SIMILAR PATTERNS OF AMINO ACIDS FOR 1L7F_A_BCZA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		5 GLU A  97
ARG A 101
ILE A 150
ARG A  95
GLU A  92
 None
 1.35A 1l7fA-1ciiA:
undetectable		 1l7fA-1ciiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma) 		5 LEU C3029
ASP C3145
ARG C3030
GLU C3208
GLU C3207
 None
 1.44A 1l7fA-1e6yC:
undetectable		 1l7fA-1e6yC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE
AMINE DEHYDROGENASE

(Pseudomonas
putida;
Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
no annotation 		5 GLU A 134
ARG B 148
ILE A 147
ARG A 142
ARG A 102
 None
None
None
None
HEC  A1001 ( 3.9A)
 1.47A 1l7fA-1jmzA:
undetectable		 1l7fA-1jmzA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU N 119
LEU N 134
ASP N 151
ARG N 156
TRP N 178
ILE N 222
ARG N 224
GLU N 227
GLU N 276
GLU N 277
ARG N 292
TYR N 406
 None
 0.63A 1l7fA-1nmbN:
73.3		 1l7fA-1nmbN:
96.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
no annotation 		5 GLU A 134
ARG B 135
ILE A 147
ARG A 142
ARG A 102
 None
None
None
None
HEM  A 992 (-3.7A)
 1.46A 1l7fA-1pbyA:
undetectable		 1l7fA-1pbyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6m ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 GLU A  67
ARG A 123
ILE A 129
GLU A  63
ARG A   5
 None
 1.32A 1l7fA-1u6mA:
undetectable		 1l7fA-1u6mA:
17.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A 125
LEU A 140
ASP A 157
ARG A 162
TRP A 185
ILE A 229
ARG A 231
GLU A 234
GLU A 283
GLU A 284
ARG A 299
TYR A 412
 None
 0.20A 1l7fA-1v0zA:
73.1		 1l7fA-1v0zA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ASP A 149
ILE A 221
ARG A 223
GLU A 275
GLU A 226
 IBA  A   1 (-3.6A)
IBA  A   1 ( 4.3A)
IBA  A   1 ( 4.5A)
IBA  A   1 (-4.1A)
IBA  A   1 (-3.9A)
 1.48A 1l7fA-1vcjA:
53.7		 1l7fA-1vcjA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		7 ASP A 149
TRP A 177
ILE A 221
ARG A 223
GLU A 275
ARG A 292
TYR A 409
 IBA  A   1 (-3.6A)
None
IBA  A   1 ( 4.3A)
IBA  A   1 ( 4.5A)
IBA  A   1 (-4.1A)
IBA  A   1 (-3.5A)
None
 1.19A 1l7fA-1vcjA:
53.7		 1l7fA-1vcjA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		11 GLU A 117
LEU A 132
ASP A 149
ARG A 154
TRP A 177
ILE A 221
ARG A 223
GLU A 226
GLU A 276
ARG A 292
TYR A 409
 IBA  A   1 (-3.9A)
None
IBA  A   1 (-3.6A)
IBA  A   1 (-4.1A)
None
IBA  A   1 ( 4.3A)
IBA  A   1 ( 4.5A)
IBA  A   1 (-3.9A)
IBA  A   1 (-3.9A)
IBA  A   1 (-3.5A)
None
 0.50A 1l7fA-1vcjA:
53.7		 1l7fA-1vcjA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 GLU A 143
LEU A  79
ARG A  83
ARG A  32
TYR A  28
 None
 1.46A 1l7fA-1wleA:
undetectable		 1l7fA-1wleA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A 120
LEU A 135
ASP A 152
ARG A 157
TRP A 180
ILE A 224
ARG A 226
GLU A 229
GLU A 278
GLU A 279
ARG A 294
TYR A 406
 ABW  A1000 (-3.7A)
None
ABW  A1000 (-3.7A)
ABW  A1000 (-4.2A)
None
ABW  A1000 ( 4.7A)
None
ABW  A1000 ( 4.0A)
ABW  A1000 (-4.1A)
ABW  A1000 (-4.5A)
ABW  A1000 (-3.4A)
ABW  A1000 (-4.9A)
 0.47A 1l7fA-1xogA:
75.0		 1l7fA-1xogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT
C-PHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 GLU B 159
LEU B 156
ILE A   5
GLU B  97
TYR B 163
 None
 1.42A 1l7fA-2bv8B:
undetectable		 1l7fA-2bv8B:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3b PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 GLU A 160
ARG A 105
ILE A  58
GLU A  87
ARG A  66
 None
None
None
GOL  A1004 (-2.7A)
GOL  A1004 (-3.1A)
 1.47A 1l7fA-2g3bA:
undetectable		 1l7fA-2g3bA:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		10 GLU A 119
LEU A 134
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 None
 1.15A 1l7fA-2htvA:
62.8		 1l7fA-2htvA:
44.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		11 LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 None
 0.76A 1l7fA-2htvA:
62.8		 1l7fA-2htvA:
44.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 GLU A 147
ARG A 131
ILE A 187
ARG A 149
GLU A 145
 None
 1.47A 1l7fA-2np5A:
undetectable		 1l7fA-2np5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 LEU A 209
ASP A 204
ILE A 236
GLU A 188
ARG A 221
 None
 1.48A 1l7fA-2nwhA:
undetectable		 1l7fA-2nwhA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		5 ASP A 372
ILE A 442
GLU A 647
ARG A 663
TYR A 752
 None
 0.81A 1l7fA-2w20A:
21.5		 1l7fA-2w20A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 GLU A 114
ARG A 111
ARG A 118
GLU A 121
GLU A 117
 None
UP2  A1268 (-3.8A)
None
None
None
 1.41A 1l7fA-2ybqA:
undetectable		 1l7fA-2ybqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 LEU A 440
ASP A 462
ARG A 533
GLU A 532
ARG A 403
 None
 1.28A 1l7fA-3aiiA:
undetectable		 1l7fA-3aiiA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 ZMR  A 469 (-3.5A)
None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
None
None
ZMR  A 469 (-4.4A)
ZMR  A 469 (-3.5A)
ZMR  A 469 (-2.8A)
ZMR  A 469 (-3.7A)
ZMR  A 469 (-3.0A)
ZMR  A 469 (-4.7A)
 0.69A 1l7fA-3ckzA:
64.4		 1l7fA-3ckzA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffu PROBABLE
PYROPHOSPHOHYDROLASE

