SIMILAR PATTERNS OF AMINO ACIDS FOR 1KIJ_B_NOVB444

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aj6 GYRASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		8 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
THR A 165
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 4.4A)
NOV  A   1 ( 4.1A)
 0.42A 1kijB-1aj6A:
28.2		 1kijB-1aj6A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b63 MUTL

(Escherichia
coli) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 ASN A  33
ASP A  58
ILE A  63
ASP A  66
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 (-3.6A)
ANP  A 380 (-4.5A)
None
ANP  A 380 (-3.7A)
 0.94A 1kijB-1b63A:
19.4		 1kijB-1b63A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		5 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
 MN  A 996 ( 2.8A)
ACP  A 998 (-3.7A)
None
ACP  A 998 (-4.3A)
ACP  A 998 (-3.8A)
 0.94A 1kijB-1i5aA:
5.7		 1kijB-1i5aA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id0 PHOQ HISTIDINE
KINASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.78A 1kijB-1id0A:
6.6		 1kijB-1id0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))

(Homo sapiens) 		PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2) 		5 GLU A 225
ILE A 233
ASP A 275
ILE A 187
ALA A 201
 None
 1.07A 1kijB-1jmcA:
undetectable		 1kijB-1jmcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 GLU A 613
ARG A 554
ILE A 553
ILE A 599
ALA A 603
 None
 1.25A 1kijB-1nneA:
undetectable		 1kijB-1nneA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		5 ILE A 300
ILE A 297
ALA A 333
ARG A 497
THR A 496
 None
 1.03A 1kijB-1on9A:
undetectable		 1kijB-1on9A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A 141
PRO A 154
ASP A 103
ILE A 112
ALA A  41
 None
 1.27A 1kijB-1oypA:
2.7		 1kijB-1oypA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 ASN A  70
ILE A 104
PRO A 105
ALA A 146
THR A 195
 MG  A 903 ( 2.6A)
ANP  A 901 (-4.9A)
None
ANP  A 901 (-3.3A)
ANP  A 901 ( 4.2A)
 0.81A 1kijB-1pvgA:
28.8		 1kijB-1pvgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 ASN A  70
ILE A 104
PRO A 105
ILE A 120
THR A 195
 MG  A 903 ( 2.6A)
ANP  A 901 (-4.9A)
None
ANP  A 901 (-3.8A)
ANP  A 901 ( 4.2A)
 0.79A 1kijB-1pvgA:
28.8		 1kijB-1pvgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASN A 434
GLU A 430
ARG A 450
PRO A 426
ALA A 390
 None
None
None
None
HEM  A 754 ( 4.8A)
 1.09A 1kijB-1qf7A:
undetectable		 1kijB-1qf7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ILE A 270
ASP A 265
ILE A  16
ALA A 100
THR A 273
 None
 1.25A 1kijB-1r0lA:
undetectable		 1kijB-1r0lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s14 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		9 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
THR A1163
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
NOV  A1300 ( 4.0A)
 0.38A 1kijB-1s14A:
24.5		 1kijB-1s14A:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		9 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ILE A1090
ARG A1132
THR A1163
 ANP  A1500 (-3.2A)
ANP  A1500 (-3.7A)
ANP  A1500 (-3.5A)
None
None
None
ANP  A1500 ( 3.2A)
None
ANP  A1500 (-3.7A)
 0.66A 1kijB-1s16A:
41.1		 1kijB-1s16A:
40.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ILE A 279
ASP A 274
ILE A  12
ALA A  99
THR A 282
 None
 1.25A 1kijB-1t1sA:
undetectable		 1kijB-1t1sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		5 GLU A 220
ASP A 217
ILE A 175
ILE A 128
ALA A 143
 None
 0.87A 1kijB-1t8hA:
undetectable		 1kijB-1t8hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tid ANTI-SIGMA F FACTOR

(Geobacillus
stearothermophilus) 		PF13581
(HATPase_c_2) 		5 ASN A  50
ASP A  81
ILE A  86
PRO A  87
THR A 130
 ATP  A 200 ( 2.8A)
ATP  A 200 (-4.0A)
ATP  A 200 (-4.2A)
None
ATP  A 200 (-3.4A)
 0.77A 1kijB-1tidA:
6.8		 1kijB-1tidA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuh HYPOTHETICAL PROTEIN
EGC068

(uncultured
bacterium) 		PF12680
(SnoaL_2) 		5 ASN A 107
ILE A 122
ASP A 133
TYR A  32
ALA A  88
 None
 1.28A 1kijB-1tuhA:
undetectable		 1kijB-1tuhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8w NUCLEOSIDE
DIPHOSPHATE KINASE I

