SIMILAR PATTERNS OF AMINO ACIDS FOR 1LHV_A_NOGA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoa T-FIMBRIN

(Homo sapiens) 		PF00307
(CH) 		4 THR A 354
ASP A 357
PHE A 352
ASN A 362
 THR  A 354 ( 0.8A)
ASP  A 357 ( 0.6A)
PHE  A 352 ( 1.3A)
ASN  A 362 ( 0.6A)
 0.97A 1lhvA-1aoaA:
undetectable		 1lhvA-1aoaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ASP A 102
PHE A 523
MET A 316
LEU A 289
 None
 0.96A 1lhvA-1e6vA:
0.3		 1lhvA-1e6vA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 THR A  35
ASP A 299
ASN A 311
LEU A  62
 None
 1.05A 1lhvA-1hp1A:
undetectable		 1lhvA-1hp1A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		4 SER A 385
THR A 396
ASP A 398
LEU A 418
 None
 1.11A 1lhvA-1hqsA:
undetectable		 1lhvA-1hqsA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		4 THR A 204
ASP A 207
ASN A 208
LEU A 181
 None
None
None
RXP  A6001 (-3.9A)
 1.03A 1lhvA-1hv5A:
0.0		 1lhvA-1hv5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 THR B2405
ASN B2408
MET B2403
LEU B2401
 None
 1.11A 1lhvA-1i4eB:
0.0		 1lhvA-1i4eB:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		8 SER A  42
THR A  60
ASP A  65
PHE A  67
ASN A  82
MET A 107
MET A 139
LEU A 171
 EST  A 301 (-2.7A)
None
EST  A 301 (-2.9A)
EST  A 301 (-4.0A)
EST  A 301 (-3.9A)
EST  A 301 ( 3.9A)
EST  A 301 ( 3.9A)
None
 0.62A 1lhvA-1lhuA:
34.1		 1lhvA-1lhuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 ASP A 156
PHE A 140
ASN A 142
LEU A 197
 None
 0.90A 1lhvA-1mlzA:
undetectable		 1lhvA-1mlzA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 SER A 250
THR A 156
ASP A 157
LEU A 150
 None
 1.06A 1lhvA-1nt4A:
0.0		 1lhvA-1nt4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
HEAVY CHAIN
ANTIBODY VARIABLE
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 SER L  42
ASP H  69
ASN L 135
LEU H 110
 None
 1.08A 1lhvA-1p4iL:
undetectable		 1lhvA-1p4iL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 SER A 590
PHE A 637
ASN A 639
LEU A 591
 None
 1.01A 1lhvA-1qhgA:
undetectable		 1lhvA-1qhgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF13361
(UvrD_C) 		4 SER D 590
PHE D 637
ASN D 639
LEU D 591
 None
 1.07A 1lhvA-1qhhD:
undetectable		 1lhvA-1qhhD:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svx ANKYRIN REPEAT
PROTEIN OFF7

