SIMILAR PATTERNS OF AMINO ACIDS FOR 1KT7_A_RTLA184

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 130
LEU A 136
ALA A 246
GLN A 132
HIS A 375
 None
 1.32A 1kt7A-1eovA:
0.0		 1kt7A-1eovA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		5 LEU A  12
LEU A  63
ALA A 129
VAL A  66
LEU A  76
 None
 1.20A 1kt7A-1hl2A:
0.0		 1kt7A-1hl2A:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		11 LEU A  35
LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.8A)
 0.32A 1kt7A-1iiuA:
32.0		 1kt7A-1iiuA:
79.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		6 LEU A  37
VAL A  61
MET A  73
LEU A  97
GLN A  98
HIS A 117
 RTL  A 176 ( 4.5A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.29A 1kt7A-1iiuA:
32.0		 1kt7A-1iiuA:
79.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 LEU B 173
VAL B 176
MET A 194
LEU A 186
GLN A 188
 None
 1.07A 1kt7A-1m1jB:
0.7		 1kt7A-1m1jB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		5 LEU A  45
ALA A  29
VAL A  49
LEU A  66
GLN A  69
 None
 1.40A 1kt7A-1m5yA:
undetectable		 1kt7A-1m5yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oft HYPOTHETICAL PROTEIN
PA3008

(Pseudomonas
aeruginosa) 		PF03846
(SulA) 		5 LEU A  69
LEU A  80
VAL A 130
LEU A  62
HIS A  89
 None
 1.25A 1kt7A-1oftA:
0.0		 1kt7A-1oftA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		5 LEU A  80
ALA A 208
VAL A  91
MET A 303
LEU A 213
 None
 1.26A 1kt7A-1qz9A:
0.0		 1kt7A-1qz9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 LEU A 131
LEU A 129
ALA A  84
VAL A 124
MET A  76
 None
 1.41A 1kt7A-1r47A:
undetectable		 1kt7A-1r47A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1e KV CHANNEL
INTERACTING PROTEIN
1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A 127
VAL A 123
MET A 206
MET A 182
GLN A 200
 None
 1.04A 1kt7A-1s1eA:
undetectable		 1kt7A-1s1eA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 343
ALA A 108
MET A 105
LEU A  91
HIS A 110
 None
 1.43A 1kt7A-1tuoA:
0.0		 1kt7A-1tuoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		5 LEU A  13
LEU A 116
VAL A 112
LEU A  82
HIS A  52
 None
 1.35A 1kt7A-1vzvA:
undetectable		 1kt7A-1vzvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		5 LEU A  13
LEU A 116
VAL A 112
LEU A  82
HIS A 139
 None
 1.31A 1kt7A-1vzvA:
undetectable		 1kt7A-1vzvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 LEU A 119
LEU A  51
ALA A  20
VAL A  80
TYR A  27
 None
 1.30A 1kt7A-1w25A:
undetectable		 1kt7A-1w25A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A 796
LEU A 759
ALA A 858
VAL A 844
TYR A 855
 None
 1.21A 1kt7A-1x9nA:
undetectable		 1kt7A-1x9nA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 LEU A1180
ALA A1160
VAL A1224
MET A1263
ARG A1233
 None
 1.43A 1kt7A-1yxoA:
undetectable		 1kt7A-1yxoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.33A 1kt7A-2akjA:
undetectable		 1kt7A-2akjA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwa ENDOGLUCANASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		5 LEU A  84
ALA A 123
VAL A 224
TYR A 198
LEU A  77
 None
 1.30A 1kt7A-2bwaA:
undetectable		 1kt7A-2bwaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9d BAG FAMILY MOLECULAR
CHAPERONE REGULATOR
5