(Arabidopsis
thaliana) 		PF00334
(NDK) 		5 GLU A  76
ILE A  74
PRO A 135
ILE A 127
ALA A 123
 None
 1.25A 1kijB-1u8wA:
undetectable		 1kijB-1u8wA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 ASP A  60
ILE A  68
PRO A  69
ILE A 202
ALA A  88
 None
 1.26A 1kijB-1xp8A:
undetectable		 1kijB-1xp8A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 ASN A  91
ILE A 125
PRO A 126
ILE A 141
THR A 215
 MG  A 900 ( 2.5A)
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
 0.87A 1kijB-1zxnA:
27.2		 1kijB-1zxnA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		5 ILE A 260
ASP A 265
ILE A 259
ALA A 295
ARG A 264
 None
 1.06A 1kijB-2czcA:
undetectable		 1kijB-2czcA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 5 ILE A  20
PRO A  21
ASP A  25
ALA A  33
THR A  69
 None
 1.25A 1kijB-2f9rA:
undetectable		 1kijB-2f9rA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		5 GLU A 135
ARG A 157
ILE A 155
ILE A 148
ALA A 151
 None
 1.24A 1kijB-2o2zA:
undetectable		 1kijB-2o2zA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 ASN A  76
GLU A 251
ILE A 155
ASP A 126
ALA A  78
 None
 1.15A 1kijB-2p2mA:
undetectable		 1kijB-2p2mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP

(Escherichia
coli) 		PF00072
(Response_reg) 		5 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.99A 1kijB-2pl1A:
undetectable		 1kijB-2pl1A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 ASP A 328
ILE A 357
ASP A 388
ILE A 382
TYR A 381
 None
 1.29A 1kijB-2py6A:
undetectable		 1kijB-2py6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		5 ASP A  13
ILE A  20
PRO A  21
ILE A  26
TYR A 162
 None
 0.77A 1kijB-2w0mA:
undetectable		 1kijB-2w0mA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		5 ILE A  20
PRO A  21
ILE A  26
TYR A 162
ARG A   4
 None
 0.99A 1kijB-2w0mA:
undetectable		 1kijB-2w0mA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ASN X 188
GLU X 187
ILE X 115
TYR X 116
ALA X 125
 None
 1.26A 1kijB-2y9eX:
undetectable		 1kijB-2y9eX:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E2 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus) 		PF00943
(Alpha_E2_glycop) 		5 ILE C 148
PRO C 149
ASP C 261
ILE C 133
THR C 146
 None
 1.28A 1kijB-2yewC:
undetectable		 1kijB-2yewC:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 ASP A  64
ILE A  97
PRO A  96
ILE A 243
THR A  91
 None
 1.28A 1kijB-3bt6A:
undetectable		 1kijB-3bt6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr5 PUTATIVE
O-METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13578
(Methyltransf_24) 		5 ILE A 190
ASP A 185
ILE A 193
ALA A 196
THR A 208
 None
 1.09A 1kijB-3dr5A:
undetectable		 1kijB-3dr5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		9 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ILE A  90
ARG A 132
THR A 163
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
1EU  A   2 (-3.7A)
 0.91A 1kijB-3fv5A:
27.6		 1kijB-3fv5A:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxd PROTEIN ICMQ
PROTEIN ICMR

(Legionella
pneumophila) 		PF09475
(Dot_icm_IcmQ)
no annotation 		5 GLU B  40
ARG A  45
ILE B  41
ILE A  13
ALA B  83
 None
 1.16A 1kijB-3fxdB:
undetectable		 1kijB-3fxdB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		5 ASP A 271
ILE A 298
ILE A 295
ALA A 279
THR A  88
 None
 1.29A 1kijB-3htzA:
undetectable		 1kijB-3htzA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 ILE D 291
ILE D 235
TYR D 217
ALA D 215
THR D 204
 None
 1.27A 1kijB-3kvdD:
undetectable		 1kijB-3kvdD:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis) 		PF02743
(dCache_1) 		5 ILE A 111
ASP A 139
ILE A  86
ALA A  81
THR A 197
 None
 1.21A 1kijB-3licA:
undetectable		 1kijB-3licA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLU A 140
ASP A 141
PRO A 161
ILE A 199
ALA A 104
 None
 1.14A 1kijB-3ljpA:
undetectable		 1kijB-3ljpA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		9 ASN A  86
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.53A 1kijB-3lpsA:
39.2		 1kijB-3lpsA:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		5 GLU A 432
ILE A 267
PRO A 268
ILE A 273
THR A 265
 None
 1.11A 1kijB-3mtjA:
undetectable		 1kijB-3mtjA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		5 ILE A 366
ASP A 168
ILE A 380
ALA A 143
ARG A 174
 None
None
GOL  A 451 (-4.5A)
None
None
 1.22A 1kijB-3mznA:
undetectable		 1kijB-3mznA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 GLU A 270
ASP A 273
ILE A 266
ALA A 196
THR A 122
 None
 1.00A 1kijB-3nvlA:
undetectable		 1kijB-3nvlA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ARG A 180
ASP A 199
ILE A 195
ALA A 192
ARG A 198
 NAP  A 330 (-4.0A)
None
None
None
NAP  A 330 (-3.6A)
 1.19A 1kijB-3nx4A:
undetectable		 1kijB-3nx4A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		5 ILE A 705
ASP A 231
ILE A 615
ALA A 619
ARG A 702
 None
 1.25A 1kijB-3o6xA:
undetectable		 1kijB-3o6xA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 ASP A1111
ILE A 739
PRO A 740
ASP A 838
ILE A 747
 None
 1.28A 1kijB-3psiA:
undetectable		 1kijB-3psiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ren GLYCOSYL HYDROLASE,
FAMILY 8

(Clostridium
perfringens) 		PF01270
(Glyco_hydro_8) 		5 ASP A 196
ARG A 139
ILE A 141
ILE A 163
THR A 199
 None
 1.28A 1kijB-3renA:
undetectable		 1kijB-3renA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl2 SENSOR HISTIDINE
KINASE YYCG

