SIMILAR PATTERNS OF AMINO ACIDS FOR 1KIJ_B_NOVB444_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		3 ASP A 212
PHE A  88
VAL A 209
 None
 0.79A 1kijB-1bt4A:
0.0		 1kijB-1bt4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		3 ASP B  96
PHE B  93
VAL B 192
 None
 0.78A 1kijB-1ezvB:
0.5		 1kijB-1ezvB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		3 ASP B 276
PHE B 139
VAL B 269
 None
 0.75A 1kijB-1fftB:
0.3		 1kijB-1fftB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		3 ASP A 140
PHE A  69
VAL A 219
 MG  A5555 (-2.6A)
None
None
 0.75A 1kijB-1fiuA:
0.0		 1kijB-1fiuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		3 ASP A 181
PHE A 222
VAL A 185
 None
 0.69A 1kijB-1ia5A:
0.0		 1kijB-1ia5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		3 ASP A 128
PHE A  87
VAL A 125
 None
 0.76A 1kijB-1mdwA:
0.0		 1kijB-1mdwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		3 ASP A 121
PHE A  16
VAL A 118
 None
 0.59A 1kijB-1miqA:
0.0		 1kijB-1miqA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ASP A  68
PHE A  40
VAL A  65
 None
 0.72A 1kijB-1pw5A:
0.0		 1kijB-1pw5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ASP A  46
PHE A  49
VAL A  43
 None
 0.66A 1kijB-1q1qA:
undetectable		 1kijB-1q1qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ASP A  61
PHE A  64
VAL A  58
 None
 0.70A 1kijB-1q20A:
undetectable		 1kijB-1q20A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 283
PHE A 349
VAL A 308
 None
 0.65A 1kijB-1qhoA:
undetectable		 1kijB-1qhoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txl METAL-BINDING
PROTEIN YODA

(Escherichia
coli) 		PF09223
(ZinT) 		3 ASP A  58
PHE A 163
VAL A 114
 None
 0.69A 1kijB-1txlA:
undetectable		 1kijB-1txlA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7i HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		3 ASP A  73
PHE A  11
VAL A 125
 None
 0.78A 1kijB-1u7iA:
undetectable		 1kijB-1u7iA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		3 ASP A 148
PHE A 151
VAL A 361
 None
 0.72A 1kijB-1v4vA:
undetectable		 1kijB-1v4vA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT

(Streptococcus
dysgalactiae) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		3 ASP A  67
PHE A  27
VAL A  98
 None
 0.69A 1kijB-1vj7A:
undetectable		 1kijB-1vj7A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwy THIOREDOXIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF06201
(PITH) 		3 ASP A  33
PHE A 149
VAL A  55
 None
 0.68A 1kijB-1wwyA:
undetectable		 1kijB-1wwyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		3 ASP A 734
PHE A 729
VAL A  23
 None
 0.69A 1kijB-2b0tA:
undetectable		 1kijB-2b0tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 ASP A 676
PHE A 708
VAL A 704
 None
 0.74A 1kijB-2cn3A:
undetectable		 1kijB-2cn3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 ASP A 244
PHE A 239
VAL A 251
 None
 0.72A 1kijB-2fgeA:
undetectable		 1kijB-2fgeA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzq PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN

(Plasmodium
vivax) 		PF01161
(PBP) 		3 ASP A  90
PHE A  74
VAL A 173
 None
 0.78A 1kijB-2gzqA:
undetectable		 1kijB-2gzqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 252
PHE A 271
VAL A 205
 None
 0.78A 1kijB-2ifyA:
undetectable		 1kijB-2ifyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		3 ASP A 323
PHE A 330
VAL A 337
 None
 0.61A 1kijB-2j6hA:
1.7		 1kijB-2j6hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8p 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		3 ASP A 114
PHE A 109
VAL A 130
 None
 0.77A 1kijB-2o8pA:
undetectable		 1kijB-2o8pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS

(Pyrococcus
abyssi) 		PF03657
(UPF0113) 		3 ASP A  42
PHE A  81
VAL A  68
 None
 0.73A 1kijB-2p38A:
undetectable		 1kijB-2p38A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 ASP B  52
PHE B  48
VAL B 117
 None
 0.67A 1kijB-2pffB:
undetectable		 1kijB-2pffB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzj TWO-COMPONENT
RESPONSE REGULATOR

