SIMILAR PATTERNS OF AMINO ACIDS FOR 1KYV_A_RBFA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6g MYOGLOBIN

(Physeter
catodon) 		PF00042
(Globin) 		5 LEU A  86
ILE A 142
ILE A 107
LEU A 104
HIS A  97
 None
None
HEM  A 154 ( 3.9A)
None
HEM  A 154 (-3.4A)
 1.14A 1kyvA-1a6gA:
undetectable
1kyvE-1a6gA:
undetectable		 1kyvA-1a6gA:
25.27
1kyvE-1a6gA:
25.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		8 TRP A  25
GLY A  58
SER A  59
TRP A  60
GLU A  61
LEU A 120
HIS A 127
ILE A 131
 LMZ  A 201 (-3.5A)
LMZ  A 201 (-2.9A)
LMZ  A 201 (-2.5A)
None
LMZ  A 201 (-2.6A)
LMZ  A 201 (-3.8A)
LMZ  A 201 ( 3.8A)
LMZ  A 201 (-4.3A)
 0.62A 1kyvA-1c41A:
26.7
1kyvE-1c41A:
27.6		 1kyvA-1c41A:
47.50
1kyvE-1c41A:
47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		6 TRP A  26
GLY A  59
SER A  60
GLU A  62
LEU A  90
ILE A 101
 INJ  A 200 (-3.9A)
INJ  A 200 (-3.3A)
INJ  A 200 (-2.8A)
INJ  A 200 (-2.9A)
INJ  A 200 (-4.2A)
INJ  A 200 (-4.5A)
 0.50A 1kyvA-1ejbA:
25.9
1kyvE-1ejbA:
26.0		 1kyvA-1ejbA:
49.10
1kyvE-1ejbA:
49.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 GLY A 323
LEU A 246
ILE A 308
ILE A  81
LEU A  52
 NDP  A1000 (-3.6A)
NDP  A1000 (-4.0A)
None
None
None
 1.02A 1kyvA-1exbA:
undetectable
1kyvE-1exbA:
undetectable		 1kyvA-1exbA:
19.22
1kyvE-1exbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 GLY A  48
SER A  44
ILE A  54
ILE A  78
LEU A  76
 None
 1.20A 1kyvA-1f7uA:
3.3
1kyvE-1f7uA:
4.2		 1kyvA-1f7uA:
14.33
1kyvE-1f7uA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 GLY A 268
GLU A 271
LEU A 263
ILE A 309
HIS A  89
 None
 1.19A 1kyvA-1gz5A:
undetectable
1kyvE-1gz5A:
4.8		 1kyvA-1gz5A:
15.20
1kyvE-1gz5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hom ANTENNAPEDIA PROTEIN

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		5 GLU A  15
LEU A  26
ILE A  45
LEU A  40
HIS A  36
 None
 1.24A 1kyvA-1homA:
undetectable
1kyvE-1homA:
undetectable		 1kyvA-1homA:
15.29
1kyvE-1homA:
15.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Aquifex
aeolicus) 		PF00885
(DMRL_synthase) 		7 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
ILE A  92
 None
 0.56A 1kyvA-1hqkA:
24.3
1kyvE-1hqkA:
23.9		 1kyvA-1hqkA:
37.89
1kyvE-1hqkA:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 GLY A  44
SER A  45
LEU A 209
ILE A  47
ILE A 108
 None
 1.24A 1kyvA-1hylA:
undetectable
1kyvE-1hylA:
undetectable		 1kyvA-1hylA:
23.08
1kyvE-1hylA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kz1 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Schizosaccharomyces
pombe) 		PF00885
(DMRL_synthase) 		7 GLY A  61
SER A  62
TRP A  63
GLU A  64
LEU A  87
HIS A  94
ILE A  98
 None
 0.21A 1kyvA-1kz1A:
30.1
1kyvE-1kz1A:
29.6		 1kyvA-1kz1A:
99.37
1kyvE-1kz1A:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 203
ILE A 169
ILE A 124
LEU A 119
HIS A  31
 None
