SIMILAR PATTERNS OF AMINO ACIDS FOR 1LF9_B_ACRB701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ALA A 276
ARG A 280
ASP A 278
GLU A 547
ARG A 519
 None
 1.31A 1lf9B-1ot5A:
undetectable		 1lf9B-1ot5A:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 ALA A 307
TRP A 330
ASP A 333
GLN A 370
GLU A 427
 ACR  A3000 (-3.4A)
ACR  A3000 (-3.7A)
ACR  A3000 (-3.1A)
ACR  A3000 (-3.5A)
None
 1.29A 1lf9B-1ulvA:
53.0		 1lf9B-1ulvA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		8 ALA A 307
TRP A 330
GLN A 384
GLU A 431
ASN A 513
ARG A 567
TYR A 573
TRP A 591
 ACR  A3000 (-3.4A)
ACR  A3000 (-3.7A)
None
ACR  A3000 (-3.5A)
ACR  A3000 (-3.5A)
ACR  A3000 (-2.9A)
ACR  A3000 (-3.7A)
None
 1.24A 1lf9B-1ulvA:
53.0		 1lf9B-1ulvA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		11 ALA A 307
TYR A 326
TRP A 330
ARG A 332
ASP A 333
GLN A 370
GLU A 431
ASN A 513
ARG A 567
TYR A 573
TRP A 591
 ACR  A3000 (-3.4A)
ACR  A3000 (-3.9A)
ACR  A3000 (-3.7A)
ACR  A3000 (-3.7A)
ACR  A3000 (-3.1A)
ACR  A3000 (-3.5A)
ACR  A3000 (-3.5A)
ACR  A3000 (-3.5A)
ACR  A3000 (-2.9A)
ACR  A3000 (-3.7A)
None
 0.35A 1lf9B-1ulvA:
53.0		 1lf9B-1ulvA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		6 ARG A 332
GLN A 426
ASN A 513
ARG A 567
TYR A 573
TRP A 591
 ACR  A3000 (-3.7A)
ACR  A3000 ( 3.8A)
ACR  A3000 (-3.5A)
ACR  A3000 (-2.9A)
ACR  A3000 (-3.7A)
None
 1.28A 1lf9B-1ulvA:
53.0		 1lf9B-1ulvA:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 ASP A 333
GLN A 380
ASN A 513
TYR A 573
TRP A 591
 ACR  A3000 (-3.1A)
ACR  A3000 ( 4.9A)
ACR  A3000 (-3.5A)
ACR  A3000 (-3.7A)
None
 1.30A 1lf9B-1ulvA:
53.0		 1lf9B-1ulvA:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		5 ALA A 360
TRP A 347
GLU A 321
ARG A  68
TRP A  70
 None
B2G  A1399 (-3.7A)
None
None
None
 1.48A 1lf9B-1ur4A:
undetectable		 1lf9B-1ur4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		9 ALA A  54
TYR A  63
TRP A  67
ARG A  69
ASP A  70
GLU A 211
ARG A 345
TYR A 351
TRP A 362
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.0A)
ACR  A 995 ( 3.7A)
None
 0.42A 1lf9B-2f6dA:
29.5		 1lf9B-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 ALA A  54
TYR A  63
TRP A 139
GLU A 211
TYR A 351
 ACR  A 995 (-3.4A)
ACR  A 995 (-4.3A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.5A)
ACR  A 995 ( 3.7A)
 0.91A 1lf9B-2f6dA:
29.5		 1lf9B-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
 None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
 1.24A 1lf9B-2vdcA:
0.0		 1lf9B-2vdcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		9 ALA A  38
TYR A  47
TRP A  51
ARG A  53
ASP A  54
GLU A 180
ARG A 309
TYR A 315
TRP A 321
 BTB  A 620 ( 3.8A)
BTB  A 620 (-3.9A)
BTB  A 620 (-3.8A)
BTB  A 620 (-3.7A)
BTB  A 620 (-2.8A)