(Clostridioides
difficile) 		PF00072
(Response_reg) 		3 ASP A 100
PHE A  53
VAL A 115
 None
 0.73A 1kijB-2qzjA:
undetectable		 1kijB-2qzjA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 239
PHE A  46
VAL A 236
 None
 0.57A 1kijB-2wyhA:
undetectable		 1kijB-2wyhA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		3 ASP A  30
PHE A 404
VAL A 468
 None
 0.78A 1kijB-2x1mA:
undetectable		 1kijB-2x1mA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 ASP C 144
PHE C 139
VAL C 202
 None
 0.76A 1kijB-3aizC:
undetectable		 1kijB-3aizC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbn CONSERVED PROTEIN
MTH639

(Methanothermobacter
thermautotrophicus) 		PF04027
(DUF371) 		3 ASP A 133
PHE A  44
VAL A  88
 None
 0.74A 1kijB-3cbnA:
undetectable		 1kijB-3cbnA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 ASP A 155
PHE A 237
VAL A 164
 None
 0.78A 1kijB-3ce6A:
undetectable		 1kijB-3ce6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ASP A 669
PHE A 736
VAL A 666
 None
 0.77A 1kijB-3cf0A:
undetectable		 1kijB-3cf0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ASP A 304
PHE A 307
VAL A 301
 None
 0.74A 1kijB-3cv2A:
undetectable		 1kijB-3cv2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989

(Ruegeria
pomeroyi) 		PF09347
(DUF1989) 		3 ASP A 128
PHE A 224
VAL A 196
 None
 0.74A 1kijB-3di4A:
undetectable		 1kijB-3di4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52

(Homo sapiens) 		PF00270
(DEAD) 		3 ASP A 321
PHE A 331
VAL A 317
 None
 0.74A 1kijB-3dkpA:
undetectable		 1kijB-3dkpA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		3 ASP A 292
PHE A 494
VAL A 472
 None
 0.78A 1kijB-3do6A:
undetectable		 1kijB-3do6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1

(Streptococcus
pneumoniae) 		PF01625
(PMSR)
PF01641
(SelR) 		3 ASP A  76
PHE A  72
VAL A 123
 None
 0.73A 1kijB-3e0mA:
undetectable		 1kijB-3e0mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		3 ASP A  38
PHE A 305
VAL A  67
 None
 0.55A 1kijB-3ekmA:
undetectable		 1kijB-3ekmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASP A 573
PHE A 667
VAL A 577
 None
 0.74A 1kijB-3fawA:
undetectable		 1kijB-3fawA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcn AN ALPHA-HELICAL
PROTEIN OF UNKNOWN
FUNCTION (PFAM01724)

(Rhodospirillum
rubrum) 		PF01724
(DUF29) 		3 ASP A 153
PHE A 150
VAL A  68
 None
 0.50A 1kijB-3fcnA:
undetectable		 1kijB-3fcnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASP A 544
PHE A 157
VAL A  99
 EDO  A  18 ( 3.6A)
None
None
 0.74A 1kijB-3ihvA:
undetectable		 1kijB-3ihvA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		3 ASP A 338
PHE A 299
VAL A 350
 None
 0.65A 1kijB-3iiwA:
undetectable		 1kijB-3iiwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		3 ASP A 392
PHE A 408
VAL A 464
 None
 0.77A 1kijB-3k40A:
undetectable		 1kijB-3k40A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		3 ASP A 141
PHE A 110
VAL A 138
 None
 0.78A 1kijB-3ll9A:
undetectable		 1kijB-3ll9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfg DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49

([Candida]
glabrata) 		PF06870
(RNA_pol_I_A49) 		3 ASP A  32
PHE A  35
VAL A  29
 None
 0.71A 1kijB-3nfgA:
undetectable		 1kijB-3nfgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 ASP A 177
PHE A 350
VAL A 156
 None
 0.52A 1kijB-3pg5A:
undetectable		 1kijB-3pg5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 3 ASP X  91
PHE X  38
VAL X  88
 None
 0.77A 1kijB-3rj2X:
undetectable		 1kijB-3rj2X:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		3 ASP X  48
PHE X 245
VAL X  42
 None
 0.71A 1kijB-3ss7X:
undetectable		 1kijB-3ss7X:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvl THIAMINE-TRIPHOSPHAT
ASE

