SIMILAR PATTERNS OF AMINO ACIDS FOR 1KQE_B_DVAB6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 ALA A  64
VAL A  41
TRP A  12
 None
 0.82A 1kqeB-1amkA:
undetectable
1kqeD-1amkA:
undetectable		 1kqeB-1amkA:
11.43
1kqeD-1amkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ego GLUTAREDOXIN

(Escherichia
coli) 		PF00462
(Glutaredoxin) 		3 ALA A  85
VAL A  79
TRP A  78
 None
 0.88A 1kqeB-1egoA:
undetectable
1kqeD-1egoA:
undetectable		 1kqeB-1egoA:
3.53
1kqeD-1egoA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		3 ALA A  72
VAL A  67
TRP A  66
 None
 0.83A 1kqeB-1fhuA:
undetectable
1kqeD-1fhuA:
undetectable		 1kqeB-1fhuA:
5.42
1kqeD-1fhuA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		3 ALA A 151
VAL A 195
TRP A 191
 None
 0.85A 1kqeB-1hjuA:
undetectable
1kqeD-1hjuA:
undetectable		 1kqeB-1hjuA:
5.38
1kqeD-1hjuA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iom CITRATE SYNTHASE

(Thermus
thermophilus) 		PF00285
(Citrate_synt) 		3 ALA A 248
VAL A 243
TRP A 242
 None
 0.77A 1kqeB-1iomA:
undetectable
1kqeD-1iomA:
undetectable		 1kqeB-1iomA:
2.50
1kqeD-1iomA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 ALA B  60
VAL B  58
TRP B  87
 None
 0.78A 1kqeB-1jtdB:
undetectable
1kqeD-1jtdB:
undetectable		 1kqeB-1jtdB:
2.94
1kqeD-1jtdB:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 ALA B 177
VAL B 175
TRP B 204
 None
 0.87A 1kqeB-1jtdB:
undetectable
1kqeD-1jtdB:
undetectable		 1kqeB-1jtdB:
2.94
1kqeD-1jtdB:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 ALA B 216
VAL B 214
TRP B 243
 None
 0.80A 1kqeB-1jtdB:
undetectable
1kqeD-1jtdB:
undetectable		 1kqeB-1jtdB:
2.94
1kqeD-1jtdB:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1le8 MATING-TYPE PROTEIN
ALPHA-2

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		3 ALA B 185
VAL B 180
TRP B 179
 None
 0.76A 1kqeB-1le8B:
undetectable
1kqeD-1le8B:
undetectable		 1kqeB-1le8B:
9.43
1kqeD-1le8B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		3 ALA A  71
VAL A  44
TRP A  12
 None
 0.89A 1kqeB-1m6jA:
undetectable
1kqeD-1m6jA:
undetectable		 1kqeB-1m6jA:
5.11
1kqeD-1m6jA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofc ISWI PROTEIN

(Drosophila
melanogaster) 		PF09110
(HAND)
PF09111
(SLIDE) 		3 ALA X 840
VAL X 835
TRP X 800
 None
 0.87A 1kqeB-1ofcX:
undetectable
1kqeD-1ofcX:
undetectable		 1kqeB-1ofcX:
3.24
1kqeD-1ofcX:
3.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqa BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN

(Homo sapiens) 		PF00533
(BRCT) 		3 ALA A  90
VAL A  85
TRP A  84
 None
 0.79A 1kqeB-1oqaA:
undetectable
1kqeD-1oqaA:
undetectable		 1kqeB-1oqaA:
10.29
1kqeD-1oqaA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		3 ALA A  65
VAL A  42
TRP A  13
 None
 0.85A 1kqeB-1tcdA:
undetectable
1kqeD-1tcdA:
undetectable		 1kqeB-1tcdA:
7.27
1kqeD-1tcdA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2q LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE

(Mycobacterium
tuberculosis) 		PF01451
(LMWPc) 		3 ALA A 158
VAL A 153
TRP A 152
 None
 0.75A 1kqeB-1u2qA:
undetectable
1kqeD-1u2qA:
undetectable		 1kqeB-1u2qA:
5.98
1kqeD-1u2qA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		3 ALA A 240
VAL A 235
TRP A 234
 None
 0.89A 1kqeB-1uz4A:
undetectable
1kqeD-1uz4A:
undetectable		 1kqeB-1uz4A:
2.42
1kqeD-1uz4A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 ALA C 842
VAL C 974
TRP C1006
 None
 0.87A 1kqeB-1w36C:
undetectable
1kqeD-1w36C:
undetectable		 1kqeB-1w36C:
1.67
1kqeD-1w36C:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		3 ALA A 331
VAL A 274
TRP A 286
 None
None
GOL  A1002 (-3.4A)
 0.78A 1kqeB-1x1nA:
undetectable
1kqeD-1x1nA:
undetectable		 1kqeB-1x1nA:
5.41
1kqeD-1x1nA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ALA A 554
VAL A 551
TRP A 549
 None
 0.77A 1kqeB-1xc6A:
undetectable
1kqeD-1xc6A:
undetectable		 1kqeB-1xc6A:
1.25
1kqeD-1xc6A:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ALA A  83
VAL A  78
TRP A  77
 None
 0.80A 1kqeB-1yr2A:
undetectable
1kqeD-1yr2A:
undetectable		 1kqeB-1yr2A:
3.08
1kqeD-1yr2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		3 ALA B 429
VAL B 427
TRP B 341
 None
 0.78A 1kqeB-1zunB:
undetectable
1kqeD-1zunB:
undetectable		 1kqeB-1zunB:
2.12
1kqeD-1zunB:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apj PUTATIVE ESTERASE

(Arabidopsis
thaliana) 		PF03629
(SASA) 		3 ALA A  34
VAL A  92
TRP A  50
 SEB  A  31 ( 3.8A)
None
None
 0.89A 1kqeB-2apjA:
undetectable
1kqeD-2apjA:
undetectable		 1kqeB-2apjA:
7.00
1kqeD-2apjA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE SMALL
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00866
(Ring_hydroxyl_B) 		3 ALA B 659
VAL B 545
TRP B 541
 None
 0.82A 1kqeB-2b24B:
undetectable
1kqeD-2b24B:
undetectable		 1kqeB-2b24B:
5.98
1kqeD-2b24B:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		3 ALA A  62
VAL A  39
TRP A   9
 None
 0.84A 1kqeB-2btmA:
undetectable
1kqeD-2btmA:
undetectable		 1kqeB-2btmA:
7.41
1kqeD-2btmA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 ALA A 286
VAL A 310
TRP A 303
 None
 0.86A 1kqeB-2e4uA:
undetectable
1kqeD-2e4uA:
undetectable		 1kqeB-2e4uA:
9.64
1kqeD-2e4uA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)

(Homo sapiens) 		PF00059
(Lectin_C) 		3 ALA B 190
VAL B 185
TRP B 184
 None
 0.86A 1kqeB-2h2tB:
undetectable
1kqeD-2h2tB:
undetectable		 1kqeB-2h2tB:
4.57
1kqeD-2h2tB:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imj HYPOTHETICAL PROTEIN
DUF1348

(Pseudomonas
protegens) 		PF07080
(DUF1348) 		3 ALA A  83
VAL A  91
TRP A 113
 None
 0.56A 1kqeB-2imjA:
undetectable
1kqeD-2imjA:
undetectable		 1kqeB-2imjA:
11.39
1kqeD-2imjA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxy MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin) 		3 ALA A 382
VAL A 396
TRP A 401
 CA  A 471 ( 4.3A)
None
None
 0.71A 1kqeB-2jxyA:
undetectable
1kqeD-2jxyA:
undetectable		 1kqeB-2jxyA:
4.42
1kqeD-2jxyA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwb TRANSLATIONALLY-CONT
ROLLED TUMOR PROTEIN
HOMOLOG

