SIMILAR PATTERNS OF AMINO ACIDS FOR 1LIK_A_ADNA699_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aor | ALDEHYDE FERREDOXINOXIDOREDUCTASE (Pyrococcusfuriosus) |
PF01314(AFOR_C)PF02730(AFOR_N) | 5 | LEU A 501GLY A 75GLY A 74THR A 497ASN A 93 | NoneNoneNoneNonePTE A 609 (-3.3A) | 1.17A | 1likA-1aorA:undetectable | 1likA-1aorA:20.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 6 | ASN A 20GLY A 68GLY A 69ASN A 73TYR A 169ASP A 318 | ADN A 375 ( 3.8A)ADN A 375 ( 4.5A)ADN A 375 (-2.9A)ADN A 375 ( 4.9A)ADN A 375 (-3.6A)ADN A 375 ( 3.1A) | 0.51A | 1likA-1dgmA:48.5 | 1likA-1dgmA:98.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 7 | ASN A 20ILE A 22ASP A 24GLY A 68GLY A 69ASN A 73ASP A 318 | ADN A 375 ( 3.8A)ADN A 375 ( 4.3A)ADN A 375 (-2.9A)ADN A 375 ( 4.5A)ADN A 375 (-2.9A)ADN A 375 ( 4.9A)ADN A 375 ( 3.1A) | 0.61A | 1likA-1dgmA:48.5 | 1likA-1dgmA:98.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 9 | ILE A 22ASP A 24LEU A 46GLY A 68GLY A 69ASN A 73CYH A 127THR A 140ASP A 318 | ADN A 375 ( 4.3A)ADN A 375 (-2.9A)NoneADN A 375 ( 4.5A)ADN A 375 (-2.9A)ADN A 375 ( 4.9A)ADN A 375 ( 4.2A)ADN A 375 ( 4.9A)ADN A 375 ( 3.1A) | 0.58A | 1likA-1dgmA:48.5 | 1likA-1dgmA:98.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1goj | KINESIN HEAVY CHAIN (Neurosporacrassa) |
PF00225(Kinesin) | 5 | ILE A 76LEU A 233GLY A 79GLY A 229ASN A 298 | None | 1.05A | 1likA-1gojA:undetectable | 1likA-1gojA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h5q | NADP-DEPENDENTMANNITOLDEHYDROGENASE (Agaricusbisporus) |
PF13561(adh_short_C2) | 5 | LEU A 197GLY A 18GLY A 19ASN A 20THR A 147 | NoneNAP A 263 ( 3.9A)NoneNAP A 263 (-3.6A)NAP A 263 ( 4.5A) | 1.16A | 1likA-1h5qA:6.3 | 1likA-1h5qA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hr7 | MITOCHONDRIALPROCESSING PEPTIDASEBETA SUBUNIT (Saccharomycescerevisiae) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | GLY B 182GLY B 67ASN B 66THR B 103TYR B 198 | None | 1.17A | 1likA-1hr7B:undetectable | 1likA-1hr7B:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hww | ALPHA-MANNOSIDASE II (Drosophilamelanogaster) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 5 | ILE A 831LEU A 847GLY A 853GLY A 854THR A 848 | None | 1.16A | 1likA-1hwwA:undetectable | 1likA-1hwwA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0a | 1-AMINOCYCLOPROPANE-1-CARBOXYLATEDEAMINASE (Pyrococcushorikoshii) |
PF00291(PALP) | 5 | ILE A 55LEU A 61GLY A 51GLY A 52ASN A 111 | None | 1.02A | 1likA-1j0aA:2.5 | 1likA-1j0aA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jr1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (Cricetulusgriseus) |
PF00478(IMPDH)PF00571(CBS) | 5 | LEU A 337GLY A 413GLY A 415CYH A 331THR A 333 | NoneIMP A1331 (-3.5A)IMP A1331 ( 3.1A)IMP A1331 (-1.7A)MOA A1332 (-3.0A) | 1.11A | 1likA-1jr1A:undetectable | 1likA-1jr1A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m5s | FORMYLMETHANOFURAN--TETRAHYDROMETHANOPTERINFORMYLTRANSFERASE (Methanosarcinabarkeri) |
