SIMILAR PATTERNS OF AMINO ACIDS FOR 1LBC_A_CYZA330_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		5 PRO A 290
LEU A 285
SER A 239
LEU A  35
ILE A 288
 None
 1.30A 1lbcA-1dmuA:
undetectable
1lbcC-1dmuA:
undetectable		 1lbcA-1dmuA:
23.81
1lbcC-1dmuA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jya YOPE REGULATOR

(Yersinia
pseudotuberculosis) 		PF05932
(CesT) 		5 PRO A  94
LEU A  74
SER A 102
LEU A  98
ILE A  73
 None
 1.36A 1lbcA-1jyaA:
undetectable
1lbcC-1jyaA:
undetectable		 1lbcA-1jyaA:
17.74
1lbcC-1jyaA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		no annotation 5 PRO D 165
SER D 116
LEU D 196
LEU D  73
ILE D 233
 None
 1.46A 1lbcA-1upfD:
undetectable
1lbcC-1upfD:
undetectable		 1lbcA-1upfD:
19.15
1lbcC-1upfD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 LYS A 429
LEU A 312
LEU A 456
ILE A 418
SER A 276
 None
 1.41A 1lbcA-2d4eA:
undetectable
1lbcC-2d4eA:
undetectable		 1lbcA-2d4eA:
18.50
1lbcC-2d4eA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsn RNASE H

(Simian foamy
virus) 		PF00075
(RNase_H) 		5 LEU A  95
LEU A 111
ILE A 120
SER A 115
LYS A 118
 None
 1.45A 1lbcA-2lsnA:
undetectable
1lbcC-2lsnA:
undetectable		 1lbcA-2lsnA:
22.57
1lbcC-2lsnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 PRO A 343
LEU A 340
LEU A  59
ILE A 346
SER A  61
 None
 1.43A 1lbcA-2qzuA:
undetectable
1lbcC-2qzuA:
undetectable		 1lbcA-2qzuA:
18.95
1lbcC-2qzuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 LEU A 135
SER A 139
LEU A 142
ILE A 158
SER A 152
 None
 1.14A 1lbcA-2vn7A:
undetectable
1lbcC-2vn7A:
undetectable		 1lbcA-2vn7A:
18.80
1lbcC-2vn7A:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.81A 1lbcA-2znsA:
37.7
1lbcC-2znsA:
37.9		 1lbcA-2znsA:
52.87
1lbcC-2znsA:
52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB

(Mus musculus) 		no annotation 5 MET L 175
SER L 174
LEU H 179
SER H 180
SER H 182
 None
 1.46A 1lbcA-3bgfL:
undetectable
1lbcC-3bgfL:
undetectable		 1lbcA-3bgfL:
20.22
1lbcC-3bgfL:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		5 LYS A 151
PRO A 150
LEU A  88
ILE A 115
SER A  98
 None
 1.42A 1lbcA-3clhA:
undetectable
1lbcC-3clhA:
undetectable		 1lbcA-3clhA:
23.89
1lbcC-3clhA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF01661
(Macro) 		5 PRO A 155
LEU A 173
SER A 169
ILE A 145
SER A 158
 None
None
None
None
1GP  A   9 (-4.8A)
 1.43A 1lbcA-3ew5A:
undetectable
1lbcC-3ew5A:
undetectable		 1lbcA-3ew5A:
23.05
1lbcC-3ew5A:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		8 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
 None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
 0.35A 1lbcA-3h6tA:
44.1
1lbcC-3h6tA:
43.4		 1lbcA-3h6tA:
100.00
1lbcC-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 LEU A  48
SER A  52
LEU A 114
LYS A 118
ILE A  73
 None
 1.35A 1lbcA-3hveA:
undetectable
1lbcC-3hveA:
undetectable		 1lbcA-3hveA:
22.11
1lbcC-3hveA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
 None
 0.80A 1lbcA-3qxmA:
37.5
1lbcC-3qxmA:
37.5		 1lbcA-3qxmA:
52.09
1lbcC-3qxmA:
52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 LYS A 478
LEU A 133
SER A 129
LEU A 127
ILE A 182
 None
 1.41A 1lbcA-3sdqA:
undetectable
1lbcC-3sdqA:
undetectable		 1lbcA-3sdqA:
15.30
1lbcC-3sdqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc3 UV DAMAGE
ENDONUCLEASE

