SIMILAR PATTERNS OF AMINO ACIDS FOR 1LHU_A_ESTA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj6 GYRASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 SER A  89
GLY A  77
MET A  95
LEU A 132
LEU A 154
 None
 1.04A 1lhuA-1aj6A:
0.1		 1lhuA-1aj6A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 511
PHE A 512
ASN A 541
ILE A 123
LEU A 143
 None
 1.33A 1lhuA-1h0hA:
0.0		 1lhuA-1h0hA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 SER A 494
ASP A 483
ASN A 482
MET A 511
ILE A 507
 None
None
None
None
MLZ  A 508 ( 3.6A)
 1.26A 1lhuA-1iv8A:
0.0		 1lhuA-1iv8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc4 METHYLMALONYL-COA
EPIMERASE

(Propionibacterium
freudenreichii) 		PF13669
(Glyoxalase_4) 		5 GLY A 135
LEU A 106
MET A 130
ILE A 140
LEU A 142
 None
 1.23A 1lhuA-1jc4A:
undetectable		 1lhuA-1jc4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1e GLUTAMATE RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 GLY A  38
SER A 101
LEU A 109
ILE A  60
LEU A  72
 None
 1.21A 1lhuA-1p1eA:
0.0		 1lhuA-1p1eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 SER A 199
LEU A 121
MET A  51
ILE A 275
LEU A   6
 EDO  A 313 ( 4.3A)
None
None
None
None
 1.12A 1lhuA-1pyfA:
0.0		 1lhuA-1pyfA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		5 SER A 299
ASN A  19
LEU A 233
MET A  23
LEU A 288
 None
 1.31A 1lhuA-1tzsA:
0.0		 1lhuA-1tzsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248

(Campylobacter
jejuni) 		PF08668
(HDOD) 		5 GLY A 149
PHE A 153
ASN A 155
SER A  12
LEU A 196
 None
 1.31A 1lhuA-1vqrA:
undetectable		 1lhuA-1vqrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x66 FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF02198
(SAM_PNT) 		5 ASN A  65
MET A  56
LEU A  61
ILE A  48
LEU A  36
 None
 1.26A 1lhuA-1x66A:
undetectable		 1lhuA-1x66A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 SER A 201
GLY A 276
PHE A 232
LEU A 219
ILE A 236
 None
 1.29A 1lhuA-1xwiA:
0.0		 1lhuA-1xwiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 290
LEU A 270
MET A 307
ILE A 302
LEU A 113
 None
 1.19A 1lhuA-1ykwA:
undetectable		 1lhuA-1ykwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 SER A 559
ASN A 491
LEU A 498
ILE A  47
LEU A  42
 None
 1.32A 1lhuA-1z68A:
undetectable		 1lhuA-1z68A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN HEAVY CHAIN

(Trichoplusia ni) 		PF00210
(Ferritin) 		5 PHE M 149
LEU M 141
MET M  25
ILE M  29
LEU M  78
 None
 1.30A 1lhuA-1z6oM:
undetectable		 1lhuA-1z6oM:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY A 170
ASP A 217
SER A 177
ILE A 212
LEU A 239
 None
 1.24A 1lhuA-1zj9A:
undetectable		 1lhuA-1zj9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		5 GLY A 171
ASN A 151
LEU A  42
ILE A 173
LEU A 253
 None
 1.13A 1lhuA-1zupA:
undetectable		 1lhuA-1zupA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 GLY A 181
MET A 259
LEU A  87
MET A 139
ILE A 182
 None
 0.90A 1lhuA-2ashA:
undetectable		 1lhuA-2ashA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 SER A 302
GLY A 295
ASN A 289
LEU A 313
LEU A 303
 None
 1.29A 1lhuA-2bnhA:
undetectable		 1lhuA-2bnhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 SER A 416
GLY A 409
ASN A 403
LEU A 427
LEU A 417
 None
 1.30A 1lhuA-2bnhA:
undetectable		 1lhuA-2bnhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 GLY A 180
ASN A 175
SER A 207
ILE A 288
LEU A 219
 None
 1.17A 1lhuA-2cvzA:
undetectable		 1lhuA-2cvzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 SER A 236
ASN A 203
LEU A 222
ILE A 232
LEU A 237
 None
 1.11A 1lhuA-2ft3A:
undetectable		 1lhuA-2ft3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 162
PHE A 163
SER A 169
ILE A 161
LEU A 293
 None
 1.08A 1lhuA-2hlpA:
undetectable		 1lhuA-2hlpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 GLY A  67
ASP A  69
SER A  16
ILE A  65
LEU A  39
 None
 1.33A 1lhuA-2hnhA:
undetectable		 1lhuA-2hnhA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg6 DNA-3-METHYLADENINE
GLYCOSIDASE

