SIMILAR PATTERNS OF AMINO ACIDS FOR 1LH6_A_NIOA155_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6g MYOGLOBIN

(Physeter
catodon) 		PF00042
(Globin) 		5 PHE A  33
PHE A  43
PHE A  46
HIS A  64
HIS A  93
 None
HEM  A 154 ( 4.0A)
None
HEM  A 154 ( 4.1A)
HEM  A 154 (-3.3A)
 1.31A 1lh6A-1a6gA:
16.2		 1lh6A-1a6gA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6g MYOGLOBIN

(Physeter
catodon) 		PF00042
(Globin) 		5 PHE A  43
PHE A  46
HIS A  64
VAL A  68
HIS A  93
 HEM  A 154 ( 4.0A)
None
HEM  A 154 ( 4.1A)
HEM  A 154 ( 3.9A)
HEM  A 154 (-3.3A)
 1.15A 1lh6A-1a6gA:
16.2		 1lh6A-1a6gA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9w HEMOGLOBIN (BETA
CHAIN)

(Homo sapiens) 		PF00042
(Globin) 		4 PHE E  42
PHE E  45
VAL E  67
HIS E  92
 HEM  E 147 (-4.3A)
None
HEM  E 147 (-4.2A)
HEM  E 147 (-3.3A)
 0.81A 1lh6A-1a9wE:
14.0		 1lh6A-1a9wE:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  63
HIS A  88
 HEM  A 142 (-3.9A)
None
HEM  A 142 (-4.0A)
HEM  A 142 ( 3.3A)
 0.92A 1lh6A-1cg8A:
13.7		 1lh6A-1cg8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA

(Homo sapiens) 		PF00042
(Globin) 		4 PHE A  42
PHE A  45
VAL A  67
HIS A  92
 HEM  A 147 (-4.2A)
HEM  A 147 (-4.7A)
HEM  A 147 (-4.2A)
HEM  A 147 (-3.3A)
 0.80A 1lh6A-1ch4A:
13.6		 1lh6A-1ch4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 PHE A 152
PHE A 128
PHE A  80
HIS A 105
 None
 0.90A 1lh6A-1czfA:
undetectable		 1lh6A-1czfA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faw HEMOGLOBIN (ALPHA
SUBUNIT)

(Anser anser) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 150 (-4.0A)
HEM  A 150 (-4.6A)
HEM  A 150 (-4.2A)
HEM  A 150 (-3.4A)
 0.96A 1lh6A-1fawA:
13.4		 1lh6A-1fawA:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fsl LEGHEMOGLOBIN A

(Glycine max) 		PF00042
(Globin) 		5 PHE A  29
PHE A  44
PHE A  46
HIS A  61
HIS A  92
 NIO  A 145 ( 4.9A)
HEM  A 144 ( 3.8A)
NIO  A 145 (-4.8A)
HEM  A 144 ( 3.6A)
HEM  A 144 (-3.4A)
 0.89A 1lh6A-1fslA:
19.4		 1lh6A-1fslA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcw PROTEIN (HEMOGLOBIN)

(Mustelus
griseus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  48
VAL B  57
HIS B  82
 HEM  B 136 (-3.6A)
None
HEM  B 136 (-4.1A)
HEM  B 136 (-3.5A)
 0.92A 1lh6A-1gcwB:
12.1		 1lh6A-1gcwB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4b POLCALCIN BET V 4

(Betula pendula) 		PF13499
(EF-hand_7) 		4 PHE A  18
PHE A  66
PHE A  69
VAL A  80
 None
 0.92A 1lh6A-1h4bA:
undetectable		 1lh6A-1h4bA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)

(Gallus gallus) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.8A)
HEM  A 142 (-4.8A)
HEM  A 142 ( 4.1A)
HEM  A 142 (-3.3A)
 0.91A 1lh6A-1hbrA:
14.4		 1lh6A-1hbrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 PHE A 381
PHE A 380
HIS A 224
HIS A 193
 None
None
CU  A 665 (-3.5A)
None
 0.95A 1lh6A-1hcyA:
undetectable		 1lh6A-1hcyA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.6A)
None
HEM  A 142 (-3.8A)
HEM  A 142 (-2.9A)
 0.87A 1lh6A-1hdsA:
13.0		 1lh6A-1hdsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ith HEMOGLOBIN (CYANO
MET)