(Bdellovibrio
bacteriovorus) 		PF00293
(NUDIX) 		5 GLU A  74
LEU A  71
ILE A  99
GLU A  51
ARG A  40
 MG  A 156 (-2.3A)
None
GTP  A4033 ( 4.9A)
GTP  A4033 (-3.5A)
GTP  A4033 (-3.1A)
 1.30A 1l7fA-3ffuA:
undetectable		 1l7fA-3ffuA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		5 GLU A 555
ARG A 623
GLU A 535
ARG A 604
TYR A 557
 None
 1.40A 1l7fA-3kt4A:
undetectable		 1l7fA-3kt4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum) 		PF00923
(TAL_FSA) 		5 GLU A  67
ASP A  92
ARG A  95
ILE A  87
GLU A  72
 None
 1.31A 1l7fA-3s1vA:
undetectable		 1l7fA-3s1vA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 LNV  A 901 (-3.6A)
None
LNV  A 901 (-3.4A)
LNV  A 901 (-4.0A)
None
None
LNV  A 901 (-4.1A)
LNV  A 901 (-3.4A)
LNV  A 901 (-2.9A)
LNV  A 901 ( 3.8A)
LNV  A 901 (-2.8A)
LNV  A 901 (-4.8A)
 0.45A 1l7fA-3ti8A:
65.0		 1l7fA-3ti8A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 GLU A 119
ARG A 156
ILE A 194
GLU A 277
TYR A 406
 LNV  A 801 (-3.5A)
LNV  A 801 (-4.0A)
None
LNV  A 801 (-3.8A)
LNV  A 801 (-4.4A)
 1.47A 1l7fA-3tiaA:
64.9		 1l7fA-3tiaA:
41.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 LNV  A 801 (-3.5A)
None
LNV  A 801 (-3.4A)
LNV  A 801 (-4.0A)
None
None
LNV  A 801 (-4.2A)
LNV  A 801 (-3.5A)
LNV  A 801 (-2.9A)
LNV  A 801 (-3.8A)
LNV  A 801 (-3.0A)
LNV  A 801 (-4.4A)
 0.45A 1l7fA-3tiaA:
64.9		 1l7fA-3tiaA:
41.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		11 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 179
ARG A 225
GLU A 228
GLU A 277
GLU A 278
ARG A 293
TYR A 402
 G39  A1470 (-3.5A)
None
G39  A1470 (-3.7A)
None
None
G39  A1470 (-4.4A)
None
G39  A1470 (-3.7A)
G39  A1470 (-4.2A)
G39  A1470 (-2.9A)
G39  A1470 (-4.5A)
 0.42A 1l7fA-4b7jA:
64.5		 1l7fA-4b7jA:
40.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 GLU V 978
LEU V 960
ARG V 860
GLU V1034
ARG V 977
 None
 1.40A 1l7fA-4bxsV:
undetectable		 1l7fA-4bxsV:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgs POLYMERASE SUBUNIT
PA