(Homo sapiens) 		PF01928
(CYTH) 		3 ASP A 147
PHE A  12
VAL A 144
 None
 0.78A 1kijB-3tvlA:
undetectable		 1kijB-3tvlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		3 ASP A 141
PHE A 101
VAL A  81
 None
 0.68A 1kijB-3uboA:
undetectable		 1kijB-3uboA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 ASP A 456
PHE A 446
VAL A 435
 None
 0.71A 1kijB-3uemA:
undetectable		 1kijB-3uemA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  34
PHE A  47
VAL A  95
 None
 0.66A 1kijB-3vwaA:
undetectable		 1kijB-3vwaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		3 ASP A 586
PHE A 617
VAL A 579
 None
 0.78A 1kijB-4bl3A:
undetectable		 1kijB-4bl3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASP A 320
PHE A 368
VAL A 350
 None
 0.75A 1kijB-4dzaA:
undetectable		 1kijB-4dzaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		3 ASP A 252
PHE A 247
VAL A 282
 None
 0.72A 1kijB-4fvaA:
undetectable		 1kijB-4fvaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im9 DNA PRIMASE

(Vibrio cholerae) 		PF08278
(DnaG_DnaB_bind) 		3 ASP A 103
PHE A  98
VAL A  31
 None
 0.71A 1kijB-4im9A:
undetectable		 1kijB-4im9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		3 ASP A 252
PHE A 319
VAL A 255
 None
 0.78A 1kijB-4jc0A:
undetectable		 1kijB-4jc0A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 147
PHE A 149
VAL A 144
 None
 0.54A 1kijB-4kt1A:
undetectable		 1kijB-4kt1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 3 ASP A 399
PHE A 382
VAL A 431
 None
 0.75A 1kijB-4l3aA:
undetectable		 1kijB-4l3aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		3 ASP A 157
PHE A 161
VAL A 154
 None
 0.73A 1kijB-4l8nA:
undetectable		 1kijB-4l8nA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 150
PHE A 152
VAL A 147
 None
 0.69A 1kijB-4li2A:
undetectable		 1kijB-4li2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		3 ASP A 139
PHE A  65
VAL A 101
 None
 0.62A 1kijB-4m0dA:
undetectable		 1kijB-4m0dA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqg MITROCOMIN

(Mitrocoma
cellularia) 		PF13202
(EF-hand_5) 		3 ASP A 163
PHE A 157
VAL A 132
 None
 0.52A 1kijB-4nqgA:
undetectable		 1kijB-4nqgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A  60
PHE A   4
VAL A  64
 None
 0.75A 1kijB-4nreA:
undetectable		 1kijB-4nreA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		3 ASP A  65
PHE A  52
VAL A 125
 None
 0.79A 1kijB-4q3rA:
undetectable		 1kijB-4q3rA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 ASP A 180
PHE A 251
VAL A 192
 None
 0.72A 1kijB-4q7gA:
undetectable		 1kijB-4q7gA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 147
PHE A 149
VAL A 144
 None
 0.59A 1kijB-4qxeA:
undetectable		 1kijB-4qxeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ASP A 147
PHE A 149
VAL A 144
 None
 0.60A 1kijB-4qxfA:
undetectable		 1kijB-4qxfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		3 ASP A 122
PHE A 136
VAL A  70
 None
None
KCX  A 138 ( 4.8A)
 0.78A 1kijB-4rdyA:
undetectable		 1kijB-4rdyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF17488
(Herpes_glycoH_C) 		3 ASP B 152
PHE B 155
VAL A 224
 None
 0.71A 1kijB-4xhjB:
undetectable		 1kijB-4xhjB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 ASP A  26
PHE A  49
VAL A  23
 None
 0.78A 1kijB-4y1yA:
undetectable		 1kijB-4y1yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ASP A 430
PHE A 538
VAL A 427
 None
 0.75A 1kijB-4zohA:
undetectable		 1kijB-4zohA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		3 ASP A 132
PHE A 253
VAL A 269
 None
 0.76A 1kijB-5a0lA:
undetectable		 1kijB-5a0lA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 ASP A  36
PHE A 141
VAL A  92
 None
 0.66A 1kijB-5aq6A:
undetectable		 1kijB-5aq6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		3 ASP A 163
PHE A 158
VAL A   6
 None
 0.66A 1kijB-5b4sA:
1.0		 1kijB-5b4sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		3 ASP A 134
PHE A 162
VAL A 178
 None
 0.77A 1kijB-5dihA:
undetectable		 1kijB-5dihA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eip YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		3 ASP A 460
PHE A 393
VAL A 374
 None
 0.75A 1kijB-5eipA:
undetectable		 1kijB-5eipA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 ZONADHESIN

