SIMILAR PATTERNS OF AMINO ACIDS FOR 1L2I_A_CCSA417_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpz PROTEIN (COPZ)

(Enterococcus
hirae) 		PF00403
(HMA) 		3 GLU A  19
LYS A  43
VAL A  31
 None
 0.88A 1l2iA-1cpzA:
undetectable		 1l2iA-1cpzA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
B

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 GLU A  94
LYS A  35
VAL A  37
 None
 0.76A 1l2iA-1cynA:
0.0		 1l2iA-1cynA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLU A 298
LYS A 496
VAL A 498
 None
 0.97A 1l2iA-1dlcA:
1.1		 1l2iA-1dlcA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5r PROLINE OXIDASE

(Streptomyces
sp. TH1) 		PF05118
(Asp_Arg_Hydrox)
PF05373
(Pro_3_hydrox_C) 		3 GLU A 269
LYS A 263
VAL A 265
 None
 0.93A 1l2iA-1e5rA:
0.0		 1l2iA-1e5rA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fig IGG1-KAPPA 1F7 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H  12
LYS H  19
VAL H  18
 None
 0.98A 1l2iA-1figH:
undetectable		 1l2iA-1figH:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
5

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		3 GLU A 110
LYS A  51
VAL A  53
 None
 0.79A 1l2iA-1h0pA:
0.0		 1l2iA-1h0pA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 GLU A  62
LYS A  58
VAL A  60
 None
 1.00A 1l2iA-1hm6A:
0.0		 1l2iA-1hm6A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLU A  10
LYS A  65
VAL A  63
 None
 0.95A 1l2iA-1iyxA:
0.0		 1l2iA-1iyxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 GLU A 360
LYS A 375
VAL A 362
 None
 0.92A 1l2iA-1jnyA:
0.0		 1l2iA-1jnyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		3 GLU A 236
LYS A 192
VAL A 190
 None
 0.96A 1l2iA-1k1xA:
0.0		 1l2iA-1k1xA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 GLU A 726
LYS A 807
VAL A 809
 None
 0.91A 1l2iA-1kz7A:
1.4		 1l2iA-1kz7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		3 GLU A  92
LYS A  51
VAL A  52
 None
 0.89A 1l2iA-1lbqA:
undetectable		 1l2iA-1lbqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbq JUNCTIONAL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07686
(V-set)
PF13927
(Ig_3) 		3 GLU A  35
LYS A 125
VAL A  38
 None
 0.96A 1l2iA-1nbqA:
undetectable		 1l2iA-1nbqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLU A 403
LYS A  81
VAL A  84
 None
 0.92A 1l2iA-1po0A:
undetectable		 1l2iA-1po0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 197
LYS A 327
VAL A 329
 None
 0.91A 1l2iA-1pvdA:
undetectable		 1l2iA-1pvdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ral 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		3 GLU A  60
LYS A  36
VAL A  34
 None
 0.87A 1l2iA-1ralA:
undetectable		 1l2iA-1ralA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		3 GLU A 279
LYS A  31
VAL A  32
 None
 1.00A 1l2iA-1szqA:
undetectable		 1l2iA-1szqA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 GLU A  67
LYS A  61
VAL A  63
 None
 0.93A 1l2iA-1szsA:
undetectable		 1l2iA-1szsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2u GENERAL CONTROL
PROTEIN GCN4

(-) 		PF00904
(Involucrin)
PF07716
(bZIP_2) 		3 GLU A  13
LYS A   7
VAL A   9
 None
 0.83A 1l2iA-1u2uA:
undetectable		 1l2iA-1u2uA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 2

(Bos taurus) 		PF00022
(Actin) 		3 GLU B 257
LYS B 253
VAL B 254
 None
 0.88A 1l2iA-1u2vB:
undetectable		 1l2iA-1u2vB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		3 GLU A 218
LYS A 212
VAL A 214
 None
 0.93A 1l2iA-1u9cA:
undetectable		 1l2iA-1u9cA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd2 PROTEIN KINASE C,
IOTA TYPE