(Dhori
thogotovirus) 		no annotation 5 ARG A 163
GLU A 162
GLU A  31
GLU A 166
ARG A  28
 None
 1.32A 1l7fA-4cgsA:
undetectable		 1l7fA-4cgsA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		12 GLU A 116
LEU A 131
ASP A 148
ARG A 153
TRP A 176
ILE A 220
ARG A 222
GLU A 225
GLU A 274
GLU A 275
ARG A 291
TYR A 408
 ZMR  A 700 (-3.5A)
None
ZMR  A 700 (-3.3A)
ZMR  A 700 (-4.2A)
None
None
ZMR  A 700 (-3.8A)
ZMR  A 700 (-3.5A)
ZMR  A 700 (-2.7A)
ZMR  A 700 (-3.4A)
ZMR  A 700 (-2.8A)
ZMR  A 700 (-4.6A)
 0.48A 1l7fA-4cpnA:
54.2		 1l7fA-4cpnA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 GLU A 119
LEU A 134
ASP A 151
ARG A 156
ARG A 371
 SLB  A 512 (-3.5A)
None
SLB  A 512 (-3.5A)
None
SLB  A 512 (-2.9A)
 1.48A 1l7fA-4h53A:
64.9		 1l7fA-4h53A:
49.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		11 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
 SLB  A 512 (-3.5A)
None
SLB  A 512 (-3.5A)
None
None
None
SLB  A 512 (-4.2A)
None
SLB  A 512 (-2.8A)
SLB  A 512 (-2.7A)
SLB  A 512 (-3.1A)
 0.48A 1l7fA-4h53A:
64.9		 1l7fA-4h53A:
49.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		5 GLU A 419
LEU A 416
ARG A 354
ILE A 423
TYR A 467
 None
 1.31A 1l7fA-4hu8A:
undetectable		 1l7fA-4hu8A:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 G39  A 509 (-3.3A)
None
G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
None
G39  A 509 ( 4.1A)
G39  A 509 ( 4.0A)
G39  A 509 (-2.8A)
G39  A 509 (-4.6A)
 0.21A 1l7fA-4hzzA:
63.2		 1l7fA-4hzzA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		5 GLU A  58
LEU A  54
ARG A 269
GLU A  23
GLU A  61
 None
 1.26A 1l7fA-4imdA:
undetectable		 1l7fA-4imdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 GLU A 208
ARG A 375
ILE A 195
ARG A 190
GLU A 204
 None
 1.43A 1l7fA-4j9vA:
undetectable		 1l7fA-4j9vA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		9 GLU A 119
LEU A 134
TRP A 178
ILE A 222
ARG A 224
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 27S  A 501 (-3.4A)
None
None
27S  A 501 ( 4.6A)
27S  A 501 (-4.3A)
27S  A 501 ( 3.7A)
27S  A 501 (-3.4A)
27S  A 501 (-3.1A)
27S  A 501 (-4.6A)
 1.01A 1l7fA-4mjuA:
62.6		 1l7fA-4mjuA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		10 LEU A 134
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 None
None
None
27S  A 501 ( 4.6A)
27S  A 501 (-4.3A)
27S  A 501 (-3.3A)
27S  A 501 ( 3.7A)
27S  A 501 (-3.4A)
27S  A 501 (-3.1A)
27S  A 501 (-4.6A)
 0.40A 1l7fA-4mjuA:
62.6		 1l7fA-4mjuA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		9 LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
 None
27S  A 501 (-3.2A)
None
None
27S  A 501 ( 4.6A)
27S  A 501 (-4.3A)
27S  A 501 (-3.3A)
27S  A 501 ( 3.7A)
27S  A 501 (-3.4A)
 0.65A 1l7fA-4mjuA:
62.6		 1l7fA-4mjuA:
43.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
 None
 1.34A 1l7fA-4o27B:
undetectable		 1l7fA-4o27B:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		12 GLU A  37
LEU A  52
ASP A  69
ARG A  74
TRP A  97
ILE A 141
ARG A 143
GLU A 146
GLU A 195
GLU A 196
ARG A 211
TYR A 324
 None
 0.23A 1l7fA-4qn3A:
71.4		 1l7fA-4qn3A:
61.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj1 ANTIGEN MTB48,
MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLU A  20
ILE A 113
ARG A  66
GLU A  65
GLU A  63
 None
 1.16A 1l7fA-4wj1A:
undetectable		 1l7fA-4wj1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
 None
 1.33A 1l7fA-4z7gA:
undetectable		 1l7fA-4z7gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guj DNA PRIMASE

