SIMILAR PATTERNS OF AMINO ACIDS FOR 1L2I_B_CCSB417_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 PRO A 261
PHE A   6
GLN A  17
VAL A  22
 None
 1.45A 1l2iB-1akoA:
undetectable		 1l2iB-1akoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1an7 RIBOSOMAL PROTEIN S8

(Thermus
thermophilus) 		PF00410
(Ribosomal_S8) 		4 PRO A  76
GLU A  22
GLN A  78
LYS A  64
 None
 1.38A 1l2iB-1an7A:
undetectable		 1l2iB-1an7A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bht HEPATOCYTE GROWTH
FACTOR

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle) 		4 PHE A 190
GLU A 199
GLN A 150
LYS A 148
 EPE  A   1 (-4.4A)
None
None
None
 1.39A 1l2iB-1bhtA:
undetectable		 1l2iB-1bhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		4 PRO A  67
PHE A  70
GLN A  66
VAL A  60
 None
 1.40A 1l2iB-1cptA:
0.0		 1l2iB-1cptA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 PRO B  80
PHE B 111
GLU B 114
LYS B  63
 None
 1.35A 1l2iB-1h4vB:
0.6		 1l2iB-1h4vB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itv MMP9

(Homo sapiens) 		PF00045
(Hemopexin) 		4 PRO A  38
PHE A  30
GLN A 191
VAL A 185
 None
 1.34A 1l2iB-1itvA:
undetectable		 1l2iB-1itvA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		4 PRO C 428
PHE C 432
GLU C 390
GLN C 433
 None
 1.44A 1l2iB-1j3jC:
0.0		 1l2iB-1j3jC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 PRO A   8
GLU A 286
GLN A 187
LYS A 284
 None
 1.46A 1l2iB-1nrkA:
undetectable		 1l2iB-1nrkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		4 PRO C  66
GLN C   9
LYS C   8
VAL C   7
 None
 1.43A 1l2iB-1o94C:
0.0		 1l2iB-1o94C:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		4 PRO A 265
GLU A 495
GLN A 390
VAL A 393
 None
 1.46A 1l2iB-1p9wA:
0.0		 1l2iB-1p9wA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 337
GLU A 339
GLN A 414
LYS A 416
VAL A 418
 None
 0.90A 1l2iB-1pcgA:
37.8		 1l2iB-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 PRO A 384
GLN A 352
LYS A 349
VAL A 368
 None
None
FNS  A 570 (-2.7A)
None
 1.17A 1l2iB-1qcwA:
0.0		 1l2iB-1qcwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 PRO A 288
PHE A 287
GLN A 294
VAL A 352
 None
 1.37A 1l2iB-1szqA:
0.0		 1l2iB-1szqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		4 PHE A 527
GLN A 526
LYS A 521
VAL A 519
 None
 1.47A 1l2iB-1upxA:
undetectable		 1l2iB-1upxA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v29 NITRILE HYDRATASE B
CHAIN

(Bacillus
smithii) 		PF02211
(NHase_beta) 		4 GLU B 123
GLN B  45
LYS B 117
VAL B 119
 None
 1.35A 1l2iB-1v29B:
undetectable		 1l2iB-1v29B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 PHE A  55
GLU A 203
LYS A 207
VAL A 205
 None
 1.38A 1l2iB-1xqmA:
undetectable		 1l2iB-1xqmA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoc HYPOTHETICAL PROTEIN
PA1835

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		4 PRO A  32
PHE A  46
GLU A  43
VAL A 106
 None
 1.37A 1l2iB-1yocA:
undetectable		 1l2iB-1yocA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zau DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden) 		4 PRO A 174
PHE A 244
GLU A 242
VAL A 178
 None
 1.42A 1l2iB-1zauA:
undetectable		 1l2iB-1zauA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 PRO A 115
GLN A 117
LYS A 121
VAL A 123
 None
 1.29A 1l2iB-2d62A:
undetectable		 1l2iB-2d62A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4l ACETAMIDASE,
PUTATIVE