PF01913(FTR)PF02741(FTR_C) | 5 | ILE A 249LEU A 190GLY A 163GLY A 164THR A 193 | None | 1.16A | 1likA-1m5sA:undetectable | 1likA-1m5sA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o9j | ALDEHYDEDEHYDROGENASE,CYTOSOLIC 1 (Elephantulusedwardii) |
PF00171(Aldedh) | 5 | ILE A 482GLY A 478GLY A 481CYH A 132TYR A 485 | None | 1.03A | 1likA-1o9jA:undetectable | 1likA-1o9jA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgu | ACTIN INTERACTINGPROTEIN 1 (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | ASP A 273LEU A 259GLY A 254GLY A 255THR A 269 | None | 1.15A | 1likA-1pguA:undetectable | 1likA-1pguA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pk9 | PURINE NUCLEOSIDEPHOSPHORYLASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 5 | ILE A 185GLY A 187GLY A 184ASN A 116THR A 198 | None | 1.09A | 1likA-1pk9A:undetectable | 1likA-1pk9A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qfx | PROTEIN (PH 2.5 ACIDPHOSPHATASE) (Aspergillusniger) |
PF00328(His_Phos_2) | 5 | ILE A 351LEU A 338GLY A 32GLY A 31ASN A 33 | None | 1.15A | 1likA-1qfxA:undetectable | 1likA-1qfxA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 5 | ASP A 16GLY A 41GLY A 42ASN A 46ASP A 255 | RIB A 311 (-2.8A)RIB A 311 (-3.3A)RIB A 311 (-3.4A)RIB A 311 (-3.3A)RIB A 311 (-3.1A) | 0.42A | 1likA-1rk2A:32.9 | 1likA-1rk2A:26.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz6 | PUTATIVE SUGARKINASE (Salmonellaenterica) |
PF00294(PfkB) | 5 | ASP A 16GLY A 30GLY A 31ASN A 35ASP A 252 | AIS A 402 (-2.5A)AIS A 402 ( 4.2A)AIS A 402 (-3.8A)AIS A 402 (-3.9A)AIS A 402 (-3.0A) | 0.34A | 1likA-1tz6A:30.4 | 1likA-1tz6A:27.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 5 | LEU A 170GLY A 33GLY A 34ASN A 38ASP A 251 | None | 0.91A | 1likA-1v19A:31.5 | 1likA-1v19A:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vm7 | RIBOKINASE (Thermotogamaritima) |
PF00294(PfkB) | 5 | ASP A 14GLY A 39GLY A 40ASN A 44ASP A 246 | None | 0.64A | 1likA-1vm7A:30.5 | 1likA-1vm7A:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w25 | STALKED-CELLDIFFERENTIATIONCONTROLLING PROTEIN (Caulobactervibrioides) |
PF00072(Response_reg)PF00990(GGDEF) | 5 | ASP A 344LEU A 297GLY A 343ASN A 335THR A 295 | C2E A 501 (-3.7A)NoneC2E A 501 (-3.7A)C2E A 501 (-3.1A)None | 1.08A | 1likA-1w25A:2.0 | 1likA-1w25A:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 5 | ASN A 8ASP A 12GLY A 36GLY A 37ASN A 41 | None | 1.14A | 1likA-2abqA:25.7 | 1likA-2abqA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36GLY A 37ASN A 41ASP A 249 | None | 0.42A | 1likA-2abqA:25.7 | 1likA-2abqA:26.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2afb | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermotogamaritima) |
PF00294(PfkB) | 5 | LEU A 171GLY A 32GLY A 33ASN A 37ASP A 280 | None | 1.03A | 1likA-2afbA:29.1 | 1likA-2afbA:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 6 | ASN A 8ASP A 12GLY A 39GLY A 40ASN A 44ASP A 261 | NoneACT A 321 (-3.1A)ACT A 321 ( 4.3A)ACT A 321 (-3.9A)ACT A 321 (-3.9A)None | 1.01A | 1likA-2ajrA:25.1 | 1likA-2ajrA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 5 | ASP A 17GLY A 42GLY A 43ASN A 47ASP A 247 | ADN A1301 (-2.8A)ADN A1301 (-3.4A)ADN A1301 (-3.3A)ADN A1301 (-3.4A)ADN A1301 (-2.9A) | 0.39A | 1likA-2c49A:30.9 | 1likA-2c49A:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2can | ORNITHINEAMINOTRANSFERASE (Homo sapiens) |
