SIMILAR PATTERNS OF AMINO ACIDS FOR 1LIK_A_ADNA699

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE


(Pyrococcus
furiosus)
PF01314
(AFOR_C)
PF02730
(AFOR_N)
5 LEU A 501
GLY A  75
GLY A  74
THR A 497
ASN A  93
None
None
None
None
PTE  A 609 (-3.3A)
1.17A 1likA-1aorA:
undetectable
1likA-1aorA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
6 ASN A  20
GLY A  68
GLY A  69
ASN A  73
TYR A 169
ASP A 318
ADN  A 375 ( 3.8A)
ADN  A 375 ( 4.5A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
ADN  A 375 (-3.6A)
ADN  A 375 ( 3.1A)
0.51A 1likA-1dgmA:
48.5
1likA-1dgmA:
98.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
7 ASN A  20
ILE A  22
ASP A  24
GLY A  68
GLY A  69
ASN A  73
ASP A 318
ADN  A 375 ( 3.8A)
ADN  A 375 ( 4.3A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.5A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
ADN  A 375 ( 3.1A)
0.61A 1likA-1dgmA:
48.5
1likA-1dgmA:
98.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
9 ILE A  22
ASP A  24
LEU A  46
GLY A  68
GLY A  69
ASN A  73
CYH A 127
THR A 140
ASP A 318
ADN  A 375 ( 4.3A)
ADN  A 375 (-2.9A)
None
ADN  A 375 ( 4.5A)
ADN  A 375 (-2.9A)
ADN  A 375 ( 4.9A)
ADN  A 375 ( 4.2A)
ADN  A 375 ( 4.9A)
ADN  A 375 ( 3.1A)
0.58A 1likA-1dgmA:
48.5
1likA-1dgmA:
98.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa)
PF00225
(Kinesin)
5 ILE A  76
LEU A 233
GLY A  79
GLY A 229
ASN A 298
None
1.05A 1likA-1gojA:
undetectable
1likA-1gojA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE


(Agaricus
bisporus)
PF13561
(adh_short_C2)
5 LEU A 197
GLY A  18
GLY A  19
ASN A  20
THR A 147
None
NAP  A 263 ( 3.9A)
None
NAP  A 263 (-3.6A)
NAP  A 263 ( 4.5A)
1.16A 1likA-1h5qA:
6.3
1likA-1h5qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT


(Saccharomyces
cerevisiae)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 GLY B 182
GLY B  67
ASN B  66
THR B 103
TYR B 198
None
1.17A 1likA-1hr7B:
undetectable
1likA-1hr7B:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
5 ILE A 831
LEU A 847
GLY A 853
GLY A 854
THR A 848
None
1.16A 1likA-1hwwA:
undetectable
1likA-1hwwA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE


(Pyrococcus
horikoshii)
PF00291
(PALP)
5 ILE A  55
LEU A  61
GLY A  51
GLY A  52
ASN A 111
None
1.02A 1likA-1j0aA:
2.5
1likA-1j0aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2


(Cricetulus
griseus)
PF00478
(IMPDH)
PF00571
(CBS)
5 LEU A 337
GLY A 413
GLY A 415
CYH A 331
THR A 333
None
IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
IMP  A1331 (-1.7A)
MOA  A1332 (-3.0A)
1.11A 1likA-1jr1A:
undetectable
1likA-1jr1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE


(Methanosarcina
barkeri)
PF01913
(FTR)
PF02741
(FTR_C)
5 ILE A 249
LEU A 190
GLY A 163
GLY A 164
THR A 193
None
1.16A 1likA-1m5sA:
undetectable
1likA-1m5sA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1


(Elephantulus
edwardii)
PF00171
(Aldedh)
5 ILE A 482
GLY A 478
GLY A 481
CYH A 132
TYR A 485
None
1.03A 1likA-1o9jA:
undetectable
1likA-1o9jA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 ASP A 273
LEU A 259
GLY A 254
GLY A 255
THR A 269
None
1.15A 1likA-1pguA:
undetectable
1likA-1pguA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Escherichia
coli)
PF01048
(PNP_UDP_1)
5 ILE A 185
GLY A 187
GLY A 184
ASN A 116
THR A 198
None
1.09A 1likA-1pk9A:
undetectable
1likA-1pk9A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)


