOMAIN PROTEIN
REPS1

(Mus musculus) 		PF12763
(EF-hand_4) 		4 GLU A  92
MET A  95
LEU A  90
GLU A  55
 None
 0.98A 1linA-1fi6A:
0.6		 1linA-1fi6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		4 GLU A 157
LEU A 155
MET A  30
MET A 200
 None
 1.02A 1linA-1fiwA:
undetectable		 1linA-1fiwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 GLU A 157
LEU A 155
MET A  30
MET A 200
 None
 1.08A 1linA-1fizA:
undetectable		 1linA-1fizA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU B  82
MET B  82
LEU B  80
MET B  48
 None
 0.94A 1linA-1fn4B:
undetectable		 1linA-1fn4B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		4 LEU A  80
MET A  23
LEU A  19
GLU A 391
 None
 0.92A 1linA-1fp3A:
undetectable		 1linA-1fp3A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 137
MET A 139
GLU A 157
LEU A 155
 FUC  A 245 (-4.0A)
None
None
None
 1.12A 1linA-1fujA:
undetectable		 1linA-1fujA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 MET A 109
GLU A 114
LEU A 116
MET A 124
 None
 0.77A 1linA-1ggzA:
14.9		 1linA-1ggzA:
84.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 MET A 109
LEU A 116
GLU A 120
MET A 124
 None
 0.73A 1linA-1ggzA:
14.9		 1linA-1ggzA:
84.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 GLU P 257
MET P  76
GLU P  77
LEU P  88
 None
 1.13A 1linA-1hynP:
0.0		 1linA-1hynP:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 LEU A 324
GLU A 224
LEU A 220
GLU A 217
 None
 1.02A 1linA-1j5xA:
undetectable		 1linA-1j5xA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 LEU A 146
MET A 536
LEU A 532
MET A 258
 None
 1.15A 1linA-1l0wA:
0.1		 1linA-1l0wA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxf PTERIDINE REDUCTASE
2

(Trypanosoma
cruzi) 		PF13561
(adh_short_C2) 		4 GLU A 227
MET A 221
LEU A 217
GLU A 239
 None
MTX  A1278 (-4.6A)
None
None
 1.10A 1linA-1mxfA:
undetectable		 1linA-1mxfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 GLU A 383
LEU A 603
GLU A 387
LEU A 484
 None
 1.00A 1linA-1rt8A:
undetectable		 1linA-1rt8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz6 CYTOCHROME C
PEROXIDASE

(Marinobacter
hydrocarbonoclasticus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLU A  40
LEU A 126
MET A 152
MET A 115
 None
None
None
CIT  A 502 ( 4.3A)
 1.14A 1linA-1rz6A:
undetectable		 1linA-1rz6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 LEU C  88
GLU C 112
LEU C  52
GLU C  74
 None
 1.06A 1linA-1sb3C:
undetectable		 1linA-1sb3C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t62 CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF04266
(ASCH) 		4 GLU A1127
LEU A1128
MET A1139
LEU A1141
 None
 1.01A 1linA-1t62A:
undetectable		 1linA-1t62A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmj HYPOTHETICAL PROTEIN
TM0723

(Thermotoga
maritima) 		PF01894
(UPF0047) 		4 LEU A  39
MET A 111
LEU A 113
GLU A 117
 None
 1.15A 1linA-1vmjA:
undetectable		 1linA-1vmjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		4 GLU A 105
LEU A 106
GLU A 133
GLU A  40
 None
 1.14A 1linA-1ytmA:
undetectable		 1linA-1ytmA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Lactococcus
lactis) 		PF01634
(HisG) 		4 LEU E  44
MET E 198
LEU E 202
MET E 181
 None
 1.01A 1linA-1z7mE:
undetectable		 1linA-1z7mE:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  82
MET H  82
LEU H  80
MET H  48
 None
 1.02A 1linA-1zanH:
undetectable		 1linA-1zanH:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 MET B 109
GLU B 114
LEU B 116
GLU B 120
MET B 124
 None
 0.98A 1linA-1zotB:
13.0		 1linA-1zotB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bap DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		no annotation 4 GLU B 230
LEU B 233
GLU B 276
MET B 280
 None
 1.11A 1linA-2bapB:
undetectable		 1linA-2bapB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 LEU A 319
GLU A 211
LEU A 207
GLU A 204
 None
 0.97A 1linA-2cb0A:
undetectable		 1linA-2cb0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 GLU A  69
LEU A 216
GLU A 198
LEU A 200
 None
 1.14A 1linA-2cb1A:
undetectable		 1linA-2cb1A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 GLU A  42
LEU A  40
LEU A  21
GLU A  22
 None
 1.04A 1linA-2dc0A:
undetectable		 1linA-2dc0A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 LEU A 319
GLU A 211
LEU A 207
GLU A 204
 None
 1.04A 1linA-2e5fA:
undetectable		 1linA-2e5fA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9f ARGININOSUCCINATE
LYASE