(Thermotoga
maritima) 		PF03069
(FmdA_AmdA) 		4 GLU A  32
GLN A  28
LYS A   2
VAL A   3
 None
 1.45A 1l2iB-2f4lA:
undetectable		 1l2iB-2f4lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 PRO A   3
PHE A   4
GLN A   7
VAL A  37
 None
 1.21A 1l2iB-2f8qA:
undetectable		 1l2iB-2f8qA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		4 PRO A 194
PHE A 189
GLN A 236
VAL A 241
 None
 1.37A 1l2iB-2gsjA:
undetectable		 1l2iB-2gsjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 PRO A 213
GLN A 212
LYS A 207
VAL A 205
 None
 1.22A 1l2iB-2hfsA:
undetectable		 1l2iB-2hfsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLU A 127
GLN A  75
LYS A  70
VAL A  68
 None
 1.38A 1l2iB-2jifA:
undetectable		 1l2iB-2jifA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnx CALCIUM BINDING
PROTEIN 2

(Entamoeba
histolytica) 		PF13499
(EF-hand_7) 		4 PHE A 132
GLU A 128
GLN A 112
LYS A 115
 None
CA  A 185 (-3.1A)
None
None
 1.34A 1l2iB-2jnxA:
undetectable		 1l2iB-2jnxA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lus THIOREDOXION

(Carcinoscorpius
rotundicauda) 		PF13905
(Thioredoxin_8) 		4 PRO A  61
PHE A  62
LYS A 117
VAL A 115
 None
 1.48A 1l2iB-2lusA:
undetectable		 1l2iB-2lusA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oc6 YDHG PROTEIN

(Bacillus
subtilis) 		PF08818
(DUF1801) 		4 PRO A  43
PHE A  55
GLU A  21
LYS A   0
 None
 1.48A 1l2iB-2oc6A:
undetectable		 1l2iB-2oc6A:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 337
GLU A 339
GLN A 414
LYS A 416
VAL A 418
 None
None
None
None
CME  A 417 ( 3.2A)
 1.07A 1l2iB-2ocfA:
36.6		 1l2iB-2ocfA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qir AMINOGLYCOSIDE
6-N-ACETYLTRANSFERAS
E TYPE IB11

(Salmonella
enterica) 		PF13523
(Acetyltransf_8) 		4 PHE A 182
GLN A 177
LYS A 138
VAL A 136
 None
 1.32A 1l2iB-2qirA:
undetectable		 1l2iB-2qirA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 PRO A 353
PHE A 290
GLU A 288
GLN A 293
 None
 0.96A 1l2iB-2uwfA:
undetectable		 1l2iB-2uwfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyf REPLICATIVE DNA
HELICASE

(Geobacillus
kaustophilus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 PRO A  40
PHE A  52
GLU A  73
VAL A  58
 None
 1.25A 1l2iB-2vyfA:
undetectable		 1l2iB-2vyfA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		4 PRO A 154
PHE A 310
GLU A 308
GLN A 313
 None
 1.37A 1l2iB-2wamA:
undetectable		 1l2iB-2wamA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 PHE A 289
GLN A 282
LYS A 300
VAL A 299
 None
None
ATP  A1607 (-2.6A)
None
 1.48A 1l2iB-2x0qA:
undetectable		 1l2iB-2x0qA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfm PIWI-LIKE PROTEIN 1

(Mus musculus) 		PF02170
(PAZ) 		4 PRO A 329
PHE A 343
GLU A 386
GLN A 327
 None
 1.27A 1l2iB-2xfmA:
undetectable		 1l2iB-2xfmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 PRO A  56
PHE A  59
GLN A  55
VAL A  49
 None
 1.42A 1l2iB-2xkrA:
undetectable		 1l2iB-2xkrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1s FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB

(Aquifex
aeolicus;
Aquifex
aeolicus) 		PF01312
(Bac_export_2)
PF01312
(Bac_export_2) 		4 PRO A 255
GLU B 300
LYS B 294
VAL B 296
 None
 0.90A 1l2iB-3b1sA:
undetectable		 1l2iB-3b1sA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		4 PRO A   5
PHE A  19
LYS A  65
VAL A  32
 None
 1.48A 1l2iB-3dhoA:
undetectable		 1l2iB-3dhoA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 PRO A 816
PHE A 386
GLU A 388
VAL A 360
 None
 1.38A 1l2iB-3f2bA:
undetectable		 1l2iB-3f2bA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		4 PRO A  40
PHE A  61
GLN A 160
VAL A 165
 None
 1.29A 1l2iB-3fcyA:
undetectable		 1l2iB-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gza PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01120
(Alpha_L_fucos) 		4 PHE A 454
GLU A 392
LYS A 425
VAL A 422
 None
 1.15A 1l2iB-3gzaA:
undetectable		 1l2iB-3gzaA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 PRO B 170
PHE B 171
GLN B 106
VAL B 289
 None
 0.91A 1l2iB-3l4gB:
undetectable		 1l2iB-3l4gB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		4 PRO A  11
GLN A  41
LYS A  25
VAL A  23
 PEG  A 217 (-4.2A)
PEG  A 217 (-2.8A)
None
None
 1.48A 1l2iB-3lacA:
undetectable		 1l2iB-3lacA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 PRO X 833
GLU X 929
GLN X 849
LYS X 830
 None
 1.21A 1l2iB-3lxuX:
undetectable		 1l2iB-3lxuX:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 4 PHE F 205
GLU F  61
GLN F 206
VAL F 201
 None
 1.29A 1l2iB-3n2nF:
undetectable		 1l2iB-3n2nF:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PHE A  39
GLU A 124
GLN A  37
VAL A 127
 None
None
FAD  A 501 (-4.5A)
None
 1.41A 1l2iB-3nixA:
undetectable		 1l2iB-3nixA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA

(Vibrio cholerae) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 PRO B 147
GLN B 145
LYS B 140
VAL B 138
 None
 1.29A 1l2iB-3o8qB:
undetectable		 1l2iB-3o8qB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 PRO A 356
PHE A 359
GLU A 396
VAL A 398
 None
 0.94A 1l2iB-3omlA:
undetectable		 1l2iB-3omlA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H

(Bacillus
subtilis) 		PF13176
(TPR_7) 		4 PHE A 356
GLU A 334
LYS A 362
VAL A 360
 None
 1.37A 1l2iB-3q15A:
undetectable		 1l2iB-3q15A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1n GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
paracasei) 		PF01263
(Aldose_epim) 		4 PRO A 249
PHE A 250
GLU A  31
VAL A  33
 None
 1.47A 1l2iB-3q1nA:
undetectable		 1l2iB-3q1nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc3 D-RIBULOSE-5-PHOSPHA
TE-3-EPIMERASE

(Homo sapiens) 		PF00834
(Ribul_P_3_epim) 		4 PRO A 168
PHE A 167
GLN A 166
VAL A 160
 None
 1.46A 1l2iB-3qc3A:
undetectable		 1l2iB-3qc3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 PRO A 174
PHE A 244
GLU A 242
VAL A 178
 None
 1.33A 1l2iB-3sgiA:
undetectable		 1l2iB-3sgiA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 PRO A  60
GLN A  88
LYS A  89
VAL A  31
 None
 1.24A 1l2iB-3stjA:
undetectable		 1l2iB-3stjA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 PRO A 278
PHE A  95
LYS A  68
VAL A  70
 None
 1.31A 1l2iB-3ttlA:
undetectable		 1l2iB-3ttlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 PRO A 302
GLU A 621
LYS A 624
VAL A 623
 None
 1.40A 1l2iB-3ttsA:
undetectable		 1l2iB-3ttsA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 PRO A 428
PHE A 432
GLU A 390
GLN A 433
 None
 1.49A 1l2iB-3um6A:
undetectable		 1l2iB-3um6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		4 PRO A 225
PHE A 224
GLN A 223
VAL A 219
 None
None
GOL  A 302 ( 4.6A)
None
 1.43A 1l2iB-3we7A:
undetectable		 1l2iB-3we7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 GLU A  54
GLN A 340
LYS A 337
VAL A 335
 None
 1.45A 1l2iB-3zbmA:
undetectable		 1l2iB-3zbmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 PHE B 473
GLU B 471
LYS B 465
VAL B 467
 None
 1.45A 1l2iB-3zg8B:
undetectable		 1l2iB-3zg8B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 PRO A 126
GLN A  91
LYS A 142
VAL A 122
 None
 1.34A 1l2iB-4ah6A:
undetectable		 1l2iB-4ah6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE

(Physcomitrella
patens) 		PF01507
(PAPS_reduct) 		4 PRO A 115
PHE A 114
LYS A 245
VAL A 246
 None
 1.40A 1l2iB-4bwvA:
undetectable		 1l2iB-4bwvA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 PHE A 355
GLN A  93
LYS A1624
VAL A1626
 None
 1.32A 1l2iB-4c3hA:
undetectable		 1l2iB-4c3hA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 GLU A 454
GLN A 525
LYS A 537
VAL A 450
 None
GLC  A1742 (-3.4A)
None
None
 1.45A 1l2iB-4c51A:
undetectable		 1l2iB-4c51A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 PHE A 167
GLN A 166
LYS A 161
VAL A 159
 None
None
SO4  A 401 ( 4.7A)
None
 1.36A 1l2iB-4dibA:
undetectable		 1l2iB-4dibA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PRO A 265
PHE A 210
LYS A 213
VAL A 261
 None
 1.46A 1l2iB-4e37A:
undetectable		 1l2iB-4e37A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 PRO A 396
PHE A 398
GLU A 400
GLN A 395
 None
 1.41A 1l2iB-4e37A:
undetectable		 1l2iB-4e37A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6z APICOPLAST TIC22,
PUTATIVE

(Plasmodium
falciparum) 		PF04278
(Tic22) 		4 PRO A 193
PHE A 195
GLN A 174
VAL A 258
 None
 1.39A 1l2iB-4e6zA:
undetectable		 1l2iB-4e6zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g43 MHC CLASS I ALPHA
CHAIN 2

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 PRO A 206
PHE A 204
GLU A 258
VAL A 210
 None
 1.44A 1l2iB-4g43A:
undetectable		 1l2iB-4g43A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 PRO A 268
GLU A 719
LYS A 377
VAL A 374
 None
 1.44A 1l2iB-4g9iA:
undetectable		 1l2iB-4g9iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		4 PRO A  64
PHE A  65
LYS A 111
VAL A  91
 None
 1.19A 1l2iB-4iqlA:
undetectable		 1l2iB-4iqlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 PRO A 253
GLN A 249
LYS A  34
VAL A  37
 None
 1.48A 1l2iB-4jypA:
undetectable		 1l2iB-4jypA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfy DIHYDROOROTASE

(Burkholderia
cenocepacia) 		PF01979
(Amidohydro_1) 		4 PHE A 183
GLN A 145
LYS A 187
VAL A 188
 None
None
EDO  A 403 (-2.8A)
None
 1.27A 1l2iB-4lfyA:
undetectable		 1l2iB-4lfyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 PRO A  94
GLU A 109
GLN A 101
VAL A 105
 None
 1.25A 1l2iB-4n78A:
undetectable		 1l2iB-4n78A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 4 PRO A 265
GLU A 237
GLN A 209
VAL A 185
 ANP  A 401 ( 4.8A)
ANP  A 401 (-3.6A)
None
ANP  A 401 (-4.9A)
 1.31A 1l2iB-4nzmA:
undetectable		 1l2iB-4nzmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 PRO A 264
PHE A 286
GLN A 256
VAL A 267
 None
 1.40A 1l2iB-4ph9A:
undetectable		 1l2iB-4ph9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN

(Acinetobacter
baumannii) 		no annotation 4 GLU A 203
GLN A 107
LYS A 177
VAL A 178
 None
 1.24A 1l2iB-4rlbA:
undetectable		 1l2iB-4rlbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 PRO A  28
PHE A  29
GLN A  26
VAL A  91
 None
 1.21A 1l2iB-5bwyA:
undetectable		 1l2iB-5bwyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 PRO A 253
GLN A 249
LYS A  34
VAL A  37
 None
 1.43A 1l2iB-5dnwA:
undetectable		 1l2iB-5dnwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PRO C 271
GLU C 157
GLN C 270
VAL C 303
 PO4  C 401 ( 4.6A)
None
None
None
 1.10A 1l2iB-5dwzC:
undetectable		 1l2iB-5dwzC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5m CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4

(Mus musculus) 		PF07686
(V-set) 		4 PRO A  20
PHE A  19
GLN A   5
VAL A   8
 None
 0.99A 1l2iB-5e5mA:
undetectable		 1l2iB-5e5mA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PRO A 273
PHE A 655
GLU A 221
GLN A 217
 None
 1.40A 1l2iB-5f7sA:
undetectable		 1l2iB-5f7sA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gle ISCHORISMATE LYASE