(Sulfolobus
acidocaldarius) 		PF03851
(UvdE) 		5 LYS A  78
LEU A  31
SER A  35
LEU A  38
LYS A  42
 None
 1.11A 1lbcA-3tc3A:
undetectable
1lbcC-3tc3A:
undetectable		 1lbcA-3tc3A:
24.54
1lbcC-3tc3A:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 103
PRO A 104
MET A 106
LEU A 234
LEU A 242
LYS A 246
 None
None
None
None
None
ZN  A 259 (-3.5A)
 0.85A 1lbcA-3u92A:
37.3
1lbcC-3u92A:
37.3		 1lbcA-3u92A:
52.09
1lbcC-3u92A:
52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0w WN1 222-5 FAB
(IGG2A) HEAVY CHAIN
WN1 222-5 FAB
(IGG2A) LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 MET L 175
SER L 174
LEU H 177
SER H 178
SER H 180
 None
 1.44A 1lbcA-3v0wL:
undetectable
1lbcC-3v0wL:
undetectable		 1lbcA-3v0wL:
20.07
1lbcC-3v0wL:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF02156
(Glyco_hydro_26)
PF16990
(CBM_35) 		5 PRO A 292
LEU A 294
LEU A 142
ILE A 223
SER A 156
 None
 1.20A 1lbcA-3zm8A:
undetectable
1lbcC-3zm8A:
undetectable		 1lbcA-3zm8A:
19.75
1lbcC-3zm8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux3 MITOTIC CHROMOSOME
DETERMINANT-RELATED
PROTEIN
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04825
(Rad21_Rec8_N) 		5 LYS A1034
SER B  54
LEU A 179
LEU B  68
ILE A1030
 None
 0.98A 1lbcA-4ux3A:
undetectable
1lbcC-4ux3A:
undetectable		 1lbcA-4ux3A:
19.78
1lbcC-4ux3A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.68A 1lbcA-4wxjA:
37.1
1lbcC-4wxjA:
37.0		 1lbcA-4wxjA:
40.36
1lbcC-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dtb CG3822

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 PRO A 109
MET A 111
LEU A 242
LEU A 250
LYS A 254
 None
 0.59A 1lbcA-5dtbA:
38.7
1lbcC-5dtbA:
38.8		 1lbcA-5dtbA:
54.14
1lbcC-5dtbA:
54.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		5 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.98A 1lbcA-5ictA:
39.8
1lbcC-5ictA:
39.9		 1lbcA-5ictA:
56.34
1lbcC-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		6 LYS A 103
PRO A 104
MET A 106
LEU A 235
LEU A 243
LYS A 247
 None
 0.84A 1lbcA-5ikbA:
36.9
1lbcC-5ikbA:
36.8		 1lbcA-5ikbA:
55.73
1lbcC-5ikbA:
55.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		5 PRO A 146
LEU A 135
SER A 131
ILE A 138
SER A 173
 None
 1.15A 1lbcA-5ix1A:
undetectable
1lbcC-5ix1A:
undetectable		 1lbcA-5ix1A:
21.93
1lbcC-5ix1A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		8 LYS A 493
PRO A 494
MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 0.67A 1lbcA-5l1bA:
22.5
1lbcC-5l1bA:
22.4		 1lbcA-5l1bA:
34.90
1lbcC-5l1bA:
34.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uje SBNI PROTEIN

(Staphylococcus
aureus) 		no annotation 5 LEU A  66
SER A  65
LEU A  27
ILE A  40
SER A  32
 None
 1.45A 1lbcA-5ujeA:
undetectable
1lbcC-5ujeA:
undetectable		 1lbcA-5ujeA:
16.15
1lbcC-5ujeA:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		8 LYS A 493
PRO A 494
MET A 496
SER A 497
LEU A 751
SER A 754
LEU A 759
LYS A 763
 None
 1.02A 1lbcA-5welA:
32.7
1lbcC-5welA:
32.3		 1lbcA-5welA:
34.03
1lbcC-5welA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
LEU A 751
SER A 754
LEU A 759
 None
CYZ  A1302 (-4.3A)
None
CYZ  A1302 ( 4.1A)
None
 0.88A 1lbcA-5weoA:
25.1
1lbcC-5weoA:
25.0		 1lbcA-5weoA:
34.03
1lbcC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
LEU A 751
SER A 754
LYS A 763
 None
CYZ  A1302 (-4.3A)
None
CYZ  A1302 ( 4.1A)
CYZ  A1302 (-2.9A)
 0.96A 1lbcA-5weoA:
25.1
1lbcC-5weoA:
25.0		 1lbcA-5weoA:
34.03
1lbcC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
SER A 497
LEU A 751
LEU A 759
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
None
 0.72A 1lbcA-5weoA:
25.1
1lbcC-5weoA:
25.0		 1lbcA-5weoA:
34.03
1lbcC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
MET A 496
SER A 497
LEU A 751
LYS A 763
 None
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
CYZ  A1302 (-2.9A)
 0.96A 1lbcA-5weoA:
25.1
1lbcC-5weoA:
25.0		 1lbcA-5weoA:
34.03
1lbcC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
PRO A 494
MET A 496
LEU A 751
SER A 754
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
None
CYZ  A1302 ( 4.1A)
 0.93A 1lbcA-5weoA:
25.1
1lbcC-5weoA:
25.0		 1lbcA-5weoA:
34.03
1lbcC-5weoA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LYS A 493
PRO A 494
MET A 496
SER A 497
LEU A 751
 None
CYZ  A1302 (-4.5A)
CYZ  A1302 (-4.3A)
CYZ  A1302 (-3.2A)
None
 0.66A 1lbcA-5weoA:
25.1
1lbcC-5weoA:
25.0		 1lbcA-5weoA:
34.03
1lbcC-5weoA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN

(Mus musculus) 		no annotation 5 MET L 179
SER L 178
LEU H 178
SER H 179
SER H 181
 None
 1.43A 1lbcA-6aq7L:
undetectable
1lbcC-6aq7L:
undetectable		 1lbcA-6aq7L:
15.59
1lbcC-6aq7L:
15.59