SIMILAR PATTERNS OF AMINO ACIDS FOR 1KQW_A_RTLA135

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coj PROTEIN (SUPEROXIDE
DISMUTASE)

(Aquifex
pyrophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A  19
VAL A 193
LEU A  88
LEU A 118
ILE A 162
 None
 1.28A 1kqwA-1cojA:
undetectable		 1kqwA-1cojA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ILE A  25
LYS A  40
THR A  53
ARG A  58
VAL A  62
LEU A 117
 None
 0.83A 1kqwA-1gglA:
23.9		 1kqwA-1gglA:
47.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmi PROTEIN KINASE C,
EPSILON TYPE

(Rattus rattus) 		PF00168
(C2) 		5 ILE A  42
VAL A  73
LEU A  44
LEU A 105
ILE A 100
 None
 0.92A 1kqwA-1gmiA:
0.1		 1kqwA-1gmiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		5 PHE A 147
ILE A 131
GLN A 145
VAL A  52
LEU A 117
 None
 1.16A 1kqwA-1gq8A:
0.0		 1kqwA-1gq8A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfo MIGRATION INHIBITORY
FACTOR

(Trichinella
spiralis) 		PF01187
(MIF) 		5 ILE A  89
VAL A  26
LEU A  83
LEU A  19
ILE A  41
 None
 1.27A 1kqwA-1hfoA:
0.0		 1kqwA-1hfoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 PHE A 426
THR A 373
VAL A 366
LEU A 380
ILE A 438
 None
 1.34A 1kqwA-1i41A:
0.0		 1kqwA-1i41A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob) 		5 PHE A 554
THR A 403
LEU A 425
LEU A 473
ILE A 459
 None
 1.34A 1kqwA-1knbA:
0.0		 1kqwA-1knbA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		8 ILE A  25
GLN A  38
LYS A  40
THR A  51
THR A  53
VAL A  62
LEU A  77
LEU A 117
 None
 0.96A 1kqwA-1kqxA:
26.9		 1kqwA-1kqxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		6 ILE A  25
GLN A  38
THR A  51
THR A  53
ARG A  58
LEU A  77
 None
 1.20A 1kqwA-1kqxA:
26.9		 1kqwA-1kqxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		10 PHE A  16
MET A  20
ILE A  25
GLN A  38
LYS A  40
THR A  51
THR A  53
VAL A  62
LEU A 117
ILE A 119
 None
 0.45A 1kqwA-1kqxA:
26.9		 1kqwA-1kqxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		7 PHE A  16
MET A  20
ILE A  25
GLN A  38
THR A  51
THR A  53
ARG A  58
 None
 0.75A 1kqwA-1kqxA:
26.9		 1kqwA-1kqxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 MET A  20
ILE A  25
LYS A  40
THR A  53
VAL A  62
LEU A 117
 None
 0.76A 1kqwA-1lpjA:
25.2		 1kqwA-1lpjA:
62.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
ILE A  25
THR A  53
ARG A  58
VAL A  62
LEU A  77
LEU A 117
 None
 0.92A 1kqwA-1lpjA:
25.2		 1kqwA-1lpjA:
62.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
MET A  20
ILE A  25
THR A  53
VAL A  62
LEU A  77
LEU A 117
 None
 0.79A 1kqwA-1lpjA:
25.2		 1kqwA-1lpjA:
62.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		5 PHE A 688
ILE A 704
VAL A 767
LEU A 756
ILE A 712
 None
 1.32A 1kqwA-1qu2A:
undetectable		 1kqwA-1qu2A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PHE A 200
ARG A 571
VAL A 598
LEU A 215
ILE A 196
 None
 1.08A 1kqwA-1s5jA:
1.1		 1kqwA-1s5jA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 PHE A 340
ILE A 391
VAL A 579
LEU A 357
ILE A 350
 None
 1.12A 1kqwA-1w8jA:
undetectable		 1kqwA-1w8jA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzo HPCE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase) 		5 THR A 124
ARG A   5
LEU A  39
LEU A 212
ILE A  46
 None
 1.30A 1kqwA-1wzoA:
undetectable		 1kqwA-1wzoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		5 ILE A 156
THR A 101
VAL A 102
LEU A 211
ILE A 254
 None
 1.28A 1kqwA-1xkgA:
undetectable		 1kqwA-1xkgA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		5 THR A  18
THR A 341
VAL A  53
LEU A 297
ILE A 325
 None
 1.21A 1kqwA-1xknA:
undetectable		 1kqwA-1xknA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		5 PHE A 117
ILE A  81
THR A  56
THR A  54
LEU A  78
 None
None
FMN  A1200 (-3.7A)
None
None
 1.30A 1kqwA-1yobA:
undetectable		 1kqwA-1yobA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		5 ILE A 344
THR A 142
THR A 144
VAL A  91
LEU A 196
 GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
None
None
 1.30A 1kqwA-2bkwA:
undetectable		 1kqwA-2bkwA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 PHE A 703
ILE A 485
THR A 635
LEU A 632
ILE A 605
 None
None
CA  A1738 ( 4.8A)
None
None
 1.22A 1kqwA-2c11A:
undetectable		 1kqwA-2c11A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ILE A 261
THR A 176
LEU A 322
LEU A 212
ILE A 160
 None
 1.19A 1kqwA-2ep5A:
undetectable		 1kqwA-2ep5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		5 PHE A 204
MET A 119
ARG A 233
LEU A 186
ILE A 219
 None
 1.30A 1kqwA-2ezvA:
undetectable		 1kqwA-2ezvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 THR A  62
VAL A  59
LEU A  43
LEU A  82
ILE A  83
 None
 1.25A 1kqwA-2ggzA:
undetectable		 1kqwA-2ggzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		5 ILE A 306
VAL A 237
LEU A 273
LEU A 241
ILE A 253
 None
 1.09A 1kqwA-2gszA:
undetectable		 1kqwA-2gszA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if5 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 7A