(Bacillus
subtilis) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2) 		5 LEU A 174
ASP A 201
ILE A 191
ARG A 202
TYR A 128
 None
 1.29A 1l7fA-5gujA:
undetectable		 1l7fA-5gujA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A 434
ARG A 509
ILE A 386
ARG A 388
GLU A 423
 None
 1.32A 1l7fA-5kbrA:
undetectable		 1l7fA-5kbrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 LEU O  11
ARG O  15
GLU O  30
GLU O  35
GLU O  34
 None
 1.11A 1l7fA-5mpdO:
undetectable		 1l7fA-5mpdO:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th3 R-SWAI PROTEIN

(Staphylococcus
warneri) 		no annotation 5 GLU A   7
LEU A 153
ILE A 118
GLU A  88
ARG A  86
 None
 1.41A 1l7fA-5th3A:
undetectable		 1l7fA-5th3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 12 GLU A 119
LEU A 134
ASP A 151
ARG A 156
TRP A 178
ILE A 222
ARG A 224
GLU A 227
GLU A 276
GLU A 277
ARG A 292
TYR A 406
 E3M  A 511 (-3.6A)
None
E3M  A 511 (-2.9A)
None
None
E3M  A 511 ( 4.3A)
E3M  A 511 (-3.8A)
E3M  A 511 ( 4.8A)
E3M  A 511 (-2.3A)
E3M  A 511 ( 3.6A)
E3M  A 511 (-2.9A)
E3M  A 511 (-4.5A)
 0.49A 1l7fA-6br6A:
64.7		 1l7fA-6br6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 5 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.60A 1l7fA-6eksA:
20.8		 1l7fA-6eksA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 ARG A 489
ARG A 484
ARG A 593
 None
 0.99A 1l7fA-1d9zA:
undetectable		 1l7fA-1d9zA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Bacillus
subtilis) 		PF00215
(OMPdecase) 		3 ARG A 185
ARG A 196
ARG A 215
 U5P  A 250 (-2.6A)
None
U5P  A 250 (-3.8A)
 1.00A 1l7fA-1dbtA:
undetectable		 1l7fA-1dbtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02240
(MCR_gamma) 		3 ARG C3152
ARG A1460
ARG C3176
 None
 0.97A 1l7fA-1e6yC:
0.0		 1l7fA-1e6yC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ARG A 427
ARG A 176
ARG A 530
 None
 1.06A 1l7fA-1hwwA:
0.0		 1l7fA-1hwwA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I
ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica;
Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG B  21
ARG B  42
ARG A 408
 None
 0.94A 1l7fA-1i1qB:
undetectable		 1l7fA-1i1qB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 ARG A 119
ARG A 117
ARG A 408
 None
 0.90A 1l7fA-1i7qA:
0.0		 1l7fA-1i7qA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE
TRPG

(Serratia
marcescens;
Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
PF00117
(GATase) 		3 ARG B  22
ARG B  43
ARG A 408
 None
 0.92A 1l7fA-1i7qB:
undetectable		 1l7fA-1i7qB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 ARG A 175
ARG A 227
ARG A 174
 None
 1.05A 1l7fA-1idmA:
undetectable		 1l7fA-1idmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		3 ARG A 108
ARG A 103
ARG A 227
 None
 0.91A 1l7fA-1ij5A:
undetectable		 1l7fA-1ij5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd3 CHORISMATE LYASE

(Escherichia
coli) 		PF04345
(Chor_lyase) 		3 ARG A 140
ARG A  37
ARG A 126
 None
 1.08A 1l7fA-1jd3A:
undetectable		 1l7fA-1jd3A:
16.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG N 118
ARG N 152
ARG N 371
 None
 0.63A 1l7fA-1nmbN:
73.3		 1l7fA-1nmbN:
96.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3t CYTIDYLATE KINASE

(Streptococcus
pneumoniae) 		PF02224
(Cytidylate_kin) 		3 ARG A 143
ARG A  52
ARG A 193
 None
 1.10A 1l7fA-1q3tA:
undetectable		 1l7fA-1q3tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufv PANTOATE-BETA-ALANIN
E LIGASE