(Urechis caupo) 		PF00042
(Globin) 		4 PHE A  44
PHE A  47
VAL A  68
HIS A  94
 HEM  A 143 ( 4.3A)
None
HEM  A 143 (-4.3A)
HEM  A 143 (-3.3A)
 0.95A 1lh6A-1ithA:
11.7		 1lh6A-1ithA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl7 MONOMER HEMOGLOBIN
COMPONENT III

(Glycera
dibranchiata) 		PF00042
(Globin) 		4 PHE A  45
PHE A  47
VAL A  62
HIS A  90
 HEM  A 148 (-3.7A)
None
HEM  A 148 ( 4.0A)
HEM  A 148 (-3.4A)
 0.72A 1lh6A-1jl7A:
13.8		 1lh6A-1jl7A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 PHE A 284
PHE A 345
PHE A 309
VAL A 286
 None
 0.99A 1lh6A-1kt8A:
undetectable		 1lh6A-1kt8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 284 (-4.1A)
HEM  A 284 (-4.7A)
HEM  A 284 ( 4.1A)
HEM  A 284 (-3.3A)
 0.88A 1lh6A-1o1jA:
14.0		 1lh6A-1o1jA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1j HEMOGLOBIN ALPHA
CHAIN

(Homo sapiens) 		PF00042
(Globin) 		4 PHE A 185
PHE A 188
VAL A 204
HIS A 229
 HEM  A 285 (-4.1A)
None
HEM  A 285 ( 4.1A)
HEM  A 285 (-3.3A)
 0.92A 1lh6A-1o1jA:
14.0		 1lh6A-1o1jA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oow PLASTOCYANIN,
CHLOROPLAST

(Spinacia
oleracea) 		PF00127
(Copper-bind) 		4 PHE A  29
PHE A  82
PHE A  41
VAL A   1
 None
 0.96A 1lh6A-1oowA:
undetectable		 1lh6A-1oowA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 148 (-4.1A)
None
HEM  B 148 (-4.2A)
HEM  B 148 (-3.3A)
 0.84A 1lh6A-1ouuB:
13.8		 1lh6A-1ouuB:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdk PROTEIN (PROTEIN
PAPK)

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 PHE B 152
PHE B 125
HIS B 108
VAL B  63
 None
 0.77A 1lh6A-1pdkB:
undetectable		 1lh6A-1pdkB:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 PHE A 181
PHE A 137
PHE A 120
PHE A 124
VAL A  97
 None
 1.50A 1lh6A-1qbgA:
undetectable		 1lh6A-1qbgA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(ALPHA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 650 (-4.1A)
None
HEM  A 650 ( 4.2A)
HEM  A 650 (-3.7A)
 0.94A 1lh6A-1qpwA:
13.3		 1lh6A-1qpwA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN

(Equus asinus) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-4.1A)
None
HEM  A 142 ( 4.5A)
HEM  A 142 (-3.3A)
 0.90A 1lh6A-1s0hA:
12.6		 1lh6A-1s0hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 148 ( 4.5A)
None
HEM  B 148 (-3.9A)
HEM  B 148 (-3.2A)
 0.78A 1lh6A-1spgB:
13.0		 1lh6A-1spgB:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN A AND D
BETA CHAIN

(Aldabrachelys
gigantea) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.3A)
HEM  B 201 (-4.7A)
HEM  B 201 ( 4.0A)
HEM  B 201 (-3.4A)
 0.82A 1lh6A-1wmuB:
13.8		 1lh6A-1wmuB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN D ALPHA
CHAIN

(Aldabrachelys
gigantea) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.9A)
HEM  A 201 (-4.5A)
HEM  A 201 ( 4.2A)
HEM  A 201 (-3.4A)
 0.92A 1lh6A-1wmuA:
15.1		 1lh6A-1wmuA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 PHE A 167
PHE A 194
PHE A 241
VAL A 137
 None
 0.99A 1lh6A-1xjeA:
undetectable		 1lh6A-1xjeA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzo HYPOTHETICAL PROTEIN
YPMQ

(Bacillus
subtilis) 		PF02630
(SCO1-SenC) 		4 PHE A  75
PHE A  16
PHE A 115
VAL A 142
 None
 1.00A 1lh6A-1xzoA:
undetectable		 1lh6A-1xzoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 200 (-3.5A)
HEM  A 200 (-4.6A)
HEM  A 200 ( 3.8A)
HEM  A 200 (-3.2A)
 0.97A 1lh6A-2b7hA:
13.4		 1lh6A-2b7hA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN BETA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 200 (-4.1A)
None
HEM  B 200 ( 3.8A)
HEM  B 200 (-3.2A)
 0.83A 1lh6A-2b7hB:
13.8		 1lh6A-2b7hB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 PHE A 191
PHE A  65
VAL A 129
HIS A 252
 None
 0.95A 1lh6A-2d0dA:
undetectable		 1lh6A-2d0dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhb HEMOGLOBIN (DEOXY)
(BETA CHAIN)