(Staphylococcus
aureus) 		PF03352
(Adenine_glyco) 		5 GLY A 101
SER A  39
LEU A  35
ILE A 105
LEU A 116
 None
 0.95A 1lhuA-2jg6A:
undetectable		 1lhuA-2jg6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jl4 MALEYLPYRUVATE
ISOMERASE

(Ralstonia sp.
U2) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 GLY A 137
PHE A 138
LEU A 145
ILE A  98
LEU A  95
 None
 1.07A 1lhuA-2jl4A:
undetectable		 1lhuA-2jl4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		5 SER A 146
GLY A  96
ASP A  51
ASN A  32
LEU A  88
 None
None
NAD  A1118 (-3.0A)
NAD  A1118 (-3.1A)
None
 1.32A 1lhuA-2p5uA:
undetectable		 1lhuA-2p5uA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 GLY A 493
PHE A 494
LEU A 513
ILE A 607
LEU A 500
 None
 1.30A 1lhuA-2p6rA:
undetectable		 1lhuA-2p6rA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qas HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF04386
(SspB) 		5 LEU A  61
LYS A  64
MET A  69
ILE A  71
LEU A 100
 None
 1.07A 1lhuA-2qasA:
undetectable		 1lhuA-2qasA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qaz SSPB PROTEIN

(Caulobacter
vibrioides) 		PF04386
(SspB) 		5 LEU A  61
LYS A  64
MET A  69
ILE A  71
LEU A 100
 None
 1.10A 1lhuA-2qazA:
undetectable		 1lhuA-2qazA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 GLY A  17
SER A 384
LEU A 386
ILE A  13
LEU A 151
 None
 1.08A 1lhuA-2r4jA:
undetectable		 1lhuA-2r4jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 SER A 105
ASN A  29
SER A  65
LEU A 120
LEU A  98
 None
 1.18A 1lhuA-2wtbA:
undetectable		 1lhuA-2wtbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 SER A 228
GLY A   7
SER A 104
ILE A   6
LEU A 229
 None
 1.30A 1lhuA-2xecA:
undetectable		 1lhuA-2xecA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D

(Homo sapiens) 		PF01388
(ARID) 		5 ASP A 111
LEU A  86
LYS A  82
ILE A 160
LEU A 100
 None
 1.19A 1lhuA-2yqeA:
undetectable		 1lhuA-2yqeA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		5 GLY A 183
MET A 240
MET A 188
ILE A 186
LEU A 225
 None
 1.31A 1lhuA-3a8rA:
undetectable		 1lhuA-3a8rA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		5 GLY A  77
PHE A  85
ASN A  81
ILE A 126
LEU A 109
 None
 1.29A 1lhuA-3aalA:
undetectable		 1lhuA-3aalA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 SER A 499
GLY A 496
LEU A 415
ILE A 432
LEU A 443
 None
 1.33A 1lhuA-3ahiA:
undetectable		 1lhuA-3ahiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		5 ASN A  74
SER A  72
LEU A  58
ILE A  87
LEU A  41
 None
 1.25A 1lhuA-3ajzA:
8.8		 1lhuA-3ajzA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay2 LIPID MODIFIED
AZURIN PROTEIN

(Neisseria
gonorrhoeae) 		PF00127
(Copper-bind) 		5 GLY A 143
ASP A  67
MET A 175
ILE A 142
LEU A  89
 None
None
ZN  A1001 (-3.5A)
None
None
 1.33A 1lhuA-3ay2A:
undetectable		 1lhuA-3ay2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1a PUTATIVE
OXIDOREDUCTASE

(Magnetospirillum
magnetotacticum) 		PF01408
(GFO_IDH_MocA) 		5 GLY A 237
PHE A 236
LEU A 137
ILE A 147
LEU A 182
 None
 0.95A 1lhuA-3c1aA:
undetectable		 1lhuA-3c1aA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 SER A 135
GLY A1015
LEU A 115
ILE A1017
LEU A 132
 None
 1.19A 1lhuA-3cmvA:
undetectable		 1lhuA-3cmvA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dn7 CYCLIC NUCLEOTIDE
BINDING REGULATORY
PROTEIN

