SIMILAR PATTERNS OF AMINO ACIDS FOR 1KT6_A_RTLA184_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 LEU A  47
LEU A 160
ALA A  70
VAL A  43
LEU A 197
 None
 1.43A 1kt6A-1b0kA:
0.0		 1kt6A-1b0kA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 307
ALA A 315
MET A 272
MET A 286
LEU A 268
 961  A 450 (-4.8A)
None
961  A 450 (-3.1A)
None
961  A 450 ( 4.9A)
 1.29A 1kt6A-1exxA:
0.0		 1kt6A-1exxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 ALA A 202
VAL A 155
MET A 100
LEU A 125
ARG A 163
 None
 1.45A 1kt6A-1gk2A:
undetectable		 1kt6A-1gk2A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0b CELLULASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		5 LEU A  84
ALA A 123
VAL A 224
TYR A 198
LEU A  77
 None
 1.31A 1kt6A-1h0bA:
0.0		 1kt6A-1h0bA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		5 LEU A  12
LEU A  63
ALA A 129
VAL A  66
LEU A  76
 None
 1.24A 1kt6A-1hl2A:
0.0		 1kt6A-1hl2A:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		11 LEU A  35
LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.8A)
 0.33A 1kt6A-1iiuA:
31.8		 1kt6A-1iiuA:
79.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		6 LEU A  37
VAL A  61
MET A  73
LEU A  97
GLN A  98
HIS A 117
 RTL  A 176 ( 4.5A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.29A 1kt6A-1iiuA:
31.8		 1kt6A-1iiuA:
79.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 531
VAL A 471
LEU A 376
GLN A 373
HIS A 538
 None
 1.45A 1kt6A-1itzA:
undetectable		 1kt6A-1itzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT
FIBRINOGEN BETA
CHAIN

(Gallus gallus;
Gallus gallus) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 LEU B 173
VAL B 176
MET A 194
LEU A 186
GLN A 188
 None
 1.09A 1kt6A-1m1jB:
1.0		 1kt6A-1m1jB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		5 LEU A  45
ALA A  29
VAL A  49
LEU A  66
GLN A  69
 None
 1.40A 1kt6A-1m5yA:
0.0		 1kt6A-1m5yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1c TORA SPECIFIC
CHAPERONE

(Shewanella
massilia) 		PF02613
(Nitrate_red_del) 		5 LEU A 159
LEU A 167
ALA A 185
VAL A 163
LEU A 140
 None
 1.45A 1kt6A-1n1cA:
undetectable		 1kt6A-1n1cA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 LEU A 131
LEU A 129
ALA A  84
VAL A 124
MET A  76
 None
 1.41A 1kt6A-1r47A:
undetectable		 1kt6A-1r47A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 LEU A 119
LEU A  51
ALA A  20
VAL A  80
TYR A  27
 None
 1.35A 1kt6A-1w25A:
undetectable		 1kt6A-1w25A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 LEU A 519
ALA A 458
VAL A 293
LEU A 439
ARG A 665
 None
 1.47A 1kt6A-1w27A:
undetectable		 1kt6A-1w27A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeb HYPOTHETICAL PROTEIN
PA0115

(Pseudomonas
aeruginosa) 		PF13673
(Acetyltransf_10) 		5 LEU A  43
LEU A  45
VAL A  46
MET A  53
ARG A  25
 None
 1.48A 1kt6A-1xebA:
undetectable		 1kt6A-1xebA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		5 LEU A 214
LEU A 201
ALA A 157
VAL A 217
LEU A 510
 None
 1.34A 1kt6A-1xocA:
undetectable		 1kt6A-1xocA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		5 LEU A1180
ALA A1160
VAL A1224
MET A1263
ARG A1233
 None
 1.43A 1kt6A-1yxoA:
undetectable		 1kt6A-1yxoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.30A 1kt6A-2akjA:
undetectable		 1kt6A-2akjA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwa ENDOGLUCANASE

