SIMILAR PATTERNS OF AMINO ACIDS FOR 1LIK_A_ADNA799

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw1 TRIOSEPHOSPHATE
ISOMERASE

(Moritella
marina) 		PF00121
(TIM) 		5 GLY A 212
VAL A 215
ALA A 185
ASN A 219
ILE A 229
 PGA  A 290 ( 4.6A)
None
None
None
None
 0.98A 1likA-1aw1A:
undetectable		 1likA-1aw1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		5 THR A  78
ALA A 159
ALA A 154
GLN A 150
ILE A 162
 None
 1.10A 1likA-1b4eA:
undetectable		 1likA-1b4eA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 GLY A 352
VAL A  26
ALA A 329
ALA A 325
ILE A 326
 None
 0.98A 1likA-1cnzA:
undetectable		 1likA-1cnzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 THR A 257
GLY A 274
ALA A 279
ALA A 280
ILE A 172
 None
 1.10A 1likA-1d6sA:
undetectable		 1likA-1d6sA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		6 THR A 278
GLY A 280
HIS A 281
VAL A 284
VAL A 302
ASN A 342
 None
 1.10A 1likA-1dgmA:
48.5		 1likA-1dgmA:
98.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		8 THR A 278
GLY A 280
VAL A 284
VAL A 302
ALA A 316
ASN A 342
ALA A 345
ILE A 349
 None
None
None
None
ACY  A 370 (-4.0A)
None
None
None
 0.58A 1likA-1dgmA:
48.5		 1likA-1dgmA:
98.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		5 GLY A 218
VAL A 221
ALA A 190
ASN A 225
ILE A 235
 None
 1.03A 1likA-1m6jA:
undetectable		 1likA-1m6jA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 THR A 223
GLY A 225
VAL A 229
ALA A 253
ALA A 282
 ADP  A 310 (-3.4A)
ADP  A 310 (-3.7A)
None
ADP  A 310 (-3.5A)
ADP  A 310 (-3.3A)
 0.44A 1likA-1rk2A:
32.9		 1likA-1rk2A:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		5 GLY A  45
ALA A  51
ASN A 142
ALA A  52
ILE A 158
 None
 1.08A 1likA-1sr8A:
undetectable		 1likA-1sr8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 GLY A 212
VAL A 215
ALA A 184
ASN A 219
ILE A 229
 None
 1.02A 1likA-1tcdA:
undetectable		 1likA-1tcdA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		5 HIS A 252
VAL A 236
VAL A 234
ALA A  95
ALA A 228
 None
 1.05A 1likA-1uc8A:
4.2		 1likA-1uc8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 148
HIS A 179
VAL A 121
ALA A 273
ILE A 274
 None
 1.07A 1likA-1y6jA:
2.7		 1likA-1y6jA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 GLY A 172
HIS A 173
VAL A 123
ALA A 130
ALA A 131
 None
 1.03A 1likA-2a7mA:
undetectable		 1likA-2a7mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 GLY A 232
VAL A 260
ALA A  35
ALA A  38
ILE A  34
 None
 0.97A 1likA-2ddwA:
18.3		 1likA-2ddwA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 174
VAL A 335
ALA A 180
ALA A 181
ILE A 170
 NAD  A1350 (-3.2A)
None
None
None
None
 1.10A 1likA-2ejvA:
undetectable		 1likA-2ejvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A  31
VAL A  60
ALA A  37
ALA A  38
ILE A  27
 FAD  A1000 (-3.2A)
None
None
None
None
 1.00A 1likA-2fjaA:
3.5		 1likA-2fjaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		5 GLY A 208
VAL A 211
ALA A 180
ASN A 215
ILE A 225
 None
 1.06A 1likA-2i9eA:
undetectable		 1likA-2i9eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k18 PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		5 VAL A  74
VAL A  28
ALA A  46
ALA A  47
ILE A  50
 None
 0.83A 1likA-2k18A:
undetectable		 1likA-2k18A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		5 GLY A 175
HIS A 181
ALA A 194
ALA A 195
ILE A 198
 None
TCB  A 500 ( 4.6A)
None
None
None
 0.98A 1likA-2o9rA:
undetectable		 1likA-2o9rA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 5 THR A 228
GLY A 226
VAL A 273
ALA A 247
ILE A 246
 None
 0.97A 1likA-2p4oA:
undetectable		 1likA-2p4oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		5 THR A 148
VAL A 151
VAL A 191
ALA A 111
ALA A 115
 None
 1.03A 1likA-2pb0A:
undetectable		 1likA-2pb0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qae DIHYDROLIPOYL
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 443
GLY A 441
ALA A 435
ALA A 430
ILE A 410
 None
 0.99A 1likA-2qaeA:
2.7		 1likA-2qaeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		5 GLY A1373
VAL A1410
ALA A1436
ALA A1433
ILE A1437
 None
 1.11A 1likA-2ri8A:
undetectable		 1likA-2ri8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		5 GLY A  18
VAL A  28
ALA A 350
ALA A 354
ILE A 197
 None
 0.96A 1likA-2uzzA:
4.0		 1likA-2uzzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		5 THR A  95
VAL A 124
ALA A  87
ALA A  32
ILE A  28
 None
 1.11A 1likA-2va1A:
undetectable		 1likA-2va1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvy PROTEIN B15