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 SER A 111
THR A  48
ASP A  44
ASN A  45
 None
 1.11A 1lhvA-1svxA:
undetectable		 1lhvA-1svxA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 SER B 502
THR B 469
MET B 225
LEU B 503
 None
 1.01A 1lhvA-1t3qB:
undetectable		 1lhvA-1t3qB:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		4 SER A 299
ASN A  19
MET A  23
LEU A 288
 None
 0.95A 1lhvA-1tzsA:
undetectable		 1lhvA-1tzsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 SER A  58
ASP A  93
PHE A  52
MET A  27
 None
 1.09A 1lhvA-1urhA:
undetectable		 1lhvA-1urhA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		4 SER A 133
PHE A 256
ASN A 286
LEU A 172
 None
 1.02A 1lhvA-1vjzA:
undetectable		 1lhvA-1vjzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 THR J 412
ASP J 153
ASN J 150
LEU J  18
 None
 1.06A 1lhvA-1wcdJ:
undetectable		 1lhvA-1wcdJ:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 THR J 412
ASP J 153
ASN J 150
LEU J  19
 None
 1.09A 1lhvA-1wcdJ:
undetectable		 1lhvA-1wcdJ:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 THR A 111
ASP A 207
ASN A 210
LEU A 158
 None
 1.05A 1lhvA-1wraA:
undetectable		 1lhvA-1wraA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Escherichia
coli) 		PF00574
(CLP_protease) 		4 ASP A  37
MET A  98
MET A  39
LEU A  31
 None
 1.02A 1lhvA-1yg8A:
undetectable		 1lhvA-1yg8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		4 SER A 366
THR A  50
ASP A 202
LEU A 363
 None
 1.10A 1lhvA-1yy5A:
undetectable		 1lhvA-1yy5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ASP A  56
PHE A  54
MET A  95
LEU A  99
 None
 1.04A 1lhvA-1zyeA:
undetectable		 1lhvA-1zyeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 THR A 166
PHE A 242
MET A 220
LEU A 176
 None
 1.03A 1lhvA-2aqwA:
undetectable		 1lhvA-2aqwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayi AMINOPEPTIDASE T

(Thermus
thermophilus) 		PF02073
(Peptidase_M29) 		4 THR A 307
ASP A 308
PHE A 348
LEU A 272
 None
 1.11A 1lhvA-2ayiA:
undetectable		 1lhvA-2ayiA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 THR A  86
ASP A 182
ASN A 185
LEU A 133
 None
 1.04A 1lhvA-2bibA:
undetectable		 1lhvA-2bibA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 SER A 164
THR A 259
ASP A 260
LEU A 165
 None
 1.08A 1lhvA-2d0dA:
undetectable		 1lhvA-2d0dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 SER A 426
ASP A  56
ASN A  58
LEU A 440
 None
 0.98A 1lhvA-2fgeA:
undetectable		 1lhvA-2fgeA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 SER B1256
THR B1226
ASN B1151
LEU B1248
 None
 0.96A 1lhvA-2nvuB:
undetectable		 1lhvA-2nvuB:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 SER A 922
ASP A 910
PHE A 906
ASN A 912
 None
 1.11A 1lhvA-2nz9A:
9.0		 1lhvA-2nz9A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzx ALPHA1,3-FUCOSYLTRAN
SFERASE

(Helicobacter
pylori) 		PF00852
(Glyco_transf_10) 		4 SER A 149
PHE A  49
ASN A  44
LEU A 145
 None
 1.11A 1lhvA-2nzxA:
undetectable		 1lhvA-2nzxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY

(Neisseria
meningitidis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		4 THR A 115
ASP A 116
PHE A 120
ASN A 118
 None
 1.05A 1lhvA-2p6tA:
undetectable		 1lhvA-2p6tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		4 SER A 258
ASP A 214
MET A 251
LEU A 228
 None
 1.09A 1lhvA-2pgeA:
undetectable		 1lhvA-2pgeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER A 126
THR A 142
ASN A 139
LEU A  86
 None
 1.06A 1lhvA-2pm9A:
undetectable		 1lhvA-2pm9A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		4 SER A  13
THR A 110
MET A 111
LEU A   9
 None
 1.11A 1lhvA-2pywA:
undetectable		 1lhvA-2pywA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 SER A  98
ASP A  28
PHE A  30
LEU A 100
 None
 0.95A 1lhvA-2qp4A:
undetectable		 1lhvA-2qp4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		4 THR A 591
ASP A 570
PHE A 572
LEU A 613
 None
 0.95A 1lhvA-2qv3A:
undetectable		 1lhvA-2qv3A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ASP A 269
ASN A 272
MET A 496
LEU A 108
 None
 0.89A 1lhvA-2v7gA:
undetectable		 1lhvA-2v7gA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5r HYPOTHETICAL PROTEIN
ORF126

