SIMILAR PATTERNS OF AMINO ACIDS FOR 1KT5_A_RTLA176_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 LEU A 434
LEU A 589
PHE A 487
LEU A 571
HIS A 458
 None
 1.34A 1kt5A-1biyA:
0.0		 1kt5A-1biyA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		5 LEU A 186
LEU A 137
ALA A 157
ALA A 161
LEU A 209
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.9A)
None
NAD  A 501 ( 4.7A)
None
 1.18A 1kt5A-1cwuA:
0.0		 1kt5A-1cwuA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 5 LEU A 290
LEU A 277
ALA A 260
ALA A 258
LEU A 297
 None
 1.23A 1kt5A-1hz4A:
undetectable		 1kt5A-1hz4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		5 LEU A 434
LEU A 589
PHE A 487
LEU A 571
HIS A 458
 None
 1.27A 1kt5A-1i6qA:
undetectable		 1kt5A-1i6qA:
15.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.1A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.7A)
None
 1.20A 1kt5A-1iiuA:
31.6		 1kt5A-1iiuA:
80.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		12 LEU A  35
LEU A  37
PHE A  45
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
HIS A 104
ARG A 121
TYR A 133
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
RTL  A 176 ( 4.8A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.8A)
None
 0.33A 1kt5A-1iiuA:
31.6		 1kt5A-1iiuA:
80.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 LEU A  37
ALA A  57
MET A  73
LEU A  97
HIS A 117
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 ( 4.6A)
 1.31A 1kt5A-1iiuA:
31.6		 1kt5A-1iiuA:
80.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 LEU A 426
LEU A 576
PHE A 479
LEU A 558
HIS A 450
 None
 1.33A 1kt5A-1jnfA:
0.0		 1kt5A-1jnfA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		5 LEU A 228
LEU A 220
ALA A 148
ALA A 154
LEU A  95
 None
 1.12A 1kt5A-1m68A:
0.0		 1kt5A-1m68A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 270
LEU A 268
ALA A 258
ALA A 286
LEU A 280
 None
 1.36A 1kt5A-1nu5A:
0.0		 1kt5A-1nu5A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 270
LEU A 268
ALA A 289
ALA A 286
LEU A 280
 None
 1.35A 1kt5A-1nu5A:
0.0		 1kt5A-1nu5A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj7 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		5 LEU A 622
ALA A 511
ALA A 509
LEU A 615
ARG A 624
 None
 1.22A 1kt5A-1sj7A:
undetectable		 1kt5A-1sj7A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv SEROTRANSFERRIN,
C-LOBE

(Homo sapiens) 		PF00405
(Transferrin) 		5 LEU E 426
LEU E 576
PHE E 479
LEU E 558
HIS E 450
 None
 1.33A 1kt5A-1suvE:
undetectable		 1kt5A-1suvE:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u84 HYPOTHETICAL PROTEIN

(Geobacillus
stearothermophilus) 		PF08958
(DUF1871) 		5 LEU A   9
LEU A  11
ALA A  32
TYR A  39
LEU A  75
 None
 1.33A 1kt5A-1u84A:
undetectable		 1kt5A-1u84A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 LEU A  55
LEU A  53
ALA A 105
ALA A 103
LEU A   7
 None
 1.34A 1kt5A-1uchA:
0.0		 1kt5A-1uchA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 379
LEU A 364
PHE A  58
ALA A  57
TYR A 212
 None
 1.25A 1kt5A-1wb0A:
undetectable		 1kt5A-1wb0A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 LEU A 235
PHE A 228
ALA A 248
ALA A 251
LEU A 120
 None
 1.17A 1kt5A-1wytA:
undetectable		 1kt5A-1wytA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		5 LEU A 239
LEU A 241
ALA A 257
ALA A 255
LEU A 204
 None
None
None
SO4  A 300 (-4.0A)
None
 0.94A 1kt5A-1ynqA:
undetectable		 1kt5A-1ynqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 152