(Komagataella
phaffii) 		no annotation 3 ASP U  25
PHE U 150
VAL U  28
 None
 0.79A 1kijB-5fx8U:
undetectable		 1kijB-5fx8U:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h34 METHIONINE-TRNA
LIGASE

(Nanoarchaeum
equitans) 		PF01588
(tRNA_bind) 		3 ASP A 681
PHE A 677
VAL A 775
 None
 0.66A 1kijB-5h34A:
undetectable		 1kijB-5h34A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		3 ASP A 460
PHE A 393
VAL A 374
 None
 0.77A 1kijB-5h8aA:
undetectable		 1kijB-5h8aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP A 212
PHE A 256
VAL A 209
 None
 0.56A 1kijB-5i2tA:
undetectable		 1kijB-5i2tA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF) 		3 ASP A 106
PHE A 118
VAL A  81
 None
 0.70A 1kijB-5iaaA:
undetectable		 1kijB-5iaaA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 ASP A 564
PHE A 681
VAL A 567
 None
 0.68A 1kijB-5ikpA:
undetectable		 1kijB-5ikpA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in7 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN

(Homo sapiens) 		PF03607
(DCX) 		3 ASP A 167
PHE A 138
VAL A 153
 None
 0.75A 1kijB-5in7A:
undetectable		 1kijB-5in7A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 ASP A 118
PHE A 101
VAL A  93
 None
 0.58A 1kijB-5jxlA:
undetectable		 1kijB-5jxlA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		3 ASP A 347
PHE A 342
VAL A 404
 None
 0.77A 1kijB-5kdxA:
undetectable		 1kijB-5kdxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		3 ASP A 694
PHE A 815
VAL A 697
 None
 0.72A 1kijB-5lrbA:
undetectable		 1kijB-5lrbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc7 COATOMER SUBUNIT
ZETA-1

(Homo sapiens) 		PF01217
(Clat_adaptor_s) 		3 ASP A  74
PHE A  77
VAL A 109
 None
 0.76A 1kijB-5mc7A:
undetectable		 1kijB-5mc7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 ASP B 215
PHE B 178
VAL B 212
 None
 0.68A 1kijB-5nd1B:
undetectable		 1kijB-5nd1B:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 3 ASP A 102
PHE A 152
VAL A 107
 None
 0.75A 1kijB-5o6kA:
undetectable		 1kijB-5o6kA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8m YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		no annotation 3 ASP A 460
PHE A 393
VAL A 374
 None
 0.72A 1kijB-5o8mA:
undetectable		 1kijB-5o8mA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oac MAJOR CAPSID PROTEIN

(unidentified
phage) 		no annotation 3 ASP A  52
PHE A  25
VAL A  56
 None
 0.75A 1kijB-5oacA:
undetectable		 1kijB-5oacA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ow6 VP1

(Cucumber mosaic
virus) 		PF00760
(Cucumo_coat) 		3 ASP A 191
PHE A 117
VAL A 121
 None
 0.70A 1kijB-5ow6A:
undetectable		 1kijB-5ow6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		3 ASP A 175
PHE A 164
VAL A 179
 None
 0.65A 1kijB-5suoA:
undetectable		 1kijB-5suoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		3 ASP A 301
PHE A 296
VAL A 203
 None
 0.74A 1kijB-5tsqA:
undetectable		 1kijB-5tsqA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		3 ASP A 230
PHE A 178
VAL A 285
 CA  A 401 (-2.6A)
None
None
 0.66A 1kijB-5uljA:
undetectable		 1kijB-5uljA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		3 ASP A 486
PHE A 517
VAL A 478
 None
 0.72A 1kijB-5uy7A:
undetectable		 1kijB-5uy7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c13 -

(-) 		no annotation 3 ASP A1242
PHE A1149
VAL A1227
 None
 0.72A 1kijB-6c13A:
undetectable		 1kijB-6c13A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 3 ASP A 116
PHE A  36
VAL A  60
 None
 0.76A 1kijB-6fm9A:
1.2		 1kijB-6fm9A:
undetectable