(Aspergillus
niger)
PF00328
(His_Phos_2)
5 ILE A 351
LEU A 338
GLY A  32
GLY A  31
ASN A  33
None
1.15A 1likA-1qfxA:
undetectable
1likA-1qfxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli)
PF00294
(PfkB)
5 ASP A  16
GLY A  41
GLY A  42
ASN A  46
ASP A 255
RIB  A 311 (-2.8A)
RIB  A 311 (-3.3A)
RIB  A 311 (-3.4A)
RIB  A 311 (-3.3A)
RIB  A 311 (-3.1A)
0.42A 1likA-1rk2A:
32.9
1likA-1rk2A:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE


(Salmonella
enterica)
PF00294
(PfkB)
5 ASP A  16
GLY A  30
GLY A  31
ASN A  35
ASP A 252
AIS  A 402 (-2.5A)
AIS  A 402 ( 4.2A)
AIS  A 402 (-3.8A)
AIS  A 402 (-3.9A)
AIS  A 402 (-3.0A)
0.34A 1likA-1tz6A:
30.4
1likA-1tz6A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Thermus
thermophilus)
PF00294
(PfkB)
5 LEU A 170
GLY A  33
GLY A  34
ASN A  38
ASP A 251
None
0.91A 1likA-1v19A:
31.5
1likA-1v19A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima)
PF00294
(PfkB)
5 ASP A  14
GLY A  39
GLY A  40
ASN A  44
ASP A 246
None
0.64A 1likA-1vm7A:
30.5
1likA-1vm7A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN


(Caulobacter
vibrioides)
PF00072
(Response_reg)
PF00990
(GGDEF)
5 ASP A 344
LEU A 297
GLY A 343
ASN A 335
THR A 295
C2E  A 501 (-3.7A)
None
C2E  A 501 (-3.7A)
C2E  A 501 (-3.1A)
None
1.08A 1likA-1w25A:
2.0
1likA-1w25A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE


(Bacillus
halodurans)
PF00294
(PfkB)
5 ASN A   8
ASP A  12
GLY A  36
GLY A  37
ASN A  41
None
1.14A 1likA-2abqA:
25.7
1likA-2abqA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE


(Bacillus
halodurans)
PF00294
(PfkB)
5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 249
None
0.42A 1likA-2abqA:
25.7
1likA-2abqA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Thermotoga
maritima)
PF00294
(PfkB)
5 LEU A 171
GLY A  32
GLY A  33
ASN A  37
ASP A 280
None
1.03A 1likA-2afbA:
29.1
1likA-2afbA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY


(Thermotoga
maritima)
PF00294
(PfkB)
6 ASN A   8
ASP A  12
GLY A  39
GLY A  40
ASN A  44
ASP A 261
None
ACT  A 321 (-3.1A)
ACT  A 321 ( 4.3A)
ACT  A 321 (-3.9A)
ACT  A 321 (-3.9A)
None
1.01A 1likA-2ajrA:
25.1
1likA-2ajrA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii)
PF00294
(PfkB)
5 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
0.39A 1likA-2c49A:
30.9
1likA-2c49A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE


(Homo sapiens)
PF00202
(Aminotran_3)
5 LEU A 305
GLY A 324
GLY A 325
ASN A 326
TYR A 123
None
1.07A 1likA-2canA:
undetectable
1likA-2canA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE


(Enterococcus
faecalis)
PF00294
(PfkB)
5 ASN A   8
ASP A  12
GLY A  36
GLY A  37
ASP A 255
None
None
None
None
ATP  A 411 (-4.1A)
1.02A 1likA-2f02A:
24.8
1likA-2f02A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE


(Enterococcus
faecalis)
PF00294
(PfkB)
5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 255
None
None
None
None
ATP  A 411 (-4.1A)
0.82A 1likA-2f02A:
24.8
1likA-2f02A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG)
PF05199
(GMC_oxred_C)
5 ILE A  57
GLY A 581
GLY A 582
ASN A 585
THR A  60
FAD  A1625 (-4.0A)
None
FAD  A1625 ( 3.9A)
None
None
0.99A 1likA-2f5vA:
2.2
1likA-2f5vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffj CONSERVED
HYPOTHETICAL PROTEIN


