SIMILAR PATTERNS OF AMINO ACIDS FOR 1L5Q_B_CFFB1864_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		3 TRP A 411
HIS A 320
MET A 414
 GLC  A3101 ( 4.2A)
None
None
 1.35A 1l5qB-1fbwA:
0.0		 1l5qB-1fbwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 TRP A 522
HIS A 459
MET A 534
 None
 1.44A 1l5qB-1kv9A:
undetectable		 1l5qB-1kv9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 TRP A 544
HIS A 528
MET A 565
 None
 1.37A 1l5qB-1nr0A:
0.0		 1l5qB-1nr0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		3 TRP A  49
HIS A 409
MET A 411
 None
 1.33A 1l5qB-1sqjA:
undetectable		 1l5qB-1sqjA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 TRP A 454
HIS A 444
MET A 448
 None
 1.14A 1l5qB-1wqlA:
0.0		 1l5qB-1wqlA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dru CHIMERA OF CD48
ANTIGEN AND T-CELL
SURFACE ANTIGEN CD2

(Rattus
norvegicus) 		PF05790
(C2-set)
PF07686
(V-set) 		3 TRP A  96
HIS A  90
MET A  88
 None
 1.22A 1l5qB-2druA:
0.0		 1l5qB-2druA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 TRP A 176
HIS A 126
MET A  93
 None
CU  A 401 (-3.2A)
None
 1.18A 1l5qB-2dwsA:
0.0		 1l5qB-2dwsA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f99 AKLANONIC ACID
METHYL ESTER
CYCLASE, AKNH

(Streptomyces
galilaeus) 		PF07366
(SnoaL) 		3 TRP A  54
HIS A  87
MET A  91
 AKV  A1335 (-3.3A)
None
AKV  A1335 (-3.7A)
 1.38A 1l5qB-2f99A:
undetectable		 1l5qB-2f99A:
10.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		3 TRP A 174
HIS A 614
MET A 618
 None
 0.24A 1l5qB-2gj4A:
55.0		 1l5qB-2gj4A:
80.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		3 TRP A  67
HIS A  43
MET A  42
 None
 1.26A 1l5qB-2pfrA:
undetectable		 1l5qB-2pfrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rae TRANSCRIPTIONAL
REGULATOR, ACRR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		3 TRP A  66
HIS A 111
MET A 115
 None
 0.96A 1l5qB-2raeA:
undetectable		 1l5qB-2raeA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rqx POLYMYXIN B
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF11183
(PmrD) 		3 TRP A   3
HIS A  70
MET A  28
 None
 1.24A 1l5qB-2rqxA:
undetectable		 1l5qB-2rqxA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		3 TRP A 121
HIS A 152
MET A 128
 None
 1.41A 1l5qB-2vdjA:
2.5		 1l5qB-2vdjA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 TRP A 506
HIS A 284
MET A 288
 None
 1.09A 1l5qB-2vobA:
undetectable		 1l5qB-2vobA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		3 TRP A 403
HIS A 318
MET A 400
 None
 1.08A 1l5qB-2x24A:
2.8		 1l5qB-2x24A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE

(Neisseria
meningitidis) 		PF07922
(Glyco_transf_52) 		3 TRP A 199
HIS A 211
MET A 222
 None
 1.32A 1l5qB-2yk6A:
undetectable		 1l5qB-2yk6A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13469
(Sulfotransfer_3) 		3 TRP A 196
HIS A 235
MET A 203
 None
 1.27A 1l5qB-2z6vA:
0.5		 1l5qB-2z6vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 TRP A 480
HIS A 443
MET A 403
 None
 1.43A 1l5qB-2zwaA:
2.8		 1l5qB-2zwaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF06920
(DHR-2) 		3 TRP A1481
HIS A1231
MET A1201
 None
 1.13A 1l5qB-3b13A:
undetectable		 1l5qB-3b13A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 TRP A 193
HIS A 171
MET A 197
 None
 0.93A 1l5qB-3b3dA:
undetectable		 1l5qB-3b3dA:
18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 TRP A 174
HIS A 614
MET A 618
 None
 0.27A 1l5qB-3cemA:
58.5		 1l5qB-3cemA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ech 25-MER FRAGMENT OF
PROTEIN ARMR
MULTIDRUG RESISTANCE
OPERON REPRESSOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR)
no annotation 		3 TRP C  45
HIS A 116
MET A 112
 None
 1.49A 1l5qB-3echC:
undetectable		 1l5qB-3echC:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 198
HIS A 234
MET A 207
 None
 0.86A 1l5qB-3eezA:
2.2		 1l5qB-3eezA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 TRP A 443
HIS A 433
MET A 437
 None
 1.16A 1l5qB-3eqqA:
undetectable		 1l5qB-3eqqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 TRP A2078
HIS A1993
MET A2075
 None
 1.07A 1l5qB-3ff6A:
3.8		 1l5qB-3ff6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 TRP A 452
HIS A 442
MET A 446
 None
 1.08A 1l5qB-3gzyA:
undetectable		 1l5qB-3gzyA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 TRP A 144
HIS A  95
MET A  62
 None
CU  A1501 (-3.2A)
CU  A1501 ( 4.3A)
 1.49A 1l5qB-3h4hA:
undetectable		 1l5qB-3h4hA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP0

(Parechovirus B) 		PF00073
(Rhv) 		3 TRP B 216
HIS B 163
MET B 166
 None
 1.31A 1l5qB-3jb4B:
undetectable		 1l5qB-3jb4B:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrv PROTEIN K7

(Vaccinia virus) 		PF06227
(Poxvirus) 		3 TRP A 112
HIS A  85
MET A  80
 None
 1.34A 1l5qB-3jrvA:
undetectable		 1l5qB-3jrvA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		3 TRP A 342
HIS A 287
MET A 291
 None
 1.48A 1l5qB-3lm3A:
2.1		 1l5qB-3lm3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr0 SENSORY BOX
HISTIDINE
KINASE/RESPONSE
REGULATOR

(Burkholderia
thailandensis) 		PF08447
(PAS_3) 		3 TRP A  20
HIS A  72
MET A 112
 PG5  A 143 (-3.5A)
None
PG5  A 143 ( 4.9A)
 1.26A 1l5qB-3mr0A:
undetectable		 1l5qB-3mr0A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH

(Actinoplanes
sp. SE50/110) 		PF01547
(SBP_bac_1) 		3 TRP A 206
HIS A 196
MET A 200
 None
 0.85A 1l5qB-3oo9A:
undetectable		 1l5qB-3oo9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		3 TRP A 298
HIS A 314
MET A 357
 None
 1.42A 1l5qB-3p9uA:
undetectable		 1l5qB-3p9uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		3 TRP A 374
HIS A 351
MET A 346
 None
 1.13A 1l5qB-3sggA:
2.3		 1l5qB-3sggA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shp PUTATIVE
ACETYLTRANSFERASE
STHE_0691

(Sphaerobacter
thermophilus) 		no annotation 3 TRP A 109
HIS A  57
MET A   1
 None
 1.40A 1l5qB-3shpA:
undetectable		 1l5qB-3shpA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 TRP B 520
HIS B 562
MET B 564
 None
 1.44A 1l5qB-3v65B:
undetectable		 1l5qB-3v65B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		3 TRP A 189
HIS A 334
MET A 321
 None
 1.39A 1l5qB-3wwxA:
undetectable		 1l5qB-3wwxA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		3 TRP B   5
HIS B  28
MET B  32
 None
 1.49A 1l5qB-3zheB:
undetectable		 1l5qB-3zheB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 TRP A2004
HIS A1919
MET A2001
 None
 1.09A 1l5qB-4asiA:
2.2		 1l5qB-4asiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		3 TRP A 128
HIS A 353
MET A 204
 None
 1.14A 1l5qB-4au2A:
undetectable		 1l5qB-4au2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		3 TRP A 370
HIS A 413
MET A 392
 None
 1.49A 1l5qB-4c90A:
undetectable		 1l5qB-4c90A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		3 TRP A 469
HIS A 491
MET A 489
 None
 1.04A 1l5qB-4fajA:
undetectable		 1l5qB-4fajA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		3 TRP A1181
HIS A 168
MET A 236
 None
 1.49A 1l5qB-4fwtA:
undetectable		 1l5qB-4fwtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4k UNCHARACTERIZED
PROTEIN SGCJ