 1.26A 1kyvA-1m2wA:
2.6
1kyvE-1m2wA:
2.7		 1kyvA-1m2wA:
16.33
1kyvE-1m2wA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		5 SER D 803
GLU D 810
ILE D 782
ILE D 730
LEU D 811
 None
 1.20A 1kyvA-1o7dD:
undetectable
1kyvE-1o7dD:
undetectable		 1kyvA-1o7dD:
20.77
1kyvE-1o7dD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 GLY A 347
GLU A  42
LEU A 136
ILE A  37
LEU A  39
 PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
None
 1.20A 1kyvA-1pieA:
undetectable
1kyvE-1pieA:
undetectable		 1kyvA-1pieA:
17.53
1kyvE-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7s BIT1

(Homo sapiens) 		PF01981
(PTH2) 		5 GLY A 154
SER A 155
LEU A  75
LEU A 142
HIS A  88
 None
 1.19A 1kyvA-1q7sA:
2.7
1kyvE-1q7sA:
2.6		 1kyvA-1q7sA:
25.66
1kyvE-1q7sA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTERCELLULAR
ADHESION MOLECULE-3

(Homo sapiens) 		PF03921
(ICAM_N) 		5 GLY B  78
SER B  79
ILE B  65
ILE B  34
LEU B  36
 None
NAG  B 302 (-2.9A)
None
None
None
 1.23A 1kyvA-1t0pB:
undetectable
1kyvE-1t0pB:
undetectable		 1kyvA-1t0pB:
21.79
1kyvE-1t0pB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		5 GLY A 496
ILE A 622
ILE A 586
LEU A 633
HIS A 626
 None
 1.18A 1kyvA-1um2A:
undetectable
1kyvE-1um2A:
undetectable		 1kyvA-1um2A:
18.71
1kyvE-1um2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger) 		PF01764
(Lipase_3) 		5 GLY A  99
LEU A 134
ILE A  48
ILE A 105
TRP A 104
 NAG  A1264 ( 4.8A)
None
None
None
None
 1.15A 1kyvA-1uswA:
undetectable
1kyvE-1uswA:
undetectable		 1kyvA-1uswA:
21.29
1kyvE-1uswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjr KIAA1617 PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 GLY A  15
SER A  16
LEU A 110
ILE A  18
LEU A  44
 None
 1.23A 1kyvA-1wjrA:
undetectable
1kyvE-1wjrA:
undetectable		 1kyvA-1wjrA:
21.47
1kyvE-1wjrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 GLY A 350
LEU A 528
ILE A 524
ILE A 318
LEU A 321
 None
 1.11A 1kyvA-2a7sA:
undetectable
1kyvE-2a7sA:
undetectable		 1kyvA-2a7sA:
14.37
1kyvE-2a7sA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Staphylococcus
aureus) 		PF00475
(IGPD) 		5 GLY A  30
LEU A  34
ILE A  68
LEU A  14
HIS A  63
 None
 1.25A 1kyvA-2ae8A:
undetectable
1kyvE-2ae8A:
undetectable		 1kyvA-2ae8A:
22.17
1kyvE-2ae8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY B 663
LEU B 498
ILE B 517
ILE B 587
LEU B 511
 None
 1.12A 1kyvA-2asuB:
undetectable
1kyvE-2asuB:
undetectable		 1kyvA-2asuB:
23.24
1kyvE-2asuB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		5 GLY A   4
LEU A  47
ILE A  70
ILE A  78
LEU A  77
 None
 1.21A 1kyvA-2dc1A:
3.1
1kyvE-2dc1A:
4.9		 1kyvA-2dc1A:
23.43
1kyvE-2dc1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		5 SER A 436
LEU A  71
ILE A 416
ILE A 379
LEU A 375
 None
 1.20A 1kyvA-2j7cA:
undetectable
1kyvE-2j7cA:
undetectable		 1kyvA-2j7cA:
18.66
1kyvE-2j7cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oix XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		5 TRP A 410
GLY A 471
LEU A 412
ILE A 478
ILE A 508
 None
 1.26A 1kyvA-2oixA:
undetectable
1kyvE-2oixA:
undetectable		 1kyvA-2oixA:
22.06
1kyvE-2oixA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		5 GLY A  46
LEU A  73
ILE A  78
ILE A   8
LEU A   7
 None
 0.98A 1kyvA-2os3A:
undetectable
1kyvE-2os3A:
undetectable		 1kyvA-2os3A:
21.74
1kyvE-2os3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		5 LEU A 201
ILE A 190
ILE A  75
LEU A  74
HIS A  67
 None
None
None
None
SAH  A 301 (-3.9A)
 1.15A 1kyvA-2pbfA:
undetectable
1kyvE-2pbfA:
undetectable		 1kyvA-2pbfA:
21.49
1kyvE-2pbfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY U  44
SER U  45
LEU U 209
ILE U  47
ILE U 108
 None
 1.20A 1kyvA-2r2wU:
undetectable
1kyvE-2r2wU:
undetectable		 1kyvA-2r2wU:
21.18
1kyvE-2r2wU:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 164
SER A 163
LEU A 254
ILE A 257
LEU A 269
 None
 1.21A 1kyvA-2v6bA:
4.6
1kyvE-2v6bA:
4.5		 1kyvA-2v6bA:
22.40
1kyvE-2v6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		5 GLY A  67
LEU A  87
ILE A 205
ILE A   3
LEU A 201
 None
 1.22A 1kyvA-2vd3A:
2.8
1kyvE-2vd3A:
undetectable		 1kyvA-2vd3A:
23.05
1kyvE-2vd3A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		5 GLY A 240
SER A 239
LEU A 264
ILE A 252
ILE A 304
 None
 1.25A 1kyvA-2veoA:
3.5
1kyvE-2veoA:
undetectable		 1kyvA-2veoA:
15.29
1kyvE-2veoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 TRP A 652
GLY A 653
LEU A 748
ILE A 610
LEU A 657
 None
5ID  A1800 (-3.9A)
None
None
None
 1.02A 1kyvA-2vuwA:
undetectable
1kyvE-2vuwA:
undetectable		 1kyvA-2vuwA:
18.08
1kyvE-2vuwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		5 GLY A 129
GLU A 130
LEU A 103
ILE A  99
LEU A  94
 None
 1.23A 1kyvA-2wsmA:
3.7
1kyvE-2wsmA:
3.2		 1kyvA-2wsmA:
22.87
1kyvE-2wsmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 GLY A 278
SER A 277
GLU A 192
ILE A 200
LEU A 199
 None
 1.08A 1kyvA-2xmrA:
undetectable
1kyvE-2xmrA:
undetectable		 1kyvA-2xmrA:
20.76
1kyvE-2xmrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		5 GLY A 320
GLU A 338
LEU A 136
ILE A 158
ILE A 242
 None
 1.10A 1kyvA-2xxlA:
undetectable
1kyvE-2xxlA:
undetectable		 1kyvA-2xxlA:
18.99
1kyvE-2xxlA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		5 GLY A 258
LEU A 347
ILE A 343
ILE A 261
LEU A 260
 None
 1.17A 1kyvA-3apoA:
undetectable
1kyvE-3apoA:
2.1		 1kyvA-3apoA:
12.08
1kyvE-3apoA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 GLY A  48
SER A  47
ILE A 106
LEU A 107
HIS A 128
 None
None
GOL  A 411 (-4.5A)
None
None
 1.25A 1kyvA-3auzA:
undetectable
1kyvE-3auzA:
undetectable		 1kyvA-3auzA:
18.94
1kyvE-3auzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 GLY A 451