(Caenorhabditis
elegans) 		PF00838
(TCTP) 		3 ALA A 129
VAL A 124
TRP A 123
 None
 0.84A 1kqeB-2kwbA:
undetectable
1kqeD-2kwbA:
undetectable		 1kqeB-2kwbA:
6.67
1kqeD-2kwbA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ms7 MITOCHONDRIAL
ANTIVIRAL-SIGNALING
PROTEIN

(Homo sapiens) 		PF16739
(CARD_2) 		3 ALA A  74
VAL A  69
TRP A  68
 None
 0.82A 1kqeB-2ms7A:
undetectable
1kqeD-2ms7A:
undetectable		 1kqeB-2ms7A:
12.12
1kqeD-2ms7A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nog ISWI PROTEIN

(Xenopus laevis) 		PF09110
(HAND) 		3 ALA A 869
VAL A 864
TRP A 829
 None
 0.87A 1kqeB-2nogA:
undetectable
1kqeD-2nogA:
undetectable		 1kqeB-2nogA:
6.38
1kqeD-2nogA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ALA A 173
VAL A 175
TRP A 217
 None
 0.76A 1kqeB-2pm9A:
undetectable
1kqeD-2pm9A:
undetectable		 1kqeB-2pm9A:
3.10
1kqeD-2pm9A:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wds HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Streptomyces
coelicolor) 		PF01648
(ACPS) 		3 ALA A  97
VAL A 101
TRP A 104
 None
 0.87A 1kqeB-2wdsA:
undetectable
1kqeD-2wdsA:
undetectable		 1kqeB-2wdsA:
9.68
1kqeD-2wdsA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		3 ALA A 252
VAL A 247
TRP A 246
 None
 0.82A 1kqeB-2yjpA:
undetectable
1kqeD-2yjpA:
undetectable		 1kqeB-2yjpA:
5.06
1kqeD-2yjpA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yka RNA AND EXPORT
FACTOR-BINDING
PROTEIN 2
52 KDA
IMMEDIATE-EARLY
PHOSPHOPROTEIN

(Mus musculus;
Saimiriine
gammaherpesvirus
2) 		PF00076
(RRM_1)
no annotation 		3 ALA A  89
VAL A  86
TRP B 108
 None
 0.78A 1kqeB-2ykaA:
undetectable
1kqeD-2ykaA:
undetectable		 1kqeB-2ykaA:
12.96
1kqeD-2ykaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		3 ALA A 462
VAL A 457
TRP A 456
 None
 0.80A 1kqeB-2ylzA:
undetectable
1kqeD-2ylzA:
undetectable		 1kqeB-2ylzA:
10.47
1kqeD-2ylzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1