(Homo sapiens) 		PF00564
(PB1) 		3 GLU A  76
LYS A  60
VAL A  71
 None
 0.91A 1l2iA-1vd2A:
undetectable		 1l2iA-1vd2A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLU A 286
LYS A 467
VAL A 469
 None
P6G  A1667 (-4.1A)
None
 0.95A 1l2iA-1w99A:
undetectable		 1l2iA-1w99A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		3 GLU A   9
LYS A   4
VAL A   5
 None
 0.92A 1l2iA-1wwsA:
undetectable		 1l2iA-1wwsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 GLU A 386
LYS A 381
VAL A 382
 None
 0.82A 1l2iA-2cfmA:
undetectable		 1l2iA-2cfmA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		3 GLU A 123
LYS A  30
VAL A  28
 None
 0.92A 1l2iA-2fqzA:
undetectable		 1l2iA-2fqzA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		3 GLU A 146
LYS A 133
VAL A 130
 None
 0.93A 1l2iA-2hlwA:
undetectable		 1l2iA-2hlwA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermotoga
maritima) 		PF01680
(SOR_SNZ) 		3 GLU A  90
LYS A  82
VAL A  83
 None
5RP  A 294 (-1.3A)
None
 0.97A 1l2iA-2issA:
undetectable		 1l2iA-2issA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		3 GLU A 400
LYS A 395
VAL A 396
 None
 0.99A 1l2iA-2iv0A:
undetectable		 1l2iA-2iv0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgq BRAZZEIN

(Pentadiplandra
brazzeana) 		no annotation 3 GLU A   9
LYS A   6
VAL A   7
 None
 1.00A 1l2iA-2kgqA:
undetectable		 1l2iA-2kgqA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		3 GLU A 732
LYS A 726
VAL A 728
 None
 1.00A 1l2iA-2o2qA:
undetectable		 1l2iA-2o2qA:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLU A 339
LYS A 416
VAL A 418
 None
None
CME  A 417 ( 3.2A)
 0.83A 1l2iA-2ocfA:
35.8		 1l2iA-2ocfA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p26 INTEGRIN BETA-2

(Homo sapiens) 		PF17205
(PSI_integrin) 		3 GLU A  13
LYS A   7
VAL A   8
 None
 0.94A 1l2iA-2p26A:
undetectable		 1l2iA-2p26A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 GLU A 227
LYS A 221
VAL A 223
 None
 0.91A 1l2iA-2p3eA:
undetectable		 1l2iA-2p3eA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 GLU A 372
LYS A 367
VAL A 368
 None
 0.95A 1l2iA-2vl8A:
undetectable		 1l2iA-2vl8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlt L-ASPARAGINASE

(Helicobacter
pylori) 		PF00710
(Asparaginase) 		3 GLU A  99
LYS A 178
VAL A 167
 None
 0.96A 1l2iA-2wltA:
undetectable		 1l2iA-2wltA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xs5 DELETED IN
AZOOSPERMIA-LIKE

(Mus musculus) 		PF00076
(RRM_1) 		3 GLU A  53
LYS A  70
VAL A  69
 C  D   5 ( 4.2A)
U  C   4 ( 2.6A)
None
 0.96A 1l2iA-2xs5A:
undetectable		 1l2iA-2xs5A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykq LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22)
PF17489
(Tnp_22_trimer)
PF17490
(Tnp_22_dsRBD) 		3 GLU A 228
LYS A 223
VAL A 224
 None
 0.83A 1l2iA-2ykqA:
undetectable		 1l2iA-2ykqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Thermus
thermophilus) 		PF01680
(SOR_SNZ) 		3 GLU A  92
LYS A  84
VAL A  85
 None
MPD  A 903 (-2.9A)
None
 0.93A 1l2iA-2zbtA:
undetectable		 1l2iA-2zbtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm7 PROTEIN OF UNKNOWN
FUNCTION WITH
FERREDOXIN-LIKE FOLD