LEU A 540
ILE A 437
ILE A 565
LEU A 563
 None
 1.11A 1kyvA-3d8bA:
undetectable
1kyvE-3d8bA:
undetectable		 1kyvA-3d8bA:
19.43
1kyvE-3d8bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 GLY A 111
SER A 112
LEU A 134
ILE A 114
HIS A 184
 None
 1.20A 1kyvA-3e38A:
2.4
1kyvE-3e38A:
2.1		 1kyvA-3e38A:
19.06
1kyvE-3e38A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF13377
(Peripla_BP_3) 		5 GLY A 307
LEU A 333
ILE A 331
ILE A 314
LEU A 313
 None
 0.91A 1kyvA-3e3mA:
7.3
1kyvE-3e3mA:
4.7		 1kyvA-3e3mA:
17.93
1kyvE-3e3mA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9u NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		5 GLY A 606
LEU A 624
ILE A 622
HIS A 641
TRP A 592
 None
 1.18A 1kyvA-3e9uA:
undetectable
1kyvE-3e9uA:
undetectable		 1kyvA-3e9uA:
23.63
1kyvE-3e9uA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 325
ILE A 271
ILE A 373
LEU A 293
HIS A 291
 None
 1.21A 1kyvA-3fd5A:
undetectable
1kyvE-3fd5A:
undetectable		 1kyvA-3fd5A:
18.27
1kyvE-3fd5A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS

(Trichormus
variabilis) 		PF01965
(DJ-1_PfpI)
PF09537
(DUF2383) 		5 GLY A 220
LEU A 258
HIS A 254
ILE A 328
LEU A 332
 None
 1.23A 1kyvA-3fseA:
4.5
1kyvE-3fseA:
4.4		 1kyvA-3fseA:
21.10
1kyvE-3fseA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLY A  64
LEU A 160
ILE A 159
ILE A 137
LEU A 140
 None
 1.14A 1kyvA-3gdeA:
undetectable
1kyvE-3gdeA:
undetectable		 1kyvA-3gdeA:
14.84
1kyvE-3gdeA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gms PUTATIVE
NADPH:QUINONE
REDUCTASE

(Bacillus
thuringiensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 241
SER A 218
ILE A 216
ILE A 263
LEU A 238
 None
 1.03A 1kyvA-3gmsA:
2.2
1kyvE-3gmsA:
undetectable		 1kyvA-3gmsA:
20.48
1kyvE-3gmsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gv0 TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Agrobacterium
fabrum) 		PF13377
(Peripla_BP_3) 		5 GLY A 255
SER A 256
ILE A 233
ILE A 278
LEU A 261
 None
 1.07A 1kyvA-3gv0A:
7.1
1kyvE-3gv0A:
7.1		 1kyvA-3gv0A:
24.07
1kyvE-3gv0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		5 GLY A 210
ILE A 221
ILE A 255
LEU A 256
HIS A 286
 None
 1.10A 1kyvA-3hbaA:
2.2
1kyvE-3hbaA:
2.5		 1kyvA-3hbaA:
19.40
1kyvE-3hbaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 GLY A  59
LEU A  53
ILE A  56
ILE A  66
LEU A  98
 None
 1.21A 1kyvA-3hidA:
undetectable
1kyvE-3hidA:
undetectable		 1kyvA-3hidA:
15.81
1kyvE-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 GLY A  59
SER A  58
LEU A  53
ILE A  56
LEU A  98
 None
 1.18A 1kyvA-3hidA:
undetectable
1kyvE-3hidA:
undetectable		 1kyvA-3hidA:
15.81
1kyvE-3hidA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 SER A 624
LEU A 603
ILE A 606
ILE A 646
HIS A 633
 None
 1.19A 1kyvA-3hzjA:
undetectable
1kyvE-3hzjA:
undetectable		 1kyvA-3hzjA:
20.32