PF00202(Aminotran_3) | 5 | LEU A 305GLY A 324GLY A 325ASN A 326TYR A 123 | None | 1.07A | 1likA-2canA:undetectable | 1likA-2canA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f02 | TAGATOSE-6-PHOSPHATEKINASE (Enterococcusfaecalis) |
PF00294(PfkB) | 5 | ASN A 8ASP A 12GLY A 36GLY A 37ASP A 255 | NoneNoneNoneNoneATP A 411 (-4.1A) | 1.02A | 1likA-2f02A:24.8 | 1likA-2f02A:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f02 | TAGATOSE-6-PHOSPHATEKINASE (Enterococcusfaecalis) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36GLY A 37ASN A 41ASP A 255 | NoneNoneNoneNoneATP A 411 (-4.1A) | 0.82A | 1likA-2f02A:24.8 | 1likA-2f02A:25.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f5v | PYRANOSE 2-OXIDASE (Peniophora sp.SG) |
PF05199(GMC_oxred_C) | 5 | ILE A 57GLY A 581GLY A 582ASN A 585THR A 60 | FAD A1625 (-4.0A)NoneFAD A1625 ( 3.9A)NoneNone | 0.99A | 1likA-2f5vA:2.2 | 1likA-2f5vA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ffj | CONSERVEDHYPOTHETICAL PROTEIN (Archaeoglobusfulgidus) |
PF01937(DUF89) | 5 | ILE A 191ASP A 194LEU A 11ASN A 215ASN A 248 | None | 1.10A | 1likA-2ffjA:2.9 | 1likA-2ffjA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fko | 173AA LONGHYPOTHETICALFERRIPYOCHELINBINDING PROTEIN (Pyrococcushorikoshii) |
PF00132(Hexapep) | 5 | ASN A 83ILE A 99GLY A 98GLY A 81ASN A 155 | None | 0.99A | 1likA-2fkoA:undetectable | 1likA-2fkoA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i3o | GAMMA-GLUTAMYLTRANSFERASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF01019(G_glu_transpept) | 5 | ILE A 112LEU A 75GLY A 56GLY A 59ASN A 350 | None | 1.16A | 1likA-2i3oA:undetectable | 1likA-2i3oA:20.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 7 | ASN A 14ASP A 18GLY A 63GLY A 64ASN A 68CYH A 123ASP A 300 | 89I A 500 (-4.0A)NoneNone89I A 500 (-3.5A)NoneNoneNone | 0.48A | 1likA-2i6bA:39.4 | 1likA-2i6bA:32.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 7 | ASP A 18LEU A 40GLY A 63GLY A 64ASN A 68CYH A 123ASP A 300 | None89I A 500 ( 4.8A)None89I A 500 (-3.5A)NoneNoneNone | 0.52A | 1likA-2i6bA:39.4 | 1likA-2i6bA:32.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36GLY A 37ASN A 41ASP A 249 | None | 0.66A | 1likA-2jg5A:24.8 | 1likA-2jg5A:24.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgv | TAGATOSE-6-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36GLY A 37ASN A 41ASP A 254 | None | 0.92A | 1likA-2jgvA:24.6 | 1likA-2jgvA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgv | TAGATOSE-6-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ASP A 12GLY A 36GLY A 37ASN A 41CYH A 90 | None | 0.96A | 1likA-2jgvA:24.6 | 1likA-2jgvA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwh | CARBOHYDRATE KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 5 | ASP A 13GLY A 37GLY A 38ASN A 42ASP A 253 | NoneNone CL A 403 (-3.5A)NoneNone | 0.99A | 1likA-2nwhA:25.6 | 1likA-2nwhA:26.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pef | SERINE PROTEASEINHIBITOR (Caldanaerobactersubterraneus) |