(Cytophaga
hutchinsonii) 		PF00027
(cNMP_binding) 		5 PHE A  50
ASN A  48
LEU A 121
ILE A   6
LEU A  15
 None
 1.30A 1lhuA-3dn7A:
undetectable		 1lhuA-3dn7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 GLY A  15
ASN A  83
LEU A 233
ILE A  17
LEU A 202
 ZN  A 500 ( 4.7A)
None
None
None
None
 1.34A 1lhuA-3e49A:
undetectable		 1lhuA-3e49A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		5 GLY A   8
ASP A 290
PHE A   7
ILE A  18
LEU A  53
 None
 1.24A 1lhuA-3hfqA:
undetectable		 1lhuA-3hfqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2v PREC/CORE PROTEIN

(Hepatitis B
virus) 		no annotation 5 GLY C  10
ASP C   4
PHE C   9
LEU C  16
LEU C 119
 None
 1.13A 1lhuA-3j2vC:
undetectable		 1lhuA-3j2vC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgl SULFATE PERMEASE
FAMILY PROTEIN

(Vibrio cholerae) 		PF01740
(STAS) 		5 GLY A 487
LEU A 477
MET A 483
ILE A 488
LEU A 518
 None
 0.85A 1lhuA-3mglA:
undetectable		 1lhuA-3mglA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		5 GLY A   4
ASP A  41
ASN A  45
ILE A  26
LEU A  16
 None
 1.23A 1lhuA-3mstA:
undetectable		 1lhuA-3mstA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 GLY A 502
ASN A 476
MET A 500
ILE A 507
LEU A 576
 None
 1.28A 1lhuA-3n23A:
undetectable		 1lhuA-3n23A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 229
MET A 240
SER A 319
LEU A 326
ILE A 228
 None
 1.28A 1lhuA-3o5aA:
undetectable		 1lhuA-3o5aA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		5 GLY A 167
ASN A 213
LEU A 119
ILE A 168
LEU A 200
 None
 1.32A 1lhuA-3orfA:
undetectable		 1lhuA-3orfA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 GLY A 215
PHE A 218
LEU A 286
ILE A 185
LEU A  50
 None
DMA  A 299 (-3.7A)
None
DMA  A 299 (-4.4A)
None
 1.03A 1lhuA-3p41A:
undetectable		 1lhuA-3p41A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		5 GLY A 150
ASN A 289
LEU A 153
ILE A 149
LEU A 124
 None
 1.17A 1lhuA-3pj0A:
undetectable		 1lhuA-3pj0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		5 ASN A 160
MET A 117
LEU A 119
ILE A  61
LEU A  13
 None
 1.12A 1lhuA-3qbtA:
undetectable		 1lhuA-3qbtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmj ENOYL-COA HYDRATASE,
ECHA8_6

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 GLY A 109
ASN A 102
LEU A  51
ILE A 108
LEU A  90
 None
 1.33A 1lhuA-3qmjA:
undetectable		 1lhuA-3qmjA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 133
LEU A  51
LYS A  55
ILE A  94
LEU A  43
 None
 1.22A 1lhuA-3rrpA:
undetectable		 1lhuA-3rrpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 GLY A 671
ASN A 489
SER A 492
LEU A 484
LEU A 646
 UE1  A 998 (-3.4A)
UE1  A 998 (-2.8A)
None
None
None
 1.26A 1lhuA-3ue1A:
undetectable		 1lhuA-3ue1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 SER A 132
GLY A 117
ASN A 140
ILE A 116
LEU A 105
 None
 1.16A 1lhuA-3v7pA:
undetectable		 1lhuA-3v7pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 PHE A 202
LEU A 260
MET A 145
ILE A 272
LEU A 270
 None
 1.21A 1lhuA-3vpzA:
undetectable		 1lhuA-3vpzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE

(Enterococcus
faecium) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLY A 137
ASN A  47
LEU A  17
ILE A  39
LEU A  57
 None
 1.16A 1lhuA-3wfjA:
undetectable		 1lhuA-3wfjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 GLY A 215
PHE A 218
LEU A 286
ILE A 185
LEU A  50
 None
 1.02A 1lhuA-3zouA:
undetectable		 1lhuA-3zouA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		5 SER A 285
GLY A 237
LEU A 253
MET A 256
ILE A 236
 None
 1.34A 1lhuA-4aa9A:
undetectable		 1lhuA-4aa9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 134
LEU A  54
LYS A  58
ILE A  97
LEU A  46
 None
 1.26A 1lhuA-4apbA:
undetectable		 1lhuA-4apbA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgu MALATE DEHYDROGENASE