(Vibrio
anguillarum) 		no annotation 4 PRO A 168
PHE A 169
GLN A 142
VAL A  33
 None
 1.22A 1l2iB-5gleA:
undetectable		 1l2iB-5gleA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 PHE A  84
GLU A 221
GLN A  87
LYS A  75
 None
 1.37A 1l2iB-5hh3A:
undetectable		 1l2iB-5hh3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 PRO A 263
PHE A 285
GLN A 255
VAL A 266
 None
 1.34A 1l2iB-5ikrA:
undetectable		 1l2iB-5ikrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8a PEROXIN 14

(Trypanosoma
brucei) 		PF04695
(Pex14_N) 		4 PRO A  55
PHE A  49
GLU A  47
GLN A  54
 None
 1.23A 1l2iB-5l8aA:
undetectable		 1l2iB-5l8aA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		4 PRO A  37
PHE A  50
GLU A  30
GLN A  39
 None
 1.47A 1l2iB-5l94A:
undetectable		 1l2iB-5l94A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE

(Jeotgalicoccus
sp. ATCC 8456) 		PF00067
(p450) 		4 PRO A 338
PHE A 341
GLU A 376
VAL A 372
 None
 1.31A 1l2iB-5m0oA:
undetectable		 1l2iB-5m0oA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 PRO A 508
PHE A 455
GLU A 458
GLN A 464
 None
 1.45A 1l2iB-5nitA:
undetectable		 1l2iB-5nitA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		4 GLU A 363
GLN A 244
LYS A 243
VAL A 247
 None
 1.37A 1l2iB-5o1mA:
undetectable		 1l2iB-5o1mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP2

(Sacbrood virus) 		no annotation 4 PRO B 220
PHE B 221
GLU B 113
VAL B 166
 None
 1.45A 1l2iB-5oypB:
undetectable		 1l2iB-5oypB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PRO A 232
PHE A 235
GLU A 199
GLN A 204
 None
 1.47A 1l2iB-5vl1A:
undetectable		 1l2iB-5vl1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn3 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 PRO G 354
PHE G 353
GLN G 352
VAL G 346
 NAG  G 623 (-4.3A)
None
None
None
 1.47A 1l2iB-5vn3G:
undetectable		 1l2iB-5vn3G:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN UL131A

(Human
betaherpesvirus
5) 		no annotation 4 PRO E  45
GLN E  47
LYS E  51
VAL E  53
 None
None
NAG  E 201 ( 4.9A)
None
 1.46A 1l2iB-5vocE:
undetectable		 1l2iB-5vocE:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4c THIOREDOXIN
REDUCTASE

(Cryptococcus
neoformans) 		no annotation 4 PRO A 123
PHE A 124
LYS A  32
VAL A  34
 None
 1.29A 1l2iB-5w4cA:
undetectable		 1l2iB-5w4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 PHE A1081
GLU A1084
LYS A1341
VAL A1347
 None
None
U  B  12 ( 2.8A)
None
 1.41A 1l2iB-5wlhA:
1.1		 1l2iB-5wlhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 PRO A 181
PHE A 201
GLU A 231
GLN A 182
 None
 0.97A 1l2iB-5xjhA:
undetectable		 1l2iB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 PRO A 154
PHE A 174
GLU A 204
GLN A 155
 None
 0.97A 1l2iB-6aneA:
undetectable		 1l2iB-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cph TCR BETA CHAIN

(Homo sapiens) 		no annotation 4 PRO E 139
PHE E 230
GLU E 172
GLN E 249
 None
 1.00A 1l2iB-6cphE:
undetectable		 1l2iB-6cphE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 4 PRO A 397
PHE A  83
GLU A  89
GLN A 399
 None
 1.11A 1l2iB-6d0nA:
undetectable		 1l2iB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fur HUMAN F11 T-CELL
RECEPTOR

(Homo sapiens) 		no annotation 4 PRO B 119
PHE B 210
GLU B 152
GLN B 229
 None
 1.07A 1l2iB-6furB:
undetectable		 1l2iB-6furB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 PRO A 276
PHE A 275
GLN A 278
VAL A 254
 None
 1.25A 1l2iB-6fv5A:
undetectable		 1l2iB-6fv5A:
undetectable