(Equus caballus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.3A)
None
HEM  B 147 (-3.9A)
HEM  B 147 (-3.4A)
 0.89A 1lh6A-2dhbB:
13.4		 1lh6A-2dhbB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 358
PHE A 459
PHE A 461
VAL A 243
 None
 0.95A 1lh6A-2dzdA:
undetectable		 1lh6A-2dzdA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 PHE A 127
PHE A 506
PHE A  32
HIS A 211
 None
 0.93A 1lh6A-2exhA:
undetectable		 1lh6A-2exhA:
15.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gdm LEGHEMOGLOBIN (OXY)

(Lupinus luteus) 		PF00042
(Globin) 		6 PHE A  29
PHE A  30
PHE A  44
PHE A  46
VAL A  67
HIS A  97
 None
None
HEM  A 154 (-4.2A)
HEM  A 154 ( 4.9A)
HEM  A 154 ( 4.1A)
HEM  A 154 (-3.3A)
 0.47A 1lh6A-2gdmA:
24.6		 1lh6A-2gdmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A  40
PHE A 113
PHE A 115
PHE A  54
VAL A  15
 None
 1.42A 1lh6A-2hq6A:
undetectable		 1lh6A-2hq6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E

(Colletotrichum
lupini) 		PF00295
(Glyco_hydro_28) 		4 PHE A 149
PHE A 125
PHE A  76
HIS A 101
 None
 0.91A 1lh6A-2iq7A:
undetectable		 1lh6A-2iq7A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		4 PHE A 310
PHE A 409
HIS A 392
VAL A 424
 None
 1.02A 1lh6A-2j6lA:
undetectable		 1lh6A-2j6lA:
15.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oif NON-LEGUME
HEMOGLOBIN

(Hordeum vulgare) 		PF00042
(Globin) 		4 PHE A  51
PHE A  53
VAL A  74
HIS A 105
 HEM  A 163 ( 3.9A)
None
HEM  A 163 ( 4.3A)
HEM  A 163 (-3.3A)
 0.68A 1lh6A-2oifA:
17.9		 1lh6A-2oifA:
43.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r50 NON-SYMBIOTIC
HEMOGLOBIN

(Zea mays) 		PF00042
(Globin) 		4 PHE A  54
PHE A  40
PHE A  44
VAL A 113
 HEM  A 166 (-4.1A)
None
None
HEM  A 166 ( 4.4A)
 0.97A 1lh6A-2r50A:
19.4		 1lh6A-2r50A:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r80 HEMOGLOBIN SUBUNIT
ALPHA-A

(Columba livia) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 150 (-3.8A)
HEM  A 150 ( 4.9A)
HEM  A 150 ( 3.8A)
HEM  A 150 (-3.3A)
 0.88A 1lh6A-2r80A:
12.7		 1lh6A-2r80A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE

(Thermotoga
maritima) 		no annotation 4 PHE A  35
PHE A  30
PHE A 160
VAL A  40
 None
 0.92A 1lh6A-2xomA:
undetectable		 1lh6A-2xomA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y IMITATION SWITCH
PROTEIN 1
(DEL_ATPASE)
ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF09110
(HAND)
PF09111
(SLIDE)
PF15612
(WHIM1) 		4 PHE A 975
PHE A 976
HIS B 613
VAL B 615
 None
 1.01A 1lh6A-2y9yA:
undetectable		 1lh6A-2y9yA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yro GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PHE A  99
PHE A  93
PHE A  71
VAL A  35
 None
 0.96A 1lh6A-2yroA:
undetectable		 1lh6A-2yroA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfb HEMOGLOBIN SUBUNIT
ALPHA