(Pyrobaculum
spherical virus) 		no annotation 4 THR A 117
ASP A 110
PHE A  43
ASN A  91
 ZN  A1127 ( 4.0A)
ZN  A1127 (-2.7A)
None
None
 1.01A 1lhvA-2x5rA:
undetectable		 1lhvA-2x5rA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ASP A  61
PHE A  59
MET A 100
LEU A 104
 None
 1.07A 1lhvA-2z9sA:
undetectable		 1lhvA-2z9sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 THR A 163
PHE A 239
MET A 217
LEU A 173
 OMP  A 500 ( 4.2A)
None
None
None
 1.09A 1lhvA-2za1A:
undetectable		 1lhvA-2za1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 THR A 108
ASP A  42
MET A 109
LEU A 286
 A  C  37 ( 2.9A)
A  C  37 ( 2.8A)
None
None
 1.07A 1lhvA-2zm5A:
undetectable		 1lhvA-2zm5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		4 SER A 255
THR A 225
ASN A 150
LEU A 247
 None
 1.12A 1lhvA-3a3cA:
undetectable		 1lhvA-3a3cA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 SER A 120
PHE A 142
ASN A 159
LEU A 121
 None
 1.05A 1lhvA-3b2dA:
undetectable		 1lhvA-3b2dA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		4 THR A 194
ASP A 252
ASN A 249
LEU A 187
 None
 1.07A 1lhvA-3bkhA:
undetectable		 1lhvA-3bkhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A 182
ASN A 250
MET A 226
LEU A 178
 None
 1.00A 1lhvA-3btzA:
undetectable		 1lhvA-3btzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Geobacter
sulfurreducens) 		PF00440
(TetR_N) 		4 SER A 150
THR A 137
MET A 136
LEU A 145
 None
 1.08A 1lhvA-3dewA:
undetectable		 1lhvA-3dewA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwt MACROPHAGE MIGRATION
INHIBITORY
FACTOR-LIKE PROTEIN

(Leishmania
major) 		PF01187
(MIF) 		4 SER A  -2
THR A  77
MET A  76
LEU A  31
 None
 1.02A 1lhvA-3fwtA:
undetectable		 1lhvA-3fwtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 THR A  88
PHE A  84
MET A  48
MET A  59
 None
 0.92A 1lhvA-3ktoA:
undetectable		 1lhvA-3ktoA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 THR A 445
ASP A 447
ASN A 448
LEU A 382
 None
 1.09A 1lhvA-3kw7A:
undetectable		 1lhvA-3kw7A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		4 SER A 100
ASP A 149
PHE A 157
ASN A 151
 None
 1.08A 1lhvA-3m70A:
undetectable		 1lhvA-3m70A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 SER A 216
THR A 246
ASP A 249
ASN A 251
 None
 0.87A 1lhvA-3mfdA:
undetectable		 1lhvA-3mfdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		4 SER A-115
THR A-145
ASN A-220
LEU A-123
 None
 1.00A 1lhvA-3n93A:
undetectable		 1lhvA-3n93A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oj1 DEHALOPEROXIDASE A