PHE A 224
ALA A 175
ALA A 228
LEU A 125
 None
 1.40A 1kt5A-1z82A:
undetectable		 1kt5A-1z82A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdv OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF13954
(PapC_N) 		5 LEU A  74
ALA A  45
MET A  44
LEU A  39
TYR A 127
 None
 1.21A 1kt5A-1zdvA:
undetectable		 1kt5A-1zdvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.30A 1kt5A-2akjA:
undetectable		 1kt5A-2akjA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 358
ALA A 265
ALA A 263
LEU A 256
ARG A 353
 None
 1.31A 1kt5A-2ebaA:
undetectable		 1kt5A-2ebaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 MET A 281
TYR A 278
LEU A 285
ARG A 304
TYR A 248
 None
 1.16A 1kt5A-2f43A:
undetectable		 1kt5A-2f43A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe8 REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 LEU A 153
LEU A 151
ALA A 130
LEU A 173
ARG A  83
 None
None
SO4  A 320 ( 4.1A)
None
None
 1.29A 1kt5A-2fe8A:
undetectable		 1kt5A-2fe8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 PHE A 257
ALA A 583
ALA A 581
TYR A 245
LEU A 557
 None
 1.33A 1kt5A-2fjaA:
undetectable		 1kt5A-2fjaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LEU A  62
LEU A  60
ALA A  50
ALA A  48
LEU A  41
 None
 1.17A 1kt5A-2g37A:
undetectable		 1kt5A-2g37A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 LEU A 367
LEU A 155
ALA A 225
ALA A 227
LEU A 234
 None
 1.35A 1kt5A-2g85A:
undetectable		 1kt5A-2g85A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwo DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 148
ALA A  80
ALA A  78
LEU A  55
TYR A 122
 None
 1.39A 1kt5A-2gwoA:
undetectable		 1kt5A-2gwoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A  95
LEU A 573
ALA A  67
MET A  61
LEU A  57
 None
 1.25A 1kt5A-2h4tA:
undetectable		 1kt5A-2h4tA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j22 FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		5 LEU A  74
ALA A  36
TYR A  77
LEU A 115
TYR A 146
 None
 1.28A 1kt5A-2j22A:
undetectable		 1kt5A-2j22A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 LEU A 471
LEU A 480
ALA A 435
ALA A 413
LEU A 464
 None
 1.29A 1kt5A-2ja2A:
undetectable		 1kt5A-2ja2A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 LEU A 302
ALA A 425
ALA A 239
LEU A 304
HIS A 218
 None
 1.38A 1kt5A-2qk4A:
undetectable		 1kt5A-2qk4A:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 1.19A 1kt5A-2wq9A:
31.7		 1kt5A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		11 LEU A  37
PHE A  45
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
LEU A  97
HIS A 104
ARG A 121
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
OLA  A1179 ( 3.7A)
 0.45A 1kt5A-2wq9A:
31.7		 1kt5A-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xv9 ABA-1A1 REPEAT UNIT

(Ascaris suum) 		PF16469
(NPA) 		5 LEU A  37
LEU A  13
ALA A  52
ALA A  56
TYR A  44
 None
 1.31A 1kt5A-2xv9A:
undetectable		 1kt5A-2xv9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.35A 1kt5A-3b0hA:
undetectable		 1kt5A-3b0hA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 315
ALA A 284
ALA A 280
TYR A 278
ARG A 318
 None
 1.30A 1kt5A-3cgdA:
undetectable		 1kt5A-3cgdA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 695
LEU A 708
ALA A 129
MET A 115
LEU A 112
 None
 1.41A 1kt5A-3dwbA:
undetectable		 1kt5A-3dwbA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap) 		5 LEU A 110
LEU A  87
HIS A  49
ARG A 112
TYR A  37
 None