PF00079(Serpin) | 5 | ASN A 286ILE A 289LEU A 420ASN A 73THR A 418 | None | 1.17A | 1likA-2pefA:undetectable | 1likA-2pefA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qcv | PUTATIVE5-DEHYDRO-2-DEOXYGLUCONOKINASE (Bacillushalodurans) |
PF00294(PfkB) | 5 | ASP A 22GLY A 43GLY A 44ASN A 48ASP A 272 | NoneNoneNoneNonePGE A 332 (-3.6A) | 0.44A | 1likA-2qcvA:31.6 | 1likA-2qcvA:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qm6 | GAMMA-GLUTAMYLTRANSPEPTIDASE (Helicobacterpylori) |
PF01019(G_glu_transpept) | 5 | ILE B 476GLY B 473GLY B 472THR B 396ASN B 400 | NoneGLU B 1 (-3.6A)GLU B 1 (-3.6A)NoneGLU B 1 (-3.5A) | 1.04A | 1likA-2qm6B:undetectable | 1likA-2qm6B:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2raa | PYRUVATE SYNTHASESUBUNIT PORC (Thermotogamaritima) |
PF01558(POR) | 5 | ASN A 57ILE A 59ASP A 61LEU A 145GLY A 60 | None | 1.12A | 1likA-2raaA:4.6 | 1likA-2raaA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rb7 | PEPTIDASE,M20/M25/M40 FAMILY (Desulfovibrioalaskensis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ASN A 144ILE A 53ASP A 74GLY A 136ASP A 309 | None | 1.11A | 1likA-2rb7A:undetectable | 1likA-2rb7A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsg | CCMAN5 (Cellulosimicrobiumcellulans) |
PF07971(Glyco_hydro_92) | 5 | ASP A 660GLY A 71GLY A 72ASN A 49THR A 626 | NoneB3P A1773 (-3.3A)B3P A1773 (-4.1A)NoneNone | 1.13A | 1likA-2xsgA:undetectable | 1likA-2xsgA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z80 | TOLL-LIKE RECEPTOR2, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13855(LRR_8) | 5 | ASN A 62ILE A 64LEU A 57GLY A 87ASN A 134 | None | 1.15A | 1likA-2z80A:undetectable | 1likA-2z80A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | ASN A 548ASP A 534GLY A 529GLY A 530ASP A 513 | None CA A 625 ( 2.4A) CA A 625 (-4.4A) CA A 625 (-4.3A)None | 1.09A | 1likA-2z8zA:undetectable | 1likA-2z8zA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai2 | NADPH-SORBOSEREDUCTASE (Gluconobacterfrateurii) |
PF13561(adh_short_C2) | 5 | ASN A 98LEU A 202GLY A 96THR A 198TYR A 153 | None | 0.92A | 1likA-3ai2A:7.6 | 1likA-3ai2A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1r | RIBOKINASE, PUTATIVE (Burkholderiathailandensis) |
PF00294(PfkB) | 5 | ASP A 12GLY A 47GLY A 48ASN A 52ASP A 253 | AMP A 501 (-2.9A)AMP A 501 ( 3.7A)AMP A 501 (-3.3A)AMP A 501 (-3.3A)AMP A 501 (-2.8A) | 0.53A | 1likA-3b1rA:25.0 | 1likA-3b1rA:25.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dkn | PREPROTEINTRANSLOCASE SUBUNITSECY (Canis lupus) |