(Vaccinia virus) 		PF06227
(Poxvirus) 		5 THR A 122
ALA A 112
ASN A 127
ALA A 128
ILE A  34
 None
 1.08A 1likA-2vvyA:
undetectable		 1likA-2vvyA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		5 THR A 167
GLY A  91
ALA A 170
ALA A 174
ILE A 138
 None
 1.08A 1likA-2yn2A:
undetectable		 1likA-2yn2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 GLY D 305
VAL D 337
ALA D 311
ALA D 312
ILE D 301
 None
 1.08A 1likA-2ynmD:
undetectable		 1likA-2ynmD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 GLY Y  54
ALA Y 289
ASN Y 302
ALA Y 301
ILE Y 285
 None
 0.98A 1likA-2zqpY:
undetectable		 1likA-2zqpY:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 GLY A 406
HIS A 600
VAL A 583
ALA A 435
ILE A 379
 None
 1.08A 1likA-2zuxA:
undetectable		 1likA-2zuxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 GLY A 373
HIS A 584
VAL A 567
ALA A 402
ILE A 346
 None
 1.07A 1likA-2zuyA:
undetectable		 1likA-2zuyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 GLY B 112
HIS B 113
ALA B  36
ALA B  35
ILE B  32
 None
 0.97A 1likA-3aqcB:
undetectable		 1likA-3aqcB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0z FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB

(Salmonella
enterica) 		PF01312
(Bac_export_2) 		5 HIS B 308
VAL B 310
ALA B 291
ALA B 276
ILE B 301
 None
 0.97A 1likA-3b0zB:
undetectable		 1likA-3b0zB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf5 RIBOKINASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00294
(PfkB) 		5 THR A 196
GLY A 198
ALA A 225
ALA A 254
ILE A 258
 PGO  A 290 (-4.0A)
PGO  A 290 (-3.8A)
PGO  A 290 ( 4.1A)
PGO  A 290 ( 3.8A)
None
 0.66A 1likA-3bf5A:
23.8		 1likA-3bf5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		5 HIS A  47
ALA A  43
ASN A 263
ALA A  38
ILE A  79
 NI  A 298 (-3.4A)
None
None
None
None
 0.96A 1likA-3c6cA:
undetectable		 1likA-3c6cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		5 THR A 230
HIS A  51
ALA A  47
ASN A 247
ALA A  42
 None
ZN  A 302 (-3.2A)
None
None
None
 0.98A 1likA-3chvA:
undetectable		 1likA-3chvA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d54 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 1

(Thermotoga
maritima) 		PF13507
(GATase_5) 		5 GLY D  96
ALA D  73
ASN D 175
ALA D  76
ILE D  72
 None
 1.03A 1likA-3d54D:
3.2		 1likA-3d54D:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 HIS A 128
ALA A 120
ALA A 124
GLN A 126
ILE A 135
 None
 1.06A 1likA-3e2dA:
undetectable		 1likA-3e2dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		5 THR A 231
HIS A  51
ALA A  47
ASN A 248
ALA A  42
 None
MG  A 282 (-3.4A)
None
None
None
 0.96A 1likA-3fa5A:
undetectable		 1likA-3fa5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		5 GLY A  32
HIS A  31
ALA A 125
ASN A 261
ALA A 123
 CL  A 401 ( 4.1A)
None
None
None
None
 0.95A 1likA-3fobA:
undetectable		 1likA-3fobA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g27 82 PROPHAGE-DERIVED
UNCHARACTERIZED
PROTEIN YBCO