(Archaeoglobus
fulgidus)
PF01937
(DUF89)
5 ILE A 191
ASP A 194
LEU A  11
ASN A 215
ASN A 248
None
1.10A 1likA-2ffjA:
2.9
1likA-2ffjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00132
(Hexapep)
5 ASN A  83
ILE A  99
GLY A  98
GLY A  81
ASN A 155
None
0.99A 1likA-2fkoA:
undetectable
1likA-2fkoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF01019
(G_glu_transpept)
5 ILE A 112
LEU A  75
GLY A  56
GLY A  59
ASN A 350
None
1.16A 1likA-2i3oA:
undetectable
1likA-2i3oA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
7 ASN A  14
ASP A  18
GLY A  63
GLY A  64
ASN A  68
CYH A 123
ASP A 300
89I  A 500 (-4.0A)
None
None
89I  A 500 (-3.5A)
None
None
None
0.48A 1likA-2i6bA:
39.4
1likA-2i6bA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i6b ADENOSINE KINASE

(Homo sapiens)
PF00294
(PfkB)
7 ASP A  18
LEU A  40
GLY A  63
GLY A  64
ASN A  68
CYH A 123
ASP A 300
None
89I  A 500 ( 4.8A)
None
89I  A 500 (-3.5A)
None
None
None
0.52A 1likA-2i6bA:
39.4
1likA-2i6bA:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 249
None
0.66A 1likA-2jg5A:
24.8
1likA-2jg5A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
ASP A 254
None
0.92A 1likA-2jgvA:
24.6
1likA-2jgvA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE


(Staphylococcus
aureus)
PF00294
(PfkB)
5 ASP A  12
GLY A  36
GLY A  37
ASN A  41
CYH A  90
None
0.96A 1likA-2jgvA:
24.6
1likA-2jgvA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum)
PF00294
(PfkB)
5 ASP A  13
GLY A  37
GLY A  38
ASN A  42
ASP A 253
None
None
CL  A 403 (-3.5A)
None
None
0.99A 1likA-2nwhA:
25.6
1likA-2nwhA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR


(Caldanaerobacter
subterraneus)
PF00079
(Serpin)
5 ASN A 286
ILE A 289
LEU A 420
ASN A  73
THR A 418
None
1.17A 1likA-2pefA:
undetectable
1likA-2pefA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE


(Bacillus
halodurans)
PF00294
(PfkB)
5 ASP A  22
GLY A  43
GLY A  44
ASN A  48
ASP A 272
None
None
None
None
PGE  A 332 (-3.6A)
0.44A 1likA-2qcvA:
31.6
1likA-2qcvA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm6 GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Helicobacter
pylori)
PF01019
(G_glu_transpept)
5 ILE B 476
GLY B 473
GLY B 472
THR B 396
ASN B 400
None
GLU  B   1 (-3.6A)
GLU  B   1 (-3.6A)
None
GLU  B   1 (-3.5A)
1.04A 1likA-2qm6B:
undetectable
1likA-2qm6B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raa PYRUVATE SYNTHASE
SUBUNIT PORC


(Thermotoga
maritima)
PF01558
(POR)
5 ASN A  57
ILE A  59
ASP A  61
LEU A 145
GLY A  60
None
1.12A 1likA-2raaA:
4.6
1likA-2raaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb7 PEPTIDASE,
M20/M25/M40 FAMILY


(Desulfovibrio
alaskensis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ASN A 144
ILE A  53
ASP A  74
GLY A 136
ASP A 309
None
1.11A 1likA-2rb7A:
undetectable
1likA-2rb7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans)
PF07971
(Glyco_hydro_92)
5 ASP A 660
GLY A  71
GLY A  72
ASN A  49
THR A 626
None
B3P  A1773 (-3.3A)
B3P  A1773 (-4.1A)
None
None
1.13A 1likA-2xsgA:
undetectable
1likA-2xsgA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13855
(LRR_8)
5 ASN A  62
ILE A  64
LEU A  57
GLY A  87
ASN A 134
None
1.15A 1likA-2z80A:
undetectable
1likA-2z80A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38)
PF00353
(HemolysinCabind)
5 ASN A 548
ASP A 534
GLY A 529
GLY A 530
ASP A 513
None
CA  A 625 ( 2.4A)
CA  A 625 (-4.4A)
CA  A 625 (-4.3A)
None
1.09A 1likA-2z8zA:
undetectable
1likA-2z8zA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE


(Gluconobacter
frateurii)
PF13561
(adh_short_C2)
5 ASN A  98
LEU A 202
GLY A  96
THR A 198
TYR A 153
None
0.92A 1likA-3ai2A:
7.6
1likA-3ai2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis)
PF00294
(PfkB)
5 ASP A  12
GLY A  47
GLY A  48
ASN A  52
ASP A 253
AMP  A 501 (-2.9A)
AMP  A 501 ( 3.7A)
AMP  A 501 (-3.3A)
AMP  A 501 (-3.3A)
AMP  A 501 (-2.8A)
0.53A 1likA-3b1rA:
25.0
1likA-3b1rA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY


(Canis lupus)
PF00344
(SecY)
5 ILE A  75
LEU A 172
GLY A  76
GLY A  74
TYR A  37
None
1.14A 1likA-3dknA:
undetectable
1likA-3dknA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
6 ASP A  13
LEU A 167
GLY A  33
GLY A  34
ASN A  38
ASP A 247
None
0.78A 1likA-3ewmA:
29.0
1likA-3ewmA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 ASP A  25
GLY A  50
GLY A  51
ASN A  55
ASP A 242
RIB  A 305 (-2.8A)
RIB  A 305 ( 3.7A)
RIB  A 305 (-3.1A)
RIB  A 305 (-3.2A)
RIB  A 305 (-2.9A)
0.46A 1likA-3go7A:
29.5
1likA-3go7A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 GLY A 169
GLY A  54
ASN A  53
THR A  90
TYR A 185
None
1.09A 1likA-3h1lA:
undetectable
1likA-3h1lA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii)
PF00294
(PfkB)
6 ASP A  33
LEU A 188
GLY A  54
GLY A  55
ASN A  59
ASP A 275
None
0.81A 1likA-3hj6A:
28.8
1likA-3hj6A:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae)
PF00294
(PfkB)
5 ASP A  12
GLY A  37
GLY A  38
ASN A  42
ASP A 232
None
0.87A 1likA-3i3yA:
26.1
1likA-3i3yA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae)
PF00294
(PfkB)
5 ASP A  12
GLY A  37
GLY A  38
ASN A  42
THR A 107
None
0.68A 1likA-3i3yA:
26.1
1likA-3i3yA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR


(Pseudomonas
aeruginosa)
PF00990
(GGDEF)
5 ASP A 226
LEU A 179
GLY A 225
ASN A 217
THR A 177
None
1.14A 1likA-3i5bA:
undetectable
1likA-3i5bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN


(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae)
PF00990
(GGDEF)
5 ASP A 226
LEU A 179
GLY A 225
ASN A 217
THR A 177
None
1.09A 1likA-3i5cA:
undetectable
1likA-3i5cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH


(Escherichia
coli)
PF00294
(PfkB)
6 ILE A  13
ASP A  15
GLY A  41
GLY A  42
ASN A  46
ASP A 260
None
0.80A 1likA-3in1A:
28.9
1likA-3in1A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY


(Chlorobaculum
tepidum)
PF00294
(PfkB)
5 ASP A  12
LEU A 101
GLY A  26
GLY A  27
ASP A 237
AMP  A 509 (-2.8A)
None
AMP  A 509 ( 3.8A)
AMP  A 509 (-3.4A)
AMP  A 509 ( 3.3A)
1.04A 1likA-3kd6A:
25.3
1likA-3kd6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa)
PF00294
(PfkB)
5 ASN A 146
ASP A  24
GLY A  44
GLY A  45
ASN A  49
None
1.04A 1likA-3lkiA:
25.5
1likA-3lkiA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
9 ASN A  14
ASP A  18
LEU A  40
GLY A  63
GLY A  64
ASN A  68
CYH A 122
ASN A 296
ASP A 300
B4P  A 349 ( 4.0A)
B4P  A 349 (-2.8A)
None
B4P  A 349 ( 3.8A)
B4P  A 349 (-3.5A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.6A)
B4P  A 349 (-3.4A)
0.76A 1likA-3looA:
44.6
1likA-3looA:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ILE A 568
LEU A 512
GLY A 567
TYR A 447
ASP A 433
None
1.00A 1likA-3mosA:
undetectable
1likA-3mosA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3otx ADENOSINE KINASE,
PUTATIVE