(Psittacula
krameri) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 150 (-3.6A)
HEM  A 150 (-4.6A)
HEM  A 150 ( 3.9A)
HEM  A 150 (-3.3A)
 0.91A 1lh6A-2zfbA:
12.8		 1lh6A-2zfbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 401 (-4.4A)
None
HEM  B 401 (-3.9A)
HEM  B 401 (-3.2A)
 0.79A 1lh6A-3a0gB:
13.2		 1lh6A-3a0gB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 ALPHAA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.9A)
HEM  A 142 (-4.8A)
HEM  A 142 (-3.8A)
HEM  A 142 (-3.3A)
 0.91A 1lh6A-3at6A:
13.4		 1lh6A-3at6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 BETA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.1A)
HEM  B 147 (-4.4A)
HEM  B 147 ( 3.9A)
HEM  B 147 (-3.5A)
 0.90A 1lh6A-3at6B:
13.3		 1lh6A-3at6B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq BETA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.1A)
HEM  B 147 ( 4.9A)
HEM  B 147 (-4.2A)
HEM  B 147 (-3.3A)
 0.82A 1lh6A-3bcqB:
13.5		 1lh6A-3bcqB:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 PHE A 161
PHE A 116
PHE A 153
PHE A 149
VAL A 191
 None
 1.46A 1lh6A-3bmaA:
undetectable		 1lh6A-3bmaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cy5 HEMOGLOBIN SUBUNIT
BETA

(Bubalus bubalis) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.0A)
None
HEM  B 147 ( 3.8A)
HEM  B 147 (-3.3A)
 0.80A 1lh6A-3cy5B:
13.2		 1lh6A-3cy5B:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2

(Capra hircus) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.5A)
HEM  A 142 (-4.6A)
HEM  A 142 ( 4.4A)
HEM  A 142 (-3.5A)
 0.94A 1lh6A-3d1aA:
13.8		 1lh6A-3d1aA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh9 HEMOGLOBIN ALPHA
CHAIN

(Pteropus
giganteus) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 ( 3.8A)
None
HEM  A 142 (-4.0A)
HEM  A 142 (-3.4A)
 0.89A 1lh6A-3fh9A:
12.7		 1lh6A-3fh9A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs4 HEMOGLOBIN SUBUNIT
BETA

(Struthio
camelus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 150 (-4.0A)
None
HEM  B 150 (-4.0A)
HEM  B 150 (-3.3A)
 0.82A 1lh6A-3fs4B:
14.0		 1lh6A-3fs4B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		4 PHE A 334
PHE A 332
PHE A  42
HIS A  38
 None
 0.98A 1lh6A-3g7uA:
undetectable		 1lh6A-3g7uA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
ALPHA

(Camelus
dromedarius) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.9A)
HEM  A 142 (-4.7A)
HEM  A 142 ( 4.0A)
HEM  A 142 (-3.5A)
 1.01A 1lh6A-3gdjA:
13.5		 1lh6A-3gdjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
BETA

(Camelus
dromedarius) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.0A)
None
HEM  B 147 ( 3.9A)
HEM  B 147 (-3.4A)
 0.80A 1lh6A-3gdjB:
14.0		 1lh6A-3gdjB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqp HEMOGLOBIN SUBUNIT
BETA-A/B

(Felis catus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 148 (-4.1A)
None
HEM  B 148 ( 4.0A)
HEM  B 148 (-3.4A)
 0.88A 1lh6A-3gqpB:
13.8		 1lh6A-3gqpB:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		4 PHE A 129
PHE A 130
PHE A  22
VAL A  89
 None
 1.01A 1lh6A-3grnA:
undetectable		 1lh6A-3grnA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3heo MYOGLOBIN

(Equus caballus) 		PF00042
(Globin) 		5 PHE A  33
PHE A  43
PHE A  46
VAL A  68
HIS A  93
 None
HEM  A 154 ( 4.0A)
None
HEM  A 154 ( 3.8A)
HEM  A 154 (-3.2A)
 1.41A 1lh6A-3heoA:
16.3		 1lh6A-3heoA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrw HEMOGLOBIN SUBUNIT
BETA-1

(Mus musculus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 200 (-3.8A)
HEM  B 200 (-4.2A)
HEM  B 200 (-3.6A)
HEM  B 200 (-2.9A)
 0.72A 1lh6A-3hrwB:
13.6		 1lh6A-3hrwB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 PHE A 222
PHE A 267
PHE A 271
VAL A 219
 None
 1.00A 1lh6A-3lfuA:
undetectable		 1lh6A-3lfuA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PHE A  91
PHE A  85
PHE A  63
VAL A  27
 None
 0.90A 1lh6A-3ojbA:
undetectable		 1lh6A-3ojbA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqr NON-LEGUME
HEMOGLOBIN