PF00344(SecY) | 5 | ILE A 75LEU A 172GLY A 76GLY A 74TYR A 37 | None | 1.14A | 1likA-3dknA:undetectable | 1likA-3dknA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 6 | ASP A 13LEU A 167GLY A 33GLY A 34ASN A 38ASP A 247 | None | 0.78A | 1likA-3ewmA:29.0 | 1likA-3ewmA:26.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3go7 | RIBOKINASE RBSK (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | ASP A 25GLY A 50GLY A 51ASN A 55ASP A 242 | RIB A 305 (-2.8A)RIB A 305 ( 3.7A)RIB A 305 (-3.1A)RIB A 305 (-3.2A)RIB A 305 (-2.9A) | 0.46A | 1likA-3go7A:29.5 | 1likA-3go7A:26.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | MITOCHONDRIALUBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEXCORE PROTEIN I (Gallus gallus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | GLY A 169GLY A 54ASN A 53THR A 90TYR A 185 | None | 1.09A | 1likA-3h1lA:undetectable | 1likA-3h1lA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hj6 | FRUCTOKINASE (Halothermothrixorenii) |
PF00294(PfkB) | 6 | ASP A 33LEU A 188GLY A 54GLY A 55ASN A 59ASP A 275 | None | 0.81A | 1likA-3hj6A:28.8 | 1likA-3hj6A:26.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 5 | ASP A 12GLY A 37GLY A 38ASN A 42ASP A 232 | None | 0.87A | 1likA-3i3yA:26.1 | 1likA-3i3yA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 5 | ASP A 12GLY A 37GLY A 38ASN A 42THR A 107 | None | 0.68A | 1likA-3i3yA:26.1 | 1likA-3i3yA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5b | WSPR RESPONSEREGULATOR (Pseudomonasaeruginosa) |
PF00990(GGDEF) | 5 | ASP A 226LEU A 179GLY A 225ASN A 217THR A 177 | None | 1.14A | 1likA-3i5bA:undetectable | 1likA-3i5bA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5c | FUSION OF GENERALCONTROL PROTEIN GCN4AND WSPR RESPONSEREGULATOR PROTEIN (Pseudomonasaeruginosa;Saccharomycescerevisiae) |
PF00990(GGDEF) | 5 | ASP A 226LEU A 179GLY A 225ASN A 217THR A 177 | None | 1.09A | 1likA-3i5cA:undetectable | 1likA-3i5cA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 6 | ILE A 13ASP A 15GLY A 41GLY A 42ASN A 46ASP A 260 | None | 0.80A | 1likA-3in1A:28.9 | 1likA-3in1A:26.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 5 | ASP A 12LEU A 101GLY A 26GLY A 27ASP A 237 | AMP A 509 (-2.8A)NoneAMP A 509 ( 3.8A)AMP A 509 (-3.4A)AMP A 509 ( 3.3A) | 1.04A | 1likA-3kd6A:25.3 | 1likA-3kd6A:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lki | FRUCTOKINASE (Xylellafastidiosa) |
PF00294(PfkB) | 5 | ASN A 146ASP A 24GLY A 44GLY A 45ASN A 49 | None | 1.04A | 1likA-3lkiA:25.5 | 1likA-3lkiA:25.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 9 | ASN A 14ASP A 18LEU A 40GLY A 63GLY A 64ASN A 68CYH A 122ASN A 296ASP A 300 | B4P A 349 ( 4.0A)B4P A 349 (-2.8A)NoneB4P A 349 ( 3.8A)B4P A 349 (-3.5A)B4P A 349 (-3.6A)B4P A 349 (-3.6A)B4P A 349 (-3.6A)B4P A 349 (-3.4A) | 0.76A | 1likA-3looA:44.6 | 1likA-3looA:34.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mos | TRANSKETOLASE (Homo sapiens) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE A 568LEU A 512GLY A 567TYR A 447ASP A 433 | None | 1.00A | 1likA-3mosA:undetectable | 1likA-3mosA:20.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 8 | ASN A 13ASP A 17LEU A 39GLY A 62GLY A 63ASN A 67CYH A 123ASP A 299 | AP5 A 346 (-4.1A)AP5 A 346 (-2.8A)NoneAP5 A 346 (-3.6A)AP5 A 346 (-3.5A)AP5 A 346 (-3.4A)AP5 A 346 (-3.7A)AP5 A 346 ( 3.2A) | 0.41A | 1likA-3otxA:44.8 | 1likA-3otxA:34.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl2 | SUGAR KINASE,RIBOKINASE FAMILY (Corynebacteriumglutamicum) |
