SIMILAR PATTERNS OF AMINO ACIDS FOR 1KQE_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		4 VAL A 345
TRP A 135
ALA A 346
TRP A 141
 None
 1.40A 1kqeB-2b2iA:
undetectable
1kqeD-2b2iA:
undetectable		 1kqeB-2b2iA:
6.71
1kqeD-2b2iA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 VAL A  10
TRP A   6
ALA A  11
TRP A   5
 None
 1.40A 1kqeB-2ze0A:
undetectable
1kqeD-2ze0A:
undetectable		 1kqeB-2ze0A:
2.87
1kqeD-2ze0A:
2.87