(Thermus
thermophilus) 		PF02569
(Pantoate_ligase) 		3 ARG A 183
ARG A  68
ARG A 117
 CL  A1001 ( 3.2A)
None
CL  A1001 ( 3.0A)
 0.83A 1l7fA-1ufvA:
undetectable		 1l7fA-1ufvA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 124
ARG A 158
ARG A 378
 None
 0.23A 1l7fA-1v0zA:
73.1		 1l7fA-1v0zA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 116
ARG A 150
ARG A 374
 IBA  A   1 (-3.3A)
IBA  A   1 (-3.9A)
IBA  A   1 (-3.2A)
 0.62A 1l7fA-1vcjA:
53.7		 1l7fA-1vcjA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 119
ARG A 153
ARG A 372
 ABW  A1000 (-3.2A)
ABW  A1000 (-4.1A)
ABW  A1000 (-2.8A)
 0.41A 1l7fA-1xogA:
75.0		 1l7fA-1xogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		3 ARG A 242
ARG A  81
ARG A 193
 None
None
SO4  A 941 (-3.7A)
 0.93A 1l7fA-2gj4A:
undetectable		 1l7fA-2gj4A:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 None
 0.72A 1l7fA-2htvA:
62.8		 1l7fA-2htvA:
44.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		3 ARG B 217
ARG B 235
ARG A 105
 None
SF4  B1358 (-4.3A)
None
 0.94A 1l7fA-2ivfB:
undetectable		 1l7fA-2ivfB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		3 ARG A 261
ARG A  48
ARG A 252
 None
 1.08A 1l7fA-2q7sA:
undetectable		 1l7fA-2q7sA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		3 ARG A 138
ARG A  71
ARG A 136
 SRT  A 247 (-3.8A)
None
SRT  A 247 (-2.9A)
 0.88A 1l7fA-2ra5A:
undetectable		 1l7fA-2ra5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		3 ARG A 127
ARG A 250
ARG A  89
 DPO  A1297 ( 3.0A)
IPE  A1298 (-3.7A)
DPO  A1297 (-2.7A)
 1.02A 1l7fA-2vg2A:
undetectable		 1l7fA-2vg2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 ARG A 337
ARG A 446
ARG A 524
 XMP  A1694 (-4.2A)
None
None
 0.88A 1l7fA-2vxoA:
undetectable		 1l7fA-2vxoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ARG A1934
ARG A1084
ARG A1930
 None
 0.87A 1l7fA-2vz9A:
undetectable		 1l7fA-2vz9A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1p RIBOSOME MATURATION
FACTOR RIMM

(Thermus
thermophilus) 		PF01782
(RimM)
PF05239
(PRC) 		3 ARG A 136
ARG A 104
ARG A 133
 None
 0.86A 1l7fA-3a1pA:
undetectable		 1l7fA-3a1pA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		3 ARG A 188
ARG A  74
ARG A 122
 ACY  A 801 (-3.2A)
None
ACY  A 801 (-3.2A)
 0.85A 1l7fA-3ag6A:
undetectable		 1l7fA-3ag6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		3 ARG A 190
ARG A 182
ARG A 314
 None
 1.00A 1l7fA-3auoA:
undetectable		 1l7fA-3auoA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 ZMR  A 469 (-2.9A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-2.9A)
 0.12A 1l7fA-3ckzA:
64.4		 1l7fA-3ckzA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		3 ARG A 375
ARG A 371
ARG A  28
 None
EDO  A 703 ( 4.6A)
None
 1.02A 1l7fA-3edyA:
undetectable		 1l7fA-3edyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C)
PF02665
(Nitrate_red_gam) 		3 ARG C 202
ARG B 221
ARG C 112
 HEM  C 806 (-3.2A)
HEM  C 806 ( 3.4A)
HEM  C 806 (-3.9A)
 1.11A 1l7fA-3egwC:
undetectable		 1l7fA-3egwC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl5 PUTATIVE DSBA
OXIDOREDUCTASE
SCO1869