(Homo sapiens) 		PF00651
(BTB) 		5 THR A  46
VAL A  35
LEU A  61
LEU A  84
ILE A  76
 None
 1.31A 1kqwA-2if5A:
undetectable		 1kqwA-2if5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		5 ILE A   8
GLN A 225
VAL A 200
LEU A  44
ILE A  25
 None
 1.22A 1kqwA-2ihyA:
undetectable		 1kqwA-2ihyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jac GLUTAREDOXIN-1

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		5 GLN A  92
THR A  36
VAL A  43
LEU A 100
ILE A  78
 None
 1.28A 1kqwA-2jacA:
undetectable		 1kqwA-2jacA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		5 PHE A 179
ILE A 201
LEU A 198
LEU A 131
ILE A 129
 None
 1.29A 1kqwA-2jaqA:
undetectable		 1kqwA-2jaqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00698
(Acyl_transf_1)
PF16197
(KAsynt_C_assoc) 		5 PHE A 796
THR A 780
VAL A 757
LEU A 567
ILE A 800
 None
 1.30A 1kqwA-2jfdA:
undetectable		 1kqwA-2jfdA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A  23
THR A  90
VAL A  49
LEU A  28
ILE A  71
 None
 1.34A 1kqwA-2piaA:
undetectable		 1kqwA-2piaA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkc SUPEROXIDE DISMUTASE
[MN]

(Homo sapiens) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A  18
VAL A 189
LEU A  81
LEU A 111
ILE A 158
 None
 1.27A 1kqwA-2qkcA:
undetectable		 1kqwA-2qkcA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkd ZINC FINGER PROTEIN
ZPR1

(Mus musculus) 		PF03367
(zf-ZPR1) 		5 PHE A 403
THR A 366
VAL A 365
LEU A 342
ILE A 335
 None
 1.28A 1kqwA-2qkdA:
undetectable		 1kqwA-2qkdA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		5 ILE A 518
VAL A 509
LEU A 500
LEU A 567
ILE A 542
 None
 1.29A 1kqwA-2qv3A:
undetectable		 1kqwA-2qv3A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 ILE A  17
VAL A 509
LEU A  40
LEU A  79
ILE A  76
 None
 1.17A 1kqwA-2r6fA:
undetectable		 1kqwA-2r6fA:
9.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LYS A  40
THR A  51
THR A  53
LEU A 119
LEU A 115
 None
 1.24A 1kqwA-2rcqA:
25.8		 1kqwA-2rcqA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  16
MET A  20
GLN A  38
LYS A  40
THR A  51
THR A  53
ARG A  58
VAL A  62
LEU A 117
 None
None
None
None
None
None
SO4  A 152 (-3.1A)
None
None
 0.80A 1kqwA-2rcqA:
25.8		 1kqwA-2rcqA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
MET A  20
GLN A  38
THR A  51
ARG A  58
VAL A  62
LEU A  77
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
None
None
 0.96A 1kqwA-2rcqA:
25.8		 1kqwA-2rcqA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  16
MET A  20
ILE A  25
GLN A  38
LYS A  40
THR A  51
THR A  53
VAL A  62
LEU A 117
 None
 0.47A 1kqwA-2rcqA:
25.8		 1kqwA-2rcqA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
MET A  20
ILE A  25
GLN A  38
THR A  51
VAL A  62
LEU A  77
LEU A 117
 None
 0.57A 1kqwA-2rcqA:
25.8		 1kqwA-2rcqA:
72.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A