PF00294(PfkB) | 5 | ASP A 19GLY A 40GLY A 41ASN A 45ASP A 264 | None | 0.45A | 1likA-3pl2A:31.4 | 1likA-3pl2A:25.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 6 | ASN A 8ASP A 12GLY A 37GLY A 38CYH A 92ASP A 251 | None | 0.90A | 1likA-3q1yA:25.9 | 1likA-3q1yA:25.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvl | PUTATIVE HYDANTOINRACEMASE (Klebsiellapneumoniae) |
PF01177(Asp_Glu_race) | 5 | LEU A 148GLY A 185GLY A 186THR A 119ASN A 12 | None5HY A 1 (-3.8A)None5HY A 1 (-3.6A)5HY A 1 (-4.0A) | 1.13A | 1likA-3qvlA:undetectable | 1likA-3qvlA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry7 | RIBOKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 5 | ASP A 14GLY A 40GLY A 41ASN A 45ASP A 254 | GOL A 401 (-3.1A)GOL A 401 ( 3.7A)GOL A 401 (-3.8A)GOL A 401 (-3.9A)None | 0.56A | 1likA-3ry7A:27.8 | 1likA-3ry7A:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tvk | DIGUANYLATE CYCLASEDGCZ (Escherichiacoli) |
PF00990(GGDEF) | 5 | ASP A 182LEU A 137GLY A 181ASN A 173THR A 135 | C2E A 501 (-3.6A)NoneC2E A 501 (-3.4A)C2E A 501 (-3.1A)None | 1.15A | 1likA-3tvkA:undetectable | 1likA-3tvkA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubm | FORMYL-COA:OXALATECOA-TRANSFERASE (Acetobacteraceti) |
PF02515(CoA_transf_3) | 5 | ILE A 50ASP A 49LEU A 55GLY A 21ASN A 70 | None | 1.17A | 1likA-3ubmA:3.5 | 1likA-3ubmA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 10 | ASN A 11ILE A 13ASP A 15LEU A 37GLY A 58GLY A 59ASN A 63THR A 129TYR A 158ASP A 278 | ADN A 353 (-3.7A)ADN A 353 (-3.7A)ADN A 353 (-2.8A)NoneADN A 353 (-3.3A)ADN A 353 (-3.2A)ADN A 353 (-3.4A)ADN A 353 (-3.3A)ADN A 353 (-3.6A)ADN A 353 (-3.3A) | 0.44A | 1likA-3uboA:40.3 | 1likA-3uboA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqe | 6-PHOSPHOFRUCTOKINASE ISOZYME 2 (Escherichiacoli) |
PF00294(PfkB) | 5 | ASP A 14GLY A 38GLY A 39ASN A 43ASP A 256 | None | 0.73A | 1likA-3uqeA:24.8 | 1likA-3uqeA:27.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 9 | ASN A 14ASP A 18LEU A 40GLY A 63GLY A 64ASN A 68THR A 136ASN A 298ASP A 302 | ADN A 401 ( 4.0A)ADN A 401 (-2.7A)NoneADN A 401 ( 3.8A)ADN A 401 (-3.7A)ADN A 401 (-3.7A)ADN A 401 (-3.1A)ADN A 401 (-3.7A)ADN A 401 (-2.9A) | 0.34A | 1likA-3vasA:45.8 | 1likA-3vasA:30.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnp | HYPOTHETICALCONSERVED PROTEIN (Geobacilluskaustophilus) |
PF00132(Hexapep) | 5 | ILE A 30LEU A 63GLY A 31ASN A 53ASP A 75 | None | 1.17A | 1likA-3vnpA:undetectable | 1likA-3vnpA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | ILE A 710LEU A 646GLY A 709GLY A 708ASP A 515 | None | 1.14A | 1likA-4bedA:undetectable | 1likA-4bedA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 10 | ASN A 9ILE A 11ASP A 13LEU A 35GLY A 56GLY A 57ASN A 61THR A 127TYR A 156ASP A 276 | ADN A 500 (-3.8A)ADN A 500 (-3.6A)ADN A 500 (-2.7A)NoneADN A 500 (-3.5A)ADN A 500 (-3.7A)ADN A 500 (-3.5A)ADN A 500 (-3.0A)ADN A 500 (-3.8A)ADN A 500 (-2.8A) | 0.42A | 1likA-4e3aA:40.6 | 1likA-4e3aA:27.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fym | OROTATEPHOSPHORIBOSYLTRANSFERASE (Plasmodiumfalciparum) |
