SIMILAR PATTERNS OF AMINO ACIDS FOR 1KT4_A_RTLA184

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		5 LEU A 143
ALA A 179
ALA A 183
VAL A 189
TYR A 130
 None
 1.16A 1kt4A-1e1kA:
0.0		 1kt4A-1e1kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 LEU A 382
LEU A 355
ALA A 278
ALA A 275
VAL A 356
 None
 1.34A 1kt4A-1gz5A:
0.0		 1kt4A-1gz5A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 LEU A  95
LEU A 110
ALA A 150
VAL A 107
TYR A 178
 None
 1.26A 1kt4A-1h7gA:
0.0		 1kt4A-1h7gA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 RTL  A 176 ( 3.8A)
RTL  A 176 ( 4.1A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.7A)
None
 1.15A 1kt4A-1iiuA:
31.6		 1kt4A-1iiuA:
79.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		12 LEU A  35
LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
ARG A 121
TYR A 133
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
RTL  A 176 ( 4.8A)
None
 0.33A 1kt4A-1iiuA:
31.6		 1kt4A-1iiuA:
79.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  57
VAL A  61
MET A  73
GLN A  98
HIS A 117
 RTL  A 176 ( 4.5A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.36A 1kt4A-1iiuA:
31.6		 1kt4A-1iiuA:
79.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp9 TATA-BINDING PROTEIN

(Sulfolobus
acidocaldarius) 		PF00352
(TBP) 		5 LEU A 115
ALA A 111
VAL A 119
HIS A 172
TYR A   9
 None
 1.11A 1kt4A-1mp9A:
1.8		 1kt4A-1mp9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1c TORA SPECIFIC
CHAPERONE

(Shewanella
massilia) 		PF02613
(Nitrate_red_del) 		5 LEU A 159
LEU A 167
ALA A 185
ALA A 187
VAL A 163
 None
 1.32A 1kt4A-1n1cA:
undetectable		 1kt4A-1n1cA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 LEU A 131
LEU A 129
ALA A  84
VAL A 124
MET A  76
 None
 1.36A 1kt4A-1r47A:
undetectable		 1kt4A-1r47A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1e KV CHANNEL
INTERACTING PROTEIN
1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A 127
VAL A 123
MET A 206
MET A 182
GLN A 200
 None
 1.00A 1kt4A-1s1eA:
undetectable		 1kt4A-1s1eA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 LEU A 140
LEU A 113
ALA A 198
ALA A 196
GLN A 143
 None
 1.32A 1kt4A-1sh2A:
0.0		 1kt4A-1sh2A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 LEU A 183
ALA A 156
ALA A 110
VAL A 203
ARG A 193
 None
 1.31A 1kt4A-1tjrA:
undetectable		 1kt4A-1tjrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 LEU A 164
ALA A 152
ALA A 156
VAL A 194
TYR A 198
 None
 1.12A 1kt4A-1v43A:
0.0		 1kt4A-1v43A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 LEU A 119
LEU A  51
ALA A  20
VAL A  80
TYR A  27
 None
 1.29A 1kt4A-1w25A:
undetectable		 1kt4A-1w25A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A 137
LEU A 145
ALA A 192
ALA A 240
VAL A 274
 None
 1.20A 1kt4A-2ejwA:
undetectable		 1kt4A-2ejwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A 137
LEU A 145
ALA A 193
ALA A 240
VAL A 274
 None
 1.21A 1kt4A-2ejwA:
undetectable		 1kt4A-2ejwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 LEU A 146
LEU A 135
ALA A  88
ALA A  86
VAL A 132
 None
 1.28A 1kt4A-2fd5A:
undetectable		 1kt4A-2fd5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 LEU A 149
ALA A 153
VAL A  25
TYR A  88
GLN A  86
 None
 1.14A 1kt4A-2i7xA:
undetectable		 1kt4A-2i7xA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ius DNA TRANSLOCASE FTSK

