SIMILAR PATTERNS OF AMINO ACIDS FOR 1KLM_A_SPPA999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		5 TYR A  75
PRO A 102
PHE A  99
LEU A 100
PRO A 140
 None
 1.40A 1klmA-1b65A:
undetectable		 1klmA-1b65A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		5 LEU A 258
PRO A 223
PHE A 224
LEU A 252
PRO A 250
 None
 1.30A 1klmA-1bc5A:
0.0		 1klmA-1bc5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bta BARSTAR

(Bacillus
amyloliquefaciens) 		PF01337
(Barstar) 		5 LEU A  20
LYS A  21
VAL A  45
LEU A  37
TYR A  30
 None
 1.43A 1klmA-1btaA:
undetectable		 1klmA-1btaA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 LEU A 217
PRO A 173
PHE A 172
LEU A 170
PRO A  34
 None
 1.42A 1klmA-1dkpA:
0.0		 1klmA-1dkpA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LEU A 100
LYS A 102
PRO A 225
TRP A 229
LEU A 234
TYR A 318
 None
 1.25A 1klmA-1mu2A:
28.7		 1klmA-1mu2A:
61.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 102
PRO A 226
TRP A 229
LEU A 234
PRO A 236
TYR A 318
 None
 0.82A 1klmA-1mu2A:
28.7		 1klmA-1mu2A:
61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prs DEVELOPMENT-SPECIFIC
PROTEIN S

(Myxococcus
xanthus) 		PF00030
(Crystall) 		5 LEU A 118
VAL A 138
LEU A 108
PRO A 110
TYR A 113
 None
 1.03A 1klmA-1prsA:
undetectable		 1klmA-1prsA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		5 LEU A 361
VAL A 331
PHE A 391
LEU A 382
PRO A 390
 None
 1.41A 1klmA-1qfxA:
0.0		 1klmA-1qfxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qiu ADENOVIRUS FIBRE

(Human
mastadenovirus
C) 		PF00541
(Adeno_knob)
PF00608
(Adeno_shaft) 		5 LEU A 445
LYS A 563
LEU A 522
PRO A 529
TYR A 564
 None
 1.48A 1klmA-1qiuA:
undetectable		 1klmA-1qiuA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		5 LEU A 230
TYR A 350
TYR A 356
LEU A 237
PRO A 235
 None
 1.11A 1klmA-2am4A:
0.0		 1klmA-2am4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 245
VAL A 258
PHE A  48
LEU A  45
TYR A 242
 None
 1.50A 1klmA-2ctzA:
undetectable		 1klmA-2ctzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A 513
TYR A 615
TYR A 614
PRO A 503
TYR A 512
 None
 1.44A 1klmA-2fafA:
undetectable		 1klmA-2fafA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 LEU A  88
VAL A  58
PHE A  73
LEU A  70
PRO A  68
 None
 1.49A 1klmA-2fqxA:
undetectable		 1klmA-2fqxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 LEU A 172
VAL A 192
PRO A 471
LEU A 473
PRO A 475
 None
 1.21A 1klmA-2gjxA:
undetectable		 1klmA-2gjxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 5 LEU I 172
VAL I 192
PRO I 471
LEU I 473
PRO I 475
 None
 1.22A 1klmA-2gk1I:
undetectable		 1klmA-2gk1I:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
LYS A 102
PRO A 226
PHE A 227
LEU A 234
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
None
None
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 1.27A 1klmA-2hnzA:
35.7		 1klmA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 102
TYR A 181
PRO A 236
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.3A)
PC0  A 999 (-4.3A)
 1.33A 1klmA-2hnzA:
35.7		 1klmA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 102
VAL A 106
TYR A 181
TYR A 188
PRO A 226
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
None
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.95A 1klmA-2hnzA:
35.7		 1klmA-2hnzA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 102
VAL A 106
TYR A 181
TYR A 188
PRO A 226
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
None
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.93A 1klmA-2hnzA:
35.7		 1klmA-2hnzA:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU B 887
LYS B 883
VAL B 878
PRO B 802
LEU B 798
 None
 1.20A 1klmA-2o8eB:
undetectable		 1klmA-2o8eB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p82 CYSTEINE PROTEASE
ATG4A