(Escherichia
coli) 		PF07102
(DUF1364) 		5 THR A  84
GLY A  80
ALA A  53
ALA A  31
ILE A  61
 None
 0.97A 1likA-3g27A:
undetectable		 1likA-3g27A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A  72
VAL A  74
ALA A 133
ALA A  85
ILE A 130
 None
 1.09A 1likA-3ghyA:
5.2		 1likA-3ghyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 GLY A  51
VAL A  65
ALA A  94
ASN A 100
ALA A  98
 None
 1.06A 1likA-3hi0A:
undetectable		 1likA-3hi0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 GLY A 211
VAL A 214
ALA A 183
ASN A 218
ILE A 228
 None
 1.07A 1likA-3krsA:
undetectable		 1likA-3krsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		5 GLY A  23
VAL A  99
ALA A 225
ALA A 228
ILE A 224
 None
 1.09A 1likA-3kvoA:
7.2		 1likA-3kvoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A  13
VAL A  99
ALA A 225
ALA A 228
ILE A 224
 None
 1.00A 1likA-3kvoA:
7.2		 1likA-3kvoA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		7 THR A 263
GLY A 265
VAL A 269
VAL A 284
ALA A 298
ALA A 327
ILE A 331
 B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
B4P  A 349 (-4.7A)
None
B4P  A 349 (-3.3A)
B4P  A 349 (-3.4A)
None
 0.47A 1likA-3looA:
44.6		 1likA-3looA:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 GLY A 320
HIS A 319
ALA A 385
ALA A 386
ILE A 389
 None
 1.04A 1likA-3lpsA:
undetectable		 1likA-3lpsA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no5 UNCHARACTERIZED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		5 THR A 226
HIS A  47
ALA A  43
ASN A 243
ALA A  38
 None
ZN  A 275 (-3.3A)
None
None
None
 0.94A 1likA-3no5A:
2.1		 1likA-3no5A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  63
GLY A  61
VAL A  51
ALA A  21
ILE A  19
 None
 0.98A 1likA-3of3A:
undetectable		 1likA-3of3A:
24.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		6 THR A 264
VAL A 283
ALA A 297
ALA A 326
GLN A 327
ILE A 330
 AP5  A 346 (-3.6A)
AP5  A 346 (-4.1A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.0A)
AP5  A 346 (-4.1A)
AP5  A 346 (-4.9A)
 0.48A 1likA-3otxA:
44.8		 1likA-3otxA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		5 THR A 351
GLY A 394
HIS A 392
ALA A 301
ILE A 359
 None
 1.01A 1likA-3qt3A:
undetectable		 1likA-3qt3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE

(Rhipicephalus
microplus) 		PF00121
(TIM) 		5 GLY A 209
VAL A 212
ALA A 181
ASN A 216
ILE A 226
 None
 1.05A 1likA-3th6A:
undetectable		 1likA-3th6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 THR A 245
ALA A 276
ASN A 302
ALA A 305
ILE A 309
 ADP  A 354 (-3.3A)
ADP  A 354 (-3.4A)
ADP  A 354 (-3.5A)
ADP  A 354 (-2.7A)
None
 0.54A 1likA-3uboA:
40.4		 1likA-3uboA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6b VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
VEGF-E

(Homo sapiens;
Orf virus) 		PF00047
(ig)
PF00341
(PDGF) 		5 THR A  43
GLY R 255
ALA R 309
ALA R 248
ILE R 223
 None
 0.94A 1likA-3v6bA:
undetectable		 1likA-3v6bA:
14.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		6 THR A 265
GLY A 267
VAL A 286
ALA A 300
ALA A 329
ILE A 333
 None
 0.41A 1likA-3vasA:
45.8		 1likA-3vasA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 HIS A 128
ALA A 120
ALA A 124
GLN A 126
ILE A 135
 None
 1.05A 1likA-3wbhA:
undetectable		 1likA-3wbhA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 GLY A 357
HIS A 439
ALA A 449
ASN A 183
ILE A 444
 None
 0.87A 1likA-3zx2A:
undetectable		 1likA-3zx2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6s 3-DEHYDROQUINATE
DEHYDRATASE

(Helicobacter
pylori) 		PF01220
(DHquinase_II) 		5 THR A 104
GLY A 130
VAL A 101
ASN A  76
ILE A  30
 2HN  A 200 (-2.9A)
None
None
2HN  A 200 (-3.0A)
None
 1.11A 1likA-4b6sA:
undetectable		 1likA-4b6sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR YWTF