(Escherichia
coli) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A1119
ALA A 997
ALA A1155
VAL A1117
TYR A1032
 None
 1.30A 1kt4A-2iusA:
undetectable		 1kt4A-2iusA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 238
ALA A 216
ALA A 214
VAL A 237
GLN A 208
 None
 1.18A 1kt4A-2jbmA:
undetectable		 1kt4A-2jbmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 LEU A   6
LEU A 258
ALA A 116
VAL A 255
TYR A 110
 None
 1.08A 1kt4A-2jh3A:
undetectable		 1kt4A-2jh3A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np5 TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 LEU A 152
LEU A 134
ALA A  88
MET A  89
GLN A 183
 None
LMT  A 204 ( 4.8A)
LMT  A 204 (-3.5A)
None
None
 1.25A 1kt4A-2np5A:
undetectable		 1kt4A-2np5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		5 LEU A 221
LEU A  59
ALA A 208
ALA A 210
VAL A  37
 None
 1.30A 1kt4A-2o2gA:
undetectable		 1kt4A-2o2gA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.14A 1kt4A-2ojqA:
undetectable		 1kt4A-2ojqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 408
ALA A 354
MET A 344
GLN A 340
ARG A 415
 None
 1.35A 1kt4A-2p8uA:
undetectable		 1kt4A-2p8uA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 391
LEU A 396
VAL A 395
GLN A 622
ARG A 566
 None
 1.05A 1kt4A-2r05A:
undetectable		 1kt4A-2r05A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		5 LEU A 106
ALA A  83
ALA A  80
VAL A 102
HIS A  66
 None
 1.27A 1kt4A-2rkbA:
undetectable		 1kt4A-2rkbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		5 LEU A 202
LEU A 207
ALA A 278
VAL A 206
TYR A 187
 None
 1.35A 1kt4A-2wa0A:
undetectable		 1kt4A-2wa0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		5 LEU A 202
LEU A 207
ALA A 280
ALA A 278
VAL A 206
 None
 1.31A 1kt4A-2wa0A:
undetectable		 1kt4A-2wa0A:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 OLA  A1179 (-3.5A)
OLA  A1179 ( 4.0A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.7A)
 1.14A 1kt4A-2wq9A:
31.7		 1kt4A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
ALA A  57
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
ARG A 121
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
OLA  A1179 ( 3.7A)
 0.46A 1kt4A-2wq9A:
31.7		 1kt4A-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  37
ALA A  55
VAL A  61
MET A  73
MET A  88
TYR A  90
GLN A  98
HIS A 104
ARG A 121
TYR A 133
 OLA  A1179 (-3.4A)
OLA  A1179 (-3.5A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
OLA  A1179 (-4.5A)
OLA  A1179 ( 3.9A)
OLA  A1179 ( 3.7A)
 0.67A 1kt4A-2wq9A:
31.7		 1kt4A-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xv9 ABA-1A1 REPEAT UNIT

(Ascaris suum) 		PF16469
(NPA) 		5 LEU A  37
LEU A  13
ALA A  52
ALA A  56
TYR A  44
 None
 1.33A 1kt4A-2xv9A:
undetectable		 1kt4A-2xv9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 LEU A 760
ALA A1048
ALA A1004
VAL A 765
GLN A 744
 None
 1.28A 1kt4A-2yocA:
undetectable		 1kt4A-2yocA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 LEU A 161
LEU A 144
ALA A 139
ALA A 141
VAL A 171
 None
 1.33A 1kt4A-2z00A:
undetectable		 1kt4A-2z00A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 315
ALA A 284
ALA A 280
TYR A 278
ARG A 318
 None
 1.30A 1kt4A-3cgdA:
undetectable		 1kt4A-3cgdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		5 LEU A 278
ALA A 267
GLN A  85
HIS A 228
TYR A 171
 None
 1.28A 1kt4A-3fa5A:
undetectable		 1kt4A-3fa5A:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ALA A  55
ALA A  43
MET A  88
HIS A 104
TYR A 133
 2T1  A 184 ( 4.3A)
2T1  A 184 ( 4.7A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.7A)
2T1  A 184 (-4.7A)
 1.17A 1kt4A-3fmzA:
30.4		 1kt4A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
ARG A 121
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.2A)
 0.88A 1kt4A-3fmzA:
30.4		 1kt4A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 LEU A  35
LEU A  37
ALA A  55
ALA A  57
VAL A  61
MET A  88
TYR A  90
HIS A 104
ARG A 121
TYR A 133
 2T1  A 184 (-4.0A)
2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
2T1  A 184 (-3.2A)
2T1  A 184 (-4.7A)
 0.65A 1kt4A-3fmzA:
30.4		 1kt4A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  37
ALA A  55
ALA A  57
MET A  73
MET A  88
GLN A  98
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.0A)
 1.06A 1kt4A-3fmzA:
30.4		 1kt4A-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  37
ALA A  55
ALA A  57
MET A  88
TYR A  90
GLN A  98
HIS A 104
 2T1  A 184 (-3.6A)
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.78A 1kt4A-3fmzA:
30.4		 1kt4A-3fmzA:
92.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 399
ALA A 196
ALA A 214
VAL A 395
TYR A 222
 None
 1.34A 1kt4A-3jq1A:
undetectable		 1kt4A-3jq1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		5 LEU A  53
ALA A  61
VAL A  42
MET A 161
HIS A 157
 None
 1.34A 1kt4A-3lacA:
undetectable		 1kt4A-3lacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		5 LEU A 217
LEU A 255
ALA A 447
VAL A 252
GLN A 220
 None
 1.36A 1kt4A-3memA:
undetectable		 1kt4A-3memA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mga ENTEROCHELIN
ESTERASE