(Homo sapiens) 		PF03416
(Peptidase_C54) 		5 LEU A  79
TYR A  57
PRO A 261
TRP A  75
PRO A 148
 None
 1.46A 1klmA-2p82A:
undetectable		 1klmA-2p82A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 LEU A1147
VAL A1358
TYR A1298
TYR A1329
PRO A1332
 None
None
None
T4K  A1500 ( 4.2A)
None
 1.01A 1klmA-2po3A:
1.8		 1klmA-2po3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 LEU A 181
PRO A 226
TRP A 159
LEU A 228
TYR A 182
 None
 1.45A 1klmA-2q6zA:
undetectable		 1klmA-2q6zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		5 LEU A 293
TYR A 220
PRO A 284
LEU A 285
PRO A 287
 None
 1.36A 1klmA-2r94A:
undetectable		 1klmA-2r94A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1o CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		5 LEU A 112
LYS A 111
PHE A  70
LEU A  71
PRO A  73
 None
 1.32A 1klmA-2v1oA:
undetectable		 1klmA-2v1oA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2van DNA POLYMERSE BETA

(Rattus
norvegicus) 		PF10391
(DNA_pol_lambd_f)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 LEU A 195
TYR A 265
PHE A 200
LEU A 210
PRO A 208
 None
 1.48A 1klmA-2vanA:
3.3		 1klmA-2vanA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU A  52
VAL A  88
PRO A  79
LEU A  81
PRO A  83
 None
 1.45A 1klmA-2vw8A:
undetectable		 1klmA-2vw8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 VAL A 382
TYR A 378
TYR A 380
PRO A 334
PRO A 570
 None
 1.45A 1klmA-2wanA:
undetectable		 1klmA-2wanA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		5 LEU A 357
VAL A 234
TYR A 325
PHE A 328
TRP A 312
 None
 1.44A 1klmA-2zj9A:
undetectable		 1klmA-2zj9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF01467
(CTP_transf_like) 		5 LEU A  58
VAL A  35
TYR A   6
PRO A  12
LEU A  13
 None
None
COD  A 201 (-4.7A)
None
None
 1.23A 1klmA-3pxuA:
undetectable		 1klmA-3pxuA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Clostridioides
difficile) 		PF12683
(DUF3798) 		5 LEU A 341
VAL A 116
PRO A 144
LEU A 160
PRO A 335
 None
 1.13A 1klmA-3qi7A:
undetectable		 1klmA-3qi7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwy CELL DEATH
ABNORMALITY PROTEIN
2

(Caenorhabditis
elegans) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 LEU A  39
LYS A 114
VAL A  33
LEU A  27
PRO A 116
 None
 1.39A 1klmA-3qwyA:
undetectable		 1klmA-3qwyA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		5 LEU A 137
LYS A 135
VAL A 150
PRO A 215
LEU A 219
 None
 1.42A 1klmA-3sp1A:
undetectable		 1klmA-3sp1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 770
LYS A 768
PRO A 790
LEU A 762
PRO A 764
 None
 1.25A 1klmA-3un9A:
undetectable		 1klmA-3un9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		5 VAL A 193
TYR A 189
TYR A 191
PRO A 146
PRO A 422
 None
 1.50A 1klmA-4aioA:
undetectable		 1klmA-4aioA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		5 LEU A 220
PRO A 175
PHE A 174
LEU A 172
PRO A  36
 None
 1.48A 1klmA-4arsA:
undetectable		 1klmA-4arsA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 VAL A2022
TYR A2118
PHE A1992
LEU A2015
PRO A2019
 None
 1.46A 1klmA-4asiA:
1.3		 1klmA-4asiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ec6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		no annotation 5 LEU A 226
VAL A 310
TYR A 246
PHE A 221
TYR A 282
 None
 1.35A 1klmA-4ec6A:
undetectable		 1klmA-4ec6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ec6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		no annotation 5 VAL A 310
TYR A 228
TYR A 246
PHE A 221
TYR A 282
 None
 1.23A 1klmA-4ec6A:
undetectable		 1klmA-4ec6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epu ANGIOPOIETIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 LEU A 373
PRO A 454
TRP A 448
LEU A 418
TYR A 389
 None
 1.40A 1klmA-4epuA:
undetectable		 1klmA-4epuA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 293
VAL A 389
TRP A 280
LEU A 283
PRO A 287
 None
 1.23A 1klmA-4fddA:
undetectable		 1klmA-4fddA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 730
LYS A 728
PRO A 716
LEU A 722
PRO A 724
 None
 1.38A 1klmA-4fm9A:
2.8		 1klmA-4fm9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		5 LEU A  24
VAL A 116
TYR A  16
PRO A 138
PHE A 101
 None
 1.43A 1klmA-4lanA:
undetectable		 1klmA-4lanA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		5 LEU A 166
LYS A 168
TYR A 186
TYR A 157
LEU A 233
 None
None
None
None
DMU  A 301 ( 4.6A)
 1.48A 1klmA-4mzvA:
2.7		 1klmA-4mzvA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmu THIOL-DISULFIDE
OXIDOREDUCTASE RESA