(Rhodothermus
marinus) 		PF01670
(Glyco_hydro_12) 		5 LEU A  84
ALA A 123
VAL A 224
TYR A 198
LEU A  77
 None
 1.29A 1kt6A-2bwaA:
undetectable		 1kt6A-2bwaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU

(Escherichia
coli) 		PF07350
(DUF1479) 		5 LEU A 289
VAL A 288
TYR A 217
LEU A 311
ARG A 240
 None
 1.28A 1kt6A-2dbnA:
undetectable		 1kt6A-2dbnA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h28 HYPOTHETICAL PROTEIN
YEEU

(Escherichia
coli) 		PF06154
(CbeA_antitoxin) 		5 LEU A 112
ALA A  65
MET A  70
TYR A  43
LEU A  41
 None
 1.42A 1kt6A-2h28A:
undetectable		 1kt6A-2h28A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A  95
LEU A 573
ALA A  67
MET A  61
LEU A  57
 None
 1.28A 1kt6A-2h4tA:
undetectable		 1kt6A-2h4tA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h98 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM

(Acinetobacter
sp. ADP1) 		PF03466
(LysR_substrate) 		5 LEU A 271
ALA A 245
VAL A 289
LEU A 105
ARG A 156
 None
 1.47A 1kt6A-2h98A:
undetectable		 1kt6A-2h98A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 246
LEU A 309
ALA A 260
VAL A 248
LEU A 140
 None
 1.43A 1kt6A-2hjsA:
undetectable		 1kt6A-2hjsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.15A 1kt6A-2i7xA:
undetectable		 1kt6A-2i7xA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU B1063
ALA B 787
VAL B 762
MET B1156
LEU B 778
 None
 1.36A 1kt6A-2o8eB:
undetectable		 1kt6A-2o8eB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.15A 1kt6A-2ojqA:
undetectable		 1kt6A-2ojqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.07A 1kt6A-2r05A:
undetectable		 1kt6A-2r05A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 LEU A 162
ALA A 143
VAL A  43
TYR A 133
LEU A  53
 None
 1.27A 1kt6A-2v5dA:
undetectable		 1kt6A-2v5dA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 LEU A  30
LEU A  35
TYR A 159
LEU A 204
HIS A 161
 None
 1.39A 1kt6A-2wdaA:
undetectable		 1kt6A-2wdaA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A 497
LEU A 475
ALA A 431
VAL A 541
LEU A 537
 None
 1.46A 1kt6A-2wpgA:
undetectable		 1kt6A-2wpgA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
ARG A 121
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
 0.73A 1kt6A-2wq9A:
30.5		 1kt6A-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9s PEROXIREDOXIN-1

(Rattus
norvegicus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  85
LEU A 104
ALA A  58
VAL A  20
MET A 100
 None
 1.44A 1kt6A-2z9sA:
undetectable		 1kt6A-2z9sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhl GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 101
ALA A   8
VAL A  47
TYR A 144
LEU A 142
 None
 1.49A 1kt6A-2zhlA:
undetectable		 1kt6A-2zhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 137
ALA A 170
VAL A 136
LEU A 113
ARG A 117
 LEU  A 137 ( 0.6A)
ALA  A 170 ( 0.0A)
VAL  A 136 ( 0.6A)
LEU  A 113 ( 0.6A)
ARG  A 117 ( 0.6A)
 1.43A 1kt6A-3ab7A:
undetectable		 1kt6A-3ab7A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy PROTEIN HEADING DATE
3A