(Amphitrite
ornata) 		PF00042
(Globin) 		4 PHE A   2
MET A  64
MET A 108
LEU A 104
 None
 1.05A 1lhvA-3oj1A:
undetectable		 1lhvA-3oj1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 SER A 120
PHE A 142
ASN A 159
LEU A 121
 None
 1.05A 1lhvA-3rg1A:
undetectable		 1lhvA-3rg1A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 SER A 423
THR A 358
ASN A 171
LEU A 421
 HEM  A1500 (-3.4A)
HEM  A1500 (-3.3A)
None
None
 0.95A 1lhvA-3ut2A:
undetectable		 1lhvA-3ut2A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 THR A 529
PHE A 547
ASN A 556
LEU A 543
 None
 1.12A 1lhvA-3v9fA:
undetectable		 1lhvA-3v9fA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 THR A 316
ASN A 319
MET A 246
LEU A 222
 None
 1.09A 1lhvA-3vv3A:
undetectable		 1lhvA-3vv3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 SER A 767
ASP A 680
PHE A 678
ASN A 690
 None
 1.11A 1lhvA-3w5nA:
undetectable		 1lhvA-3w5nA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 THR A 629
PHE A 647
MET A 655
LEU A 661
 None
 1.10A 1lhvA-3w5nA:
undetectable		 1lhvA-3w5nA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		4 SER A  79
THR A 106
MET A 107
LEU A 114
 None
 0.80A 1lhvA-3zwfA:
undetectable		 1lhvA-3zwfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 SER A 338
PHE A 370
ASN A 277
LEU A 339
 None
 1.09A 1lhvA-4azvA:
undetectable		 1lhvA-4azvA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 SER A 255
THR A 225
ASN A 150
LEU A 247
 None
 1.04A 1lhvA-4b3nA:
5.9		 1lhvA-4b3nA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 SER A 126
THR A 142
ASN A 139
LEU A  86
 None
 1.06A 1lhvA-4bzkA:
undetectable		 1lhvA-4bzkA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 SER A 173
THR A 481
ASN A 654
LEU A 175
 None
 1.00A 1lhvA-4db1A:
undetectable		 1lhvA-4db1A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1)
no annotation 		4 SER C 134
THR B  76
PHE C 170
ASN C 167
 None
 1.09A 1lhvA-4ejsC:
undetectable		 1lhvA-4ejsC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 SER A 179
ASP A 195
PHE A 158
LEU A 218
 None
 1.08A 1lhvA-4emyA:
undetectable		 1lhvA-4emyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 THR A 254
ASP A 283
MET A 173
LEU A 242
 None
 1.09A 1lhvA-4j16A:
undetectable		 1lhvA-4j16A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le5 S-ADENOSYLMETHIONINE
SYNTHETASE

(Campylobacter
jejuni) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 SER A 220
THR A 193
MET A 214
LEU A 150
 None
 1.07A 1lhvA-4le5A:
undetectable		 1lhvA-4le5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 115
THR A 319
PHE A 350
LEU A 112
 None
 1.11A 1lhvA-4mksA:
undetectable		 1lhvA-4mksA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 SER A 407
THR A 343
ASN A 322
LEU A 411
 None
 0.94A 1lhvA-4oe6A:
undetectable		 1lhvA-4oe6A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 SER A 255
THR A 225
ASN A 150
LEU A 247
 None
 1.01A 1lhvA-4pe2A:
undetectable		 1lhvA-4pe2A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		4 SER A 256
THR A 226
ASN A 151
LEU A 248
 None
 1.05A 1lhvA-4pqkA:
undetectable		 1lhvA-4pqkA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		4 SER B  33
THR B 221
ASP B 111
LEU B  26
 None
None
MG  B 301 ( 4.1A)
None
 1.11A 1lhvA-4s1iB:
undetectable		 1lhvA-4s1iB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 THR A2303
ASP A2301
MET A2429
LEU A2437
 None
 1.02A 1lhvA-4tvcA:
undetectable		 1lhvA-4tvcA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		4 ASP A 363
PHE A 380
ASN A 378
LEU A 417
 None
 1.10A 1lhvA-4yj1A:
undetectable		 1lhvA-4yj1A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 ASP A 243
ASN A 239
MET A 245
LEU A 265
 None
 0.87A 1lhvA-5bymA:
undetectable		 1lhvA-5bymA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		4 SER A 255
THR A 225
ASN A 150
LEU A 247
 None
 1.00A 1lhvA-5c7rA:
undetectable		 1lhvA-5c7rA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 SER B 363
THR B 333
ASN B 258
LEU B 355
 None
 1.07A 1lhvA-5eduB:
undetectable		 1lhvA-5eduB:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		5 THR A 440
ASP A 391
ASN A 380
MET A 441
LEU A 461
 None
 1.43A 1lhvA-5g0aA:
undetectable		 1lhvA-5g0aA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 ASP A 287
PHE A 245
ASN A 284
LEU A 295
 None
 1.09A 1lhvA-5gmhA:
undetectable		 1lhvA-5gmhA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 SER A 256
THR A 226
ASN A 151
LEU A 248
 None
 0.91A 1lhvA-5gppA:
undetectable		 1lhvA-5gppA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 SER A 256
THR A 226
ASN A 151
LEU A 248
 None
 1.02A 1lhvA-5gpqA:
undetectable		 1lhvA-5gpqA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3v CAG8