(Parasponia
andersonii) 		PF00042
(Globin) 		4 PHE A  36
PHE A  37
PHE A  51
VAL A  74
 None
None
HEM  A 163 (-3.8A)
HEM  A 163 ( 4.4A)
 0.83A 1lh6A-3qqrA:
19.6		 1lh6A-3qqrA:
41.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqr NON-LEGUME
HEMOGLOBIN

(Parasponia
andersonii) 		PF00042
(Globin) 		4 PHE A  36
PHE A  37
VAL A  74
HIS A 105
 None
None
HEM  A 163 ( 4.4A)
HEM  A 163 (-3.1A)
 0.80A 1lh6A-3qqrA:
19.6		 1lh6A-3qqrA:
41.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqr NON-LEGUME
HEMOGLOBIN

(Parasponia
andersonii) 		PF00042
(Globin) 		4 PHE A  37
PHE A  51
VAL A  74
HIS A 105
 None
HEM  A 163 (-3.8A)
HEM  A 163 ( 4.4A)
HEM  A 163 (-3.1A)
 0.79A 1lh6A-3qqrA:
19.6		 1lh6A-3qqrA:
41.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 PHE A  57
PHE A 156
PHE A 182
HIS A 127
 None
 0.92A 1lh6A-3r0zA:
undetectable		 1lh6A-3r0zA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 PHE X  59
PHE X 158
PHE X 184
HIS X 129
 None
 0.82A 1lh6A-3ss7X:
undetectable		 1lh6A-3ss7X:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.7A)
HEM  A 201 (-4.4A)
HEM  A 201 (-4.2A)
HEM  A 201 (-3.4A)
 0.97A 1lh6A-3vreA:
13.2		 1lh6A-3vreA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.4A)
None
HEM  B 201 (-3.8A)
HEM  B 201 (-3.4A)
 0.90A 1lh6A-3vreB:
13.8		 1lh6A-3vreB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4u HEMOGLOBIN SUBUNIT
ZETA

(Homo sapiens) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.9A)
HEM  A 201 (-4.4A)
HEM  A 201 (-4.1A)
HEM  A 201 ( 3.2A)
 0.96A 1lh6A-3w4uA:
13.8		 1lh6A-3w4uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 719
PHE A 743
PHE A 771
VAL A 714
 None
 0.92A 1lh6A-3wpeA:
undetectable		 1lh6A-3wpeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtg HEMOGLOBIN SUBUNIT
ALPHA-A

(Dromaius
novaehollandiae) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.6A)
HEM  A 201 (-4.7A)
HEM  A 201 (-3.9A)
HEM  A 201 ( 3.2A)
 0.88A 1lh6A-3wtgA:
13.2		 1lh6A-3wtgA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dp0 PLASTOCYANIN B,
CHLOROPLASTIC

(Populus nigra) 		PF00127
(Copper-bind) 		4 PHE X  29
PHE X  82
PHE X  41
VAL X   1
 None
 0.99A 1lh6A-4dp0X:
undetectable		 1lh6A-4dp0X:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 202 (-4.1A)
None
HEM  B 202 (-3.9A)
HEM  B 202 (-3.3A)
 0.91A 1lh6A-4esaB:
13.9		 1lh6A-4esaB:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqz GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 PHE A 267
PHE A 261
PHE A 239
VAL A 203
 None
 0.89A 1lh6A-4fqzA:
undetectable		 1lh6A-4fqzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		4 PHE A  40
PHE A 251
PHE A  99
HIS A 248
 None
 1.01A 1lh6A-4g8dA:
undetectable		 1lh6A-4g8dA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2l BETA GLOBIN

(Peromyscus
maniculatus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.0A)
None
HEM  B 201 ( 4.0A)
HEM  B 201 (-3.4A)
 0.88A 1lh6A-4h2lB:
13.4		 1lh6A-4h2lB:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		4 PHE A 204
PHE A  78
HIS A 218
VAL A 215
 None
None
GOL  A 401 (-3.2A)
None
 1.01A 1lh6A-4lryA:
undetectable		 1lh6A-4lryA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.0A)
None
HEM  B 201 ( 3.8A)
HEM  B 201 (-3.3A)
 0.82A 1lh6A-4mqjB:
13.4		 1lh6A-4mqjB:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A  40
PHE A 113
PHE A 115
PHE A  54
VAL A  15
 None
 1.46A 1lh6A-4r3eA:
undetectable		 1lh6A-4r3eA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		5 PHE A  40
PHE A 139
PHE A 141
PHE A  54
VAL A  15
 None
 1.42A 1lh6A-4r3fA:
undetectable		 1lh6A-4r3fA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzv HEMOGLOBIN