(Trypanosoma
brucei)
PF00294
(PfkB)
8 ASN A  13
ASP A  17
LEU A  39
GLY A  62
GLY A  63
ASN A  67
CYH A 123
ASP A 299
AP5  A 346 (-4.1A)
AP5  A 346 (-2.8A)
None
AP5  A 346 (-3.6A)
AP5  A 346 (-3.5A)
AP5  A 346 (-3.4A)
AP5  A 346 (-3.7A)
AP5  A 346 ( 3.2A)
0.41A 1likA-3otxA:
44.8
1likA-3otxA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY


(Corynebacterium
glutamicum)
PF00294
(PfkB)
5 ASP A  19
GLY A  40
GLY A  41
ASN A  45
ASP A 264
None
0.45A 1likA-3pl2A:
31.4
1likA-3pl2A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
6 ASN A   8
ASP A  12
GLY A  37
GLY A  38
CYH A  92
ASP A 251
None
0.90A 1likA-3q1yA:
25.9
1likA-3q1yA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvl PUTATIVE HYDANTOIN
RACEMASE


(Klebsiella
pneumoniae)
PF01177
(Asp_Glu_race)
5 LEU A 148
GLY A 185
GLY A 186
THR A 119
ASN A  12
None
5HY  A   1 (-3.8A)
None
5HY  A   1 (-3.6A)
5HY  A   1 (-4.0A)
1.13A 1likA-3qvlA:
undetectable
1likA-3qvlA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ry7 RIBOKINASE

(Staphylococcus
aureus)
PF00294
(PfkB)
5 ASP A  14
GLY A  40
GLY A  41
ASN A  45
ASP A 254
GOL  A 401 (-3.1A)
GOL  A 401 ( 3.7A)
GOL  A 401 (-3.8A)
GOL  A 401 (-3.9A)
None
0.56A 1likA-3ry7A:
27.8
1likA-3ry7A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvk DIGUANYLATE CYCLASE
DGCZ


(Escherichia
coli)
PF00990
(GGDEF)
5 ASP A 182
LEU A 137
GLY A 181
ASN A 173
THR A 135
C2E  A 501 (-3.6A)
None
C2E  A 501 (-3.4A)
C2E  A 501 (-3.1A)
None
1.15A 1likA-3tvkA:
undetectable
1likA-3tvkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE


(Acetobacter
aceti)
PF02515
(CoA_transf_3)
5 ILE A  50
ASP A  49
LEU A  55
GLY A  21
ASN A  70
None
1.17A 1likA-3ubmA:
3.5
1likA-3ubmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
10 ASN A  11
ILE A  13
ASP A  15
LEU A  37
GLY A  58
GLY A  59
ASN A  63
THR A 129
TYR A 158
ASP A 278
ADN  A 353 (-3.7A)
ADN  A 353 (-3.7A)
ADN  A 353 (-2.8A)
None
ADN  A 353 (-3.3A)
ADN  A 353 (-3.2A)
ADN  A 353 (-3.4A)
ADN  A 353 (-3.3A)
ADN  A 353 (-3.6A)
ADN  A 353 (-3.3A)
0.44A 1likA-3uboA:
40.3
1likA-3uboA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2


(Escherichia
coli)
PF00294
(PfkB)
5 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
None
0.73A 1likA-3uqeA:
24.8
1likA-3uqeA:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
9 ASN A  14
ASP A  18
LEU A  40
GLY A  63
GLY A  64
ASN A  68
THR A 136
ASN A 298
ASP A 302
ADN  A 401 ( 4.0A)
ADN  A 401 (-2.7A)
None
ADN  A 401 ( 3.8A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.1A)
ADN  A 401 (-3.7A)
ADN  A 401 (-2.9A)
0.34A 1likA-3vasA:
45.8
1likA-3vasA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN


(Geobacillus
kaustophilus)
PF00132
(Hexapep)
5 ILE A  30
LEU A  63
GLY A  31
ASN A  53
ASP A  75
None
1.17A 1likA-3vnpA:
undetectable
1likA-3vnpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
5 ILE A 710
LEU A 646
GLY A 709
GLY A 708
ASP A 515
None
1.14A 1likA-4bedA:
undetectable
1likA-4bedA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3a SUGAR KINASE PROTEIN

(Rhizobium etli)
PF00294
(PfkB)
10 ASN A   9
ILE A  11
ASP A  13
LEU A  35
GLY A  56
GLY A  57
ASN A  61
THR A 127
TYR A 156
ASP A 276
ADN  A 500 (-3.8A)
ADN  A 500 (-3.6A)
ADN  A 500 (-2.7A)
None
ADN  A 500 (-3.5A)
ADN  A 500 (-3.7A)
ADN  A 500 (-3.5A)
ADN  A 500 (-3.0A)
ADN  A 500 (-3.8A)
ADN  A 500 (-2.8A)
0.42A 1likA-4e3aA:
40.6
1likA-4e3aA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fym OROTATE
PHOSPHORIBOSYLTRANSF
ERASE


(Plasmodium
falciparum)
PF00156
(Pribosyltran)
5 ILE A 207
LEU A 148
GLY A 137
GLY A 132
THR A 144
None
1.04A 1likA-4fymA:
undetectable
1likA-4fymA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gm6 PFKB FAMILY
CARBOHYDRATE KINASE


(Listeria grayi)
PF00294
(PfkB)
5 LEU A 172
GLY A  33
GLY A  34
ASN A  38
ASP A 270
None
GOL  A 401 ( 4.1A)
GOL  A 401 (-3.7A)
GOL  A 401 (-4.4A)
GOL  A 401 (-3.0A)
0.93A 1likA-4gm6A:
28.2
1likA-4gm6A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 ASP A  12
GLY A  47
GLY A  48
ASN A  52
ASP A 257
HO4  A 401 (-2.4A)
HO4  A 401 (-3.5A)
HO4  A 401 (-3.5A)
HO4  A 401 (-3.8A)
HO4  A 401 (-3.3A)
0.42A 1likA-4pvvA:
28.6
1likA-4pvvA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
5 ASN A 468
ILE A 308
GLY A 307
THR A 326
ASP A 243
None
1.12A 1likA-4r4zA:
undetectable
1likA-4r4zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 GLY A  67
GLY A  66
ASN A  48
TYR A 191
ASP A  51
None
1.17A 1likA-4rvwA:
undetectable
1likA-4rvwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urs DIGUANYLATE CYCLASE

(Thermotoga
maritima)
PF00990
(GGDEF)
5 ASP A 143
LEU A  96
GLY A 142
ASN A 134
THR A  94
ASP  A 143 ( 0.6A)
LEU  A  96 ( 0.6A)
GLY  A 142 ( 0.0A)
ASN  A 134 ( 0.6A)
THR  A  94 ( 0.8A)
1.15A 1likA-4ursA:
undetectable
1likA-4ursA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 ASP A  11
GLY A  29
GLY A  30
ASN A  34
ASP A 249
None
None
None
None
ANP  A 401 ( 4.3A)
0.60A 1likA-4wjmA:
28.7
1likA-4wjmA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 LEU A 162
GLY A  29
GLY A  30
ASN A  34
ASP A 249
None
None
None
None
ANP  A 401 ( 4.3A)
0.93A 1likA-4wjmA:
28.7
1likA-4wjmA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
5 ASP A  13
GLY A  38
GLY A  39
ASN A  43
ASP A 252
None
0.62A 1likA-4x8fA:
29.3
1likA-4x8fA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY


(Thermococcus
kodakarensis)
no annotation 5 ASP A  12
GLY A  25
GLY A  26
THR A  73
ASP A 219
INS  A 301 (-2.8A)
INS  A 301 (-3.1A)
INS  A 301 (-3.1A)
None
INS  A 301 (-2.7A)
1.16A 1likA-4xf7A:
22.9
1likA-4xf7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo7 SUGAR ABC
TRANSPORTER
(SUGAR-BINDING
PROTEIN)


(Bacillus
halodurans)
PF13407
(Peripla_BP_4)
5 ILE A 148
GLY A 151
GLY A 186
ASN A 187
ASN A 232
None
1.03A 1likA-4yo7A:
3.9
1likA-4yo7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 269
GLY A 359
GLY A 361
ASN A 362
ASN A  74
None
1.16A 1likA-4yzoA:
undetectable
1likA-4yzoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa)
PF00990
(GGDEF)
PF01590
(GAF)
5 ASP A 236
LEU A 189
GLY A 235
ASN A 227
THR A 187
None
1.07A 1likA-4zmuA:
undetectable
1likA-4zmuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
5 ILE A1374
LEU A1274
GLY A1310
ASN A1312
CYH A1306
None
1.07A 1likA-5a31A:
undetectable
1likA-5a31A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)


(Helicobacter
pylori)
PF01019
(G_glu_transpept)
5 ILE C 476
GLY C 473
GLY C 472
THR C 396
ASN C 400
None
4UD  C 701 (-3.5A)
4UD  C 701 (-4.4A)
None
4UD  C 701 (-3.4A)
1.01A 1likA-5bpkC:
undetectable
1likA-5bpkC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens)
PF00294
(PfkB)
5 ASP A  27
GLY A  52
GLY A  53
ASN A  57
ASP A 269
None
None
None
None
NA  A 403 ( 4.7A)
0.56A 1likA-5c41A:
32.4
1likA-5c41A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE


(Clostridium
sporogenes)
PF01053
(Cys_Met_Meta_PP)
5 ILE A  92
LEU A 112
GLY A  90
GLY A  88
THR A 116
None
None
None
PLP  A 501 (-3.1A)
None
1.18A 1likA-5dx5A:
undetectable
1likA-5dx5A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 365
LEU A 372
GLY A 209
GLY A 208
THR A 369
None
1.09A 1likA-5erbA:
undetectable
1likA-5erbA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
5 ASP A  30
GLY A  44
GLY A  45
ASN A  49
ASP A 266
None
0.48A 1likA-5ey7A:
30.0
1likA-5ey7A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE


(Francisella
tularensis)
PF01761
(DHQ_synthase)
5 ILE A 107
LEU A  99
GLY A 104
GLY A 103
THR A 111
None
None
NAD  A 401 (-3.4A)
None
None
1.10A 1likA-5hvnA:
undetectable
1likA-5hvnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA


(Caldalkalibacillus
thermarum)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
5 ILE A 150
ASP A 154
LEU A 344
GLY A 149
ASN A 185
None
1.17A 1likA-5ik2A:
undetectable
1likA-5ik2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa)
no annotation 5 ASP A 863
LEU A 816
GLY A 862
ASN A 854
THR A 814
GTP  A1304 (-3.6A)
None
GTP  A1304 (-3.4A)
GTP  A1304 (-2.9A)
None
1.11A 1likA-5m3cA:
undetectable
1likA-5m3cA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE


(Elizabethkingia
anophelis)
PF00202
(Aminotran_3)
5 LEU A 274
GLY A 293
GLY A 294
ASN A 295
TYR A  90
None
1.04A 1likA-5viuA:
undetectable
1likA-5viuA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysq TM0415

(Thermotoga
maritima)
no annotation 5 LEU A  37
GLY A 231
GLY A 233
THR A  33
ASN A 114
None
INS  A 301 ( 4.7A)
SO4  A 302 (-3.2A)
None
None
1.01A 1likA-5ysqA:
24.6
1likA-5ysqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans)
no annotation 5 ASP A  16
GLY A  41
GLY A  42
ASN A  46
ASP A 273
GOL  A 400 (-2.8A)
GOL  A 400 (-3.5A)
GOL  A 400 (-3.3A)
GOL  A 400 (-3.3A)
None
0.45A 1likA-6cw5A:
31.2
1likA-6cw5A:
14.33