(Bacillus
subtilis) 		PF02518
(HATPase_c) 		5 ASN A 503
ASP A 533
ILE A 538
PRO A 539
THR A 592
 MG  A 701 ( 2.5A)
ATP  A 703 (-3.5A)
ATP  A 703 (-4.5A)
None
ATP  A 703 (-3.9A)
 0.76A 1kijB-3sl2A:
undetectable		 1kijB-3sl2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		5 ASN A 139
ILE A 169
PRO A 170
ILE A 234
ALA A 198
 None
None
EDO  A 610 (-3.8A)
None
None
 1.27A 1kijB-3u24A:
undetectable		 1kijB-3u24A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2k DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		10 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.61A 1kijB-3u2kA:
27.2		 1kijB-3u2kA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		5 GLU A  23
ARG A  55
ILE A  21
ILE A  40
TYR A  14
 None
 1.01A 1kijB-3vseA:
undetectable		 1kijB-3vseA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 GLU A 356
ARG A 396
ILE A 394
ILE A 389
ALA A 385
 None
 1.10A 1kijB-3wfzA:
undetectable		 1kijB-3wfzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		5 ASP B 312
ILE B 229
TYR B 213
ALA B 209
ARG B 251
 None
 1.24A 1kijB-3zg8B:
undetectable		 1kijB-3zg8B:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		7 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
None
 0.71A 1kijB-3zkbA:
44.3		 1kijB-3zkbA:
43.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLU A 317
ARG A 252
ILE A 315
TYR A 323
ALA A 322
 1PE  A1719 (-3.6A)
1PE  A1719 ( 4.6A)
None
None
None
 1.00A 1kijB-4aj9A:
undetectable		 1kijB-4aj9A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b6c DNA GYRASE SUBUNIT B

(Mycolicibacterium
smegmatis) 		PF02518
(HATPase_c) 		8 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
THR A 169
 B5U  A1256 (-3.2A)
B5U  A1256 (-3.6A)
B5U  A1256 (-3.5A)
B5U  A1256 (-3.4A)
B5U  A1256 (-4.3A)
B5U  A1256 (-4.2A)
B5U  A1256 ( 4.4A)
B5U  A1256 (-3.6A)
 0.54A 1kijB-4b6cA:
22.9		 1kijB-4b6cA:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 224
PRO A 225
ILE A  69
ALA A  63
ARG A 214
 None
 1.25A 1kijB-4c23A:
undetectable		 1kijB-4c23A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		7 ASN A  51
GLU A  55
ASP A  78
ARG A  81
ILE A  98
ARG A 140
THR A 172
 0RA  A 301 (-4.7A)
0RA  A 301 (-3.4A)
0RA  A 301 (-3.6A)
0RA  A 301 ( 3.8A)
None
0RA  A 301 (-2.5A)
0RA  A 301 ( 3.9A)
 0.49A 1kijB-4em7A:
29.3		 1kijB-4em7A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		7 ASN A  51
GLU A  55
ASP A  78
ARG A  81
PRO A  84
ILE A  98
THR A 172
 0RA  A 301 (-4.7A)
0RA  A 301 (-3.4A)
0RA  A 301 (-3.6A)
0RA  A 301 ( 3.8A)
0RA  A 301 ( 4.8A)
None
0RA  A 301 ( 3.9A)
 0.71A 1kijB-4em7A:
29.3		 1kijB-4em7A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		5 ARG A2070
ILE A2071
ILE A2061
ALA A2052
THR A2047
 None
 1.14A 1kijB-4f6cA:
undetectable		 1kijB-4f6cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 ASN A  70
ILE A 104
PRO A 105
ILE A 120
THR A 195
 ANP  A1202 ( 2.7A)
None
None
ANP  A1202 (-3.8A)
ANP  A1202 (-3.4A)
 0.82A 1kijB-4gfhA:
28.5		 1kijB-4gfhA:
15.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hxw DNA GYRASE SUBUNIT B

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		7 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.54A 1kijB-4hxwA:
28.8		 1kijB-4hxwA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		8 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.76A 1kijB-4hymA:
37.1		 1kijB-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		7 ASN A  41
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.04A 1kijB-4hymA:
37.1		 1kijB-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		9 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ALA A 122
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.1A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.58A 1kijB-4hz5A:
28.2		 1kijB-4hz5A:
40.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLU A 203
ASP A 581
ARG A 162
TYR A 683
ALA A 211
 None
None
BGC  A 901 (-3.0A)
None
None
 1.14A 1kijB-4i3gA:
undetectable		 1kijB-4i3gA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r HEAVY CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASP H  62
ILE H  82
ILE H 109
TYR H  90
ALA H  88
 None
 1.12A 1kijB-4i3rH:
undetectable		 1kijB-4i3rH:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A 617
ARG A 673
ILE A 618
PRO A 619
ILE A 630
 None
 1.23A 1kijB-4idtA:
undetectable		 1kijB-4idtA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jas HISTIDINE KINASE