PF00156(Pribosyltran) | 5 | ILE A 207LEU A 148GLY A 137GLY A 132THR A 144 | None | 1.04A | 1likA-4fymA:undetectable | 1likA-4fymA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gm6 | PFKB FAMILYCARBOHYDRATE KINASE (Listeria grayi) |
PF00294(PfkB) | 5 | LEU A 172GLY A 33GLY A 34ASN A 38ASP A 270 | NoneGOL A 401 ( 4.1A)GOL A 401 (-3.7A)GOL A 401 (-4.4A)GOL A 401 (-3.0A) | 0.93A | 1likA-4gm6A:28.2 | 1likA-4gm6A:24.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 5 | ASP A 12GLY A 47GLY A 48ASN A 52ASP A 257 | HO4 A 401 (-2.4A)HO4 A 401 (-3.5A)HO4 A 401 (-3.5A)HO4 A 401 (-3.8A)HO4 A 401 (-3.3A) | 0.42A | 1likA-4pvvA:28.6 | 1likA-4pvvA:26.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r4z | PNGF-II (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 5 | ASN A 468ILE A 308GLY A 307THR A 326ASP A 243 | None | 1.12A | 1likA-4r4zA:undetectable | 1likA-4r4zA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvw | ZNUD (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY A 67GLY A 66ASN A 48TYR A 191ASP A 51 | None | 1.17A | 1likA-4rvwA:undetectable | 1likA-4rvwA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urs | DIGUANYLATE CYCLASE (Thermotogamaritima) |
PF00990(GGDEF) | 5 | ASP A 143LEU A 96GLY A 142ASN A 134THR A 94 | ASP A 143 ( 0.6A)LEU A 96 ( 0.6A)GLY A 142 ( 0.0A)ASN A 134 ( 0.6A)THR A 94 ( 0.8A) | 1.15A | 1likA-4ursA:undetectable | 1likA-4ursA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | ASP A 11GLY A 29GLY A 30ASN A 34ASP A 249 | NoneNoneNoneNoneANP A 401 ( 4.3A) | 0.60A | 1likA-4wjmA:28.7 | 1likA-4wjmA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | LEU A 162GLY A 29GLY A 30ASN A 34ASP A 249 | NoneNoneNoneNoneANP A 401 ( 4.3A) | 0.93A | 1likA-4wjmA:28.7 | 1likA-4wjmA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8f | RIBOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 5 | ASP A 13GLY A 38GLY A 39ASN A 43ASP A 252 | None | 0.62A | 1likA-4x8fA:29.3 | 1likA-4x8fA:24.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xf7 | CARBOHYDRATE/PYRIMIDINE KINASE, PFKBFAMILY (Thermococcuskodakarensis) |
no annotation | 5 | ASP A 12GLY A 25GLY A 26THR A 73ASP A 219 | INS A 301 (-2.8A)INS A 301 (-3.1A)INS A 301 (-3.1A)NoneINS A 301 (-2.7A) | 1.16A | 1likA-4xf7A:22.9 | 1likA-4xf7A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yo7 | SUGAR ABCTRANSPORTER(SUGAR-BINDINGPROTEIN) (Bacillushalodurans) |
PF13407(Peripla_BP_4) | 5 | ILE A 148GLY A 151GLY A 186ASN A 187ASN A 232 | None | 1.03A | 1likA-4yo7A:3.9 | 1likA-4yo7A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzo | PUTATIVE ACYL-COAACYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 269GLY A 359GLY A 361ASN A 362ASN A 74 | None | 1.16A | 1likA-4yzoA:undetectable | 1likA-4yzoA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zmu | DIGUANYLATE CYCLASE (Pseudomonasaeruginosa) |