(Haloferax
volcanii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 143
PHE A 144
SER A 150
ILE A 142
LEU A 268
 None
 1.04A 1lhuA-4bguA:
undetectable		 1lhuA-4bguA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		5 SER A 467
GLY A 518
ASN A 457
LEU A 538
ILE A 519
 None
 1.27A 1lhuA-4fj6A:
undetectable		 1lhuA-4fj6A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 PHE A 537
SER A 412
LYS A 431
MET A 471
LEU A 524
 None
0WB  A 701 ( 4.9A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
 1.26A 1lhuA-4g3fA:
undetectable		 1lhuA-4g3fA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		5 GLY A 267
SER A 185
LEU A 275
ILE A  81
LEU A 244
 None
 1.22A 1lhuA-4j72A:
undetectable		 1lhuA-4j72A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 SER A 250
GLY A 279
ASN A 218
LEU A 282
LEU A 248
 None
 1.27A 1lhuA-4pbvA:
undetectable		 1lhuA-4pbvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 SER A 118
GLY A  10
ASP A  84
LYS A 154
ILE A  12
 None
PO4  A 401 (-3.6A)
PO4  A 401 (-3.0A)
PO4  A 401 ( 4.2A)
None
 1.25A 1lhuA-4q0mA:
undetectable		 1lhuA-4q0mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmh LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 GLY A 899
ASN A 937
LEU A 927
ILE A 861
LEU A 884
 None
 1.10A 1lhuA-4qmhA:
undetectable		 1lhuA-4qmhA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		5 SER A 142
PHE A 137
SER A 126
LEU A 123
LEU A 153
 None
 1.24A 1lhuA-4r1iA:
undetectable		 1lhuA-4r1iA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 SER A 118
GLY A  10
ASP A  84
LYS A 154
ILE A  12
 None
 1.27A 1lhuA-4ra6A:
undetectable		 1lhuA-4ra6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN

(Lactococcus
phage 1358) 		no annotation 5 GLY A  53
MET A 148
LEU A 150
ILE A  64
LEU A 118
 None
 1.03A 1lhuA-4rggA:
undetectable		 1lhuA-4rggA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		5 GLY A 265
PHE A 183
ASN A 244
LEU A 255
MET A 259
 None
 1.08A 1lhuA-4rk9A:
undetectable		 1lhuA-4rk9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		5 GLY A 386
MET A 401
LEU A  71
ILE A  19
LEU A 357
 None
None
None
FAD  A 502 (-3.9A)
None
 1.10A 1lhuA-4rslA:
undetectable		 1lhuA-4rslA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 GLY A 257
LEU A 228
LYS A 219
ILE A 254
LEU A 193
 None
 1.31A 1lhuA-4tx8A:
undetectable		 1lhuA-4tx8A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uht TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR

(Escherichia
coli) 		PF00486
(Trans_reg_C) 		5 ASP A 194
LEU A 186
LYS A 188
ILE A 201
LEU A 164
 None
 1.33A 1lhuA-4uhtA:
undetectable		 1lhuA-4uhtA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 GLY A 144
ASP A 104
PHE A 147
SER A 187
LEU A 225
 None
 1.33A 1lhuA-4z8zA:
undetectable		 1lhuA-4z8zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zel DOPAMINE
BETA-HYDROXYLASE

(Homo sapiens) 		PF01082
(Cu2_monooxygen)
PF03351
(DOMON)
PF03712
(Cu2_monoox_C) 		5 SER A  58
GLY A  84
LEU A  76
ILE A 172
LEU A  59
 None
 1.34A 1lhuA-4zelA:
undetectable		 1lhuA-4zelA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 GLY A 383
PHE A 115
LEU A 149
ILE A 381
LEU A 395
 None
 1.18A 1lhuA-4zpjA:
undetectable		 1lhuA-4zpjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 505
LYS E 531
MET E 553
ILE E 485
LEU E 487
 None
 1.20A 1lhuA-4zxbE:
undetectable		 1lhuA-4zxbE:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a98 POLYHEDRIN

(Cypovirus 15) 		no annotation 5 GLY A 152
LEU A 113
MET A 155
ILE A 151
LEU A 111
 None
 1.05A 1lhuA-5a98A:
undetectable		 1lhuA-5a98A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0s LIN0857 PROTEIN

(Listeria
innocua) 		PF04041
(Glyco_hydro_130) 		5 SER A 208
GLY A  99
ASP A  87
PHE A 100
LEU A 215
 None
None
None
None
MAN  A 403 ( 4.8A)
 1.15A 1lhuA-5b0sA:
undetectable		 1lhuA-5b0sA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 SER A 138
GLY A 131
ASP A 502
SER A 225
LEU A 139
 None
 1.25A 1lhuA-5bp8A:
undetectable		 1lhuA-5bp8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8p MOCVNH3 VARIANT