None
BTB  A 620 (-3.6A)
BTB  A 620 ( 4.9A)
None
 0.48A 1lf9B-2vn7A:
6.8		 1lf9B-2vn7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		6 ALA A  38
TYR A  47
TRP A 120
GLU A 180
TYR A 315
TRP A 321
 BTB  A 620 ( 3.8A)
BTB  A 620 (-3.9A)
None
None
BTB  A 620 ( 4.9A)
None
 1.01A 1lf9B-2vn7A:
6.8		 1lf9B-2vn7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 GLN A 124
TRP A 120
GLU A 180
TYR A 315
TRP A 321
 None
None
None
BTB  A 620 ( 4.9A)
None
 1.31A 1lf9B-2vn7A:
6.8		 1lf9B-2vn7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		6 TRP A  51
GLN A 124
GLU A 180
ARG A 309
TYR A 315
TRP A 321
 BTB  A 620 (-3.8A)
None
None
BTB  A 620 (-3.6A)
BTB  A 620 ( 4.9A)
None
 1.44A 1lf9B-2vn7A:
6.8		 1lf9B-2vn7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 ALA A 500
ARG A 494
GLN A 577
GLU A 227
ARG A 291
 None
 1.42A 1lf9B-3cf4A:
0.0		 1lf9B-3cf4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		9 ALA A  63
TYR A  72
TRP A  76
ARG A  78
ASP A  79
GLU A 204
ARG A 329
TYR A 335
TRP A 341
 TRS  A 701 ( 3.8A)
TRS  A 701 (-4.5A)
TRS  A 701 (-3.8A)
TRS  A 701 (-3.8A)
TRS  A 701 (-2.8A)
GOL  A 801 (-3.6A)
GOL  A 801 (-3.3A)
GOL  A 801 ( 4.1A)
None
 0.46A 1lf9B-3eqaA:
30.0		 1lf9B-3eqaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		6 ALA A  63
TYR A  72
TRP A 144
GLU A 204
TYR A 335
TRP A 341
 TRS  A 701 ( 3.8A)
TRS  A 701 (-4.5A)
None
GOL  A 801 (-3.6A)
GOL  A 801 ( 4.1A)
None
 1.03A 1lf9B-3eqaA:
30.0		 1lf9B-3eqaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		5 GLN A 148
TRP A 144
GLU A 204
TYR A 335
TRP A 341
 None
None
GOL  A 801 (-3.6A)
GOL  A 801 ( 4.1A)
None
 1.35A 1lf9B-3eqaA:
30.0		 1lf9B-3eqaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		6 TRP A  76
GLN A 148
GLU A 204
ARG A 329
TYR A 335
TRP A 341
 TRS  A 701 (-3.8A)
None
GOL  A 801 (-3.6A)
GOL  A 801 (-3.3A)
GOL  A 801 ( 4.1A)
None
 1.46A 1lf9B-3eqaA:
30.0		 1lf9B-3eqaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		5 ALA A  47
TRP A 424
GLN A 428
GLU A 452
ASN A 454
 None
None
None
IFL  A 503 (-3.1A)
NA  A 502 (-3.1A)
 1.46A 1lf9B-4ayrA:
14.9		 1lf9B-4ayrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		7 ALA A  36
TYR A  47
ARG A  53
ASP A  54
ASN A 365
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
None
FRU  A 501 (-4.8A)
None
 1.21A 1lf9B-5gooA:
9.6		 1lf9B-5gooA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 458
TRP A 435
ASN A  40
ARG A 113
TYR A  42
 None
 1.42A 1lf9B-5lm8A:
undetectable		 1lf9B-5lm8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 ALA A  31
TRP A  40
ASP A  43
TYR A 375
TRP A 381
 GOL  A 501 ( 4.0A)
GOL  A 501 ( 4.0A)
GOL  A 501 (-2.9A)
None
None
 0.96A 1lf9B-5oieA:
9.2		 1lf9B-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 ALA A  31