 1.40A 1kt5A-3dwdA:
undetectable		 1kt5A-3dwdA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 2T1  A 184 ( 4.3A)
2T1  A 184 ( 4.7A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
2T1  A 184 (-4.7A)
 1.20A 1kt5A-3fmzA:
30.4		 1kt5A-3fmzA:
93.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		9 LEU A  35
LEU A  37
PHE A  45
ALA A  55
ALA A  57
MET A  73
MET A  88
HIS A 104
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
 0.68A 1kt5A-3fmzA:
30.4		 1kt5A-3fmzA:
93.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  35
LEU A  37
PHE A  45
ALA A  55
ALA A  57
MET A  88
TYR A  90
HIS A 104
ARG A 121
TYR A 133
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
2T1  A 184 (-4.7A)
 0.49A 1kt5A-3fmzA:
30.4		 1kt5A-3fmzA:
93.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		5 LEU A 160
LEU A  66
LEU A  22
ARG A  85
TYR A  89
 None
 1.15A 1kt5A-3fsnA:
undetectable		 1kt5A-3fsnA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		5 LEU A 214
LEU A 219
ALA A  94
LEU A 195
ARG A 142
 None
 1.38A 1kt5A-3gqmA:
undetectable		 1kt5A-3gqmA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA(YGIT)
MOTILITY
QUORUM-SENSING
REGULATOR MQSR

(Escherichia
coli;
Escherichia
coli) 		PF15731
(MqsA_antitoxin)
PF15723
(MqsR_toxin) 		5 LEU B  37
ALA A  59
ALA A  55
MET A  54
LEU B  29
 None
 1.31A 1kt5A-3hi2B:
undetectable		 1kt5A-3hi2B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		5 LEU A 244
PHE A   8
ALA A   6
ALA A 149
TYR A 249
 None
 1.29A 1kt5A-3hvmA:
undetectable		 1kt5A-3hvmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 218
ALA A 214
ALA A 216
TYR A 264
LEU A 266
 None
 1.34A 1kt5A-3ifeA:
undetectable		 1kt5A-3ifeA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		5 LEU A 161
LEU A 223
ALA A 193
ALA A 116
LEU A 135
 None
None
SAH  A 300 (-3.4A)
None
None
 1.30A 1kt5A-3ndcA:
undetectable		 1kt5A-3ndcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 369
ALA A 397
ALA A 393
HIS A 333
ARG A 168
 None
 1.31A 1kt5A-3nksA:
undetectable		 1kt5A-3nksA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		5 PHE A 394
ALA A 373
ALA A 369
MET A 368
LEU A 437
 None
 1.34A 1kt5A-3rdeA:
undetectable		 1kt5A-3rdeA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  31
LEU A  94
ALA A 185
TYR A 208
LEU A 244
 None
 0.98A 1kt5A-3rg2A:
undetectable		 1kt5A-3rg2A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A  41
ALA A 197
ALA A  53
LEU A 116
ARG A 216
 None
 1.33A 1kt5A-3swxA:
undetectable		 1kt5A-3swxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfd SPASTIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 349
PHE A 403
ALA A 396
ALA A 394
MET A 484
 None
 1.25A 1kt5A-3vfdA:
undetectable		 1kt5A-3vfdA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.39A 1kt5A-3vlyA:
undetectable		 1kt5A-3vlyA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.13A 1kt5A-3whlA:
undetectable		 1kt5A-3whlA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		5 LEU A 294
ALA A 197
ALA A 256
MET A 253
LEU A 225
 None
 1.09A 1kt5A-4b3kA:
undetectable		 1kt5A-4b3kA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 358
PHE A 218
ALA A 372
ALA A 344
LEU A 327
 None
 1.07A 1kt5A-4bhtA:
undetectable		 1kt5A-4bhtA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 ALA A 383
ALA A 391
MET A 450
LEU A 446
ARG A 464
 None
 1.40A 1kt5A-4btpA:
undetectable		 1kt5A-4btpA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 LEU A 485
ALA A 391
MET A 450
LEU A 446