(Caulobacter
vibrioides) 		PF03992
(ABM) 		3 GLU A  55
LYS A  52
VAL A  53
 None
 1.00A 1l2iA-3bm7A:
undetectable		 1l2iA-3bm7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 146
LYS A 159
VAL A 135
 None
MG  A 401 ( 4.1A)
None
 0.83A 1l2iA-3dfyA:
undetectable		 1l2iA-3dfyA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtd INVASION-ASSOCIATED
PROTEIN B

(Bartonella
henselae) 		PF06776
(IalB) 		3 GLU A  69
LYS A 150
VAL A 168
 None
 0.92A 1l2iA-3dtdA:
undetectable		 1l2iA-3dtdA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 3 GLU A 364
LYS A 358
VAL A 360
 None
 0.89A 1l2iA-3e05A:
undetectable		 1l2iA-3e05A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		3 GLU A 228
LYS A 222
VAL A 224
 None
 0.93A 1l2iA-3e96A:
undetectable		 1l2iA-3e96A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxh PUTATIVE PHOSPHATASE
(DUF442)

(Shewanella
putrefaciens) 		PF04273
(DUF442) 		3 GLU A 107
LYS A 102
VAL A 103
 None
 0.88A 1l2iA-3gxhA:
undetectable		 1l2iA-3gxhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 GLU A  40
LYS A  37
VAL A  38
 None
 0.94A 1l2iA-3h4hA:
undetectable		 1l2iA-3h4hA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hck HCK SH2

(Homo sapiens) 		PF00017
(SH2) 		3 GLU A  17
LYS A  58
VAL A  57
 None
 0.97A 1l2iA-3hckA:
undetectable		 1l2iA-3hckA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 GLU A 342
LYS A 336
VAL A 338
 None
 0.95A 1l2iA-3k17A:
undetectable		 1l2iA-3k17A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfg MAJOR URINARY
PROTEIN 4

(Mus musculus) 		PF00061
(Lipocalin) 		3 GLU A 139
LYS A 133
VAL A 135
 None
 0.97A 1l2iA-3kfgA:
undetectable		 1l2iA-3kfgA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		3 GLU A 248
LYS A 242
VAL A 244
 None
SO4  A 432 (-3.2A)
None
 0.87A 1l2iA-3l0oA:
undetectable		 1l2iA-3l0oA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq1 MITE ALLERGEN DER P
5

(Dermatophagoides
pteronyssinus) 		PF11642
(Blo-t-5) 		3 GLU A 124
LYS A  70
VAL A  72
 None
MPD  A 210 ( 3.3A)
None
 0.87A 1l2iA-3mq1A:
undetectable		 1l2iA-3mq1A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1

(Saccharomyces
cerevisiae) 		PF01680
(SOR_SNZ) 		3 GLU A  88
LYS A  80
VAL A  81
 None
 0.95A 1l2iA-3o07A:
undetectable		 1l2iA-3o07A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		3 GLU A 511
LYS A 520
VAL A 522
 None
 0.92A 1l2iA-3pfqA:
undetectable		 1l2iA-3pfqA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		3 GLU A 232
LYS A 153
VAL A 144
 None
 0.85A 1l2iA-3pkmA:
undetectable		 1l2iA-3pkmA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r13 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Thermotoga
maritima) 		PF01791
(DeoC) 		3 GLU A 243
LYS A 237
VAL A 239
 None
 1.00A 1l2iA-3r13A:
undetectable		 1l2iA-3r13A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00160
(Pro_isomerase) 		3 GLU A 214
LYS A 208
VAL A 210
 None
 0.91A 1l2iA-3rfyA:
undetectable		 1l2iA-3rfyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 GLU A 397
LYS A 392
VAL A 393
 None
 0.89A 1l2iA-3rr5A:
undetectable		 1l2iA-3rr5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 GLU A 148
LYS A 275
VAL A 277
 None
 0.75A 1l2iA-3sxfA:
undetectable		 1l2iA-3sxfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		3 GLU A  19
LYS A 287
VAL A 285
 None
 0.96A 1l2iA-3t5qA:
undetectable		 1l2iA-3t5qA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyt HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN L

(Mus musculus) 		PF13893
(RRM_5) 		3 GLU A 511
LYS A 530
VAL A 529
 None
 0.98A 1l2iA-3tytA:
undetectable		 1l2iA-3tytA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3von UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
2