(Salmonella
enterica) 		PF00756
(Esterase)
PF11806
(DUF3327) 		5 LEU A 395
LEU A 307
ALA A 382
VAL A 343
GLN A 391
 None
 1.29A 1kt4A-3mgaA:
undetectable		 1kt4A-3mgaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 LEU A 380
LEU A 183
ALA A 261
VAL A 180
MET A 360
 MTN  A 801 ( 4.9A)
None
None
None
None
 1.35A 1kt4A-3mpnA:
undetectable		 1kt4A-3mpnA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n54 SPORE GERMINATION
PROTEIN B3

(Bacillus
subtilis) 		PF05504
(Spore_GerAC) 		5 LEU B 319
LEU B 330
VAL B 328
TYR B 360
HIS B 272
 None
 1.22A 1kt4A-3n54B:
undetectable		 1kt4A-3n54B:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		5 LEU A 221
LEU A 212
ALA A 207
ALA A 209
VAL A  13
 None
 1.21A 1kt4A-3ndoA:
undetectable		 1kt4A-3ndoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 369
ALA A 397
ALA A 393
HIS A 333
ARG A 168
 None
 1.29A 1kt4A-3nksA:
undetectable		 1kt4A-3nksA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 LEU A 779
ALA A 789
ALA A 783
VAL A 728
GLN A 772
 None
 1.22A 1kt4A-3opyA:
undetectable		 1kt4A-3opyA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		5 LEU A 144
LEU A 138
ALA A 124
ALA A 136
VAL A 173
 None
None
None
AP5  A 346 (-3.5A)
None
 1.34A 1kt4A-3otxA:
undetectable		 1kt4A-3otxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 533
ALA A 598
ALA A 594
VAL A 578
TYR A 544
 None
 1.21A 1kt4A-3wmeA:
undetectable		 1kt4A-3wmeA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 579
ALA A 647
ALA A 643
VAL A 627
TYR A 590
 None
 1.35A 1kt4A-4ayxA:
undetectable		 1kt4A-4ayxA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		5 LEU A 227
LEU A 193
ALA A 138
ALA A 136
VAL A 229
 None
 1.20A 1kt4A-4bucA:
undetectable		 1kt4A-4bucA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		5 LEU B 366
LEU B 357
ALA B 502
ALA B 497
VAL B 360
 None
P6G  B1546 ( 4.1A)
None
P6G  B1546 (-4.3A)
None
 1.27A 1kt4A-4bwcB:
undetectable		 1kt4A-4bwcB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 LEU A 168
LEU A 143
ALA A  64
ALA A  89
VAL A 170
 None
 1.24A 1kt4A-4bx0A:
undetectable		 1kt4A-4bx0A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ALA A  69
VAL A 226
GLN A 236
ARG A 264
TYR A 261
 None
 1.34A 1kt4A-4c30A:
undetectable		 1kt4A-4c30A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 LEU A 337
ALA A 318
ALA A 163
TYR A 330
GLN A 334
 None
 1.07A 1kt4A-4g6cA:
undetectable		 1kt4A-4g6cA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 LEU B 506
LEU B 489
ALA B 484
ALA B 486
VAL B 516
 None
KCX  B 490 ( 4.0A)
None
None
None
 1.23A 1kt4A-4g7eB:
undetectable		 1kt4A-4g7eB:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 151
ALA A 334
VAL A 154
GLN A 309
HIS A 108
 None
 1.13A 1kt4A-4ip4A:
undetectable		 1kt4A-4ip4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A  79
LEU A 114
ALA A 110
VAL A 165
ARG A 121
 None
 1.18A 1kt4A-4jatA:
undetectable		 1kt4A-4jatA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE

(Xanthobacter
autotrophicus) 		PF00378
(ECH_1) 		5 LEU A  19
ALA A  45
ALA A  43
VAL A  54
TYR A   3
 None
 1.29A 1kt4A-4k29A:
undetectable		 1kt4A-4k29A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 LEU A 154
LEU A 141
VAL A 152
MET A 211
MET A 164
 None
 1.24A 1kt4A-4krfA:
undetectable		 1kt4A-4krfA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0q MEMBRANE-ASSOCIATED
PROTEIN VP24

(Zaire
ebolavirus) 		PF06389
(Filo_VP24) 		5 LEU A 147
LEU A 145
ALA A 116
ALA A 118
VAL A  22
 None
 1.22A 1kt4A-4m0qA:
undetectable		 1kt4A-4m0qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 400
LEU B 345
ALA B 315
GLN B 380
HIS B 370
 None
 1.22A 1kt4A-4mbgB:
undetectable		 1kt4A-4mbgB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 LEU A 214
LEU A 188
ALA A 176
ALA A 180
VAL A 211
 None
 1.26A 1kt4A-4ng4A:
undetectable		 1kt4A-4ng4A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  38
ALA A  69
ALA A  73
VAL A  43
MET A  53
 None
 1.17A 1kt4A-4o99A:
undetectable		 1kt4A-4o99A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		5 LEU A 342
LEU A 362
ALA A 262
ALA A 266
VAL A 358
 None
 1.03A 1kt4A-4oerA:
undetectable		 1kt4A-4oerA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		5 LEU A 323
LEU A 358
ALA A 196
TYR A 277
GLN A 306
 None
 1.23A 1kt4A-4pevA:
undetectable		 1kt4A-4pevA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 LEU A 261
LEU A 280
ALA A 276
ALA A 278
VAL A 309
 None
 1.29A 1kt4A-4r33A:
undetectable		 1kt4A-4r33A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4l BETA-LACTAMASE NDM-1

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A  78
ALA A 141
VAL A 196
MET A 129
HIS A 133
 None
 1.24A 1kt4A-4u4lA:
undetectable		 1kt4A-4u4lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 LEU A 117
LEU A 102
VAL A 101
MET A  60
TYR A  63
 None
 1.31A 1kt4A-4xniA:
undetectable		 1kt4A-4xniA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		5 LEU A 610
ALA A 639
ALA A 637
VAL A 667
MET A 633
 4KZ  A 801 (-4.2A)
None
None
None
4KZ  A 801 (-3.6A)
 1.26A 1kt4A-4yplA:
undetectable		 1kt4A-4yplA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		5 LEU A 132
LEU A 130
ALA A 168
ALA A 172
MET A 173
 None
 1.31A 1kt4A-4yxfA:
undetectable		 1kt4A-4yxfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		5 LEU A  74
ALA A 159
ALA A 161
VAL A  68
HIS A 154
 None
None
None
None
4T7  A 501 (-4.1A)
 1.22A 1kt4A-4zxwA:
undetectable		 1kt4A-4zxwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 LEU A 592
ALA A 490
ALA A 494
MET A 495
TYR A 130
 None
 1.33A 1kt4A-5aeeA:
undetectable		 1kt4A-5aeeA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 LEU A1109
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.08A 1kt4A-5amqA:
undetectable		 1kt4A-5amqA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 LEU E  80
LEU E  90
ALA E 102
VAL E  43
TYR E 108
 None
 1.04A 1kt4A-5b04E:
undetectable		 1kt4A-5b04E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		5 LEU A  93
ALA A 443
MET A 442
MET A 425
ARG A 490
 None
 1.23A 1kt4A-5cg0A:
undetectable		 1kt4A-5cg0A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		5 LEU A 117
LEU A 195
ALA A 235
ALA A 200
VAL A 177
 None
 1.24A 1kt4A-5dl5A:
undetectable		 1kt4A-5dl5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 LEU C 371
LEU C 252
ALA C 268
ALA C 272
VAL C 249
 None
 0.93A 1kt4A-5ex6C:
undetectable		 1kt4A-5ex6C:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 LEU X  78
LEU X 119
ALA X 154
VAL X 142
TYR X  69
 ALY  X  79 ( 3.6A)
None
ALY  X 157 ( 3.2A)
None
None
 1.08A 1kt4A-5eztX:
undetectable		 1kt4A-5eztX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D 382
ALA D 179
ALA D 362
GLN D 406
ARG A 388
 None
 1.25A 1kt4A-5fl7D:
undetectable		 1kt4A-5fl7D:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 LEU C 236
LEU C 219
ALA C 214
ALA C 216
VAL C 246
 None
KCX  C 220 ( 4.0A)
None
None
None
 1.17A 1kt4A-5fseC:
undetectable		 1kt4A-5fseC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1n CAD PROTEIN