(Streptomyces
coelicolor) 		PF01323
(DSBA) 		3 ARG A 189
ARG A 172
ARG A   2
 None
 1.10A 1l7fA-3gl5A:
undetectable		 1l7fA-3gl5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		3 ARG A 355
ARG A 347
ARG A 356
 None
 0.91A 1l7fA-3hjcA:
undetectable		 1l7fA-3hjcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		3 ARG A 187
ARG A  73
ARG A 121
 UNX  A 303 ( 3.2A)
None
UNX  A 303 ( 3.3A)
 0.80A 1l7fA-3innA:
undetectable		 1l7fA-3innA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		3 ARG A  94
ARG A  49
ARG A  87
 None
 0.80A 1l7fA-3isaA:
undetectable		 1l7fA-3isaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 3 ARG A 124
ARG A  33
ARG A 128
 None
 1.09A 1l7fA-3iusA:
undetectable		 1l7fA-3iusA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		3 ARG A 689
ARG A 700
ARG A 685
 None
 1.05A 1l7fA-3j9dA:
undetectable		 1l7fA-3j9dA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 ARG A 413
ARG A 645
ARG A 386
 None
 0.84A 1l7fA-3k30A:
undetectable		 1l7fA-3k30A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 ARG A 429
ARG A 365
ARG A 622
 None
 0.97A 1l7fA-3k30A:
undetectable		 1l7fA-3k30A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		3 ARG A 512
ARG A 344
ARG A 197
 None
 1.00A 1l7fA-3k9yA:
undetectable		 1l7fA-3k9yA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		3 ARG A 431
ARG A 112
ARG A 426
 None
 1.05A 1l7fA-3lmmA:
undetectable		 1l7fA-3lmmA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		3 ARG A 366
ARG A 283
ARG A 343
 None
 0.99A 1l7fA-3m6cA:
undetectable		 1l7fA-3m6cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		3 ARG A 174
ARG A 181
ARG A  77
 None
 0.72A 1l7fA-3msvA:
undetectable		 1l7fA-3msvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd1 PRECORRIN-6A
SYNTHASE/COBF
PROTEIN

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		3 ARG A 172
ARG A 232
ARG A 169
 None
 1.10A 1l7fA-3nd1A:
undetectable		 1l7fA-3nd1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 ARG B 800
ARG B 828
ARG B 241
 None
 0.91A 1l7fA-3opyB:
undetectable		 1l7fA-3opyB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owq LIN1025 PROTEIN

(Listeria
innocua) 		PF03816
(LytR_cpsA_psr) 		3 ARG A 113
ARG A 205
ARG A  90
 None
 1.06A 1l7fA-3owqA:
undetectable		 1l7fA-3owqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis) 		PF01137
(RTC)
PF05189
(RTC_insert) 		3 ARG A  14
ARG A  36
ARG A 319
 None
None
TAR  A 401 ( 3.9A)
 0.93A 1l7fA-3pqvA:
undetectable		 1l7fA-3pqvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		3 ARG A 189
ARG A  73
ARG A 123
 CL  A 607 (-3.4A)
None
CL  A 607 (-3.1A)
 0.78A 1l7fA-3q10A:
undetectable		 1l7fA-3q10A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtn UNCHARACTERIZED
PROTEIN C4B3.07

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		3 ARG B 174
ARG B 181
ARG B  77
 None
 0.82A 1l7fA-3qtnB:
undetectable		 1l7fA-3qtnB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4j HISTIDINE KINASE 4

(Arabidopsis
thaliana) 		PF03924
(CHASE) 		3 ARG A 268
ARG A 263
ARG A 383
 None
 0.96A 1l7fA-3t4jA:
undetectable		 1l7fA-3t4jA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 LNV  A 901 (-3.0A)
LNV  A 901 (-4.0A)
LNV  A 901 (-2.9A)
 0.13A 1l7fA-3ti8A:
65.0		 1l7fA-3ti8A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 LNV  A 801 (-2.8A)
LNV  A 801 (-3.9A)
LNV  A 801 (-2.9A)
 0.13A 1l7fA-3tiaA:
64.9		 1l7fA-3tiaA:
41.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 ARG A 865
ARG A 910
ARG A 445
 None
 1.11A 1l7fA-3u44A:
undetectable		 1l7fA-3u44A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		3 ARG A 184
ARG A  69
ARG A 118
 MLT  A 284 (-3.1A)
None
MLT  A 284 (-3.3A)
 0.81A 1l7fA-3uk2A:
undetectable		 1l7fA-3uk2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uy4 PANTOTHENATE
SYNTHETASE

(Campylobacter
jejuni) 		PF02569
(Pantoate_ligase) 		3 ARG A 186
ARG A  72
ARG A 120
 PAU  A 302 (-3.2A)
None
PAU  A 302 (-3.1A)
 0.80A 1l7fA-3uy4A:
undetectable		 1l7fA-3uy4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		3 ARG A 421
ARG A 432
ARG A 423
 None
 1.08A 1l7fA-3w1jA:
undetectable		 1l7fA-3w1jA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 368
 G39  A1470 (-3.1A)
G39  A1470 (-3.9A)
G39  A1470 (-3.0A)
 0.20A 1l7fA-4b7jA:
64.5		 1l7fA-4b7jA:
40.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwi PHYTOCHROME-LIKE
PROTEIN CPH2