(Thermotoga
maritima) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 ASN A 380
ASP A 411
ILE A 416
PRO A 417
ILE A 424
 ADP  A 501 ( 2.7A)
ADP  A 501 (-3.4A)
ADP  A 501 (-4.6A)
None
ADP  A 501 (-3.7A)
 1.23A 1kijB-4jasA:
5.9		 1kijB-4jasA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ASN A 505
ASP A 364
ILE A 496
ALA A 501
THR A 438
 None
 1.21A 1kijB-4jzyA:
undetectable		 1kijB-4jzyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		5 ILE A 118
PRO A 119
ILE A  98
ALA A 130
THR A 141
 None
 1.25A 1kijB-4mo9A:
undetectable		 1kijB-4mo9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		5 GLU A 374
ARG A 372
ILE A 396
PRO A 397
ILE A  84
 2QH  A 602 ( 4.8A)
None
None
None
None
 1.14A 1kijB-4ny4A:
undetectable		 1kijB-4ny4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py5 RIBONUCLEASE

(Thermovibrio
ammonificans) 		PF01351
(RNase_HII) 		5 ARG A 103
ILE A 127
ILE A 216
ALA A 220
THR A 128
 None
 1.25A 1kijB-4py5A:
undetectable		 1kijB-4py5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 ASN A 250
ARG A 285
ILE A 287
PRO A 288
THR A 324
 MG  A 401 ( 2.4A)
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
 1.19A 1kijB-4r39A:
4.6		 1kijB-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 ASN A 250
ASP A 282
ILE A 287
PRO A 288
THR A 324
 MG  A 401 ( 2.4A)
ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
ANP  A 402 (-3.6A)
 0.95A 1kijB-4r39A:
4.6		 1kijB-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 ASP A 282
ILE A 287
PRO A 288
ASP A 290
THR A 324
 ANP  A 402 (-2.7A)
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
ANP  A 402 (-3.6A)
 1.00A 1kijB-4r39A:
4.6		 1kijB-4r39A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 ASN A 250
ARG A 285
ILE A 287
PRO A 288
THR A 324
 MG  A 400 ( 2.5A)
None
ANP  A 401 (-4.3A)
ANP  A 401 ( 4.7A)
ANP  A 401 ( 4.1A)
 1.12A 1kijB-4r3aA:
3.8		 1kijB-4r3aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 ASN A 250
ASP A 282
ILE A 287
PRO A 288
THR A 324
 MG  A 400 ( 2.5A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.3A)
ANP  A 401 ( 4.7A)
ANP  A 401 ( 4.1A)
 0.97A 1kijB-4r3aA:
3.8		 1kijB-4r3aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 ASP A 282
ILE A 287
PRO A 288
ASP A 290
THR A 324
 ANP  A 401 (-3.3A)
ANP  A 401 (-4.3A)
ANP  A 401 ( 4.7A)
None
ANP  A 401 ( 4.1A)
 1.16A 1kijB-4r3aA:
3.8		 1kijB-4r3aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A 291
ILE A 296
TYR A 320
ARG A 292
THR A   9
 None
 1.21A 1kijB-4rybA:
undetectable		 1kijB-4rybA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 GLU A 273
ARG A 219
ASP A 128
ILE A 174
ALA A 190
 None
None
ATP  A 801 (-2.6A)
None
None
 1.10A 1kijB-4u1rA:
undetectable		 1kijB-4u1rA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		7 ASN A  49
GLU A  53
ASP A  76
ARG A  79
ALA A 122
ARG A 138
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 ( 4.3A)
None
XAM  A2000 (-3.6A)
 0.71A 1kijB-4urlA:
44.2		 1kijB-4urlA:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		8 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ALA A 122
THR A 168
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
XAM  A2000 ( 4.3A)
XAM  A2000 (-3.6A)
 0.79A 1kijB-4urlA:
44.2		 1kijB-4urlA:
46.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4urm DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		9 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
THR A 173
 XAM  A2000 (-3.7A)
XAM  A2000 (-2.6A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.5A)
XAM  A2000 ( 4.9A)
None
XAM  A2000 (-4.5A)
XAM  A2000 (-3.8A)
 0.92A 1kijB-4urmA:
29.0		 1kijB-4urmA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4urm DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		9 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ILE A 102
ARG A 144
THR A 173
 XAM  A2000 (-3.7A)
XAM  A2000 (-2.6A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.5A)
XAM  A2000 ( 4.9A)
XAM  A2000 (-4.5A)
None
XAM  A2000 (-3.8A)
 0.58A 1kijB-4urmA:
29.0		 1kijB-4urmA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4urn DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		9 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ALA A 122
ARG A 138
THR A 168
 NOV  A2000 (-3.8A)
NOV  A2000 (-3.4A)
NOV  A2000 (-3.5A)
NOV  A2000 (-3.2A)
NOV  A2000 (-4.1A)
NOV  A2000 (-4.2A)
NOV  A2000 ( 4.6A)
NOV  A2000 (-2.9A)
NOV  A2000 (-3.9A)
 0.78A 1kijB-4urnA:
28.2		 1kijB-4urnA:
32.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		5 ASN A 409
ASP A 449
ARG A 452
ILE A 454
THR A 531
 ACP  A 601 (-2.9A)
ACP  A 601 (-3.8A)
None
ACP  A 601 ( 4.6A)
ACP  A 601 (-3.9A)
 0.88A 1kijB-4xivA:
5.6		 1kijB-4xivA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		9 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ILE A  94
ARG A 136
THR A 165
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
4S4  A 401 ( 3.8A)
 0.48A 1kijB-4zviA:
42.4		 1kijB-4zviA:
45.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2j 4-OXALOCROTONATE
DECARBOXYLASE NAHK