1kyvE-3hzjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikf 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF02542
(YgbB) 		5 GLY A  23
LEU A  79
ILE A  46
ILE A 100
HIS A  12
 None
None
None
None
ZN  A 201 ( 3.2A)
 1.05A 1kyvA-3ikfA:
undetectable
1kyvE-3ikfA:
undetectable		 1kyvA-3ikfA:
24.32
1kyvE-3ikfA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 373
GLU A 375
HIS A  34
ILE A 328
ILE A  52
 None
None
None
SF4  A 801 ( 3.6A)
None
 0.97A 1kyvA-3k30A:
3.9
1kyvE-3k30A:
7.6		 1kyvA-3k30A:
13.48
1kyvE-3k30A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 SER A 714
LEU A 680
ILE A 687
ILE A 753
LEU A 719
 None
 1.19A 1kyvA-3k49A:
undetectable
1kyvE-3k49A:
undetectable		 1kyvA-3k49A:
19.13
1kyvE-3k49A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 GLY A 959
GLU A 962
ILE A 890
ILE A 967
LEU A 966
 None
 1.26A 1kyvA-3l4kA:
undetectable
1kyvE-3l4kA:
undetectable		 1kyvA-3l4kA:
12.17
1kyvE-3l4kA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLY A 365
SER A 612
GLU A 570
LEU A 422
HIS A 332
 None
 1.24A 1kyvA-3ldrA:
undetectable
1kyvE-3ldrA:
undetectable		 1kyvA-3ldrA:
14.83
1kyvE-3ldrA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS
RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
no annotation 		5 GLY A1386
LEU G 544
ILE G 541
ILE A1310
LEU A1311
 None
 1.24A 1kyvA-3mmpA:
undetectable
1kyvE-3mmpA:
3.6		 1kyvA-3mmpA:
13.42
1kyvE-3mmpA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		5 GLY A 373
LEU A 321
ILE A 324
ILE A 474
LEU A 475
 None
 1.18A 1kyvA-3nybA:
undetectable
1kyvE-3nybA:
undetectable		 1kyvA-3nybA:
17.37
1kyvE-3nybA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3m BETA SUBUNIT
2-HYDROXYACYL-COA
DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		5 GLY B 142
LEU B 147
ILE B  42
ILE B 137
HIS B 123
 None
 1.21A 1kyvA-3o3mB:
3.5
1kyvE-3o3mB:
3.5		 1kyvA-3o3mB:
20.11
1kyvE-3o3mB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		5 GLY A 606
LEU A 624
ILE A 622
HIS A 641
TRP A 592
 None
 1.18A 1kyvA-3rb5A:
undetectable
1kyvE-3rb5A:
undetectable		 1kyvA-3rb5A:
20.91
1kyvE-3rb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 5 GLY A  41
SER A 273
HIS A 247
ILE A 248
HIS A 133
 None
 1.21A 1kyvA-3rxyA:
undetectable
1kyvE-3rxyA:
undetectable		 1kyvA-3rxyA:
23.94
1kyvE-3rxyA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		5 TRP A 108
LEU A 242
ILE A 257
ILE A 106
LEU A 109
 None
 1.23A 1kyvA-3visA:
3.5
1kyvE-3visA:
3.5		 1kyvA-3visA:
19.61
1kyvE-3visA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 GLY A 237
LEU A 251
ILE A 212
ILE A 121
LEU A 120
 None
 1.22A 1kyvA-4a5qA:
undetectable
1kyvE-4a5qA:
undetectable		 1kyvA-4a5qA:
15.05
1kyvE-4a5qA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 GLY A 319
LEU A 361
ILE A 309
ILE A 279
LEU A 312
 None
 1.22A 1kyvA-4a5qA:
undetectable