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 GLU A  95
MET A  87
LEU A  82
GLU A  81
 None
 1.14A 1linA-2e9fA:
undetectable		 1linA-2e9fA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej9 PUTATIVE BIOTIN
LIGASE

(Methanocaldococcus
jannaschii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 GLU A 164
LEU A 160
MET A  56
LEU A  58
 None
 1.04A 1linA-2ej9A:
undetectable		 1linA-2ej9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 LEU A 601
GLU A 488
LEU A 484
GLU A 481
 None
G6Q  A1610 (-2.5A)
None
None
 1.03A 1linA-2j6hA:
undetectable		 1linA-2j6hA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		4 GLU A  91
LEU A  96
GLU A 100
MET A 104
 None
 0.91A 1linA-2j85A:
undetectable		 1linA-2j85A:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kz2 CALMODULIN

(Gallus gallus) 		PF13499
(EF-hand_7) 		4 MET A 109
GLU A 114
LEU A 116
MET A 124
 None
 1.01A 1linA-2kz2A:
9.3		 1linA-2kz2A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 GLU A 147
LEU A 146
GLU A 148
GLU A 153
 GLU  A 147 ( 0.6A)
LEU  A 146 ( 0.6A)
GLU  A 148 ( 0.6A)
GLU  A 153 ( 0.5A)
 0.89A 1linA-2qv2A:
undetectable		 1linA-2qv2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		4 GLU A   2
LEU A   4
LEU A 240
GLU A 239
 None
 0.97A 1linA-2rccA:
undetectable		 1linA-2rccA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 280
MET A 160
LEU A 162
GLU A 164
 None
 1.14A 1linA-2uxtA:
undetectable		 1linA-2uxtA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 GLU A  84
LEU A  88
LEU A  70
MET A 114
 None
 0.91A 1linA-2xdqA:
undetectable		 1linA-2xdqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 4 LEU E 332
GLU E 328
LEU E 323
GLU E 317
 None
 1.07A 1linA-3aoeE:
undetectable		 1linA-3aoeE:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 4 LEU H  82
MET H  82
LEU H  80
MET H  48
 None
 1.05A 1linA-3b9kH:
undetectable		 1linA-3b9kH:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLU A  66
LEU A 121
MET A 274
GLU A 273
 None
 1.06A 1linA-3eb7A:
undetectable		 1linA-3eb7A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg5 PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 GLU B 230
LEU B 233
GLU B 276
MET B 280
 None
 0.99A 1linA-3eg5B:
undetectable		 1linA-3eg5B:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 MET A 412
GLU A 417
LEU A 419
MET A 427
 None
 0.78A 1linA-3evrA:
18.7		 1linA-3evrA:
38.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 MET A 412
LEU A 419
GLU A 423
MET A 427
 None
 0.77A 1linA-3evrA:
18.7		 1linA-3evrA:
38.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		4 GLU A 144
LEU A 145
MET A 123
GLU A  92
 SAH  A 500 (-3.8A)
None
SAH  A 500 (-4.3A)
SAH  A 500 (-2.8A)
 1.08A 1linA-3g2pA:
undetectable		 1linA-3g2pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf9 INTERSECTIN 2

(Homo sapiens) 		PF00621
(RhoGEF) 		4 LEU A1301
MET A1211
LEU A1217
GLU A1221
 None
 1.01A 1linA-3gf9A:
undetectable		 1linA-3gf9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 LEU A  82
GLU A 248
LEU A 127
GLU A 124
 None
 1.10A 1linA-3gszA:
undetectable		 1linA-3gszA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 MET B1105
LEU A  14
GLU A  18
MET A  22
 None
 1.15A 1linA-3hkzB:
undetectable		 1linA-3hkzB:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io5 RECOMBINATION AND
REPAIR PROTEIN

(Escherichia
virus T4) 		PF00154
(RecA) 		4 LEU A 242
MET A  39
LEU A  43
MET A  73
 None
 0.94A 1linA-3io5A:
undetectable		 1linA-3io5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx8 FLUOROACETYL-COA
THIOESTERASE