(Magnaporthe
oryzae) 		PF01476
(LysM)
PF08881
(CVNH) 		5 GLY A  70
ASP A  46
PHE A  77
ASN A  47
ILE A  69
 None
None
NAG  A 201 (-4.4A)
None
None
 1.31A 1lhuA-5c8pA:
undetectable		 1lhuA-5c8pA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmc ML032222A IGLUR

(Mnemiopsis
leidyi) 		PF10613
(Lig_chan-Glu_bd) 		5 PHE A  20
SER A  14
MET A  41
ILE A 241
LEU A 232
 None
 1.16A 1lhuA-5cmcA:
undetectable		 1lhuA-5cmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 GLY B1136
ASP B1091
ASN B1093
ILE B1135
LEU B1156
 None
 1.31A 1lhuA-5gztB:
undetectable		 1lhuA-5gztB:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 SER A  27
GLY A 129
LEU A  58
ILE A 130
LEU A 132
 None
 1.32A 1lhuA-5jpnA:
undetectable		 1lhuA-5jpnA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 GLY A 274
MET A 265
LEU A 263
ILE A 206
LEU A 204
 None
 1.24A 1lhuA-5k3jA:
undetectable		 1lhuA-5k3jA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l20 CLOSTRIPAIN-RELATED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03415
(Peptidase_C11)
no annotation 		5 PHE A  79
LEU A 122
MET A 136
ILE A 138
LEU B 188
 None
 1.24A 1lhuA-5l20A:
undetectable		 1lhuA-5l20A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 SER A1543
GLY A1553
ASN A1395
ILE A1552
LEU A1508
 None
 1.24A 1lhuA-5m59A:
undetectable		 1lhuA-5m59A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1

(Homo sapiens) 		no annotation 5 GLY A  71
PHE A  70
MET A   1
LEU A 142
ILE A 149
 None
None
Z90  A 201 (-4.2A)
None
Z90  A 201 ( 4.2A)
 1.26A 1lhuA-5mnwA:
undetectable		 1lhuA-5mnwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 GLY E  29
ASP E  82
MET E  77
ILE E  28
LEU E 113
 None
 1.13A 1lhuA-5nkmE:
undetectable		 1lhuA-5nkmE:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 GLY A 401
ASP A 359
LYS A 362
ILE A 395
LEU A 478
 None
 1.01A 1lhuA-5opqA:
undetectable		 1lhuA-5opqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szi RAS-RELATED PROTEIN
RAB-8A

(Homo sapiens) 		PF00071
(Ras) 		5 ASN A 160
MET A 117
LEU A 119
ILE A  61
LEU A  13
 None
 1.11A 1lhuA-5sziA:
undetectable		 1lhuA-5sziA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 5 GLY A 200
MET A 278
LEU A 100
MET A 153
ILE A 201
 None
None
None
None
GGB  A 403 ( 4.9A)
 0.98A 1lhuA-5utiA:
undetectable		 1lhuA-5utiA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 368
PHE A 367
SER A 335
ILE A 248
LEU A 261
 None
None
None
COA  A 401 ( 4.9A)
COA  A 401 (-3.8A)
 1.30A 1lhuA-5wx3A:
undetectable		 1lhuA-5wx3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 SER A 162
LEU A 172
MET A 174
ILE A 155
LEU A 158
 None
 1.23A 1lhuA-5y3jA:
undetectable		 1lhuA-5y3jA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3x BETA-XYLANASE

(Caldicellulosiruptor
owensensis) 		no annotation 5 GLY A 298
PHE A 296
SER A 293
ILE A 299
LEU A  39
 None
 1.16A 1lhuA-5y3xA:
undetectable		 1lhuA-5y3xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 SER A 162
LEU A 172
MET A 174
ILE A 155
LEU A 158
 None
 1.30A 1lhuA-5zlnA:
undetectable		 1lhuA-5zlnA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5

(Homo sapiens) 		no annotation 5 GLY A 428
PHE A 353
ASN B  58
LEU C1304
LEU A1084
 None
 1.30A 1lhuA-6en4A:
1.0		 1lhuA-6en4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT RPAC1

(Saccharomyces
cerevisiae) 		no annotation 5 GLY C 102
SER C  77
LEU C 106
ILE C 101
LEU C 167
 None
 1.22A 1lhuA-6f42C:
undetectable		 1lhuA-6f42C:
19.37