(Homo sapiens) 		PF00179
(UQ_con) 		3 GLU B 121
LYS B 108
VAL B 105
 None
 0.89A 1l2iA-3vonB:
undetectable		 1l2iA-3vonB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		3 GLU A 367
LYS A 406
VAL A 407
 None
 0.95A 1l2iA-3wryA:
undetectable		 1l2iA-3wryA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 GLU A 318
LYS A  54
VAL A  52
 None
 0.91A 1l2iA-3wzfA:
undetectable		 1l2iA-3wzfA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		3 GLU A  92
LYS A  84
VAL A  85
 None
 0.98A 1l2iA-4adsA:
undetectable		 1l2iA-4adsA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 GLU A 490
LYS A 484
VAL A 486
 None
 0.97A 1l2iA-4b8jA:
undetectable		 1l2iA-4b8jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbv COME

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF04397
(LytTR) 		3 GLU A  43
LYS A  38
VAL A  39
 None
 1.00A 1l2iA-4cbvA:
undetectable		 1l2iA-4cbvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 GLU A 295
LYS A  -1
VAL A   9
 None
 0.91A 1l2iA-4czpA:
undetectable		 1l2iA-4czpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		3 GLU A 315
LYS A 426
VAL A 427
 None
 0.75A 1l2iA-4dqvA:
undetectable		 1l2iA-4dqvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6x PROTEIN
DISULFIDE-ISOMERASE
A5

(Homo sapiens) 		no annotation 3 GLU A 109
LYS A  98
VAL A  99
 None
 0.93A 1l2iA-4i6xA:
undetectable		 1l2iA-4i6xA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		3 GLU A 175
LYS A 209
VAL A 208
 None
 0.86A 1l2iA-4ijrA:
undetectable		 1l2iA-4ijrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Mycobacterium
tuberculosis) 		PF01680
(SOR_SNZ) 		3 GLU A  94
LYS A  86
VAL A  87
 None
GOL  A 301 (-2.8A)
None
 0.94A 1l2iA-4jdyA:
undetectable		 1l2iA-4jdyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		3 GLU A 272
LYS A  49
VAL A  50
 None
 0.86A 1l2iA-4k1pA:
2.8		 1l2iA-4k1pA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		3 GLU A 423
LYS A  66
VAL A  67
 None
 0.97A 1l2iA-4k2bA:
undetectable		 1l2iA-4k2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjs PROTEIN KINASE C
ZETA TYPE

(Rattus
norvegicus) 		PF00564
(PB1) 		3 GLU A  75
LYS A  59
VAL A  70
 None
 0.92A 1l2iA-4mjsA:
undetectable		 1l2iA-4mjsA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2p PROTEIN ARCHEASE

(Pyrococcus
horikoshii) 		PF01951
(Archease) 		3 GLU A  28
LYS A  87
VAL A  86
 None
 0.89A 1l2iA-4n2pA:
undetectable		 1l2iA-4n2pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n58 PECTOCIN M2

(Pectobacterium
carotovorum) 		PF00111
(Fer2)
PF14859
(Colicin_M) 		3 GLU A  26
LYS A   2
VAL A  17
 None
 0.71A 1l2iA-4n58A:
undetectable		 1l2iA-4n58A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyn RIBONUCLEASE HI

(Halobacterium
salinarum) 		PF13456
(RVT_3) 		3 GLU A 167
LYS A 161
VAL A 163
 None
 0.92A 1l2iA-4nynA:
undetectable		 1l2iA-4nynA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okq HUT OPERON POSITIVE
REGULATORY PROTEIN

(Geobacillus
thermodenitrificans) 		PF09021
(HutP) 		3 GLU A  56
LYS A  50
VAL A  52
 None
 1.00A 1l2iA-4okqA:
undetectable		 1l2iA-4okqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyd COMPUTATIONALLY
DESIGNED INHIBITOR

(synthetic
construct) 		no annotation 3 GLU B  70
LYS B   4
VAL B   6
 None
 0.95A 1l2iA-4oydB:
2.3		 1l2iA-4oydB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2
HISTONE H4 TYPE VIII