(Deinococcus
radiodurans) 		PF00005
(ABC_tran) 		5 ILE A  29
VAL A 404
LEU A  52
LEU A  91
ILE A  88
 None
 1.14A 1kqwA-2vf8A:
undetectable		 1kqwA-2vf8A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdh COHESIN

(Archaeoglobus
fulgidus) 		PF00963
(Cohesin) 		5 ILE A  71
THR A   6
VAL A 145
LEU A  38
ILE A  75
 None
 1.30A 1kqwA-2xdhA:
undetectable		 1kqwA-2xdhA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 THR A 396
ARG A 351
VAL A 359
LEU A 338
LEU A 464
 None
 1.32A 1kqwA-2xqyA:
1.2		 1kqwA-2xqyA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		5 ILE A 293
THR A 278
LEU A 288
LEU A 338
ILE A 336
 None
 1.28A 1kqwA-2xubA:
undetectable		 1kqwA-2xubA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4f DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 THR A 102
VAL A 180
LEU A  34
LEU A 155
ILE A  97
 None
 1.13A 1kqwA-2z4fA:
undetectable		 1kqwA-2z4fA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE B 261
ILE B 322
VAL B 273
LEU B 251
ILE B 264
 None
 1.31A 1kqwA-2z7xB:
undetectable		 1kqwA-2z7xB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 335
THR A 436
VAL A 425
LEU A 460
ILE A 405
 None
 1.35A 1kqwA-3al8A:
undetectable		 1kqwA-3al8A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpj GTP-BINDING PROTEIN
YPT31/YPT8

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE B  62
THR B 155
VAL B 163
LEU B  18
ILE B  66
 None
 1.09A 1kqwA-3cpjB:
undetectable		 1kqwA-3cpjB:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6s ALLERGEN DER F I

(Dermatophagoides
farinae) 		PF00112
(Peptidase_C1) 		5 ILE A  77
THR A  22
VAL A  23
LEU A 132
ILE A 175
 None
 1.27A 1kqwA-3d6sA:
undetectable		 1kqwA-3d6sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc6 SUPEROXIDE DISMUTASE
[MN] 1

(Caenorhabditis
elegans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A  18
VAL A 188
LEU A  81
LEU A 110
ILE A 157
 None
 1.30A 1kqwA-3dc6A:
undetectable		 1kqwA-3dc6A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE A  17
VAL A 290
LEU A  14
LEU A  39
ILE A  35
 None
 1.32A 1kqwA-3dm5A:
undetectable		 1kqwA-3dm5A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 ILE A  17
VAL A 290
LEU A  14
LEU A  52
ILE A  56
 None
 1.09A 1kqwA-3dm5A:
undetectable		 1kqwA-3dm5A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvw PUTATIVE
NAD(P)H-DEPENDENT
FMN REDUCTASE

(Streptococcus
mutans) 		PF03358
(FMN_red) 		5 ILE A  82
VAL A 107
LEU A  90
LEU A   6
ILE A   8
 None
 1.16A 1kqwA-3fvwA:
undetectable		 1kqwA-3fvwA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		5 ILE A 183
THR A  76
LEU A 142
LEU A  71
ILE A 145
 None
 1.33A 1kqwA-3gf7A:
undetectable		 1kqwA-3gf7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz5 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		5 PHE A  27
THR A 103
VAL A  90
LEU A  52
ILE A 146
 None
 1.22A 1kqwA-3gz5A:
undetectable		 1kqwA-3gz5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz8 MUTT/NUDIX FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00293
(NUDIX) 		5 PHE A  27
THR A 103
VAL A  90
LEU A  52
ILE A 146
 None
APR  A 302 ( 4.2A)
None
None
None
 1.28A 1kqwA-3gz8A:
undetectable		 1kqwA-3gz8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 ILE A 455
THR A 335
VAL A 334
LEU A 444
ILE A 383
 None
 1.29A 1kqwA-3kxwA:
undetectable		 1kqwA-3kxwA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		5 THR A 111
ARG A   5
VAL A 108
LEU A  33
LEU A  46
 None
 1.27A 1kqwA-3ky9A:
undetectable		 1kqwA-3ky9A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lku UPF0363 PROTEIN
YOR164C