(Streptomyces
cattleya) 		no annotation 4 LEU A 100
MET A  57
LEU A  61
GLU A  65
 None
 0.92A 1linA-3kx8A:
undetectable		 1linA-3kx8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 393
GLU A 422
LEU A 423
GLU A 426
 None
 0.86A 1linA-3lewA:
undetectable		 1linA-3lewA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		4 MET A 150
GLU A 153
LEU A 154
GLU A 116
 None
 1.03A 1linA-3lp5A:
undetectable		 1linA-3lp5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 GLU A 175
GLU A 171
LEU A 189
GLU A 186
 None
 1.08A 1linA-3m7dA:
undetectable		 1linA-3m7dA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 GLU B  22
LEU B 106
GLU B 136
MET B 156
 None
 1.10A 1linA-3mcaB:
undetectable		 1linA-3mcaB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Marinobacter
hydrocarbonoclasticus) 		PF00440
(TetR_N)
PF13972
(TetR) 		4 GLU A 193
LEU A 133
MET A  80
LEU A  84
 None
None
UNL  A 230 ( 4.3A)
UNL  A 230 ( 4.9A)
 1.11A 1linA-3nnrA:
undetectable		 1linA-3nnrA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLU A  69
GLU A  68
GLU A 105
MET A  76
 None
 1.11A 1linA-3pdwA:
undetectable		 1linA-3pdwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		4 LEU A 433
MET A 431
LEU A 429
MET A 290
 None
 1.13A 1linA-3s7iA:
undetectable		 1linA-3s7iA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 381
GLU A 411
LEU A 412
GLU A 415
 None
 0.81A 1linA-3snxA:
undetectable		 1linA-3snxA:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 LEU A 312
MET A 403
GLU A 408
LEU A 410
GLU A 414
MET A 418
 None
 1.01A 1linA-3u0kA:
17.9		 1linA-3u0kA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 MET C 198
GLU C 202
LEU C 204
MET C 277
 None
 0.86A 1linA-3vtiC:
undetectable		 1linA-3vtiC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 GLU B 217
LEU B 218
LEU B 400
GLU B 364
 None
 1.07A 1linA-3x17B:
undetectable		 1linA-3x17B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 GLU A  95
LEU A  99
MET A  47
LEU A  43
 None
 1.10A 1linA-3zheA:
undetectable		 1linA-3zheA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU A 920
MET A1314
GLU A 929
LEU A 931
 None
 1.08A 1linA-4acqA:
undetectable		 1linA-4acqA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		4 GLU A 252
LEU A 249
LEU A 374
GLU A 377
 None
 1.10A 1linA-4bx9A:
undetectable		 1linA-4bx9A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 GLU B 246
LEU B 226
MET B 177
LEU B 173
 None
 1.15A 1linA-4dvgB:
undetectable		 1linA-4dvgB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 GLU A 175
GLU A 171
LEU A 189
GLU A 186
 None
 1.12A 1linA-4gfjA:
undetectable		 1linA-4gfjA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 2

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 GLU A 221
LEU A 218
LEU A  36
GLU A  34
 None
 0.84A 1linA-4hzuA:
undetectable		 1linA-4hzuA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 LEU A 321
MET A 412
LEU A 419
GLU A 423
MET A 427
 None
 0.84A 1linA-4i2yA:
18.4		 1linA-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 MET A 412
GLU A 417
LEU A 419
GLU A 423
MET A 427
 None
 0.68A 1linA-4i2yA:
18.4		 1linA-4i2yA:
65.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kop SINGLE-STRANDED
DNA-BINDING PROTEIN
WHY2, MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF08536
(Whirly) 		4 LEU A 167
MET A  94
LEU A 115
GLU A 119
 None
 0.88A 1linA-4kopA:
undetectable		 1linA-4kopA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0j DNA HELICASE I

(Escherichia
coli) 		no annotation 4 LEU A 624
GLU A 716
LEU A 718
MET A 745
 None
 1.15A 1linA-4l0jA:
undetectable		 1linA-4l0jA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6c UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF08020
(DUF1706) 		4 MET A 116
GLU A  62
LEU A 120
GLU A 124
 None
 1.13A 1linA-4n6cA:
undetectable		 1linA-4n6cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		4 GLU A 132
LEU A 136
MET A 225
LEU A 116
 None
 1.10A 1linA-4o2xA:
undetectable		 1linA-4o2xA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovb PROTEIN OSA

(Shigella
flexneri) 		no annotation 4 LEU A  91
GLU A  12
LEU A  16
GLU A  19
 None
 0.98A 1linA-4ovbA:
undetectable		 1linA-4ovbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B