(Pseudomonas
putida) 		no annotation 5 GLU A 109
ILE A 237
ILE A 112
TYR A 253
THR A 238
 MG  A 301 ( 2.8A)
None
None
None
None
 1.28A 1kijB-5d2jA:
undetectable		 1kijB-5d2jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idj CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 ASN A 434
ASP A 479
ILE A 484
PRO A 485
ASP A 487
 ADP  A 600 ( 2.9A)
ADP  A 600 (-3.3A)
ADP  A 600 (-4.5A)
None
None
 1.25A 1kijB-5idjA:
6.6		 1kijB-5idjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idj CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 ASN A 434
ASP A 479
ILE A 484
PRO A 485
ILE A 492
 ADP  A 600 ( 2.9A)
ADP  A 600 (-3.3A)
ADP  A 600 (-4.5A)
None
ADP  A 600 (-4.3A)
 1.14A 1kijB-5idjA:
6.6		 1kijB-5idjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idm CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF02518
(HATPase_c) 		6 ASN A 434
ASP A 479
ILE A 484
PRO A 485
ASP A 487
ILE A 492
 MG  A 602 ( 2.6A)
ANP  A 601 (-3.5A)
ANP  A 601 (-4.5A)
None
None
ANP  A 601 ( 4.0A)
 1.32A 1kijB-5idmA:
6.6		 1kijB-5idmA:
20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		8 ASN A  51
GLU A  55
ASP A  78
ARG A  81
PRO A  84
ILE A  98
ARG A 140
THR A 172
 MG  A 503 ( 2.5A)
ANP  A 501 (-3.2A)
ANP  A 501 (-2.6A)
None
None
ANP  A 501 ( 3.4A)
None
ANP  A 501 (-3.5A)
 0.71A 1kijB-5j5pA:
46.0		 1kijB-5j5pA:
46.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 ILE A 280
ASP A 275
ILE A  13
ALA A 100
THR A 283
 None
 1.17A 1kijB-5ks1A:
2.7		 1kijB-5ks1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		5 GLU A 228
ASP A 155
ILE A  32
ALA A  35
THR A 232
 None
NAP  A 301 ( 3.8A)
NAP  A 301 (-3.7A)
None
None
 1.28A 1kijB-5tgdA:
undetectable		 1kijB-5tgdA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 GLU A 161
ASP A 420
ARG A 120
TYR A 520
ALA A 169
 None
None
GOL  A 801 (-3.6A)
None
None
 1.09A 1kijB-5wabA:
undetectable		 1kijB-5wabA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 ASP A 192
ILE A 392
PRO A 391
ILE A 361
ALA A 257
 MDO  A 190 ( 4.4A)
None
None
None
None
 1.14A 1kijB-6at7A:
undetectable		 1kijB-6at7A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		no annotation 5 ILE A 257
PRO A 258
ASP A 260
ILE A 191
TYR A 248
 None
 1.16A 1kijB-6fthA:
undetectable		 1kijB-6fthA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 5 ASN N 197
ILE N 265
PRO N 262
ILE N 344
THR N 268
 None
 1.18A 1kijB-6g72N:
undetectable		 1kijB-6g72N:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		3 ASP A 212
PHE A  88
VAL A 209
 None
 0.79A 1kijB-1bt4A:
0.0		 1kijB-1bt4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		3 ASP B  96
PHE B  93
VAL B 192
 None
 0.78A 1kijB-1ezvB:
0.5		 1kijB-1ezvB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		3 ASP B 276
PHE B 139
VAL B 269
 None
 0.75A 1kijB-1fftB:
0.3		 1kijB-1fftB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		3 ASP A 140
PHE A  69
VAL A 219
 MG  A5555 (-2.6A)
None
None
 0.75A 1kijB-1fiuA:
0.0		 1kijB-1fiuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		3 ASP A 181
PHE A 222
VAL A 185
 None
 0.69A 1kijB-1ia5A:
0.0		 1kijB-1ia5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		3 ASP A 128
PHE A  87
VAL A 125
 None
 0.76A 1kijB-1mdwA:
0.0		 1kijB-1mdwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		3 ASP A 121
PHE A  16
VAL A 118
 None
 0.59A 1kijB-1miqA:
0.0		 1kijB-1miqA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ASP A  68
PHE A  40
VAL A  65
 None
 0.72A 1kijB-1pw5A:
0.0		 1kijB-1pw5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ASP A  46
PHE A  49
VAL A  43
 None
 0.66A 1kijB-1q1qA:
undetectable		 1kijB-1q1qA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ASP A  61
PHE A  64
VAL A  58
 None
 0.70A 1kijB-1q20A:
undetectable		 1kijB-1q20A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 283
PHE A 349
VAL A 308
 None
 0.65A 1kijB-1qhoA:
undetectable		 1kijB-1qhoA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txl METAL-BINDING
PROTEIN YODA