(Homo sapiens) 		PF02732
(ERCC4) 		3 ALA B 318
VAL B 364
TRP B 429
 None
 0.82A 1kqeB-2ziuB:
undetectable
1kqeD-2ziuB:
undetectable		 1kqeB-2ziuB:
2.46
1kqeD-2ziuB:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 ALA A 478
VAL A 476
TRP A 956
 None
 0.68A 1kqeB-3aibA:
undetectable
1kqeD-3aibA:
undetectable		 1kqeB-3aibA:
1.74
1kqeD-3aibA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		3 ALA A 340
VAL A 338
TRP A 163
 None
 0.85A 1kqeB-3bqwA:
undetectable
1kqeD-3bqwA:
undetectable		 1kqeB-3bqwA:
4.30
1kqeD-3bqwA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 ALA A 121
VAL A 116
TRP A 115
 None
 0.76A 1kqeB-3d1jA:
undetectable
1kqeD-3d1jA:
undetectable		 1kqeB-3d1jA:
6.49
1kqeD-3d1jA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7q TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 ALA A 202
VAL A 197
TRP A 196
 None
 0.75A 1kqeB-3e7qA:
undetectable
1kqeD-3e7qA:
undetectable		 1kqeB-3e7qA:
5.52
1kqeD-3e7qA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		3 ALA A  44
VAL A 115
TRP A 111
 None
 0.84A 1kqeB-3ee4A:
undetectable
1kqeD-3ee4A:
undetectable		 1kqeB-3ee4A:
4.60
1kqeD-3ee4A:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		3 ALA A  33
VAL A  79
TRP A 230
 FAD  A 298 (-3.5A)
FAD  A 298 (-4.0A)
None
 0.86A 1kqeB-3fbsA:
undetectable
1kqeD-3fbsA:
undetectable		 1kqeB-3fbsA:
10.34
1kqeD-3fbsA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		3 ALA A 327
VAL A 325
TRP A 272
 None
 0.57A 1kqeB-3gq2A:
undetectable
1kqeD-3gq2A:
undetectable		 1kqeB-3gq2A:
2.26
1kqeD-3gq2A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ALA A 275
VAL A 270
TRP A 269
 None
 0.84A 1kqeB-3hxlA:
undetectable
1kqeD-3hxlA:
undetectable		 1kqeB-3hxlA:
9.52
1kqeD-3hxlA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		3 ALA A 197
VAL A 191
TRP A 194
 None
 0.83A 1kqeB-3i4iA:
undetectable
1kqeD-3i4iA:
undetectable		 1kqeB-3i4iA:
3.98
1kqeD-3i4iA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		3 ALA A 325
VAL A 204
TRP A 205
 None
 0.87A 1kqeB-3if9A:
undetectable
1kqeD-3if9A:
undetectable		 1kqeB-3if9A:
2.56
1kqeD-3if9A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		3 ALA A 281
VAL A 276
TRP A 275
 None
 0.78A 1kqeB-3lmlA:
undetectable
1kqeD-3lmlA:
undetectable		 1kqeB-3lmlA:
2.90
1kqeD-3lmlA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfn UNCHARACTERIZED
PROTEIN

(Dyadobacter
fermentans) 		no annotation 3 ALA A 132
VAL A 127
TRP A 126
 None
 0.87A 1kqeB-3mfnA:
undetectable
1kqeD-3mfnA:
undetectable		 1kqeB-3mfnA:
5.65
1kqeD-3mfnA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ALA A  50
VAL A  45
TRP A  44
 None
 0.85A 1kqeB-3muoA:
undetectable
1kqeD-3muoA:
undetectable		 1kqeB-3muoA:
2.11
1kqeD-3muoA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz1 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Sinorhizobium
meliloti) 		PF03466
(LysR_substrate) 		3 ALA A 290
VAL A 285
TRP A 284
 None
 0.79A 1kqeB-3mz1A:
undetectable
1kqeD-3mz1A:
undetectable		 1kqeB-3mz1A:
2.14
1kqeD-3mz1A:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqp SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ALA A 414
VAL A 409
TRP A 408
 None
 0.85A 1kqeB-3nqpA:
undetectable
1kqeD-3nqpA:
undetectable		 1kqeB-3nqpA:
2.11
1kqeD-3nqpA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 3 ALA A 400
VAL A 395
TRP A 389
 None
 0.89A 1kqeB-3orjA:
undetectable
1kqeD-3orjA:
undetectable		 1kqeB-3orjA:
3.12
1kqeD-3orjA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE (INO1)

(Archaeoglobus
fulgidus) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ALA A 363
VAL A 359
TRP A 387
 None
 0.82A 1kqeB-3qw2A:
undetectable
1kqeD-3qw2A:
undetectable		 1kqeB-3qw2A:
4.76
1kqeD-3qw2A:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN

(Leptographium
truncatum) 		PF00961
(LAGLIDADG_1) 		3 ALA A 182
VAL A 177
TRP A 176
 None
 0.79A 1kqeB-3r7pA:
undetectable
1kqeD-3r7pA:
undetectable		 1kqeB-3r7pA:
4.65
1kqeD-3r7pA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE

(Rhipicephalus
microplus) 		PF00121
(TIM) 		3 ALA A  63
VAL A  41
TRP A  12
 None
 0.89A 1kqeB-3th6A:
undetectable
1kqeD-3th6A:
undetectable		 1kqeB-3th6A:
7.02
1kqeD-3th6A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		3 ALA A  73
VAL A  75
TRP A  83
 None
 0.81A 1kqeB-3vglA:
undetectable
1kqeD-3vglA:
undetectable		 1kqeB-3vglA:
3.66
1kqeD-3vglA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE

(Archaeoglobus
fulgidus) 		no annotation 3 ALA A 479
VAL A 475
TRP A 471
 None
 0.81A 1kqeB-3vgpA:
undetectable
1kqeD-3vgpA:
undetectable		 1kqeB-3vgpA:
6.19
1kqeD-3vgpA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		3 ALA A 374
VAL A 232
TRP A 233
 EDO  A1003 ( 4.0A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
 0.87A 1kqeB-3vqrA:
undetectable
1kqeD-3vqrA:
undetectable		 1kqeB-3vqrA:
2.65
1kqeD-3vqrA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		3 ALA A 593
VAL A 602
TRP A 469
 None
 0.83A 1kqeB-3wrfA:
undetectable
1kqeD-3wrfA:
undetectable		 1kqeB-3wrfA:
1.90
1kqeD-3wrfA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 ALA A 468
VAL A 448
TRP A 437
 None
 0.76A 1kqeB-3zxlA:
undetectable
1kqeD-3zxlA:
undetectable		 1kqeB-3zxlA:
2.00
1kqeD-3zxlA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ALA A1025
VAL A1023
TRP A1510
 None
 0.78A 1kqeB-4amcA:
undetectable
1kqeD-4amcA:
undetectable		 1kqeB-4amcA:
3.86
1kqeD-4amcA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		3 ALA A 467
VAL A 462
TRP A 461
 None
 0.84A 1kqeB-4ap3A:
undetectable
1kqeD-4ap3A:
undetectable		 1kqeB-4ap3A:
11.11
1kqeD-4ap3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ALA A1026
VAL A1024
TRP A1505
 GOL  A2791 (-3.6A)
None
None
 0.73A 1kqeB-4aygA:
undetectable
1kqeD-4aygA:
undetectable		 1kqeB-4aygA:
3.45
1kqeD-4aygA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		3 ALA A 173
VAL A 175
TRP A 217
 None
 0.77A 1kqeB-4bzkA:
undetectable
1kqeD-4bzkA:
undetectable		 1kqeB-4bzkA:
1.09
1kqeD-4bzkA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		3 ALA A 241
VAL A 236
TRP A 235
 ALA  A 241 ( 0.0A)
VAL  A 236 ( 0.6A)
TRP  A 235 ( 0.5A)
 0.88A 1kqeB-4c9gA:
undetectable
1kqeD-4c9gA:
undetectable		 1kqeB-4c9gA:
3.45
1kqeD-4c9gA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		3 ALA A  10
VAL A   8
TRP A 279
 None
 0.83A 1kqeB-4gxwA:
undetectable
1kqeD-4gxwA:
undetectable		 1kqeB-4gxwA:
3.32
1kqeD-4gxwA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 327
VAL A  15
TRP A 295
 None
 0.85A 1kqeB-4h2hA:
undetectable
1kqeD-4h2hA:
undetectable		 1kqeB-4h2hA:
3.02
1kqeD-4h2hA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 328
VAL A  15
TRP A 296
 None
 0.85A 1kqeB-4izgA:
undetectable
1kqeD-4izgA:
undetectable		 1kqeB-4izgA:
5.59
1kqeD-4izgA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3z MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 358
VAL A 352
TRP A 318
 None
 0.89A 1kqeB-4j3zA:
undetectable
1kqeD-4j3zA:
undetectable		 1kqeB-4j3zA:
2.42
1kqeD-4j3zA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		3 ALA A  98
VAL A  93
TRP A  92
 None
 0.79A 1kqeB-4jndA:
undetectable
1kqeD-4jndA:
undetectable		 1kqeB-4jndA:
2.13
1kqeD-4jndA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzh L,D-TRANSPEPTIDASE