(Homo sapiens) 		PF00012
(HSP70) 		4 LEU A 456
LEU A 510
GLU A 514
MET A 518
 None
 1.02A 1linA-4po2A:
undetectable		 1linA-4po2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  72
MET A  70
GLU A  77
LEU A  79
 None
 0.98A 1linA-4qaeA:
undetectable		 1linA-4qaeA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		4 GLU A  64
LEU A 159
GLU A  35
MET A  71
 None
None
MN  A 301 (-2.0A)
None
 1.15A 1linA-4r42A:
undetectable		 1linA-4r42A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 GLU A 155
LEU A 159
MET A 248
LEU A 139
 None
 1.08A 1linA-4wrnA:
undetectable		 1linA-4wrnA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 806
MET A 775
LEU A 751
GLU A 754
 None
 1.11A 1linA-4wz9A:
undetectable		 1linA-4wz9A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 GLU A 133
LEU A 137
MET A 226
LEU A 117
 None
 1.12A 1linA-4xaiA:
undetectable		 1linA-4xaiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvs VRC07_1995
45-VRC01.H01+07.O-86
3513/45-VRC01.L01+07
.O-110653 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  86
MET H  83
LEU H  81
MET H  48
 None
 1.10A 1linA-4xvsH:
undetectable		 1linA-4xvsH:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yd8 PROTEIN PTHB1

(Homo sapiens) 		PF14727
(PHTB1_N) 		4 GLU A  71
LEU A  68
LEU A  14
GLU A  18
 None
 1.14A 1linA-4yd8A:
undetectable		 1linA-4yd8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 GLU A 316
LEU A 250
LEU A 340
MET A 344
 None
 0.95A 1linA-5allA:
1.9		 1linA-5allA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		4 LEU B  40
MET B 196
LEU A  86
GLU A  69
 None
 1.00A 1linA-5c5bB:
undetectable		 1linA-5c5bB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 408
GLU A 431
LEU A 432
GLU A 435
 None
 0.86A 1linA-5cx8A:
undetectable		 1linA-5cx8A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 LEU A 112
GLU A 179
LEU A  96
GLU A 152
 None
 1.08A 1linA-5czzA:
undetectable		 1linA-5czzA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm7 50S RIBOSOMAL
PROTEIN L5

(Deinococcus
radiodurans) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 GLU D  56
LEU D  57
GLU D  38
LEU D  40
 None
 0.90A 1linA-5dm7D:
undetectable		 1linA-5dm7D:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 227
GLU A 186
LEU A 182
MET A 264
 None
 1.14A 1linA-5e8lA:
0.5		 1linA-5e8lA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 327
MET A 583
LEU A 582
MET A 230
 None
 1.08A 1linA-5favA:
undetectable		 1linA-5favA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1

(Sorangium
cellulosum) 		PF00067
(p450) 		4 LEU A 142
MET A 180
LEU A 223
MET A 157
 None
 1.15A 1linA-5hiwA:
undetectable		 1linA-5hiwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLU A 205
GLU A 293
LEU A 276
GLU A 280
 None
 1.13A 1linA-5ip9A:
undetectable		 1linA-5ip9A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 4 GLU A  40
GLU A  36
LEU A  49
GLU A  48
 None
 1.14A 1linA-5jvbA:
undetectable		 1linA-5jvbA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 LEU A  85
MET A 328
LEU A 324
GLU A 287
 None
 1.05A 1linA-5nijA:
undetectable		 1linA-5nijA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 LEU A  85
MET E 328
LEU E 324
GLU E 287
 None
 1.05A 1linA-5obtA:
undetectable		 1linA-5obtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tic ACYL-COA
THIOESTERASE I

(Escherichia
coli) 		PF13472
(Lipase_GDSL_2) 		4 MET A 105
GLU A  69
LEU A  67
MET A 170
 None
 0.84A 1linA-5ticA:
undetectable		 1linA-5ticA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 297
MET A 222
LEU A 205
GLU A 200
 None
 1.00A 1linA-5tufA:
undetectable		 1linA-5tufA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLU A  49
GLU A  45
LEU A 132
GLU A 135
 None
 1.03A 1linA-5wu7A:
undetectable		 1linA-5wu7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A  57
LEU A  56
GLU A  60
GLU A  64
 None
 1.06A 1linA-5y58A:
undetectable		 1linA-5y58A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b FRIZZLED-2
TOXIN B

(Clostridioides
difficile;
Homo sapiens) 		no annotation 4 LEU B 124
MET A1437
LEU A1433
GLU A1471
 PAM  B 202 ( 4.6A)
PAM  B 202 (-3.6A)
PAM  B 202 (-4.2A)
None
 0.94A 1linA-6c0bB:
undetectable		 1linA-6c0bB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 4 GLU A  52
LEU A  65
LEU A   7
GLU A  11
 None
 0.95A 1linA-6dawA:
undetectable		 1linA-6dawA:
19.01