(Saccharomyces
cerevisiae;
Ophiophagus
hannah) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
no annotation 		3 GLU B  13
LYS C  46
VAL C  45
 None
 0.92A 1l2iA-4pswB:
undetectable		 1l2iA-4pswB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		3 GLU B 304
LYS B 332
VAL B 333
 None
 0.90A 1l2iA-4yjfB:
undetectable		 1l2iA-4yjfB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 GLU A 101
LYS A 394
VAL A 395
 None
 0.84A 1l2iA-4ynuA:
undetectable		 1l2iA-4ynuA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLU A  12
LYS A  67
VAL A  65
 None
 0.94A 1l2iA-4z17A:
undetectable		 1l2iA-4z17A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 3 GLU A 312
LYS A 128
VAL A 126
 None
 0.80A 1l2iA-5b5xA:
undetectable		 1l2iA-5b5xA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boe ENOLASE

(Staphylococcus
aureus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 GLU A  11
LYS A  66
VAL A  64
 None
 0.90A 1l2iA-5boeA:
undetectable		 1l2iA-5boeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		3 GLU A 124
LYS A 121
VAL A 122
 None
 0.91A 1l2iA-5dlkA:
undetectable		 1l2iA-5dlkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyr CYTOCHROME C'

(Allochromatium
vinosum) 		PF01322
(Cytochrom_C_2) 		3 GLU A   6
LYS A  70
VAL A  69
 None
 0.98A 1l2iA-5gyrA:
undetectable		 1l2iA-5gyrA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 GLU A 349
LYS A 470
VAL A 468
 None
 0.78A 1l2iA-5jqkA:
undetectable		 1l2iA-5jqkA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 GLU A 138
LYS A 152
VAL A 151
 None
 0.91A 1l2iA-5ljoA:
undetectable		 1l2iA-5ljoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lyn SMALL GLUTAMINE-RICH
TETRATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN 2

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A 187
LYS A 218
VAL A 219
 None
 0.95A 1l2iA-5lynA:
undetectable		 1l2iA-5lynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		3 GLU A 363
LYS A 243
VAL A 247
 None
 1.00A 1l2iA-5o1mA:
1.8		 1l2iA-5o1mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oac MAJOR CAPSID PROTEIN

(unidentified
phage) 		no annotation 3 GLU A 297
LYS A 291
VAL A 293
 None
 0.90A 1l2iA-5oacA:
undetectable		 1l2iA-5oacA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5win -

(-) 		no annotation 3 GLU A 627
LYS A 630
VAL A 629
 None
None
SKE  A 901 (-3.9A)
 0.95A 1l2iA-5winA:
undetectable		 1l2iA-5winA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 3 GLU A  42
LYS A  24
VAL A  25
 None
 0.85A 1l2iA-5wtkA:
1.5		 1l2iA-5wtkA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeb ENVELOPE
GLYCOPROTEIN

(Dhori
thogotovirus) 		PF03273
(Baculo_gp64) 		3 GLU A 288
LYS A  54
VAL A  53
 None
 0.78A 1l2iA-5xebA:
undetectable		 1l2iA-5xebA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae) 		PF00514
(Arm) 		3 GLU A 287
LYS A 255
VAL A 253
 None
 0.89A 1l2iA-5xjgA:
undetectable		 1l2iA-5xjgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		3 GLU C 176
LYS C 181
VAL C 179
 None
 0.95A 1l2iA-5xn6C:
undetectable		 1l2iA-5xn6C:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13

(Homo sapiens) 		PF06212
(GRIM-19) 		3 GLU W  94
LYS W 105
VAL W 106
 None
 0.90A 1l2iA-5xtcW:
undetectable		 1l2iA-5xtcW:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A 332
LYS A 327
VAL A 325
 None
 0.93A 1l2iA-6amnA:
undetectable		 1l2iA-6amnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 3 GLU A 517
LYS A 511
VAL A 513
 None
 0.97A 1l2iA-6gnfA:
undetectable		 1l2iA-6gnfA:
undetectable