(Helicobacter
pylori) 		PF03524
(CagX) 		4 THR A  31
ASP A  26
ASN A   5
LEU A  83
 None
 0.92A 1lhvA-5h3vA:
undetectable		 1lhvA-5h3vA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyd PROTEIN S100-Z

(Homo sapiens) 		PF01023
(S_100) 		4 ASP A  71
PHE A  75
ASN A  73
LEU A  62
 None
 1.12A 1lhvA-5hydA:
undetectable		 1lhvA-5hydA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 SER A 622
THR A 592
ASN A 517
LEU A 614
 None
 1.07A 1lhvA-5hzvA:
undetectable		 1lhvA-5hzvA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 SER A 310
THR A 280
ASN A 205
LEU A 302
 None
 1.05A 1lhvA-5hzwA:
undetectable		 1lhvA-5hzwA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 THR A  57
ASP A  64
MET A  85
LEU A 112
 None
 1.09A 1lhvA-5j44A:
undetectable		 1lhvA-5j44A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ASP A  56
PHE A  54
MET A  95
LEU A  99
 None
 0.97A 1lhvA-5jcgA:
undetectable		 1lhvA-5jcgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		4 SER A 234
ASN A 423
MET A  84
LEU A  96
 None
 1.10A 1lhvA-5m95A:
undetectable		 1lhvA-5m95A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 SER A1253
ASP A1209
ASN A1211
LEU A1241
 None
 1.10A 1lhvA-5me3A:
undetectable		 1lhvA-5me3A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 THR A 225
ASP A 253
MET A 172
LEU A 192
 None
 0.91A 1lhvA-5mp7A:
undetectable		 1lhvA-5mp7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 SER A 516
ASP A 570
ASN A 571
LEU A 453
 None
 1.06A 1lhvA-5n4lA:
undetectable		 1lhvA-5n4lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 THR A  93
PHE A  39
MET A  94
LEU A  55
 None
 0.76A 1lhvA-5tlcA:
undetectable		 1lhvA-5tlcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 SER A 922
ASP A 910
PHE A 906
ASN A 912
 None
 1.07A 1lhvA-5tpcA:
8.9		 1lhvA-5tpcA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		4 ASP A 156
PHE A 140
ASN A 142
LEU A 197
 None
 1.05A 1lhvA-5uc7A:
undetectable		 1lhvA-5uc7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A 131
THR A  80
ASP A  79
LEU A 226
 None
 1.02A 1lhvA-5vk4A:
undetectable		 1lhvA-5vk4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 THR A 500
PHE A 520
MET A 813
LEU A 529
 None
 0.99A 1lhvA-5wugA:
2.8		 1lhvA-5wugA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 SER A 321
THR A 375
PHE A 367
MET A 307
 None
 1.09A 1lhvA-5wx3A:
undetectable		 1lhvA-5wx3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Enterococcus
faecalis) 		PF01867
(Cas_Cas1) 		4 ASP A 216
PHE A 211
ASN A 212
MET A 218
 None
 1.10A 1lhvA-5xvnA:
undetectable		 1lhvA-5xvnA:
21.95