SIMILAR PATTERNS OF AMINO ACIDS FOR 1KYV_B_RBFB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		7 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
 0.47A 1kyvA-1c41A:
26.7
1kyvB-1c41A:
26.7		 1kyvA-1c41A:
47.50
1kyvB-1c41A:
47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 ILE A 265
GLY A 184
SER A 240
GLU A 243
LEU A 193
 None
 1.36A 1kyvA-1dysA:
undetectable
1kyvB-1dysA:
undetectable		 1kyvA-1dysA:
19.35
1kyvB-1dysA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		5 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
 0.25A 1kyvA-1ejbA:
25.9
1kyvB-1ejbA:
26.0		 1kyvA-1ejbA:
49.10
1kyvB-1ejbA:
49.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		5 ILE A 286
LEU A 285
HIS A 282
GLY A 301
SER A 350
 None
None
None
NA  A1378 ( 4.0A)
None
 1.30A 1kyvA-1f6dA:
3.3
1kyvB-1f6dA:
4.1		 1kyvA-1f6dA:
18.64
1kyvB-1f6dA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Aquifex
aeolicus) 		PF00885
(DMRL_synthase) 		6 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.27A 1kyvA-1hqkA:
24.3
1kyvB-1hqkA:
24.3		 1kyvA-1hqkA:
37.89
1kyvB-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		6 GLY A  61
SER A  62
TRP A  63
GLU A  64
LEU A  87
HIS A  94
 None
 0.12A 1kyvA-1kz1A:
30.1
1kyvB-1kz1A:
30.0		 1kyvA-1kz1A:
99.37
1kyvB-1kz1A:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		5 GLY A  61
SER A  62
TRP A  63
GLU A  64
LEU A 121
 None
 1.39A 1kyvA-1kz1A:
30.1
1kyvB-1kz1A:
30.0		 1kyvA-1kz1A:
99.37
1kyvB-1kz1A:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE B 252
LEU B 224
GLY B 219
SER B 220
GLU B 250
 None
 1.37A 1kyvA-1olxB:
2.4
1kyvB-1olxB:
7.1		 1kyvA-1olxB:
20.00
1kyvB-1olxB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE B 326
HIS B 141
GLY B 137
GLU B 280
LEU B 193
 None
 1.49A 1kyvA-1olxB:
2.4
1kyvB-1olxB:
7.1		 1kyvA-1olxB:
20.00
1kyvB-1olxB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 5 ILE A  68
LEU A  67
GLY A  13
SER A  12
LEU A 104
 None
 1.34A 1kyvA-1oy1A:
4.5
1kyvB-1oy1A:
3.5		 1kyvA-1oy1A:
20.26
1kyvB-1oy1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7s BIT1

(Homo sapiens) 		PF01981
(PTH2) 		5 LEU A 142
HIS A  88
GLY A 154
SER A 155
LEU A  75
 None
 1.19A 1kyvA-1q7sA:
2.7
1kyvB-1q7sA:
2.6		 1kyvA-1q7sA:
25.66
1kyvB-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 HIS A 174
GLY A 125
SER A 124
LEU A 383
HIS A 296
 None
 1.46A 1kyvA-1yfmA:
undetectable
1kyvB-1yfmA:
undetectable		 1kyvA-1yfmA:
14.81
1kyvB-1yfmA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 ILE A 411
LEU A 412
HIS A 434
GLY A 556
SER A 558
 None
None
None
ADP  A1001 (-3.6A)
ADP  A1001 (-3.3A)
 1.46A 1kyvA-2d0oA:
3.0
1kyvB-2d0oA:
3.0		 1kyvA-2d0oA:
15.93
1kyvB-2d0oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ILE A  54
LEU A  51
HIS A 265
TRP A 258
GLY A  66
 None
 1.35A 1kyvA-2f3oA:
undetectable
1kyvB-2f3oA:
undetectable		 1kyvA-2f3oA:
13.36
1kyvB-2f3oA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv0 LYSOZYME C

(Pelodiscus
sinensis) 		PF00062
(Lys) 		5 HIS A  35
TRP A 125
GLY A  27
TRP A  29
LEU A   9
 None
 1.44A 1kyvA-2gv0A:
undetectable
1kyvB-2gv0A:
undetectable		 1kyvA-2gv0A:
21.69
1kyvB-2gv0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 ILE A 115
HIS A  98
GLY A   6
LEU A  23
HIS A  93
 None
 1.42A 1kyvA-2jjmA:
2.3
1kyvB-2jjmA:
2.3		 1kyvA-2jjmA:
20.05
1kyvB-2jjmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 ILE A 610
LEU A 657
TRP A 652
GLY A 653
LEU A 748
 None
None
None
5ID  A1800 (-3.9A)
None
 1.01A 1kyvA-2vuwA:
undetectable
1kyvB-2vuwA:
undetectable		 1kyvA-2vuwA:
18.08
1kyvB-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuy POLYHEDRIN