ARG A 464
 None
 1.23A 1kt5A-4btpA:
undetectable		 1kt5A-4btpA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 LEU A  43
ALA A  80
ALA A 161
LEU A  38
TYR A  45
 None
 1.22A 1kt5A-4c22A:
undetectable		 1kt5A-4c22A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 LEU A 207
ALA A 261
ALA A 243
LEU A 230
HIS A 281
 None
 1.29A 1kt5A-4e79A:
undetectable		 1kt5A-4e79A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		5 PHE A 228
ALA A 224
ALA A 222
LEU A 216
ARG A 245
 None
PI  A 301 (-3.8A)
None
None
None
 1.28A 1kt5A-4evzA:
undetectable		 1kt5A-4evzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A 409
LEU A 407
ALA A 351
MET A 354
TYR A 278
 None
 1.39A 1kt5A-4fysA:
undetectable		 1kt5A-4fysA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  23
LEU A  50
PHE A  60
ALA A   4
LEU A  16
 None
 1.36A 1kt5A-4hk1A:
undetectable		 1kt5A-4hk1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A  43
ALA A  47
MET A 338
TYR A 341
LEU A  62
 None
 1.32A 1kt5A-4iigA:
undetectable		 1kt5A-4iigA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		5 LEU A 318
LEU A 100
ALA A 271
ALA A 275
LEU A 132
 None
 1.15A 1kt5A-4kjrA:
undetectable		 1kt5A-4kjrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7w PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Leptotrichia
buccalis) 		PF01048
(PNP_UDP_1) 		5 LEU A  86
LEU A 198
ALA A 142
ALA A 138
LEU A 236
 None
 1.35A 1kt5A-4m7wA:
undetectable		 1kt5A-4m7wA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		5 LEU A 150
PHE A 138
ALA A 132
ALA A 130
LEU A 222
 None
 1.38A 1kt5A-4pj3A:
undetectable		 1kt5A-4pj3A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		5 LEU A 264
LEU A 262
PHE A 368
LEU A 204
TYR A 283
 None
 1.25A 1kt5A-4r6iA:
undetectable		 1kt5A-4r6iA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r81 NADH DEHYDROGENASE

(Methanothermobacter
marburgensis) 		PF02525
(Flavodoxin_2) 		5 LEU A 186
LEU A 130
ALA A  81
ALA A  83
LEU A  20
 None
 1.37A 1kt5A-4r81A:
undetectable		 1kt5A-4r81A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro5 SAT DOMAIN FROM CAZM

(Chaetomium
globosum) 		PF16073
(SAT) 		5 PHE A  19
ALA A 161
ALA A 165
TYR A 313
ARG A 355
 None
 1.36A 1kt5A-4ro5A:
undetectable		 1kt5A-4ro5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 LEU D 247
ALA D 116
ALA D 259
LEU D 207
TYR D 264
 None
 1.24A 1kt5A-4s1vD:
undetectable		 1kt5A-4s1vD:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 223
ALA A 169
MET A 220
LEU A 206
ARG A 303
 None
 1.28A 1kt5A-4uy9A:
undetectable		 1kt5A-4uy9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 LEU B  34
LEU B   6
ALA B 112
ALA B 108
LEU B  80
 None
 1.38A 1kt5A-4xsrB:
undetectable		 1kt5A-4xsrB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 LEU A 481
LEU A 478
PHE A 444
ALA A 320
LEU A 414
 None
 1.38A 1kt5A-4ysjA:
undetectable		 1kt5A-4ysjA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		5 LEU A 132
LEU A 130
ALA A 168
ALA A 172
MET A 173
 None
 1.28A 1kt5A-4yxfA:
undetectable		 1kt5A-4yxfA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 LEU A 592
ALA A 490
ALA A 494
MET A 495
TYR A 130
 None
 1.32A 1kt5A-5aeeA:
undetectable		 1kt5A-5aeeA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 LEU A1109
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.05A 1kt5A-5amqA:
undetectable		 1kt5A-5amqA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 LEU A  93
ALA A 443
MET A 442
MET A 425
ARG A 490
 None