(Homo sapiens) 		PF02179
(BAG) 		5 LEU A  46
LEU A  16
VAL A  72
LEU A  50
GLN A  49
 None
 1.45A 1kt7A-2d9dA:
undetectable		 1kt7A-2d9dA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		5 LEU A 155
ALA A 115
VAL A 154
LEU A  19
HIS A 112
 None
OMT  A 114 (-3.1A)
OCS  A 150 ( 3.9A)
None
OMT  A 114 ( 3.9A)
 1.42A 1kt7A-2f1kA:
undetectable		 1kt7A-2f1kA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 238
LEU A 246
ALA A 205
VAL A 242
LEU A  46
 None
 1.43A 1kt7A-2gjuA:
undetectable		 1kt7A-2gjuA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h28 HYPOTHETICAL PROTEIN
YEEU

(Escherichia
coli) 		PF06154
(CbeA_antitoxin) 		5 LEU A 112
ALA A  65
MET A  70
TYR A  43
LEU A  41
 None
 1.41A 1kt7A-2h28A:
undetectable		 1kt7A-2h28A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h28 HYPOTHETICAL PROTEIN
YEEU

(Escherichia
coli) 		PF06154
(CbeA_antitoxin) 		5 LEU A 112
ALA A  65
VAL A 110
MET A  70
LEU A  41
 None
 1.31A 1kt7A-2h28A:
undetectable		 1kt7A-2h28A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A  95
LEU A 573
ALA A  67
MET A  61
LEU A  57
 None
 1.29A 1kt7A-2h4tA:
undetectable		 1kt7A-2h4tA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.16A 1kt7A-2i7xA:
undetectable		 1kt7A-2i7xA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mu3 ACINIFORM SPIDROIN 1

(Argiope
trifasciata) 		PF12042
(RP1-2) 		5 LEU A 117
ALA A  13
VAL A 120
LEU A  94
GLN A  42
 None
 1.31A 1kt7A-2mu3A:
undetectable		 1kt7A-2mu3A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU B1063
ALA B 787
VAL B 762
MET B1156
LEU B 778
 None
 1.36A 1kt7A-2o8eB:
undetectable		 1kt7A-2o8eB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.16A 1kt7A-2ojqA:
undetectable		 1kt7A-2ojqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwv UPF0217 PROTEIN
VC_A1059

(Vibrio cholerae) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A  90
LEU A  57
ALA A 187
VAL A  71
LEU A  43
 None
 1.13A 1kt7A-2qwvA:
undetectable		 1kt7A-2qwvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.05A 1kt7A-2r05A:
undetectable		 1kt7A-2r05A:
13.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
 0.71A 1kt7A-2wq9A:
31.7		 1kt7A-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 LEU A 208
ALA A 365
VAL A 195
TYR A 179
LEU A 181
 None
 1.43A 1kt7A-2ychA:
undetectable		 1kt7A-2ychA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  85
LEU A 104
ALA A  58
VAL A  20
MET A 100
 None
 1.41A 1kt7A-2z9sA:
undetectable		 1kt7A-2z9sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhl GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 101
ALA A   8
VAL A  47
TYR A 144
LEU A 142
 None
 1.45A 1kt7A-2zhlA:
undetectable		 1kt7A-2zhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.38A 1kt7A-3b0hA:
undetectable		 1kt7A-3b0hA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cne PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		5 LEU A  60
LEU A  93
ALA A 112
VAL A  96
LEU A  70
 None
None
ZN  A 301 (-4.1A)
None
None
 1.20A 1kt7A-3cneA:
undetectable		 1kt7A-3cneA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		5 LEU A 157
ALA A  53
VAL A 155
MET A  90
LEU A  69
 None
 1.42A 1kt7A-3e7fA:
undetectable		 1kt7A-3e7fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 287
LEU A 285
ALA A 132
LEU A 298
HIS A 315
 None
 1.44A 1kt7A-3fcpA:
undetectable		 1kt7A-3fcpA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
HIS A 104
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
 0.85A 1kt7A-3fmzA:
30.6		 1kt7A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  55
VAL A  61
MET A  88
TYR A  90
HIS A 104
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
 0.63A 1kt7A-3fmzA:
30.6		 1kt7A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  55
MET A  73
MET A  88
GLN A  98
HIS A 104
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 1.07A 1kt7A-3fmzA:
30.6		 1kt7A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  55
MET A  88
TYR A  90
GLN A  98
HIS A 104
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.74A 1kt7A-3fmzA:
30.6		 1kt7A-3fmzA:
92.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  30
LEU A 145
ALA A 211
VAL A 142
LEU A  19
 None
 1.19A 1kt7A-3gd5A:
undetectable		 1kt7A-3gd5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		5 LEU A 249
LEU A 254
ALA A 127
LEU A 230
ARG A 178
 None
 1.36A 1kt7A-3gqjA:
undetectable		 1kt7A-3gqjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		5 LEU A 214
LEU A 219
ALA A  94
LEU A 195
ARG A 142
 None
 1.38A 1kt7A-3gqmA:
undetectable		 1kt7A-3gqmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.32A 1kt7A-3gvhA:
undetectable		 1kt7A-3gvhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 5 LEU A 144
VAL A 249
TYR A 189
LEU A 196
GLN A 148
 None
 1.31A 1kt7A-3i9wA:
undetectable		 1kt7A-3i9wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijf CYTIDINE DEAMINASE