(Saccharomyces
cerevisiae) 		PF04190
(DUF410) 		5 ILE A 219
VAL A 195
LEU A 215
LEU A 250
ILE A 236
 None
 1.34A 1kqwA-3lkuA:
undetectable		 1kqwA-3lkuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8n POSSIBLE GLUTATHIONE
S-TRANSFERASE

(Rhodopseudomonas
palustris) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 THR A 193
ARG A  17
VAL A 190
LEU A  80
ILE A 158
 None
 1.33A 1kqwA-3m8nA:
undetectable		 1kqwA-3m8nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 937
THR A1035
LEU A 507
LEU A 564
ILE A 566
 None
 1.14A 1kqwA-3nafA:
undetectable		 1kqwA-3nafA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		5 PHE A 268
ILE A 409
THR A 235
LEU A 373
LEU A 194
 None
 1.32A 1kqwA-3ogzA:
undetectable		 1kqwA-3ogzA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8s JACALIN

(Artocarpus
heterophyllus) 		PF01419
(Jacalin) 		5 PHE A 110
ILE A  49
LEU A  52
LEU A  82
ILE A  80
 None
 1.21A 1kqwA-3p8sA:
undetectable		 1kqwA-3p8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 ILE A  17
VAL A 489
LEU A  40
LEU A  79
ILE A  76
 None
 1.33A 1kqwA-3pihA:
undetectable		 1kqwA-3pihA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		6 ILE A  59
THR A 160
THR A 156
VAL A 129
LEU A 121
ILE A 137
 None
 1.41A 1kqwA-3q1yA:
undetectable		 1kqwA-3q1yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rvx PEPTIDASE 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		5 ILE A  76
THR A  21
VAL A  22
LEU A 131
ILE A 174
 None
 1.29A 1kqwA-3rvxA:
undetectable		 1kqwA-3rvxA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ILE A 742
GLN A  17
LEU A 296
LEU A 285
ILE A 289
 None
 1.29A 1kqwA-3snhA:
undetectable		 1kqwA-3snhA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6o SULFATE
TRANSPORTER/ANTISIGM
A-FACTOR ANTAGONIST
STAS

(Planctopirus
limnophila) 		no annotation 5 PHE A  17
ILE A  32
THR A  97
LEU A  83
ILE A  50
 None
 1.22A 1kqwA-3t6oA:
undetectable		 1kqwA-3t6oA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 ILE A  17
VAL A 509
LEU A  40
LEU A  80
ILE A  77
 None
 1.14A 1kqwA-3ux8A:
undetectable		 1kqwA-3ux8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		5 PHE A 349
ARG A 251
VAL A 265
LEU A 354
ILE A 350
 None
 1.08A 1kqwA-3wryA:
undetectable		 1kqwA-3wryA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		5 ILE A 372
THR A 455
VAL A 453
LEU A 212
ILE A 201
 None
 1.28A 1kqwA-4a1fA:
0.9		 1kqwA-4a1fA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ILE A 701
GLN A  12
LEU A 304
LEU A 293
ILE A 297
 None
 1.33A 1kqwA-4bejA:
undetectable		 1kqwA-4bejA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0m RAS-RELATED PROTEIN
RAB-11A

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B  60
THR B 153
VAL B 161
LEU B  16
ILE B  64
 None
 1.01A 1kqwA-4d0mB:
undetectable		 1kqwA-4d0mB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		5 MET A  73
ILE A   5
THR A  83
THR A 111
LEU A 118
 None
 1.16A 1kqwA-4eysA:
undetectable		 1kqwA-4eysA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g79 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 PHE A 132
ILE A 105
LEU A  36
LEU A  69
ILE A 134
 None
 1.33A 1kqwA-4g79A:
undetectable		 1kqwA-4g79A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B  60
THR B 153
VAL B 161
LEU B  16
ILE B  64
 None
 1.08A 1kqwA-4jvsB:
undetectable		 1kqwA-4jvsB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k35 GLYCOSIDE HYDROLASE
FAMILY 81
ENDO-BETA-1,3-GLUCAN
ASE

(Rhizomucor
miehei) 		PF03639
(Glyco_hydro_81) 		5 THR A 299
ARG A 590
LEU A 339
LEU A 137
ILE A 272
 None
 0.93A 1kqwA-4k35A:
undetectable		 1kqwA-4k35A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		5 ILE A 269
THR A 206
LEU A 270
LEU A 215
ILE A 183
 None
 1.26A 1kqwA-4n03A:
0.8		 1kqwA-4n03A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 ILE A 238
THR A 274
LEU A 282
LEU A 305
ILE A 328
 None
 1.30A 1kqwA-4q3rA:
undetectable		 1kqwA-4q3rA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 MET A1836
THR A1741
ARG A1779
LEU A1667
ILE A1759
 None
 1.26A 1kqwA-5a22A:
undetectable		 1kqwA-5a22A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euh PUTATIVE GGDEF
DOMAIN MEMBRANE
PROTEIN