1kyvE-4a5qA:
undetectable		 1kyvA-4a5qA:
15.05
1kyvE-4a5qA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		5 TRP A  69
LEU A 203
ILE A 218
ILE A  67
LEU A  70
 None
 1.19A 1kyvA-4cg1A:
4.4
1kyvE-4cg1A:
4.2		 1kyvA-4cg1A:
23.19
1kyvE-4cg1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		5 SER A  78
TRP A 173
GLU A 169
LEU A  87
ILE A 234
 None
 1.23A 1kyvA-4co6A:
undetectable
1kyvE-4co6A:
undetectable		 1kyvA-4co6A:
20.34
1kyvE-4co6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 TRP A  98
GLU A 101
LEU A 157
HIS A 194
ILE A  97
 None
 1.10A 1kyvA-4dykA:
undetectable
1kyvE-4dykA:
undetectable		 1kyvA-4dykA:
18.14
1kyvE-4dykA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 239
GLU A 236
ILE A 171
ILE A 259
LEU A 260
 None
None
CL  A 419 ( 4.8A)
None
None
 1.06A 1kyvA-4ej6A:
2.8
1kyvE-4ej6A:
2.8		 1kyvA-4ej6A:
19.34
1kyvE-4ej6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 TRP A  96
GLU A  99
HIS A 219
ILE A  95
LEU A  91
 NOS  A 501 ( 4.4A)
NOS  A 501 ( 2.8A)
NOS  A 501 (-3.5A)
NOS  A 501 (-4.2A)
NOS  A 501 ( 4.8A)
 1.14A 1kyvA-4f0sA:
undetectable
1kyvE-4f0sA:
undetectable		 1kyvA-4f0sA:
16.29
1kyvE-4f0sA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 GLY C 129
SER C 298
ILE C 315
ILE C 191
LEU C 139
 None
 1.25A 1kyvA-4f4oC:
undetectable
1kyvE-4f4oC:
undetectable		 1kyvA-4f4oC:
19.32
1kyvE-4f4oC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A 417
SER A 416
LEU A 433
ILE A 297
LEU A 298
 None
 1.10A 1kyvA-4i3uA:
3.5
1kyvE-4i3uA:
2.8		 1kyvA-4i3uA:
17.21
1kyvE-4i3uA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc5 TRANSMEMBRANE
PROTEIN 173

(Mus musculus) 		PF15009
(TMEM173) 		5 GLY A 193
SER A 194
LEU A 189
ILE A 257
LEU A 197
 None
 1.18A 1kyvA-4jc5A:
2.2
1kyvE-4jc5A:
2.2		 1kyvA-4jc5A:
20.48
1kyvE-4jc5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF13201
(PCMD) 		5 GLY A 248
LEU A 347
ILE A 345
ILE A 372
LEU A 371
 None
 1.14A 1kyvA-4jrlA:
undetectable
1kyvE-4jrlA:
undetectable		 1kyvA-4jrlA:
18.48
1kyvE-4jrlA:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		6 GLY A  60
SER A  61
GLU A  63
LEU A  91
HIS A  98
ILE A 102
 None
None
None
None
SO4  A 202 ( 4.7A)
None
 0.58A 1kyvA-4kq6A:
26.9
1kyvE-4kq6A:
26.5		 1kyvA-4kq6A:
49.44
1kyvE-4kq6A:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0m PUTATIVE
5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Borreliella
burgdorferi) 		PF01048
(PNP_UDP_1) 		5 GLY A  81
LEU A 165
ILE A 168
ILE A 152
LEU A 153
 ADE  A 301 (-3.6A)
None
None
None
None
 1.13A 1kyvA-4l0mA:
6.0
1kyvE-4l0mA:
5.9		 1kyvA-4l0mA:
21.84
1kyvE-4l0mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0m PUTATIVE
5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Borreliella
burgdorferi) 		PF01048
(PNP_UDP_1) 		5 GLY A  82
LEU A 165
ILE A 168
ILE A 152
LEU A 153
 None
 1.16A 1kyvA-4l0mA:
6.0
1kyvE-4l0mA:
5.9		 1kyvA-4l0mA:
21.84
1kyvE-4l0mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 GLY A 322
SER A 321
LEU A 310
ILE A 271
LEU A 268
 None
 0.77A 1kyvA-4p72A:
undetectable
1kyvE-4p72A:
undetectable		 1kyvA-4p72A:
11.34
1kyvE-4p72A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		5 GLU A  93
LEU A  82
ILE A  85
ILE A 155
LEU A 158
 None
 1.21A 1kyvA-4p9fA:
undetectable
1kyvE-4p9fA:
undetectable		 1kyvA-4p9fA:
22.90
1kyvE-4p9fA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		5 GLY A 146
SER A 145
GLU A 452
HIS A 138
ILE A 255
 None
None
None
MN  A 501 (-3.5A)
None
 1.08A 1kyvA-4pxbA:
3.5
1kyvE-4pxbA:
3.7		 1kyvA-4pxbA:
18.46
1kyvE-4pxbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		5 GLY A  42
SER A  39
ILE A 123
ILE A 153
LEU A 152
 None
 1.27A 1kyvA-4py9A:
undetectable
1kyvE-4py9A:
undetectable		 1kyvA-4py9A:
19.13
1kyvE-4py9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 GLY A 382
SER A 383
ILE A  33
ILE A 393
LEU A 392
 None
 1.17A 1kyvA-4v1yA:
undetectable
1kyvE-4v1yA:
undetectable		 1kyvA-4v1yA:
16.17
1kyvE-4v1yA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 GLY C 184
SER C 353
ILE C 370
ILE C 246
LEU C 194
 None
 1.25A 1kyvA-4wjgC:
undetectable
1kyvE-4wjgC:
undetectable		 1kyvA-4wjgC:
20.69
1kyvE-4wjgC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 GLY A 208
SER A 209
GLU A 241
ILE A 162
LEU A 113
 None
FAD  A 402 (-3.7A)
None
None
None
 1.26A 1kyvA-4wqmA:
undetectable
1kyvE-4wqmA:
undetectable		 1kyvA-4wqmA:
18.83
1kyvE-4wqmA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 SER C 226
ILE C 147
ILE C 220
LEU C 218
HIS C 233
 None
 1.12A 1kyvA-4wsbC:
undetectable
1kyvE-4wsbC:
undetectable		 1kyvA-4wsbC:
11.97
1kyvE-4wsbC:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY C 188
SER C 357
ILE C 374
ILE C 250
LEU C 198
 None
 1.21A 1kyvA-4x0lC:
undetectable
1kyvE-4x0lC:
undetectable		 1kyvA-4x0lC:
24.33
1kyvE-4x0lC:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 LEU A1405
ILE A1419
ILE A1379
LEU A1378
HIS A1373
 None
 1.02A 1kyvA-4z3oA:
2.4
1kyvE-4z3oA:
2.3		 1kyvA-4z3oA:
13.04
1kyvE-4z3oA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 GLY A1132
LEU A1081
ILE A1311
ILE A1260
LEU A1261
 None
 1.27A 1kyvA-4zxiA:
2.2
1kyvE-4zxiA:
undetectable		 1kyvA-4zxiA:
8.33
1kyvE-4zxiA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 GLY A1133
LEU A1081
ILE A1311
ILE A1260
LEU A1261
 None
 0.97A 1kyvA-4zxiA:
2.2
1kyvE-4zxiA:
undetectable		 1kyvA-4zxiA:
8.33
1kyvE-4zxiA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE

(Burkholderia
cenocepacia) 		PF03309
(Pan_kinase) 		5 GLY A 250
SER A 249
LEU A  26
ILE A  83
TRP A  54
 None
None
None
AMP  A 304 (-3.8A)
None
 1.23A 1kyvA-5b8hA:
undetectable
1kyvE-5b8hA:
undetectable		 1kyvA-5b8hA:
20.48
