SIMILAR PATTERNS OF AMINO ACIDS FOR 1L7Q_A_BEZA600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		5 ALA A 410
TRP A 472
PHE A 431
LEU A 433
PHE A 437
 None
 1.40A 1l7qA-2z1kA:
0.0		 1l7qA-2z1kA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6l TCR 2W20 ALPHA CHAIN
TCR 2W20 BETA CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968)
PF07654
(C1-set)
PF07686
(V-set) 		5 ALA B  90
TYR B 100
PRO A  43
LEU B  41
PHE A 101
 None
 1.08A 1l7qA-3c6lB:
0.0		 1l7qA-3c6lB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 ALA A  52
TYR A 238
PHE A 235
LEU A 208
PHE A 205
 None
 1.37A 1l7qA-3gf6A:
1.5		 1l7qA-3gf6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 TYR A  76
TYR A 170
HIS A 274
LEU A 273
PHE A 213
 PLM  A 563 (-4.5A)
None
None
None
None
 1.40A 1l7qA-3ib3A:
32.5		 1l7qA-3ib3A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 TYR A  76
TYR A 170
TRP A 217
HIS A 274
PHE A 213
 PLM  A 563 (-4.5A)
None
None
None
None
 1.31A 1l7qA-3ib3A:
32.5		 1l7qA-3ib3A:
27.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		8 TYR A  44
TYR A 118
PRO A 150
TRP A 151
TRP A 166
HIS A 287
LEU A 407
PHE A 408
 None
 0.58A 1l7qA-4p08A:
64.8		 1l7qA-4p08A:
99.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		8 TYR A  44
TYR A 118
PRO A 150
TRP A 151
TRP A 166
PHE A 261
LEU A 407
PHE A 408
 None
 0.18A 1l7qA-4p08A:
64.8		 1l7qA-4p08A:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		5 TYR A 172
ALA A 205
PHE A 121
LEU A 118
PHE A 113
 None
 1.48A 1l7qA-5ecjA:
0.0		 1l7qA-5ecjA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltv CHEMOTACTIC
TRANSDUCER PCTC

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		5 TYR A 196
ALA A 262
PRO A 228
PHE A 248
LEU A 219
 None
 1.26A 1l7qA-5ltvA:
0.0		 1l7qA-5ltvA:
20.17