(Escherichia
coli) 		PF09223
(ZinT) 		3 ASP A  58
PHE A 163
VAL A 114
 None
 0.69A 1kijB-1txlA:
undetectable		 1kijB-1txlA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7i HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		3 ASP A  73
PHE A  11
VAL A 125
 None
 0.78A 1kijB-1u7iA:
undetectable		 1kijB-1u7iA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		3 ASP A 148
PHE A 151
VAL A 361
 None
 0.72A 1kijB-1v4vA:
undetectable		 1kijB-1v4vA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT

(Streptococcus
dysgalactiae) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		3 ASP A  67
PHE A  27
VAL A  98
 None
 0.69A 1kijB-1vj7A:
undetectable		 1kijB-1vj7A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwy THIOREDOXIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF06201
(PITH) 		3 ASP A  33
PHE A 149
VAL A  55
 None
 0.68A 1kijB-1wwyA:
undetectable		 1kijB-1wwyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		3 ASP A 734
PHE A 729
VAL A  23
 None
 0.69A 1kijB-2b0tA:
undetectable		 1kijB-2b0tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 ASP A 676
PHE A 708
VAL A 704
 None
 0.74A 1kijB-2cn3A:
undetectable		 1kijB-2cn3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 ASP A 244
PHE A 239
VAL A 251
 None
 0.72A 1kijB-2fgeA:
undetectable		 1kijB-2fgeA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzq PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN

(Plasmodium
vivax) 		PF01161
(PBP) 		3 ASP A  90
PHE A  74
VAL A 173
 None
 0.78A 1kijB-2gzqA:
undetectable		 1kijB-2gzqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 252
PHE A 271
VAL A 205
 None
 0.78A 1kijB-2ifyA:
undetectable		 1kijB-2ifyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		3 ASP A 323
PHE A 330
VAL A 337
 None
 0.61A 1kijB-2j6hA:
1.7		 1kijB-2j6hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8p 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		3 ASP A 114
PHE A 109
VAL A 130
 None
 0.77A 1kijB-2o8pA:
undetectable		 1kijB-2o8pA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS

(Pyrococcus
abyssi) 		PF03657
(UPF0113) 		3 ASP A  42
PHE A  81
VAL A  68
 None
 0.73A 1kijB-2p38A:
undetectable		 1kijB-2p38A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 ASP B  52
PHE B  48
VAL B 117
 None
 0.67A 1kijB-2pffB:
undetectable		 1kijB-2pffB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzj TWO-COMPONENT
RESPONSE REGULATOR

(Clostridioides
difficile) 		PF00072
(Response_reg) 		3 ASP A 100
PHE A  53
VAL A 115
 None
 0.73A 1kijB-2qzjA:
undetectable		 1kijB-2qzjA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ASP A 239
PHE A  46
VAL A 236
 None
 0.57A 1kijB-2wyhA:
undetectable		 1kijB-2wyhA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		3 ASP A  30
PHE A 404
VAL A 468
 None
 0.78A 1kijB-2x1mA:
undetectable		 1kijB-2x1mA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 ASP C 144
PHE C 139
VAL C 202
 None
 0.76A 1kijB-3aizC:
undetectable		 1kijB-3aizC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbn CONSERVED PROTEIN
MTH639

(Methanothermobacter
thermautotrophicus) 		PF04027
(DUF371) 		3 ASP A 133
PHE A  44
VAL A  88
 None
 0.74A 1kijB-3cbnA:
undetectable		 1kijB-3cbnA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 ASP A 155
PHE A 237
VAL A 164
 None
 0.78A 1kijB-3ce6A:
undetectable		 1kijB-3ce6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ASP A 669
PHE A 736
VAL A 666
 None
 0.77A 1kijB-3cf0A:
undetectable		 1kijB-3cf0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv2 MALATE SYNTHASE A

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ASP A 304
PHE A 307
VAL A 301
 None
 0.74A 1kijB-3cv2A:
undetectable		 1kijB-3cv2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989

(Ruegeria
pomeroyi) 		PF09347
(DUF1989) 		3 ASP A 128
PHE A 224
VAL A 196
 None
 0.74A 1kijB-3di4A:
undetectable		 1kijB-3di4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52

(Homo sapiens) 		PF00270
(DEAD) 		3 ASP A 321
PHE A 331
VAL A 317
 None
 0.74A 1kijB-3dkpA:
undetectable		 1kijB-3dkpA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		3 ASP A 292
PHE A 494
VAL A 472
 None
 0.78A 1kijB-3do6A:
undetectable		 1kijB-3do6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1

(Streptococcus
pneumoniae) 		PF01625
(PMSR)
PF01641
(SelR) 		3 ASP A  76
PHE A  72
VAL A 123
 None
 0.73A 1kijB-3e0mA:
undetectable		 1kijB-3e0mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		3 ASP A  38
PHE A 305
VAL A  67
 None
 0.55A 1kijB-3ekmA:
undetectable		 1kijB-3ekmA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASP A 573
PHE A 667
VAL A 577
 None
 0.74A 1kijB-3fawA:
undetectable		 1kijB-3fawA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcn AN ALPHA-HELICAL
PROTEIN OF UNKNOWN
FUNCTION (PFAM01724)