TYR A  36
ASP A  43
ASN A 183
TYR A 375
 GOL  A 501 ( 4.0A)
GOL  A 501 ( 3.7A)
GOL  A 501 (-2.9A)
None
None
 1.04A 1lf9B-5oieA:
9.2		 1lf9B-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 ALA A  31
TYR A  36
ASP A  43
TYR A 375
TRP A 381
 GOL  A 501 ( 4.0A)
GOL  A 501 ( 3.7A)
GOL  A 501 (-2.9A)
None
None
 0.95A 1lf9B-5oieA:
9.2		 1lf9B-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 6 ALA A  37
ARG A  54
ASP A  55
ASN A 366
TYR A 371
TRP A 377
 GOL  A 501 ( 3.8A)
GOL  A 501 (-4.1A)
GOL  A 501 (-2.7A)
None
None
None
 1.22A 1lf9B-5z73A:
3.8		 1lf9B-5z73A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 9 ALA A  66
TYR A  75
TRP A  79
ARG A  81
ASP A  82
GLU A 214
ARG A 341
TYR A 347
TRP A 353
 B3P  A 652 ( 3.9A)
B3P  A 652 (-4.1A)
B3P  A 652 ( 4.1A)
B3P  A 652 (-4.0A)
B3P  A 652 (-2.8A)
B3P  A 652 (-3.4A)
B3P  A 652 (-2.8A)
B3P  A 652 ( 3.8A)
None
 0.36A 1lf9B-6fhvA:
10.4		 1lf9B-6fhvA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 5 ALA A  66
TYR A  75
TRP A 154
GLU A 214
TYR A 347
 B3P  A 652 ( 3.9A)
B3P  A 652 (-4.1A)
B3P  A 652 (-4.3A)
B3P  A 652 (-3.4A)
B3P  A 652 ( 3.8A)
 1.00A 1lf9B-6fhvA:
10.4		 1lf9B-6fhvA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 6 TRP A  79
GLN A 158
GLU A 214
ARG A 341
TYR A 347
TRP A 353
 B3P  A 652 ( 4.1A)
None
B3P  A 652 (-3.4A)
B3P  A 652 (-2.8A)
B3P  A 652 ( 3.8A)
None
 1.39A 1lf9B-6fhvA:
10.4		 1lf9B-6fhvA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 9 ALA A  67
TYR A  76
TRP A  80
ARG A  82
ASP A  83
GLU A 209
ARG A 335
TYR A 341
TRP A 347
 ACR  A 801 (-3.5A)
ACR  A 801 (-4.3A)
ACR  A 801 (-3.3A)
ACR  A 801 (-4.0A)
ACR  A 801 (-2.7A)
ACR  A 801 (-3.9A)
ACR  A 801 (-2.8A)
ACR  A 801 ( 3.9A)
None
 0.41A 1lf9B-6fhwA:
8.1		 1lf9B-6fhwA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 5 ALA A  67
TYR A  76
TRP A 149
GLU A 209
TYR A 341
 ACR  A 801 (-3.5A)
ACR  A 801 (-4.3A)
ACR  A 801 (-3.7A)
ACR  A 801 (-3.9A)
ACR  A 801 ( 3.9A)
 0.90A 1lf9B-6fhwA:
8.1		 1lf9B-6fhwA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 6 ASP A  83
GLN A 153
GLU A 209
ARG A 335
TYR A 341
TRP A 347
 ACR  A 801 (-2.7A)
None
ACR  A 801 (-3.9A)
ACR  A 801 (-2.8A)
ACR  A 801 ( 3.9A)
None
 1.29A 1lf9B-6fhwA:
8.1		 1lf9B-6fhwA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 9 ALA A  63
TYR A  72
TRP A  76
ARG A  78
ASP A  79
GLU A 204
ARG A 329
TYR A 335
TRP A 341
 None
 0.46A 1lf9B-6frvA:
5.4		 1lf9B-6frvA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 ALA A  63
TYR A  72
TRP A 144
GLU A 204
TYR A 335
 None
 0.98A 1lf9B-6frvA:
5.4		 1lf9B-6frvA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 ASP A  79
GLN A 148
GLU A 204
TYR A 335
TRP A 341
 None
 1.34A 1lf9B-6frvA:
5.4		 1lf9B-6frvA:
9.26