SIMILAR PATTERNS OF AMINO ACIDS FOR 1LF9_A_ACRA700_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 TRP A 429
GLU A 430
TRP A 591
LEU A 653
 ACR  A3000 (-4.9A)
ACR  A3000 (-3.6A)
None
None
 0.21A 1lf9A-1ulvA:
53.0		 1lf9A-1ulvA:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		4 TRP A 209
GLU A 210
TRP A 362
LEU A 471
 None
ACR  A 995 (-3.7A)
None
None
 0.36A 1lf9A-2f6dA:
29.6		 1lf9A-2f6dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 TRP A 178
GLU A 179
TRP A 321
LEU A 419
 None
BTB  A 620 (-3.6A)
None
None
 0.27A 1lf9A-2vn7A:
6.9		 1lf9A-2vn7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		4 TRP A 202
GLU A 203
TRP A 341
LEU A 439
 None
TRS  A 701 ( 3.8A)
None
None
 0.31A 1lf9A-3eqaA:
30.1		 1lf9A-3eqaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		4 TRP A 783
GLU A 780
TRP A 823
LEU A 820
 None
 1.33A 1lf9A-4i2wA:
2.1		 1lf9A-4i2wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE

(Micromonospora
echinospora) 		no annotation 4 TRP A 415
GLU A 412
TRP A 391
LEU A 397
 None
 1.19A 1lf9A-6cboA:
0.0		 1lf9A-6cboA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 4 TRP A 212
GLU A 213
TRP A 353
LEU A 451
 None
B3P  A 652 (-3.7A)
None
None
 0.30A 1lf9A-6fhvA:
10.4		 1lf9A-6fhvA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 TRP A 207
GLU A 208
TRP A 347
LEU A 447
 None
ACR  A 801 (-3.9A)
None
None
 0.54A 1lf9A-6fhwA:
8.1		 1lf9A-6fhwA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 4 TRP A 202
GLU A 203
TRP A 341
LEU A 439
 None
 0.40A 1lf9A-6frvA:
5.4		 1lf9A-6frvA:
9.26