(Homo sapiens) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A2067
ALA A2056
VAL A2141
MET A1937
TYR A2097
 None
 1.34A 1kt4A-5g1nA:
undetectable		 1kt4A-5g1nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 349
ALA A 418
ALA A 319
TYR A 415
ARG A 466
 None
 1.30A 1kt4A-5h3kA:
undetectable		 1kt4A-5h3kA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 349
ALA A 418
ALA A 319
TYR A 423
ARG A 466
 None
 1.03A 1kt4A-5h3kA:
undetectable		 1kt4A-5h3kA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		5 LEU A 410
ALA A  61
VAL A  78
HIS A 417
ARG A 396
 None
 1.27A 1kt4A-5jrlA:
undetectable		 1kt4A-5jrlA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 LEU H  38
ALA H  69
ALA H  73
VAL H  43
MET H  53
 None
 0.99A 1kt4A-5lp7H:
undetectable		 1kt4A-5lp7H:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		5 LEU A  73
LEU A 106
VAL A 214
MET A 220
TYR A 116
 None
 1.20A 1kt4A-5mqcA:
undetectable		 1kt4A-5mqcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		5 LEU A 433
ALA A 384
ALA A 340
VAL A 692
HIS A 379
 None
 1.33A 1kt4A-5mqoA:
undetectable		 1kt4A-5mqoA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		5 LEU A 234
ALA A 229
VAL A 219
GLN A 186
ARG A 256
 None
 1.26A 1kt4A-5muaA:
undetectable		 1kt4A-5muaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 5 LEU A 697
LEU A 687
ALA A 654
ALA A 656
MET A 643
 None
 1.34A 1kt4A-5n8dA:
undetectable		 1kt4A-5n8dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 LEU T2853
LEU T2800
ALA T2915
ALA T2804
VAL T2813
 None
 1.05A 1kt4A-5ojsT:
undetectable		 1kt4A-5ojsT:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 5 LEU A 249
LEU A 247
MET A 479
TYR A 475
HIS A 231
 None
 1.33A 1kt4A-5ukhA:
undetectable		 1kt4A-5ukhA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 421
ALA A 291
ALA A 384
VAL A 276
MET A 498
 None
 1.34A 1kt4A-5xqoA:
undetectable		 1kt4A-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 183
LEU A 206
ALA A  36
ALA A 220
MET A 223
 None
DXP  A 301 (-4.7A)
None
None
None
 1.36A 1kt4A-5z9yA:
undetectable		 1kt4A-5z9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 5 ALA A 457
VAL A 432
MET A 209
TYR A 206
ARG A 238
 None
GOL  A 704 ( 4.8A)
None
MLI  A 703 (-4.3A)
MLI  A 703 ( 4.8A)
 1.35A 1kt4A-6b3bA:
1.8		 1kt4A-6b3bA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 255
ALA A 193
ALA A 195
VAL A 251
GLN A 229
 None
None
PLP  A 401 (-4.3A)
None
None
 1.21A 1kt4A-6c2hA:
undetectable		 1kt4A-6c2hA:
undetectable