 1.22A 1kt5A-5cg0A:
undetectable		 1kt5A-5cg0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 105
PHE A 146
ALA A 160
ALA A 164
LEU A 117
 None
 1.37A 1kt5A-5ddbA:
undetectable		 1kt5A-5ddbA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 LEU A 974
LEU A1026
ALA A1007
ALA A1003
LEU A 956
 None
 1.31A 1kt5A-5e02A:
undetectable		 1kt5A-5e02A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A 228
LEU A 298
ALA A  20
LEU A 197
ARG A 305
 None
 1.38A 1kt5A-5e8lA:
undetectable		 1kt5A-5e8lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		5 LEU A 281
ALA A 293
ALA A 291
MET A 288
LEU A 284
 None
 1.38A 1kt5A-5e9hA:
undetectable		 1kt5A-5e9hA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 145
ALA A 161
ALA A 157
MET A 156
LEU A 111
 None
None
None
None
ADP  A 401 (-4.2A)
 1.06A 1kt5A-5eqtA:
undetectable		 1kt5A-5eqtA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 LEU A 241
LEU A 270
ALA A 289
ALA A 291
LEU A 298
 None
None
None
None
HG  A 402 ( 4.6A)
 1.39A 1kt5A-5ez7A:
undetectable		 1kt5A-5ez7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmi BCL-2 HOMOLOGOUS
ANTAGONIST/KILLER

(Homo sapiens) 		PF00452
(Bcl-2) 		5 LEU A 140
PHE A 119
LEU A  97
ARG A  42
TYR A  38
 None
 1.24A 1kt5A-5fmiA:
undetectable		 1kt5A-5fmiA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 LEU A 397
LEU A 338
PHE A  23
ALA A 374
LEU A 390
 None
 1.12A 1kt5A-5h05A:
undetectable		 1kt5A-5h05A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 349
ALA A 418
ALA A 319
TYR A 415
ARG A 466
 None
 1.30A 1kt5A-5h3kA:
undetectable		 1kt5A-5h3kA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 349
ALA A 418
ALA A 319
TYR A 423
ARG A 466
 None
 1.07A 1kt5A-5h3kA:
undetectable		 1kt5A-5h3kA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 LEU A 104
PHE A 263
ALA A 287
ALA A 285
LEU A 563
 None
 1.30A 1kt5A-5j84A:
undetectable		 1kt5A-5j84A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 288
LEU A 438
ALA A 295
ALA A 436
LEU A 270
 None
 1.29A 1kt5A-5lnqA:
undetectable		 1kt5A-5lnqA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 5 LEU A 697
LEU A 687
ALA A 654
ALA A 656
MET A 643
 None
 1.31A 1kt5A-5n8dA:
undetectable		 1kt5A-5n8dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		5 LEU A 480
PHE A 660
ALA A 562
ALA A 558
HIS A 510
 None
 1.05A 1kt5A-5nnpA:
undetectable		 1kt5A-5nnpA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 5 LEU A 237
PHE A 361
ALA A 248
ALA A 246
LEU A  65
 None
 1.40A 1kt5A-5ou3A:
undetectable		 1kt5A-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 5 LEU A 105
PHE A 264
ALA A 288
ALA A 286
LEU A 573
 None
 1.38A 1kt5A-5oynA:
undetectable		 1kt5A-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 LEU A 249
LEU A 247
MET A 479
TYR A 475
HIS A 231
 None
 1.32A 1kt5A-5ukhA:
undetectable		 1kt5A-5ukhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 LEU A 110
LEU A 163
ALA A 532
LEU A 105
ARG A 117
 None
 1.38A 1kt5A-5vylA:
undetectable		 1kt5A-5vylA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 LEU A 152
ALA A  67
ALA A  70
LEU A 194
ARG A 217
 None
 1.29A 1kt5A-5xn6A:
undetectable		 1kt5A-5xn6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 661
ALA A  29
ALA A 506
LEU A  34
HIS A  92
 None
 1.38A 1kt5A-5xqoA:
undetectable		 1kt5A-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A  81
LEU A 138
ALA A 109
ALA A 134
LEU A 127
 None
 1.35A 1kt5A-6bu3A:
undetectable		 1kt5A-6bu3A:
undetectable