(Synechocystis
sp.) 		PF00360
(PHY)
PF01590
(GAF) 		3 ARG A 373
ARG A  85
ARG A 383
 CYC  A1422 ( 4.3A)
None
None
 1.08A 1l7fA-4bwiA:
undetectable		 1l7fA-4bwiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ARG A  65
ARG A  81
ARG A  94
 None
 0.89A 1l7fA-4bx0A:
undetectable		 1l7fA-4bx0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 115
ARG A 149
ARG A 373
 ZMR  A 700 (-2.9A)
ZMR  A 700 (-4.0A)
ZMR  A 700 (-3.0A)
 0.28A 1l7fA-4cpnA:
54.2		 1l7fA-4cpnA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		3 ARG A  62
ARG A 172
ARG A 141
 None
 0.71A 1l7fA-4ctaA:
undetectable		 1l7fA-4ctaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		3 ARG B 256
ARG B 254
ARG B 116
 None
 1.12A 1l7fA-4di4B:
undetectable		 1l7fA-4di4B:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 200
ARG A 139
ARG A 233
 None
 1.08A 1l7fA-4e4fA:
undetectable		 1l7fA-4e4fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans) 		PF01036
(Bac_rhodopsin) 		3 ARG A 174
ARG A 172
ARG A 160
 SO4  A 307 (-3.1A)
None
SO4  A 307 (-3.6A)
 1.04A 1l7fA-4fbzA:
undetectable		 1l7fA-4fbzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 ARG A 916
ARG A 807
ARG A 939
 None
 0.95A 1l7fA-4fxdA:
undetectable		 1l7fA-4fxdA:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 SLB  A 512 (-2.7A)
SLB  A 512 (-3.8A)
SLB  A 512 (-2.9A)
 0.15A 1l7fA-4h53A:
64.9		 1l7fA-4h53A:
49.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Staphylococcus
aureus) 		PF01255
(Prenyltransf) 		3 ARG A  84
ARG A 207
ARG A  46
 FPP  A 302 (-3.0A)
SO4  A 303 (-3.7A)
FPP  A 302 (-2.8A)
 0.88A 1l7fA-4h8eA:
undetectable		 1l7fA-4h8eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 338
ARG A 155
ARG A  29
 None
 1.04A 1l7fA-4hpnA:
undetectable		 1l7fA-4hpnA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 G39  A 509 (-3.0A)
G39  A 509 (-3.9A)
G39  A 509 (-2.9A)
 0.19A 1l7fA-4hzzA:
63.2		 1l7fA-4hzzA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Gallus gallus;
Rattus
norvegicus;
Discosoma sp.) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		3 ARG A  55
ARG A 304
ARG A  51
 None
 1.03A 1l7fA-4i2yA:
undetectable		 1l7fA-4i2yA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 118
ARG A 152
ARG A 371
 27S  A 501 (-3.0A)
27S  A 501 (-4.2A)
27S  A 501 (-3.1A)
 0.51A 1l7fA-4mjuA:
62.6		 1l7fA-4mjuA:
43.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mob ACYL-COENZYME A
THIOESTERASE 12

(Homo sapiens) 		PF03061
(4HBT) 		3 ARG A 313
ARG A 179
ARG A 312
 ADP  A 402 (-3.4A)
None
ADP  A 402 (-3.7A)
 1.03A 1l7fA-4mobA:
undetectable		 1l7fA-4mobA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7w L-PROLINE
CIS-4-HYDROXYLASE