(Rhodospirillum
rubrum) 		PF01724
(DUF29) 		3 ASP A 153
PHE A 150
VAL A  68
 None
 0.50A 1kijB-3fcnA:
undetectable		 1kijB-3fcnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ASP A 544
PHE A 157
VAL A  99
 EDO  A  18 ( 3.6A)
None
None
 0.74A 1kijB-3ihvA:
undetectable		 1kijB-3ihvA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		3 ASP A 338
PHE A 299
VAL A 350
 None
 0.65A 1kijB-3iiwA:
undetectable		 1kijB-3iiwA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		3 ASP A 392
PHE A 408
VAL A 464
 None
 0.77A 1kijB-3k40A:
undetectable		 1kijB-3k40A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		3 ASP A 141
PHE A 110
VAL A 138
 None
 0.78A 1kijB-3ll9A:
undetectable		 1kijB-3ll9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfg DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49

([Candida]
glabrata) 		PF06870
(RNA_pol_I_A49) 		3 ASP A  32
PHE A  35
VAL A  29
 None
 0.71A 1kijB-3nfgA:
undetectable		 1kijB-3nfgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg5 UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF13614
(AAA_31) 		3 ASP A 177
PHE A 350
VAL A 156
 None
 0.52A 1kijB-3pg5A:
undetectable		 1kijB-3pg5A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 3 ASP X  91
PHE X  38
VAL X  88
 None
 0.77A 1kijB-3rj2X:
undetectable		 1kijB-3rj2X:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		3 ASP X  48
PHE X 245
VAL X  42
 None
 0.71A 1kijB-3ss7X:
undetectable		 1kijB-3ss7X:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvl THIAMINE-TRIPHOSPHAT
ASE

(Homo sapiens) 		PF01928
(CYTH) 		3 ASP A 147
PHE A  12
VAL A 144
 None
 0.78A 1kijB-3tvlA:
undetectable		 1kijB-3tvlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		3 ASP A 141
PHE A 101
VAL A  81
 None
 0.68A 1kijB-3uboA:
undetectable		 1kijB-3uboA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 ASP A 456
PHE A 446
VAL A 435
 None
 0.71A 1kijB-3uemA:
undetectable		 1kijB-3uemA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A  34
PHE A  47
VAL A  95
 None
 0.66A 1kijB-3vwaA:
undetectable		 1kijB-3vwaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		3 ASP A 586
PHE A 617
VAL A 579
 None
 0.78A 1kijB-4bl3A:
undetectable		 1kijB-4bl3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASP A 320
PHE A 368
VAL A 350
 None
 0.75A 1kijB-4dzaA:
undetectable		 1kijB-4dzaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		3 ASP A 252
PHE A 247
VAL A 282
 None
 0.72A 1kijB-4fvaA:
undetectable		 1kijB-4fvaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im9 DNA PRIMASE

(Vibrio cholerae) 		PF08278
(DnaG_DnaB_bind) 		3 ASP A 103
PHE A  98
VAL A  31
 None
 0.71A 1kijB-4im9A:
undetectable		 1kijB-4im9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		3 ASP A 252
PHE A 319
VAL A 255
 None
 0.78A 1kijB-4jc0A:
undetectable		 1kijB-4jc0A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 147
PHE A 149
VAL A 144
 None
 0.54A 1kijB-4kt1A:
undetectable		 1kijB-4kt1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 3 ASP A 399
PHE A 382
VAL A 431
 None
 0.75A 1kijB-4l3aA:
undetectable		 1kijB-4l3aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8n PDZ DOMAIN PROTEIN

(Parabacteroides
distasonis) 		PF00595
(PDZ)
PF13590
(DUF4136) 		3 ASP A 157
PHE A 161
VAL A 154
 None
 0.73A 1kijB-4l8nA:
undetectable		 1kijB-4l8nA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 150
PHE A 152
VAL A 147
 None
 0.69A 1kijB-4li2A:
undetectable		 1kijB-4li2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		3 ASP A 139
PHE A  65
VAL A 101
 None
 0.62A 1kijB-4m0dA:
undetectable		 1kijB-4m0dA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqg MITROCOMIN

(Mitrocoma
cellularia) 		PF13202
(EF-hand_5) 		3 ASP A 163
PHE A 157
VAL A 132
 None
 0.52A 1kijB-4nqgA:
undetectable		 1kijB-4nqgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASP A  60
PHE A   4
VAL A  64
 None
 0.75A 1kijB-4nreA:
undetectable		 1kijB-4nreA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		3 ASP A  65
PHE A  52
VAL A 125
 None
 0.79A 1kijB-4q3rA:
undetectable		 1kijB-4q3rA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7g LEUCOTOXIN LUKDV