(Oryza sativa) 		PF01161
(PBP) 		5 LEU A 130
ALA A 101
TYR A  67
LEU A 155
GLN A 128
 None
 1.45A 1kt6A-3axyA:
undetectable		 1kt6A-3axyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.36A 1kt6A-3b0hA:
undetectable		 1kt6A-3b0hA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		5 LEU A 157
ALA A  53
VAL A 155
MET A  90
LEU A  69
 None
 1.40A 1kt6A-3e7fA:
undetectable		 1kt6A-3e7fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 LEU A 151
VAL A 155
MET A 175
TYR A 180
LEU A 199
 None
 1.45A 1kt6A-3eegA:
undetectable		 1kt6A-3eegA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  35
LEU A  37
ALA A  55
VAL A  61
MET A  73
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.2A)
 0.89A 1kt6A-3fmzA:
29.9		 1kt6A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  55
VAL A  61
MET A  88
TYR A  90
HIS A 104
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
 0.53A 1kt6A-3fmzA:
29.9		 1kt6A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  55
MET A  88
TYR A  90
GLN A  98
HIS A 104
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.72A 1kt6A-3fmzA:
29.9		 1kt6A-3fmzA:
92.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 362
LEU A  20
ALA A 132
VAL A  25
TYR A 332
 None
 1.37A 1kt6A-3g5sA:
undetectable		 1kt6A-3g5sA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  30
LEU A 145
ALA A 211
VAL A 142
LEU A  19
 None
 1.19A 1kt6A-3gd5A:
undetectable		 1kt6A-3gd5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		5 LEU A 249
LEU A 254
ALA A 127
LEU A 230
ARG A 178
 None
 1.44A 1kt6A-3gqjA:
undetectable		 1kt6A-3gqjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.42A 1kt6A-3gvhA:
undetectable		 1kt6A-3gvhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 5 LEU A 144
VAL A 249
TYR A 189
LEU A 196
GLN A 148
 None
 1.35A 1kt6A-3i9wA:
undetectable		 1kt6A-3i9wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		5 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.34A 1kt6A-3lacA:
undetectable		 1kt6A-3lacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		5 LEU A 217
LEU A 255
ALA A 447
VAL A 252
GLN A 220
 None
 1.35A 1kt6A-3memA:
undetectable		 1kt6A-3memA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		5 LEU B  63
ALA B 453
MET B 393
LEU B  32
GLN B  30
 None
None
None
None
HEM  B 801 (-3.5A)
 1.23A 1kt6A-3o0rB:
undetectable		 1kt6A-3o0rB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 LEU A 228
MET A 171
TYR A 174
LEU A  46
HIS A 241
 None
 1.48A 1kt6A-3pdiA:
undetectable		 1kt6A-3pdiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 LEU A 202
LEU A 235
VAL A 238
LEU A 205
HIS A 219
 None
 1.40A 1kt6A-3q3hA:
undetectable		 1kt6A-3q3hA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyy RESPONSE REGULATOR

(Xanthomonas
campestris) 		PF00990
(GGDEF) 		5 LEU A 196
ALA A 254
VAL A 192
MET A 174
LEU A 177
 None
None
None
None
C2E  A 487 (-4.1A)
 1.42A 1kt6A-3qyyA:
undetectable		 1kt6A-3qyyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 LEU A  99
LEU A 392
VAL A 134
MET A 350
LEU A  92
 None
 1.20A 1kt6A-3rv6A:
undetectable		 1kt6A-3rv6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 LEU A 210
LEU A 265
VAL A 267
TYR A 256
LEU A 218
 None
 1.29A 1kt6A-3tefA:
undetectable		 1kt6A-3tefA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.40A 1kt6A-3vlyA:
undetectable		 1kt6A-3vlyA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A 105
ALA A 144
VAL A 104
LEU A  37
HIS A 192
 None
 1.17A 1kt6A-4dllA:
undetectable		 1kt6A-4dllA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		5 LEU A 579
LEU A 577
ALA A 382
MET A 372
LEU A 369
 None
 1.42A 1kt6A-4e2iA:
undetectable		 1kt6A-4e2iA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 LEU A 111
LEU A 113
VAL A 178
TYR A 152
LEU A 145
 None
 1.26A 1kt6A-4g4pA:
undetectable		 1kt6A-4g4pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdf LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind)
PF06431
(Polyoma_lg_T_C) 		5 LEU A 579
LEU A 577
ALA A 382
MET A 372
LEU A 369
 None
 1.48A 1kt6A-4gdfA:
undetectable		 1kt6A-4gdfA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 LEU A 199
ALA A 178
LEU A 183
GLN A 210
ARG A 142
 None
None
None
ACT  A 402 ( 4.9A)
18W  A 401 (-3.8A)
 1.26A 1kt6A-4htgA:
undetectable		 1kt6A-4htgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 106
ALA A 148
VAL A 109
LEU A  60
GLN A 102
 None
 1.17A 1kt6A-4im7A:
undetectable		 1kt6A-4im7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU A 497
ALA A 520
MET A 515
TYR A 475
LEU A 468
 None
 1.22A 1kt6A-4knhA:
undetectable		 1kt6A-4knhA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 154
LEU A 141
VAL A 152
MET A 211
MET A 164
 None
 1.26A 1kt6A-4krfA:
undetectable		 1kt6A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		5 LEU A 286
ALA A  77
VAL A 299
LEU A  87
GLN A  88
 None
 1.25A 1kt6A-4lcmA:
undetectable		 1kt6A-4lcmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 LEU A  96
ALA A  50
VAL A  97
LEU A 293
GLN A  73
 None
 1.35A 1kt6A-4mlcA:
undetectable		 1kt6A-4mlcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  50
LEU A  57
ALA A  74
VAL A  53
LEU A  39
 None
 1.37A 1kt6A-4n5aA:
undetectable		 1kt6A-4n5aA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		5 LEU A 158
VAL A 153
MET A 274
LEU A 143
ARG A 289
 None
 1.28A 1kt6A-4n78A:
undetectable		 1kt6A-4n78A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 281
LEU A 313
ALA A 327
VAL A 284
LEU A 271
 None
 1.20A 1kt6A-4perA:
undetectable		 1kt6A-4perA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE

(Sphaerobacter
thermophilus) 		no annotation 5 LEU B 125
LEU B 359
ALA B 278
VAL B 356
LEU B 130
 GOL  B 505 ( 4.2A)
None
None
None
None
 1.44A 1kt6A-4ritB:
undetectable		 1kt6A-4ritB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		5 LEU A 245
ALA A 230
VAL A 239
MET A 261
LEU A 288
 None
 1.34A 1kt6A-4v33A:
undetectable		 1kt6A-4v33A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		5 LEU A 203
VAL A 206
MET A 121
LEU A 103
HIS A  70
 None
 1.40A 1kt6A-4x3fA:
undetectable		 1kt6A-4x3fA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 176
ALA A 122
MET A 317
LEU A 323
HIS A  82
 None
 1.48A 1kt6A-4zk3A:
undetectable		 1kt6A-4zk3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		5 LEU A 110
ALA A 178
VAL A 101
LEU A 141
ARG A 128
 None
 1.45A 1kt6A-4zpdA:
undetectable		 1kt6A-4zpdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN

(Gallus gallus) 		PF03828
(PAP_assoc) 		5 LEU A 300
LEU A 306
ALA A 327
VAL A 307
ARG A 272
 None
None
AGS  A1529 (-3.7A)
None
None
 1.42A 1kt6A-5a30A:
undetectable		 1kt6A-5a30A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 156
LEU A  83
ALA A 106
VAL A  84
LEU A 133
 None
 1.44A 1kt6A-5avmA:
undetectable		 1kt6A-5avmA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 LEU E  80
LEU E  90
ALA E 102
VAL E  43
TYR E 108
 None
 1.13A 1kt6A-5b04E:
undetectable		 1kt6A-5b04E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 LEU A  48
ALA A 168
VAL A  54
MET A   6
LEU A  11
 None
 1.45A 1kt6A-5bt8A:
undetectable		 1kt6A-5bt8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 LEU A 501
ALA A 453
VAL A 483
MET A 464
LEU A 468
 None
 1.43A 1kt6A-5c0yA:
undetectable		 1kt6A-5c0yA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		5 LEU B 442
VAL B 387
MET B 435
LEU B 385
HIS B  77
 None
 1.49A 1kt6A-5c53B:
undetectable		 1kt6A-5c53B:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 370
LEU A 249
ALA A 261
VAL A 246
LEU A 368
 None
 1.47A 1kt6A-5cweA:
undetectable		 1kt6A-5cweA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 ALA A 209
VAL A 385
TYR A 188
LEU A 148
GLN A 147
 None
 1.34A 1kt6A-5d2eA:
undetectable		 1kt6A-5d2eA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcf TYROSINE RECOMBINASE
XERD,DNA TRANSLOCASE
FTSK