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00738
(Polyhedrin) 		5 ILE A 153
LEU A  85
HIS A 139
GLY A 211
LEU A 222
 None
 1.32A 1kyvA-2wuyA:
undetectable
1kyvB-2wuyA:
undetectable		 1kyvA-2wuyA:
20.87
1kyvB-2wuyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 ILE A 200
LEU A 199
GLY A 278
SER A 277
GLU A 192
 None
 1.10A 1kyvA-2xmrA:
undetectable
1kyvB-2xmrA:
undetectable		 1kyvA-2xmrA:
20.76
1kyvB-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE

(Escherichia
coli) 		PF03588
(Leu_Phe_trans) 		5 ILE A 132
LEU A 170
HIS A  82
GLY A 142
SER A 160
 None
None
None
None
TAR  A 501 ( 2.6A)
 1.48A 1kyvA-2z3kA:
undetectable
1kyvB-2z3kA:
undetectable		 1kyvA-2z3kA:
22.36
1kyvB-2z3kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		5 ILE A 220
HIS A 223
GLY A 157
SER A 159
LEU A 153
 None
RDF  A2001 (-3.5A)
None
None
None
 1.43A 1kyvA-3dbkA:
undetectable
1kyvB-3dbkA:
undetectable		 1kyvA-3dbkA:
19.27
1kyvB-3dbkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		5 ILE A 169
LEU A 195
GLY A 198
SER A 222
LEU A 250
 None
 1.28A 1kyvA-3en0A:
2.0
1kyvB-3en0A:
undetectable		 1kyvA-3en0A:
21.31
1kyvB-3en0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 ILE A  66
GLY A  94
SER A  93
LEU A  88
HIS A  87
 None
None
PLM  A 501 (-2.8A)
None
None
 1.41A 1kyvA-3fysA:
undetectable
1kyvB-3fysA:
undetectable		 1kyvA-3fysA:
21.15
1kyvB-3fysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 ILE A  66
LEU A  69
GLY A  94
LEU A  88
HIS A  87
 None
 1.35A 1kyvA-3fysA:
undetectable
1kyvB-3fysA:
undetectable		 1kyvA-3fysA:
21.15
1kyvB-3fysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 ILE A 113
LEU A 112
GLY A 106
SER A 105
LEU A  40
 None
 1.47A 1kyvA-3h04A:
3.3
1kyvB-3h04A:
3.2		 1kyvA-3h04A:
20.36
1kyvB-3h04A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A  77
LEU A  76
HIS A   5
SER A  67
LEU A  37
 None
 1.33A 1kyvA-3h2zA:
2.6
1kyvB-3h2zA:
3.0		 1kyvA-3h2zA:
17.40
1kyvB-3h2zA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		5 ILE A 171
LEU A 222
GLY A 167
SER A 166
LEU A 251
 EDO  A 335 (-3.8A)
None
None
HEM  A 305 (-3.6A)
None
 1.29A 1kyvA-3hdlA:
undetectable
1kyvB-3hdlA:
undetectable		 1kyvA-3hdlA:
20.45
1kyvB-3hdlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		5 ILE A 246
LEU A 243
HIS A 210
GLY A 122
HIS A 129
 None
 1.41A 1kyvA-3i1aA:
undetectable
1kyvB-3i1aA:
undetectable		 1kyvA-3i1aA:
16.82
1kyvB-3i1aA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 HIS A 332
GLY A 365
SER A 612
GLU A 570
LEU A 422
 None
 1.26A 1kyvA-3ldrA:
undetectable
1kyvB-3ldrA:
undetectable		 1kyvA-3ldrA:
14.83
1kyvB-3ldrA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojc PUTATIVE
ASPARTATE/GLUTAMATE
RACEMASE

(Yersinia pestis) 		PF01177
(Asp_Glu_race) 		5 ILE A  49
HIS A  88
GLY A  10
SER A  43
LEU A  41
 None
 1.49A 1kyvA-3ojcA:
5.6
1kyvB-3ojcA:
5.6		 1kyvA-3ojcA:
23.55
1kyvB-3ojcA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-BETA-1

(Mus musculus) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ILE C 731
LEU C 729
GLY C 791
SER C 790
LEU C 811
 None
 1.34A 1kyvA-3tadC:
undetectable
1kyvB-3tadC:
undetectable		 1kyvA-3tadC:
20.58
1kyvB-3tadC:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8e PAPAIN-LIKE CYSTEINE
PROTEASE