(Klebsiella
pneumoniae) 		PF03734
(YkuD) 		3 ALA A 168
VAL A 170
TRP A 149
 None
 0.84A 1kqeB-4lzhA:
undetectable
1kqeD-4lzhA:
undetectable		 1kqeB-4lzhA:
7.87
1kqeD-4lzhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ALA A 200
VAL A 100
TRP A 172
 TRS  A 601 ( 4.0A)
None
None
 0.80A 1kqeB-4m8uA:
undetectable
1kqeD-4m8uA:
undetectable		 1kqeB-4m8uA:
6.63
1kqeD-4m8uA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		3 ALA A  65
VAL A 214
TRP A 120
 None
 0.77A 1kqeB-4magA:
undetectable
1kqeD-4magA:
undetectable		 1kqeB-4magA:
4.05
1kqeD-4magA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 3 ALA A 398
VAL A 393
TRP A 392
 None
 0.76A 1kqeB-4o7pA:
undetectable
1kqeD-4o7pA:
undetectable		 1kqeB-4o7pA:
2.06
1kqeD-4o7pA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otm SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF12745
(HGTP_anticodon2) 		3 ALA A1566
VAL A1561
TRP A1560
 None
 0.76A 1kqeB-4otmA:
undetectable
1kqeD-4otmA:
undetectable		 1kqeB-4otmA:
7.14
1kqeD-4otmA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		3 ALA A 219
VAL A 214
TRP A 213
 None
 0.80A 1kqeB-4s38A:
undetectable
1kqeD-4s38A:
undetectable		 1kqeB-4s38A:
2.97
1kqeD-4s38A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trg SIDC

(Legionella
pneumophila) 		no annotation 3 ALA A 316
VAL A 318
TRP A 323
 None
 0.82A 1kqeB-4trgA:
undetectable
1kqeD-4trgA:
undetectable		 1kqeB-4trgA:
3.05
1kqeD-4trgA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		3 ALA A 385
VAL A 380
TRP A 379
 None
 0.74A 1kqeB-4u98A:
undetectable
1kqeD-4u98A:
undetectable		 1kqeB-4u98A:
1.87
1kqeD-4u98A:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		3 ALA A  52
VAL A  49
TRP A 145
 None
 0.85A 1kqeB-4wrwA:
undetectable
1kqeD-4wrwA:
undetectable		 1kqeB-4wrwA:
8.64
1kqeD-4wrwA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ALA A 241
VAL A 306
TRP A 308
 None
 0.74A 1kqeB-4xhbA:
undetectable
1kqeD-4xhbA:
undetectable		 1kqeB-4xhbA:
1.44
1kqeD-4xhbA:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 ALA A 480
VAL A 475
TRP A 474
 None
 0.87A 1kqeB-4xwhA:
undetectable
1kqeD-4xwhA:
undetectable		 1kqeB-4xwhA:
1.77
1kqeD-4xwhA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		3 ALA A 210
VAL A 208
TRP A 206
 None
 0.71A 1kqeB-4z1pA:
undetectable
1kqeD-4z1pA:
undetectable		 1kqeB-4z1pA:
3.74
1kqeD-4z1pA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		3 ALA A 210
VAL A 208
TRP A 206
 None
 0.77A 1kqeB-4z23A:
undetectable
1kqeD-4z23A:
undetectable		 1kqeB-4z23A:
3.74
1kqeD-4z23A:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		3 ALA A 476
VAL A 470
TRP A 466
 None
 0.79A 1kqeB-4zfmA:
undetectable
1kqeD-4zfmA:
undetectable		 1kqeB-4zfmA:
2.19
1kqeD-4zfmA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		3 ALA A 179
VAL A 181
TRP A 184
 None
 0.85A 1kqeB-5a29A:
undetectable
1kqeD-5a29A:
undetectable		 1kqeB-5a29A:
2.75
1kqeD-5a29A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ALA A 682
VAL A 677
TRP A 716
 None
 0.84A 1kqeB-5bp1A:
undetectable
1kqeD-5bp1A:
undetectable		 1kqeB-5bp1A:
1.63
1kqeD-5bp1A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cho FLAVIN REDUCTASE