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF09397
(Ftsk_gamma) 		5 LEU A  72
VAL A  58
TYR A 170
LEU A  38
HIS A 172
 None
 1.36A 1kt6A-5dcfA:
undetectable		 1kt6A-5dcfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  77
ALA A  22
LEU A  42
HIS A  13
ARG A  11
 None
 1.17A 1kt6A-5e7qA:
undetectable		 1kt6A-5e7qA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A 228
LEU A 298
ALA A  20
LEU A 197
ARG A 305
 None
 1.46A 1kt6A-5e8lA:
undetectable		 1kt6A-5e8lA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gan SPLICEOSOMAL PROTEIN
DIB1

(Saccharomyces
cerevisiae) 		PF02966
(DIM1) 		5 LEU D 103
VAL D  82
MET D 113
LEU D  46
HIS D 139
 None
 1.30A 1kt6A-5ganD:
undetectable		 1kt6A-5ganD:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb0 NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		no annotation 5 LEU B1285
LEU B1283
ALA B1320
VAL B1287
LEU B1255
 None
 1.41A 1kt6A-5hb0B:
undetectable		 1kt6A-5hb0B:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B 497
ALA B 520
MET B 515
TYR B 475
LEU B 468
 None
 1.20A 1kt6A-5hb4B:
undetectable		 1kt6A-5hb4B:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		5 LEU A  91
ALA A 461
VAL A  95
MET A 455
LEU A 302
 None
 1.33A 1kt6A-5i6cA:
undetectable		 1kt6A-5i6cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isx GRAMICIDIN S
SYNTHASE 1

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		5 LEU A 920
VAL A 918
MET A 935
LEU A 939
HIS A1055
 None
 1.35A 1kt6A-5isxA:
undetectable		 1kt6A-5isxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		5 LEU A 191
VAL A 211
MET A 316
TYR A 330
LEU A 200
 None
 1.42A 1kt6A-5ketA:
undetectable		 1kt6A-5ketA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		5 LEU A  73
LEU A 106
VAL A 214
MET A 220
TYR A 116
 None
 1.23A 1kt6A-5mqcA:
undetectable		 1kt6A-5mqcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 LEU A 893
LEU A 993
VAL A 971
LEU A1001
HIS A 812
 None
 1.21A 1kt6A-5n4lA:
undetectable		 1kt6A-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
 1.42A 1kt6A-5ulvA:
undetectable		 1kt6A-5ulvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 5 LEU A 556
LEU A 523
ALA A 471
VAL A 519
TYR A 568
 None
 1.41A 1kt6A-5xpgA:
undetectable		 1kt6A-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT
ALDEHYDE OXIDASE
MEDIUM SUBUNIT
ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation
no annotation 		5 LEU C 706
LEU C 710
ALA B 243
VAL C 711
GLN A  47
 None
None
GOL  B 407 ( 3.7A)
None
None
 1.40A 1kt6A-5y6qC:
undetectable		 1kt6A-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 5 LEU A 619
LEU A 736
VAL A 733
MET A 681
LEU A 664
 None
 1.35A 1kt6A-5yh1A:
undetectable		 1kt6A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG

(Homo sapiens) 		no annotation 5 LEU A 201
LEU A 206
LEU A 301
HIS A 165
ARG A 163
 None
None
None
None
GOL  A 401 (-3.9A)
 1.46A 1kt6A-6au8A:
undetectable		 1kt6A-6au8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 203
VAL A 206
MET A 121
LEU A 103
HIS A  70
 None
 1.48A 1kt6A-6b2qA:
undetectable		 1kt6A-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 5 LEU A   5
ALA A 287
VAL A   9
LEU A 117
GLN A 116
 None
 1.27A 1kt6A-6b7pA:
undetectable		 1kt6A-6b7pA:
undetectable