(Pseudomonas
fluorescens) 		PF00990
(GGDEF) 		5 ILE A 438
THR A 345
ARG A 409
VAL A 347
ILE A 376
 C2E  A 601 (-4.8A)
None
C2E  A 601 ( 4.0A)
None
None
 1.16A 1kqwA-5euhA:
undetectable		 1kqwA-5euhA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF02465
(FliD_N)
PF07195
(FliD_C) 		5 ILE A 130
THR A 112
THR A 110
LEU A 150
ILE A 153
 None
 1.15A 1kqwA-5h5vA:
undetectable		 1kqwA-5h5vA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5w FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Escherichia
coli) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		5 ILE A 130
THR A 112
THR A 110
LEU A 150
ILE A 153
 None
 1.14A 1kqwA-5h5wA:
undetectable		 1kqwA-5h5wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ILE A 314
VAL A  38
LEU A 310
LEU A  80
ILE A  68
 None
 1.06A 1kqwA-5h7wA:
undetectable		 1kqwA-5h7wA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 ILE A 270
THR A 242
VAL A 146
LEU A 353
ILE A 356
 None
HEM  A 401 (-4.1A)
None
HEM  A 401 (-3.9A)
None
 1.14A 1kqwA-5it1A:
undetectable		 1kqwA-5it1A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Homo sapiens;
Homo sapiens) 		PF03874
(RNA_pol_Rpb4)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		5 PHE D  26
THR G  37
THR G  39
LEU G   7
ILE G   5
 None
 1.24A 1kqwA-5iy9D:
undetectable		 1kqwA-5iy9D:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Thermosynechococcus
elongatus) 		no annotation 5 PHE A 713
ILE A 616
THR A 625
LEU A 618
ILE A 704
 None
 1.27A 1kqwA-5jyuA:
undetectable		 1kqwA-5jyuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 THR A  85
ARG A  45
LEU A  47
LEU A  24
ILE A  58
 None
 1.23A 1kqwA-5k6zA:
undetectable		 1kqwA-5k6zA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 637
THR A 585
VAL A 650
LEU A 641
LEU A 581
 None
 1.15A 1kqwA-5oasA:
undetectable		 1kqwA-5oasA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		5 ILE A  70
THR A 187
LEU A  71
LEU A  82
ILE A  74
 None
 1.31A 1kqwA-5t2kA:
undetectable		 1kqwA-5t2kA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 PHE A 133
ILE A 160
THR A 188
VAL A  83
LEU A 116
 None
 1.21A 1kqwA-5wl7A:
1.1		 1kqwA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		no annotation 5 ILE A 197
THR A 305
VAL A 218
LEU A 269
ILE A 202
 None
 1.28A 1kqwA-5x9uA:
undetectable		 1kqwA-5x9uA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		5 ILE A 780
THR A 793
LEU A 788
LEU A 798
ILE A 749
 None
 1.33A 1kqwA-5xmcA:
undetectable		 1kqwA-5xmcA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 ILE A  91
VAL A 127
LEU A  90
LEU A  64
ILE A  99
 None
 1.25A 1kqwA-5zqzA:
undetectable		 1kqwA-5zqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c87 RAB GDP DISSOCIATION
INHIBITOR ALPHA

(Naegleria
fowleri) 		no annotation 5 PHE A 432
THR A  97
VAL A  96
LEU A  87
ILE A 420
 None
 1.25A 1kqwA-6c87A:
undetectable		 1kqwA-6c87A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8s LOGANIC ACID
O-METHYLTRANSFERASE

(Catharanthus
roseus) 		no annotation 5 ILE A 261
VAL A 317
LEU A 337
LEU A 271
ILE A 184
 None
 1.09A 1kqwA-6c8sA:
undetectable		 1kqwA-6c8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 5 PHE M 979
ILE M 993
THR M 466
LEU M 431
ILE M1034
 None
 1.30A 1kqwA-6d6qM:
undetectable		 1kqwA-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6deg BETA SLIDING CLAMP

(Bartonella
birtlesii) 		no annotation 5 PHE A 345
ILE A 334
VAL A 277
LEU A 331
LEU A 297
 None
 1.30A 1kqwA-6degA:
undetectable		 1kqwA-6degA:
undetectable