(Thermobifida
fusca) 		PF01152
(Bac_globin) 		4 PHE A  53
PHE A  54
PHE A  67
HIS A 106
 None
None
HEM  A1157 ( 3.7A)
HEM  A1157 (-3.3A)
 0.78A 1lh6A-4uzvA:
2.9		 1lh6A-4uzvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wch ISOLATED CHAIN D OF
GIGANT HEMOGLOBIN
FROM GLOSSOSCOLEX
PAULISTUS

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 PHE D  36
PHE D  47
PHE D  60
HIS D  95
 HEM  D 201 ( 4.6A)
HEM  D 201 ( 3.3A)
None
HEM  D 201 (-3.3A)
 0.97A 1lh6A-4wchD:
12.8		 1lh6A-4wchD:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 PHE A 198
PHE A 200
PHE A 208
VAL A 171
 None
 1.01A 1lh6A-4y9vA:
undetectable		 1lh6A-4y9vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 PHE A 200
PHE A 208
PHE A 216
VAL A 171
 None
 0.98A 1lh6A-4y9vA:
undetectable		 1lh6A-4y9vA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.8A)
HEM  A 201 ( 4.9A)
HEM  A 201 (-4.2A)
HEM  A 201 (-3.3A)
 0.85A 1lh6A-4yu4A:
12.8		 1lh6A-4yu4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.4A)
None
OXY  B 202 (-4.1A)
HEM  B 201 (-3.3A)
 0.82A 1lh6A-4yu4B:
13.7		 1lh6A-4yu4B:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 PHE A 289
PHE A 286
PHE A 343
PHE A 369
 None
 0.83A 1lh6A-5dztA:
undetectable		 1lh6A-5dztA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eui HBB PROTEIN

(Ochotona
princeps) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.0A)
None
HEM  B 201 ( 4.0A)
HEM  B 201 (-3.3A)
 0.81A 1lh6A-5euiB:
14.1		 1lh6A-5euiB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flj QUERCETINASE QUED

(Streptomyces
sp. FLA) 		PF07883
(Cupin_2) 		4 PHE A 141
PHE A  56
VAL A 174
HIS A 115
 QUE  A 301 (-4.8A)
None
None
NI  A 300 (-3.2A)
 0.91A 1lh6A-5fljA:
undetectable		 1lh6A-5fljA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		4 PHE A 444
PHE A 447
PHE A 500
PHE A 496
 None
 1.01A 1lh6A-5h11A:
2.3		 1lh6A-5h11A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu6 HEMOGLOBIN SUBUNIT
BETA

(Homo sapiens) 		PF00042
(Globin) 		4 PHE B  43
PHE B  46
VAL B  68
HIS B  93
 HEM  B 201 ( 4.4A)
None
HEM  B 201 ( 3.6A)
HEM  B 201 (-3.5A)
 0.90A 1lh6A-5hu6B:
13.4		 1lh6A-5hu6B:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnz BETA CHAIN

(Acipenser
stellatus) 		PF00042
(Globin) 		4 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.2A)
None
HEM  B 201 (-4.1A)
HEM  B 201 (-3.4A)
 0.80A 1lh6A-5jnzB:
14.2		 1lh6A-5jnzB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		4 PHE A 212
PHE A 111
HIS A 241
VAL A 239
 None
 0.94A 1lh6A-5o9eA:
undetectable		 1lh6A-5o9eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 351
PHE A 452
PHE A 454
VAL A 237
 None
 0.86A 1lh6A-5vywA:
undetectable		 1lh6A-5vywA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wog HEMOGLOBIN SUBUNIT
ALPHA

(Homo sapiens) 		no annotation 4 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.8A)
HEM  A 201 ( 4.9A)
HEM  A 201 ( 3.9A)
HEM  A 201 (-3.3A)
 0.93A 1lh6A-5wogA:
13.8		 1lh6A-5wogA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 PHE A 373
PHE A 347
VAL A 276
HIS A 308
 None
 0.99A 1lh6A-5ybbA:
undetectable		 1lh6A-5ybbA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 PHE A  91
PHE A  92
PHE A 135
VAL A 131
 None
 0.93A 1lh6A-6eroA:
undetectable		 1lh6A-6eroA:
21.52