PF00990(GGDEF)PF01590(GAF) | 5 | ASP A 236LEU A 189GLY A 235ASN A 227THR A 187 | None | 1.07A | 1likA-4zmuA:undetectable | 1likA-4zmuA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 5 | ILE A1374LEU A1274GLY A1310ASN A1312CYH A1306 | None | 1.07A | 1likA-5a31A:undetectable | 1likA-5a31A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bpk | GAMMA-GLUTAMYLTRANSPEPTIDASE (GGT) (Helicobacterpylori) |
PF01019(G_glu_transpept) | 5 | ILE C 476GLY C 473GLY C 472THR C 396ASN C 400 | None4UD C 701 (-3.5A)4UD C 701 (-4.4A)None4UD C 701 (-3.4A) | 1.01A | 1likA-5bpkC:undetectable | 1likA-5bpkC:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 5 | ASP A 27GLY A 52GLY A 53ASN A 57ASP A 269 | NoneNoneNoneNone NA A 403 ( 4.7A) | 0.56A | 1likA-5c41A:32.4 | 1likA-5c41A:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx5 | METHIONINEGAMMA-LYASE (Clostridiumsporogenes) |
PF01053(Cys_Met_Meta_PP) | 5 | ILE A 92LEU A 112GLY A 90GLY A 88THR A 116 | NoneNoneNonePLP A 501 (-3.1A)None | 1.18A | 1likA-5dx5A:undetectable | 1likA-5dx5A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erb | POLYKETIDE SYNTHASE (Bacillusamyloliquefaciens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A 365LEU A 372GLY A 209GLY A 208THR A 369 | None | 1.09A | 1likA-5erbA:undetectable | 1likA-5erbA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey7 | FRUCTOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 5 | ASP A 30GLY A 44GLY A 45ASN A 49ASP A 266 | None | 0.48A | 1likA-5ey7A:30.0 | 1likA-5ey7A:28.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvn | 3-DEHYDROQUINATESYNTHASE (Francisellatularensis) |
PF01761(DHQ_synthase) | 5 | ILE A 107LEU A 99GLY A 104GLY A 103THR A 111 | NoneNoneNAD A 401 (-3.4A)NoneNone | 1.10A | 1likA-5hvnA:undetectable | 1likA-5hvnA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ik2 | ATP SYNTHASE SUBUNITALPHA (Caldalkalibacillusthermarum) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | ILE A 150ASP A 154LEU A 344GLY A 149ASN A 185 | None | 1.17A | 1likA-5ik2A:undetectable | 1likA-5ik2A:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3c | DIGUANYLATE CYCLASE (Pseudomonasaeruginosa) |
no annotation | 5 | ASP A 863LEU A 816GLY A 862ASN A 854THR A 814 | GTP A1304 (-3.6A)NoneGTP A1304 (-3.4A)GTP A1304 (-2.9A)None | 1.11A | 1likA-5m3cA:undetectable | 1likA-5m3cA:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5viu | ACETYLORNITHINEAMINOTRANSFERASE (Elizabethkingiaanophelis) |
PF00202(Aminotran_3) | 5 | LEU A 274GLY A 293GLY A 294ASN A 295TYR A 90 | None | 1.04A | 1likA-5viuA:undetectable | 1likA-5viuA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysq | TM0415 (Thermotogamaritima) |
no annotation | 5 | LEU A 37GLY A 231GLY A 233THR A 33ASN A 114 | NoneINS A 301 ( 4.7A)SO4 A 302 (-3.2A)NoneNone | 1.01A | 1likA-5ysqA:24.6 | 1likA-5ysqA:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw5 | RIBOKINASE (Cryptococcusneoformans) |
no annotation | 5 | ASP A 16GLY A 41GLY A 42ASN A 46ASP A 273 | GOL A 400 (-2.8A)GOL A 400 (-3.5A)GOL A 400 (-3.3A)GOL A 400 (-3.3A)None | 0.45A | 1likA-6cw5A:31.2 | 1likA-6cw5A:14.33 |