(Bacillus
anthracis) 		PF00578
(AhpC-TSA) 		5 LEU A  71
VAL A 107
TYR A 105
PHE A 114
PRO A 111
 None
 1.18A 1klmA-4nmuA:
undetectable		 1klmA-4nmuA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04146
(YTH) 		5 LEU A 461
PRO A 493
PHE A 492
LEU A 491
PRO A 454
 None
 1.25A 1klmA-4r3iA:
undetectable		 1klmA-4r3iA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus) 		PF04055
(Radical_SAM) 		5 LEU B  11
LYS B   5
PRO B 243
LEU B 241
TYR B 253
 None
 1.37A 1klmA-4u0pB:
undetectable		 1klmA-4u0pB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 259
VAL E 221
TYR E 229
TYR E 226
LEU E 203
 None
 1.12A 1klmA-4xgcE:
undetectable		 1klmA-4xgcE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 LEU A 367
TYR A  58
TYR A  55
PRO A 386
LEU A 388
 None
 1.36A 1klmA-4xnuA:
undetectable		 1klmA-4xnuA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.48A 1klmA-5amqA:
4.6		 1klmA-5amqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3

(Homo sapiens) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3) 		5 LEU A1162
PHE A1252
LEU A1249
PRO A1247
TYR A1161
 None
 1.32A 1klmA-5b16A:
undetectable		 1klmA-5b16A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f84 O-GLUCOSYLTRANSFERAS
E RUMI

(Drosophila
melanogaster) 		PF05686
(Glyco_transf_90) 		5 LEU A 145
VAL A 137
TRP A 380
LEU A 384
PRO A 141
 None
 1.42A 1klmA-5f84A:
undetectable		 1klmA-5f84A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		5 VAL A  71
PHE A  60
LEU A  63
PRO A  65
TYR A  23
 None
 1.23A 1klmA-5i2cA:
undetectable		 1klmA-5i2cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcn OS09G0567300 PROTEIN

(Oryza sativa) 		PF07992
(Pyr_redox_2) 		5 LEU A 177
VAL A 221
TYR A 212
TYR A 215
PHE A 353
 None
 1.44A 1klmA-5jcnA:
undetectable		 1klmA-5jcnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mra SORCIN

(Homo sapiens) 		no annotation 5 LEU A 129
LYS A 127
VAL A 120
TYR A 148
PHE A 109
 None
 1.08A 1klmA-5mraA:
undetectable		 1klmA-5mraA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		5 LEU A  97
VAL A 110
TYR A 126
PRO A 107
LEU A 101
 None
 1.45A 1klmA-5ncrA:
undetectable		 1klmA-5ncrA:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 LEU A  99
VAL A 105
PRO A 225
LEU A 233
PRO A 235
TYR A 317
 None
 0.72A 1klmA-5ovnA:
25.9		 1klmA-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 115
VAL A 151
TYR A 132
PRO A 137
LEU A 139
 None
 1.22A 1klmA-5z9yA:
undetectable		 1klmA-5z9yA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 458
VAL A 378
PRO A 435
PHE A 439
LEU A 436
 None
 1.39A 1klmA-6fyoA:
undetectable		 1klmA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 458
VAL A 378
PRO A 435
PHE A 439
LEU A 436
 None
 1.41A 1klmA-6fyvA:
undetectable		 1klmA-6fyvA:
undetectable