(Bacillus
subtilis) 		PF03816
(LytR_cpsA_psr) 		5 HIS A 205
VAL A 177
VAL A 179
ALA A 214
ILE A 190
 None
 1.03A 1likA-4de9A:
undetectable		 1likA-4de9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 GLY A 225
VAL A 229
VAL A 242
ALA A 254
ALA A 283
 None
 0.42A 1likA-4e69A:
31.8		 1likA-4e69A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus) 		PF00285
(Citrate_synt) 		5 THR A 389
GLY A 391
HIS A 395
VAL A 239
ALA A 162
 None
 1.03A 1likA-4e6yA:
undetectable		 1likA-4e6yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE

(Burkholderia
thailandensis) 		PF00121
(TIM) 		5 GLY A 211
VAL A 214
ALA A 187
ASN A 218
ILE A 228
 None
 1.06A 1likA-4g1kA:
undetectable		 1likA-4g1kA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6b CITRATE SYNTHASE

(Escherichia
coli) 		PF00285
(Citrate_synt) 		5 THR A 388
GLY A 390
HIS A 394
VAL A 238
ALA A 161
 None
 1.08A 1likA-4g6bA:
undetectable		 1likA-4g6bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		5 GLY A 212
VAL A 215
ALA A 184
ASN A 219
ILE A 229
 None
 1.07A 1likA-4gnjA:
undetectable		 1likA-4gnjA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb0 UNCHARACTERIZED
PROTEIN

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
 ACT  A 401 (-2.8A)
None
None
None
None
 0.90A 1likA-4lb0A:
undetectable		 1likA-4lb0A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq4 50S RIBOSOMAL
PROTEIN L1

(Methanocaldococcus
jannaschii) 		PF00687
(Ribosomal_L1) 		5 VAL A 164
VAL A 181
ALA A 199
ALA A  30
ILE A 196
 None
 1.05A 1likA-4lq4A:
undetectable		 1likA-4lq4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7w PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Leptotrichia
buccalis) 		PF01048
(PNP_UDP_1) 		5 THR A  50
GLY A  48
VAL A  38
ALA A   8
ILE A   6
 None
 1.10A 1likA-4m7wA:
undetectable		 1likA-4m7wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE

(Chlamydomonas
reinhardtii) 		PF00121
(TIM) 		5 GLY A 211
VAL A 214
ALA A 183
ASN A 218
ILE A 228
 None
 1.09A 1likA-4mknA:
undetectable		 1likA-4mknA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 182
VAL A 149
ALA A 229
ALA A 225
ILE A 226
 None
 0.91A 1likA-4mksA:
undetectable		 1likA-4mksA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		5 GLY A 210
VAL A 213
ALA A 182
ASN A 217
ILE A 227
 None
 1.05A 1likA-4ohqA:
undetectable		 1likA-4ohqA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		5 THR A 257
GLY A 173
VAL A 147
ALA A  91
ILE A 222
 BCT  A 401 (-2.8A)
None
None
None
None
 0.92A 1likA-4q2hA:
undetectable		 1likA-4q2hA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 ALA A 180
ASN A 125
ALA A 128
GLN A 129
ILE A 132
 None
 0.92A 1likA-4q69A:
undetectable		 1likA-4q69A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH

(Homo sapiens) 		no annotation 5 HIS A1073
ALA A1043
ASN A1028
ALA A1031
ILE A1035
 None
 0.89A 1likA-4qn1A:
undetectable		 1likA-4qn1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk6 GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Weissella
paramesenteroides) 		PF13377
(Peripla_BP_3) 		5 GLY A 225
VAL A 229
ALA A 245
ALA A 243
ILE A 271
 None
 0.83A 1likA-4rk6A:
5.3		 1likA-4rk6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN

(Legionella
pneumophila) 		PF14566
(PTPlike_phytase) 		5 GLY A  68
VAL A 254
ALA A  59
ASN A  65
ILE A  58
 None
CL  A 403 ( 4.1A)
None
CL  A 403 (-4.2A)
None
 0.89A 1likA-4tvvA:
undetectable		 1likA-4tvvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tym PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Streptococcus
agalactiae) 		PF01048
(PNP_UDP_1) 		5 THR A  71
GLY A  69
VAL A  59
ALA A  29
ILE A  27
 None
None
CSO  A  60 ( 3.1A)
None
None
 1.07A 1likA-4tymA:
undetectable		 1likA-4tymA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 VAL A   4
ALA A  24
ALA A 103
GLN A 104
ILE A 107
 None
 1.08A 1likA-4w97A:
undetectable		 1likA-4w97A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 THR A 217
GLY A 219
HIS A 221
ALA A 247
ALA A 289
 ANP  A 401 (-3.5A)
ANP  A 401 (-3.6A)
None
ANP  A 401 (-3.3A)
ANP  A 401 (-3.5A)
 0.88A 1likA-4wjmA:
28.7		 1likA-4wjmA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x22 TRIOSEPHOSPHATE
ISOMERASE