(Streptomyces
globisporus) 		PF14534
(DUF4440) 		3 TRP A  29
HIS A  63
MET A  64
 None
CIT  A 201 (-3.6A)
None
 1.38A 1l5qB-4i4kA:
undetectable		 1l5qB-4i4kA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 TRP A 340
HIS A 283
MET A 284
 None
GOL  A 606 (-3.8A)
None
 1.17A 1l5qB-4m8uA:
undetectable		 1l5qB-4m8uA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		3 TRP A 161
HIS A 126
MET A 128
 GOL  A 511 ( 4.0A)
GOL  A 510 (-3.9A)
None
 1.22A 1l5qB-4nxkA:
1.9		 1l5qB-4nxkA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TRP A 186
HIS A 232
MET A 136
 None
 0.78A 1l5qB-4uplA:
undetectable		 1l5qB-4uplA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whn APXC

(Actinobacillus
pleuropneumoniae) 		PF02794
(HlyC) 		3 TRP A  60
HIS A 107
MET A 108
 None
 1.40A 1l5qB-4whnA:
undetectable		 1l5qB-4whnA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2m MTR2

(Chaetomium
thermophilum) 		no annotation 3 TRP A 159
HIS A 113
MET A 109
 None
 1.44A 1l5qB-4x2mA:
undetectable		 1l5qB-4x2mA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 TRP A 454
HIS A 444
MET A 448
 None
 1.07A 1l5qB-5aewA:
undetectable		 1l5qB-5aewA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		3 TRP A  77
HIS A  50
MET A 106
 None
LSS  A1818 (-4.0A)
None
 1.22A 1l5qB-5ah5A:
undetectable		 1l5qB-5ah5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		3 TRP X  85
HIS X 224
MET X 217
 None
 0.83A 1l5qB-5evyX:
undetectable		 1l5qB-5evyX:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 TRP A 158
HIS A 138
MET A 143
 None
 1.16A 1l5qB-5ikbA:
undetectable		 1l5qB-5ikbA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 3 TRP A 153
HIS A 201
MET A 205
 None
 0.83A 1l5qB-5mrjA:
0.4		 1l5qB-5mrjA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1r GNA2132

(Neisseria
meningitidis) 		no annotation 3 TRP A 381
HIS A 325
MET A 363
 None
 1.44A 1l5qB-5o1rA:
undetectable		 1l5qB-5o1rA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 TRP A 276
HIS A 144
MET A 130
 None
 1.34A 1l5qB-5x1nA:
undetectable		 1l5qB-5x1nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1

(Escherichia
virus T4;
Homo sapiens) 		no annotation 3 TRP A 276
HIS A 306
MET A 310
 None
 0.85A 1l5qB-5zbhA:
undetectable		 1l5qB-5zbhA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		no annotation 3 TRP A 276
HIS A 306
MET A 310
 None
 1.04A 1l5qB-5zbqA:
undetectable		 1l5qB-5zbqA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 TRP A 265
HIS A 359
MET A 260
 None
 1.20A 1l5qB-6cc2A:
undetectable		 1l5qB-6cc2A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 3 TRP C 132
HIS C 235
MET C 233
 None
 1.26A 1l5qB-6f5oC:
2.3		 1l5qB-6f5oC:
7.21