(Mesorhizobium
japonicum) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		3 ARG A  93
ARG A  56
ARG A 118
 PRO  A 303 (-2.5A)
None
PRO  A 303 ( 2.9A)
 0.80A 1l7fA-4p7wA:
undetectable		 1l7fA-4p7wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 3 ARG B 141
ARG B 103
ARG B 144
 None
 0.66A 1l7fA-4pl2B:
undetectable		 1l7fA-4pl2B:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A  36
ARG A  70
ARG A 290
 None
 0.28A 1l7fA-4qn3A:
71.4		 1l7fA-4qn3A:
61.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		3 ARG A 152
ARG A 168
ARG A 299
 None
 0.94A 1l7fA-4s0vA:
undetectable		 1l7fA-4s0vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens) 		no annotation 3 ARG A  87
ARG A 255
ARG A  94
 None
 1.11A 1l7fA-4txdA:
undetectable		 1l7fA-4txdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		3 ARG A1283
ARG A1319
ARG A1286
 None
 1.05A 1l7fA-4xqkA:
undetectable		 1l7fA-4xqkA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 ARG A1088
ARG A1704
ARG A1038
 None
 1.05A 1l7fA-4yknA:
undetectable		 1l7fA-4yknA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		3 ARG A1219
ARG A1436
ARG A1220
 None
 1.09A 1l7fA-5a42A:
undetectable		 1l7fA-5a42A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		3 ARG A  41
ARG A  55
ARG A 203
 None
 1.00A 1l7fA-5bp8A:
undetectable		 1l7fA-5bp8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 ARG A 245
ARG A 146
ARG A 288
 None
 1.01A 1l7fA-5cioA:
undetectable		 1l7fA-5cioA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		3 ARG A 475
ARG A 466
ARG A 535
 None
 1.01A 1l7fA-5fg3A:
undetectable		 1l7fA-5fg3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 3 ARG B 409
ARG B 295
ARG B 461
 None
 1.09A 1l7fA-5hzgB:
undetectable		 1l7fA-5hzgB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ARG A  22
ARG A 264
ARG A  86
 None
A3P  A 401 (-3.6A)
None
 1.05A 1l7fA-5iufA:
undetectable		 1l7fA-5iufA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 ARG T3439
ARG T2680
ARG T3438
 None
 1.05A 1l7fA-5ojsT:
undetectable		 1l7fA-5ojsT:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 3 ARG A 395
ARG A 447
ARG A 411
 None
 1.10A 1l7fA-5oydA:
undetectable		 1l7fA-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 ARG A 256
ARG A 375
ARG A 401
 None
 0.92A 1l7fA-5tw7A:
undetectable		 1l7fA-5tw7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		3 ARG A  75
ARG A  87
ARG A 445
 None
 1.03A 1l7fA-5txeA:
undetectable		 1l7fA-5txeA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		3 ARG A 135
ARG A   8
ARG A 231
 None
 1.10A 1l7fA-5u2wA:
undetectable		 1l7fA-5u2wA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		no annotation 3 ARG W 122
ARG W 137
ARG W  59
 None
 1.12A 1l7fA-5vtmW:
undetectable		 1l7fA-5vtmW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxm U3 SMALL NUCLEOLAR
RIBONUCLEOPROTEIN
PROTEIN IMP3

(Saccharomyces
cerevisiae) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		3 ARG A  55
ARG A  28
ARG A  56
 None
 0.89A 1l7fA-5wxmA:
undetectable		 1l7fA-5wxmA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		3 ARG A 273
ARG A 331
ARG A 274
 None
 1.03A 1l7fA-5x3eA:
undetectable		 1l7fA-5x3eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 3 ARG A 301
ARG A 139
ARG A 405
 FUM  A 702 (-2.9A)
None
FUM  A 702 ( 3.0A)
 1.10A 1l7fA-5xmjA:
undetectable		 1l7fA-5xmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 3 ARG A 651
ARG A 661
ARG A 615
 None
 1.05A 1l7fA-5xpgA:
undetectable		 1l7fA-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 3 ARG B 113
ARG B 209
ARG B 115
 SO4  B 403 ( 2.4A)
None
FAD  B 401 ( 3.5A)
 1.09A 1l7fA-5y6qB:
undetectable		 1l7fA-5y6qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S7
RIBOSOMAL PROTEIN
S28E

(Leishmania
donovani;
Leishmania
donovani) 		no annotation
no annotation 		3 ARG d  61
ARG H 108
ARG d  80
 None
 1.08A 1l7fA-6az1d:
undetectable		 1l7fA-6az1d:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 3 ARG A 118
ARG A 152
ARG A 371
 E3M  A 511 (-3.0A)
E3M  A 511 (-3.8A)
E3M  A 511 (-2.9A)
 0.17A 1l7fA-6br6A:
undetectable		 1l7fA-6br6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 3 ARG B  49
ARG B  91
ARG B  29
 None
 1.02A 1l7fA-6dftB:
undetectable		 1l7fA-6dftB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 3 ARG B 460
ARG B 157
ARG B 720
 None
 1.05A 1l7fA-6f42B:
undetectable		 1l7fA-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 3 ARG F 112
ARG F  28
ARG F 108
 None
 0.78A 1l7fA-6g2jF:
undetectable		 1l7fA-6g2jF:
undetectable