(Leptospira
interrogans) 		PF00121
(TIM) 		5 GLY A 215
VAL A 218
ALA A 185
ASN A 222
ILE A 232
 None
 1.03A 1likA-4x22A:
undetectable		 1likA-4x22A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 THR A 220
GLY A 222
VAL A 226
ALA A 250
ALA A 279
 None
 0.67A 1likA-4x8fA:
29.3		 1likA-4x8fA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		5 THR A 323
GLY A 321
VAL A 273
ALA A 314
GLN A 313
 None
 1.05A 1likA-4y0xA:
undetectable		 1likA-4y0xA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		5 GLY A 220
VAL A 223
ALA A 192
ASN A 227
ILE A 237
 None
 1.03A 1likA-4y9aA:
undetectable		 1likA-4y9aA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Myxococcus
xanthus) 		PF00753
(Lactamase_B) 		5 THR A  64
GLY A  67
VAL A  77
ALA A 222
ALA A  84
 None
 1.04A 1likA-4ysbA:
undetectable		 1likA-4ysbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 GLY D 129
HIS D 130
VAL D 122
ASN D 352
ALA D 356
 None
 0.99A 1likA-4zhsD:
2.9		 1likA-4zhsD:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 GLY D 129
HIS D 130
VAL D 122
ASN D 352
ILE D 134
 None
 0.94A 1likA-4zhsD:
2.9		 1likA-4zhsD:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 THR A 235
GLY A 237
ALA A 267
ASN A 295
ALA A 298
 ACP  A 401 (-3.2A)
ACP  A 401 (-3.3A)
ACP  A 401 (-3.5A)
ACP  A 401 (-3.5A)
ACP  A 401 (-3.3A)
 0.48A 1likA-5c41A:
32.4		 1likA-5c41A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 HIS A1109
VAL A1219
ALA A1129
ALA A1130
ILE A1112
 None
 1.03A 1likA-5d0fA:
undetectable		 1likA-5d0fA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00603
(Flu_PA)
PF00604
(Flu_PB2) 		5 GLY A  66
VAL C 767
ALA A  24
ALA A  21
ILE A  38
 None
 1.10A 1likA-5d9aA:
2.1		 1likA-5d9aA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		5 HIS A 412
VAL A 410
VAL A 424
ALA A  74
ALA A  75
 None
 1.11A 1likA-5hp6A:
undetectable		 1likA-5hp6A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ila PROTEASE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13365
(Trypsin_2) 		5 VAL A 131
VAL A 177
ALA A 168
ALA A 202
ILE A 195
 None
 1.11A 1likA-5ilaA:
undetectable		 1likA-5ilaA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 VAL F 760
ALA F 733
ASN F 764
ALA F 768
ILE F 644
 None
 0.98A 1likA-5it5F:
undetectable		 1likA-5it5F:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		5 GLY A  18
VAL A  36
VAL A  34
ALA A  72
ILE A  23
 None
FAD  A1001 (-4.4A)
None
None
None
 1.07A 1likA-5m5jA:
undetectable		 1likA-5m5jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 5 GLY A 189
VAL A   5
ALA A 201
ALA A 206
ILE A 175
 None
 1.11A 1likA-5n2pA:
undetectable		 1likA-5n2pA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyj ANBU

(Hyphomicrobium
sp. MC1) 		PF00227
(Proteasome) 		5 THR A   1
GLY A 151
HIS A 153
VAL A 191
ILE A 117
 None
 1.10A 1likA-5nyjA:
undetectable		 1likA-5nyjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 THR A  31
GLY A 145
VAL A  27
ALA A 149
GLN A 148
 None
 1.11A 1likA-5oc9A:
undetectable		 1likA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 5 GLY A  48
ALA A  34
ASN A  12
ALA A  11
ILE A   8
 None
 1.00A 1likA-5ugjA:
6.1		 1likA-5ugjA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 GLY A 168
VAL A 166
ALA A 153
ALA A 361
ILE A 360
 None
 1.09A 1likA-5xwyA:
undetectable		 1likA-5xwyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 THR A 157
GLY A 108
VAL A 110
VAL A  82
ALA A  49
 None
 1.01A 1likA-6blbA:
undetectable		 1likA-6blbA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 GLY A 323
VAL A 319
ALA A 268
ALA A 271
ILE A 329
 None
 1.10A 1likA-6chjA:
undetectable		 1likA-6chjA:
12.40