(Mycobacterium
tuberculosis) 		PF00383
(dCMP_cyt_deam_1) 		5 LEU X 105
LEU X   9
ALA X  64
VAL X   4
LEU X  74
 None
 1.18A 1kt7A-3ijfX:
undetectable		 1kt7A-3ijfX:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3r ADAPTER PROTEIN MECA
1

(Bacillus
subtilis) 		PF05389
(MecA) 		5 LEU 1 127
LEU 1 179
VAL 1 175
TYR 1 164
GLN 1 128
 None
 1.43A 1kt7A-3j3r1:
undetectable		 1kt7A-3j3r1:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A 608
ALA A 580
VAL A 602
MET A 585
LEU A 629
 None
 1.37A 1kt7A-3j97A:
undetectable		 1kt7A-3j97A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		5 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.32A 1kt7A-3lacA:
undetectable		 1kt7A-3lacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9i LENS FIBER MAJOR
INTRINSIC PROTEIN

(Ovis aries) 		PF00230
(MIP) 		5 LEU A 170
LEU A 168
ALA A 186
MET A 183
LEU A 137
 None
 1.42A 1kt7A-3m9iA:
undetectable		 1kt7A-3m9iA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		5 LEU A 217
LEU A 255
ALA A 447
VAL A 252
GLN A 220
 None
 1.31A 1kt7A-3memA:
undetectable		 1kt7A-3memA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n54 SPORE GERMINATION
PROTEIN B3

(Bacillus
subtilis) 		PF05504
(Spore_GerAC) 		5 LEU B 319
LEU B 330
VAL B 328
TYR B 360
HIS B 272
 None
 1.20A 1kt7A-3n54B:
undetectable		 1kt7A-3n54B:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 193
LEU A 191
ALA A  67
VAL A 188
LEU A 160
 None
None
None
MCA  A 486 ( 4.1A)
None
 0.95A 1kt7A-3nyqA:
undetectable		 1kt7A-3nyqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		5 LEU B  63
ALA B 453
MET B 393
LEU B  32
GLN B  30
 None
None
None
None
HEM  B 801 (-3.5A)
 1.16A 1kt7A-3o0rB:
undetectable		 1kt7A-3o0rB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 LEU A 202
LEU A 235
VAL A 238
LEU A 205
HIS A 219
 None
 1.40A 1kt7A-3q3hA:
undetectable		 1kt7A-3q3hA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyy RESPONSE REGULATOR

(Xanthomonas
campestris) 		PF00990
(GGDEF) 		5 LEU A 196
ALA A 254
VAL A 192
MET A 174
LEU A 177
 None
None
None
None
C2E  A 487 (-4.1A)
 1.39A 1kt7A-3qyyA:
undetectable		 1kt7A-3qyyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU R 295
LEU R 324
VAL R 298
LEU R 314
GLN R 318
 None
 1.36A 1kt7A-4bv4R:
undetectable		 1kt7A-4bv4R:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A 105
ALA A 144
VAL A 104
LEU A  37
HIS A 192
 None
 1.17A 1kt7A-4dllA:
undetectable		 1kt7A-4dllA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		5 LEU A 112
ALA A  82
VAL A 108
LEU A 298
HIS A  78
 None
 1.39A 1kt7A-4ffcA:
undetectable		 1kt7A-4ffcA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 LEU A 111
LEU A 113
VAL A 178
TYR A 152
LEU A 145
 None
 1.23A 1kt7A-4g4pA:
undetectable		 1kt7A-4g4pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gve NUCLEOPROTEIN