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 ASP A 180
PHE A 251
VAL A 192
 None
 0.72A 1kijB-4q7gA:
undetectable		 1kijB-4q7gA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 147
PHE A 149
VAL A 144
 None
 0.59A 1kijB-4qxeA:
undetectable		 1kijB-4qxeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ASP A 147
PHE A 149
VAL A 144
 None
 0.60A 1kijB-4qxfA:
undetectable		 1kijB-4qxfA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		3 ASP A 122
PHE A 136
VAL A  70
 None
None
KCX  A 138 ( 4.8A)
 0.78A 1kijB-4rdyA:
undetectable		 1kijB-4rdyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF05259
(Herpes_UL1)
PF17488
(Herpes_glycoH_C) 		3 ASP B 152
PHE B 155
VAL A 224
 None
 0.71A 1kijB-4xhjB:
undetectable		 1kijB-4xhjB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 ASP A  26
PHE A  49
VAL A  23
 None
 0.78A 1kijB-4y1yA:
undetectable		 1kijB-4y1yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ASP A 430
PHE A 538
VAL A 427
 None
 0.75A 1kijB-4zohA:
undetectable		 1kijB-4zohA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0l FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pyogenes) 		PF08341
(TED) 		3 ASP A 132
PHE A 253
VAL A 269
 None
 0.76A 1kijB-5a0lA:
undetectable		 1kijB-5a0lA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 ASP A  36
PHE A 141
VAL A  92
 None
 0.66A 1kijB-5aq6A:
undetectable		 1kijB-5aq6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		3 ASP A 163
PHE A 158
VAL A   6
 None
 0.66A 1kijB-5b4sA:
1.0		 1kijB-5b4sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		3 ASP A 134
PHE A 162
VAL A 178
 None
 0.77A 1kijB-5dihA:
undetectable		 1kijB-5dihA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eip YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		3 ASP A 460
PHE A 393
VAL A 374
 None
 0.75A 1kijB-5eipA:
undetectable		 1kijB-5eipA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 ZONADHESIN

(Komagataella
phaffii) 		no annotation 3 ASP U  25
PHE U 150
VAL U  28
 None
 0.79A 1kijB-5fx8U:
undetectable		 1kijB-5fx8U:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h34 METHIONINE-TRNA
LIGASE

(Nanoarchaeum
equitans) 		PF01588
(tRNA_bind) 		3 ASP A 681
PHE A 677
VAL A 775
 None
 0.66A 1kijB-5h34A:
undetectable		 1kijB-5h34A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8a YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		3 ASP A 460
PHE A 393
VAL A 374
 None
 0.77A 1kijB-5h8aA:
undetectable		 1kijB-5h8aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ASP A 212
PHE A 256
VAL A 209
 None
 0.56A 1kijB-5i2tA:
undetectable		 1kijB-5i2tA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF) 		3 ASP A 106
PHE A 118
VAL A  81
 None
 0.70A 1kijB-5iaaA:
undetectable		 1kijB-5iaaA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		3 ASP A 564
PHE A 681
VAL A 567
 None
 0.68A 1kijB-5ikpA:
undetectable		 1kijB-5ikpA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in7 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN

(Homo sapiens) 		PF03607
(DCX) 		3 ASP A 167
PHE A 138
VAL A 153
 None
 0.75A 1kijB-5in7A:
undetectable		 1kijB-5in7A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 ASP A 118
PHE A 101
VAL A  93
 None
 0.58A 1kijB-5jxlA:
undetectable		 1kijB-5jxlA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		3 ASP A 347
PHE A 342
VAL A 404
 None
 0.77A 1kijB-5kdxA:
undetectable		 1kijB-5kdxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		3 ASP A 694
PHE A 815
VAL A 697
 None
 0.72A 1kijB-5lrbA:
undetectable		 1kijB-5lrbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc7 COATOMER SUBUNIT
ZETA-1

(Homo sapiens) 		PF01217
(Clat_adaptor_s) 		3 ASP A  74
PHE A  77
VAL A 109
 None
 0.76A 1kijB-5mc7A:
undetectable		 1kijB-5mc7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 ASP B 215
PHE B 178
VAL B 212
 None
 0.68A 1kijB-5nd1B:
undetectable		 1kijB-5nd1B:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE

(Meiothermus
ruber) 		no annotation 3 ASP A 102
PHE A 152
VAL A 107
 None
 0.75A 1kijB-5o6kA:
undetectable		 1kijB-5o6kA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8m YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		no annotation 3 ASP A 460
PHE A 393
VAL A 374
 None
 0.72A 1kijB-5o8mA:
undetectable		 1kijB-5o8mA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oac MAJOR CAPSID PROTEIN

(unidentified
phage) 		no annotation 3 ASP A  52
PHE A  25
VAL A  56
 None
 0.75A 1kijB-5oacA:
undetectable		 1kijB-5oacA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ow6 VP1

(Cucumber mosaic
virus) 		PF00760
(Cucumo_coat) 		3 ASP A 191
PHE A 117
VAL A 121
 None
 0.70A 1kijB-5ow6A:
undetectable		 1kijB-5ow6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		3 ASP A 175
PHE A 164
VAL A 179
 None
 0.65A 1kijB-5suoA:
undetectable		 1kijB-5suoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		3 ASP A 301
PHE A 296
VAL A 203
 None
 0.74A 1kijB-5tsqA:
undetectable		 1kijB-5tsqA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		3 ASP A 230
PHE A 178
VAL A 285
 CA  A 401 (-2.6A)
None
None
 0.66A 1kijB-5uljA:
undetectable		 1kijB-5uljA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		3 ASP A 486
PHE A 517
VAL A 478
 None
 0.72A 1kijB-5uy7A:
undetectable		 1kijB-5uy7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c13 -

(-) 		no annotation 3 ASP A1242
PHE A1149
VAL A1227
 None
 0.72A 1kijB-6c13A:
undetectable		 1kijB-6c13A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 3 ASP A 116
PHE A  36
VAL A  60
 None
 0.76A 1kijB-6fm9A:
1.2		 1kijB-6fm9A:
undetectable