1kyvE-5b8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLY B 120
SER B 121
LEU B  87
HIS B 126
ILE B 164
 SAM  B 401 (-3.3A)
SAM  B 401 (-3.1A)
None
None
None
 1.16A 1kyvA-5ergB:
undetectable
1kyvE-5ergB:
undetectable		 1kyvA-5ergB:
18.68
1kyvE-5ergB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF01855
(POR_N)
PF17147
(PFOR_II) 		5 GLY A  97
SER A  96
GLU A  98
ILE A 208
HIS A 197
 None
 1.21A 1kyvA-5exeA:
4.2
1kyvE-5exeA:
6.0		 1kyvA-5exeA:
17.81
1kyvE-5exeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 GLY C1092
LEU C1087
ILE C1119
ILE C1112
HIS C1217
 None
 1.09A 1kyvA-5exrC:
undetectable
1kyvE-5exrC:
undetectable		 1kyvA-5exrC:
9.50
1kyvE-5exrC:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 GLY A 278
GLU A 281
LEU A 273
ILE A 319
HIS A  98
 None
 1.21A 1kyvA-5hxaA:
4.3
1kyvE-5hxaA:
4.3		 1kyvA-5hxaA:
15.51
1kyvE-5hxaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		5 GLY A  21
SER A  20
ILE A  17
ILE A 451
HIS A  29
 FAD  A 601 (-3.1A)
FAD  A 601 ( 4.4A)
None
None
None
 1.16A 1kyvA-5j7xA:
2.4
1kyvE-5j7xA:
2.4		 1kyvA-5j7xA:
15.93
1kyvE-5j7xA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		5 GLY A   8
LEU A   3
ILE A  72
ILE A  55
LEU A  52
 None
 1.23A 1kyvA-5jufA:
undetectable
1kyvE-5jufA:
undetectable		 1kyvA-5jufA:
22.96
1kyvE-5jufA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 5 GLY A1196
SER A1197
ILE A1199
ILE A1114
LEU A1104
 None
 1.16A 1kyvA-5kk5A:
undetectable
1kyvE-5kk5A:
undetectable		 1kyvA-5kk5A:
7.76
1kyvE-5kk5A:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhs UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR

(Mus musculus) 		no annotation 5 GLY B  44
SER B  45
LEU B 209
ILE B  47
ILE B 108
 None
 1.17A 1kyvA-5lhsB:
undetectable
1kyvE-5lhsB:
undetectable		 1kyvA-5lhsB:
21.16
1kyvE-5lhsB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		5 GLY A 271
GLU A 274
LEU A 266
ILE A 312
HIS A  91
 None
 1.14A 1kyvA-5tvgA:
4.4
1kyvE-5tvgA:
4.3		 1kyvA-5tvgA:
14.97
1kyvE-5tvgA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 5 GLY A 103
LEU A 127
ILE A 131
ILE B 240
TRP B 239
 None
 1.22A 1kyvA-5u7zA:
undetectable
1kyvE-5u7zA:
undetectable		 1kyvA-5u7zA:
18.88
1kyvE-5u7zA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 GLY A 283
GLU A 286
LEU A 278
ILE A 324
HIS A  99
 None
FMT  A 512 (-3.7A)
None
None
None
 1.13A 1kyvA-5v0tA:
4.4
1kyvE-5v0tA:
4.2		 1kyvA-5v0tA:
16.40
1kyvE-5v0tA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLY A 149
SER A 148
LEU A 142
LEU A 155
HIS A 193
 None
 1.26A 1kyvA-5w3fA:
2.5
1kyvE-5w3fA:
2.8		 1kyvA-5w3fA:
17.05
1kyvE-5w3fA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 GLY A 348
SER A 344
ILE A 354
ILE A 271
LEU A 279
 None
None
None
MGD  A 902 ( 4.6A)
None
 1.02A 1kyvA-6czaA:
undetectable
1kyvE-6czaA:
undetectable		 1kyvA-6czaA:
undetectable
1kyvE-6czaA:
undetectable