(Tacaribe
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 LEU A 556
LEU A 443
VAL A 446
LEU A 399
HIS A 428
 None
 1.01A 1kt7A-4gveA:
undetectable		 1kt7A-4gveA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 154
LEU A 141
VAL A 152
MET A 211
MET A 164
 None
 1.24A 1kt7A-4krfA:
undetectable		 1kt7A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 748
ALA A  23
LEU A 777
GLN A 778
HIS A 740
 None
 1.42A 1kt7A-4krfA:
undetectable		 1kt7A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 295
LEU A 324
VAL A 298
LEU A 314
GLN A 318
 None
 1.37A 1kt7A-4lxrA:
undetectable		 1kt7A-4lxrA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 LEU A  96
ALA A  50
VAL A  97
LEU A 293
GLN A  73
 None
 1.36A 1kt7A-4mlcA:
undetectable		 1kt7A-4mlcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  50
LEU A  57
ALA A  74
VAL A  53
LEU A  39
 None
 1.41A 1kt7A-4n5aA:
undetectable		 1kt7A-4n5aA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 158
VAL A 153
MET A 274
LEU A 143
ARG A 289
 None
 1.27A 1kt7A-4n78A:
undetectable		 1kt7A-4n78A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		5 LEU A 342
LEU A 362
ALA A 262
VAL A 358
LEU A 463
 None
 1.24A 1kt7A-4oerA:
undetectable		 1kt7A-4oerA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 281
LEU A 313
ALA A 327
VAL A 284
LEU A 271
 None
 1.16A 1kt7A-4perA:
undetectable		 1kt7A-4perA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		5 LEU A 323
LEU A 358
ALA A 196
TYR A 277
GLN A 306
 None
 1.20A 1kt7A-4pevA:
undetectable		 1kt7A-4pevA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 252
LEU A 187
ALA A 275
VAL A 254
LEU A 213
 None
 1.13A 1kt7A-4ppzA:
undetectable		 1kt7A-4ppzA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		5 LEU A  56
LEU A  37
VAL A  33
MET A 140
LEU A  98
 None
 1.29A 1kt7A-4q1lA:
undetectable		 1kt7A-4q1lA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2882
ALA A2862
VAL A2934
LEU A2926
HIS A2969
 None
 1.39A 1kt7A-4qyrA:
undetectable		 1kt7A-4qyrA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 LEU B 125
LEU B 359
ALA B 278
VAL B 356
LEU B 130
 GOL  B 505 ( 4.2A)
None
None
None
None
 1.38A 1kt7A-4ritB:
undetectable		 1kt7A-4ritB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ua3 UNCHARACTERIZED
N-ACETYLTRANSFERASE
C825.04C

(Schizosaccharomyces
pombe) 		PF00583
(Acetyltransf_1) 		5 LEU A  31
LEU A  25
ALA A 143
VAL A  38
LEU A 135
 None
 1.42A 1kt7A-4ua3A:
undetectable		 1kt7A-4ua3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		5 LEU A 245
ALA A 230
VAL A 239
MET A 261
LEU A 288
 None
 1.33A 1kt7A-4v33A:
undetectable		 1kt7A-4v33A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 LEU A 117
LEU A 102
VAL A 101
MET A  60
TYR A  63
 None
 1.30A 1kt7A-4xniA:
undetectable		 1kt7A-4xniA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxx DTOR_6X35L

(synthetic
construct) 		no annotation 5 LEU A   3
ALA A 163
VAL A 199
LEU A 174
GLN A 180
 None
 1.39A 1kt7A-4yxxA:
undetectable		 1kt7A-4yxxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN

(Gallus gallus) 		PF03828
(PAP_assoc) 		5 LEU A 300
LEU A 306
ALA A 327
VAL A 307
ARG A 272
 None
None
AGS  A1529 (-3.7A)
None
None
 1.37A 1kt7A-5a30A:
undetectable		 1kt7A-5a30A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 LEU E  80
LEU E  90
ALA E 102
VAL E  43
TYR E 108
 None
 1.08A 1kt7A-5b04E:
undetectable		 1kt7A-5b04E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 LEU A 501
ALA A 453
VAL A 483
MET A 464
LEU A 468
 None
 1.45A 1kt7A-5c0yA:
undetectable		 1kt7A-5c0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		5 LEU B 442
VAL B 387
MET B 435
LEU B 385
HIS B  77
 None
 1.43A 1kt7A-5c53B:
undetectable		 1kt7A-5c53B:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 5 LEU B1285
LEU B1283
ALA B1320
VAL B1287
LEU B1255
 None
 1.43A 1kt7A-5hb0B:
undetectable		 1kt7A-5hb0B:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		5 LEU A  91
ALA A 461
VAL A  95
MET A 455
LEU A 302
 None
 1.27A 1kt7A-5i6cA:
undetectable		 1kt7A-5i6cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		5 LEU A  84
LEU A 148
VAL A 147
TYR A  99
LEU A  96
 None
 1.37A 1kt7A-5idiA:
undetectable		 1kt7A-5idiA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isx GRAMICIDIN S
SYNTHASE 1

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		5 LEU A 920
VAL A 918
MET A 935
LEU A 939
HIS A1055
 None
 1.36A 1kt7A-5isxA:
undetectable		 1kt7A-5isxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 LEU A 528
LEU A 442
VAL A 541
LEU A 526
ARG A 582
 None
 1.15A 1kt7A-5kdxA:
undetectable		 1kt7A-5kdxA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 210
ALA A 418
VAL A 121
LEU A  21
HIS A 136
 None
 1.37A 1kt7A-5keiA:
undetectable		 1kt7A-5keiA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 LEU B 213
LEU B 114
VAL B 191
MET B 184
MET B 202
 None
 1.45A 1kt7A-5kswB:
undetectable		 1kt7A-5kswB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 LEU H  38
ALA H  69
VAL H  43
MET H  75
MET H  53
 None
 1.45A 1kt7A-5lp7H:
undetectable		 1kt7A-5lp7H:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		5 LEU A  73
LEU A 106
VAL A 214
MET A 220
TYR A 116
 None
 1.20A 1kt7A-5mqcA:
undetectable		 1kt7A-5mqcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		5 LEU A 234
ALA A 229
VAL A 219
GLN A 186
ARG A 256
 None
 1.28A 1kt7A-5muaA:
undetectable		 1kt7A-5muaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 LEU A 893
LEU A 993
VAL A 971
LEU A1001
HIS A 812
 None
 1.28A 1kt7A-5n4lA:
undetectable		 1kt7A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 LEU A 249
LEU A 247
MET A 479
TYR A 475
HIS A 231
 None
 1.37A 1kt7A-5ukhA:
undetectable		 1kt7A-5ukhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
 1.32A 1kt7A-5ulvA:
undetectable		 1kt7A-5ulvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT
ALDEHYDE OXIDASE
MEDIUM SUBUNIT
ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation
no annotation 		5 LEU C 706
LEU C 710
ALA B 243
VAL C 711
GLN A  47
 None
None
GOL  B 407 ( 3.7A)
None
None
 1.36A 1kt7A-5y6qC:
undetectable		 1kt7A-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 5 LEU A 619
LEU A 736
VAL A 733
MET A 681
LEU A 664
 None
 1.32A 1kt7A-5yh1A:
undetectable		 1kt7A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 5 LEU A   5
ALA A 287
VAL A   9
LEU A 117
GLN A 116
 None
 1.24A 1kt7A-6b7pA:
undetectable		 1kt7A-6b7pA:
undetectable