(uncultured
bacterium) 		PF01613
(Flavin_Reduct) 		3 ALA A 154
VAL A 164
TRP A 152
 None
 0.87A 1kqeB-5choA:
undetectable
1kqeD-5choA:
undetectable		 1kqeB-5choA:
7.69
1kqeD-5choA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		3 ALA A 383
VAL A 326
TRP A 338
 None
None
HMC  A 606 ( 3.6A)
 0.82A 1kqeB-5csuA:
undetectable
1kqeD-5csuA:
undetectable		 1kqeB-5csuA:
4.44
1kqeD-5csuA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ALA A  96
VAL A 158
TRP A 163
 None
 0.85A 1kqeB-5dgtA:
undetectable
1kqeD-5dgtA:
undetectable		 1kqeB-5dgtA:
2.38
1kqeD-5dgtA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		3 ALA A 181
VAL A 215
TRP A 226
 None
 0.85A 1kqeB-5g5uA:
undetectable
1kqeD-5g5uA:
undetectable		 1kqeB-5g5uA:
3.30
1kqeD-5g5uA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 461
VAL A 464
TRP A 465
 None
 0.88A 1kqeB-5gn5A:
undetectable
1kqeD-5gn5A:
undetectable		 1kqeB-5gn5A:
1.56
1kqeD-5gn5A:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ALA A 157
VAL A 152
TRP A 163
 None
 0.86A 1kqeB-5irpA:
undetectable
1kqeD-5irpA:
undetectable		 1kqeB-5irpA:
2.11
1kqeD-5irpA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 3 ALA A 549
VAL A 544
TRP A 543
 None
 0.75A 1kqeB-5na7A:
undetectable
1kqeD-5na7A:
undetectable		 1kqeB-5na7A:
3.44
1kqeD-5na7A:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		3 ALA B 227
VAL B 222
TRP B 221
 None
 0.81A 1kqeB-5njfB:
undetectable
1kqeD-5njfB:
undetectable		 1kqeB-5njfB:
2.41
1kqeD-5njfB:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 ALA A  27
VAL A  22
TRP A  21
 None
 0.80A 1kqeB-5nl7A:
undetectable
1kqeD-5nl7A:
undetectable		 1kqeB-5nl7A:
undetectable
1kqeD-5nl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		3 ALA A  77
VAL A 212
TRP A 215
 None
 0.84A 1kqeB-5uxbA:
undetectable
1kqeD-5uxbA:
undetectable		 1kqeB-5uxbA:
4.02
1kqeD-5uxbA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 141
VAL A 136
TRP A 135
 None
 0.87A 1kqeB-5vm1A:
undetectable
1kqeD-5vm1A:
undetectable		 1kqeB-5vm1A:
5.70
1kqeD-5vm1A:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE

(Trichomonas
vaginalis) 		no annotation 3 ALA A 193
VAL A 191
TRP A 152
 None
 0.75A 1kqeB-5vwnA:
undetectable
1kqeD-5vwnA:
undetectable		 1kqeB-5vwnA:
undetectable
1kqeD-5vwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 3 ALA A 367
VAL A 359
TRP A 358
 None
 0.89A 1kqeB-5yj6A:
undetectable
1kqeD-5yj6A:
undetectable		 1kqeB-5yj6A:
undetectable
1kqeD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6v ABC-TYPE
UNCHARACTERIZED
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Rhodothermus
marinus) 		no annotation 3 ALA A 144
VAL A 146
TRP A 148
 None
 0.87A 1kqeB-5z6vA:
undetectable
1kqeD-5z6vA:
undetectable		 1kqeB-5z6vA:
undetectable
1kqeD-5z6vA:
undetectable