(Crocus sativus) 		PF00112
(Peptidase_C1) 		5 ILE A 166
LEU A 165
HIS A 162
GLY A 214
SER A 215
 None
SO4  A 227 ( 4.3A)
None
None
None
 1.36A 1kyvA-3u8eA:
undetectable
1kyvB-3u8eA:
undetectable		 1kyvA-3u8eA:
20.35
1kyvB-3u8eA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		5 ILE A 369
LEU A 370
HIS A 162
SER A 376
GLU A 372
 None
 1.50A 1kyvA-4a0wA:
undetectable
1kyvB-4a0wA:
undetectable		 1kyvA-4a0wA:
16.41
1kyvB-4a0wA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		5 ILE A1668
LEU A1650
GLY A1644
SER A1645
LEU A1583
 None
 1.35A 1kyvA-4by6A:
undetectable
1kyvB-4by6A:
undetectable		 1kyvA-4by6A:
14.31
1kyvB-4by6A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ILE A  97
TRP A  98
GLU A 101
LEU A 157
HIS A 194
 None
 1.12A 1kyvA-4dykA:
undetectable
1kyvB-4dykA:
undetectable		 1kyvA-4dykA:
18.14
1kyvB-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A  34
GLY A 114
SER A 116
GLU A  37
LEU A  15
 None
 1.29A 1kyvA-4hymA:
undetectable
1kyvB-4hymA:
undetectable		 1kyvA-4hymA:
18.91
1kyvB-4hymA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		5 GLY A  60
SER A  61
GLU A  63
LEU A  91
HIS A  98
 None
None
None
None
SO4  A 202 ( 4.7A)
 0.30A 1kyvA-4kq6A:
26.9
1kyvB-4kq6A:
26.9		 1kyvA-4kq6A:
49.44
1kyvB-4kq6A:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		5 ILE A 255
GLY A 146
SER A 145
GLU A 452
HIS A 138
 None
None
None
None
MN  A 501 (-3.5A)
 1.07A 1kyvA-4pxbA:
3.5
1kyvB-4pxbA:
3.6		 1kyvA-4pxbA:
18.46
1kyvB-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE

(Burkholderia
cenocepacia) 		PF03309
(Pan_kinase) 		5 ILE A  83
TRP A  54
GLY A 250
SER A 249
LEU A  26
 AMP  A 304 (-3.8A)
None
None
None
None
 1.23A 1kyvA-5b8hA:
undetectable
1kyvB-5b8hA:
undetectable		 1kyvA-5b8hA:
20.48
1kyvB-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c30 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF02026
(RyR) 		5 LEU A 932
HIS A 866
GLY A 926
SER A 925
LEU A 874
 None
 1.32A 1kyvA-5c30A:
undetectable
1kyvB-5c30A:
undetectable		 1kyvA-5c30A:
20.79
1kyvB-5c30A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 ILE A 116
HIS A  99
GLY A   7
LEU A  24
HIS A  94
 None
 1.47A 1kyvA-5d01A:
5.2
1kyvB-5d01A:
5.1		 1kyvA-5d01A:
19.05
1kyvB-5d01A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 ILE B 164
GLY B 120
SER B 121
LEU B  87
HIS B 126
 None
SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
 1.14A 1kyvA-5ergB:
undetectable
1kyvB-5ergB:
undetectable		 1kyvA-5ergB:
18.68
1kyvB-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		5 ILE A 208
HIS A 197
GLY A  97
SER A  96
GLU A  98
 None
 1.18A 1kyvA-5exeA:
4.2
1kyvB-5exeA:
3.1		 1kyvA-5exeA:
17.81
1kyvB-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lir SIGMA CROSS-REACTING
PROTEIN 27A
(SCRP-27A)

(Salmonella
enterica) 		PF01965
(DJ-1_PfpI) 		5 ILE A  68
LEU A  67
GLY A  13
SER A  12
LEU A 104
 None
 1.39A 1kyvA-5lirA:
5.9
1kyvB-5lirA:
5.9		 1kyvA-5lirA:
19.68
1kyvB-5lirA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 155
HIS A 193
GLY A 149
SER A 148
LEU A 142
 None
 1.30A 1kyvA-5w3fA:
2.5
1kyvB-5w3fA:
undetectable		 1kyvA-5w3fA:
17.05
1kyvB-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ILE A 512
HIS A 565
GLY A 525
SER A 526
LEU A 580
 None
 1.31A 1kyvA-5xv7A:
undetectable
1kyvB-5xv7A:
undetectable		 1kyvA-5xv7A:
21.15
1kyvB-5xv7A:
21.15