SIMILAR PATTERNS OF AMINO ACIDS FOR 1KIF_D_BEZD349

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 TYR A 207
TYR A 208
ILE A 102
GLY A 125
 None
 1.18A 1kifD-1aj8A:
undetectable		 1kifD-1aj8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.08A 1kifD-1cwuA:
4.7		 1kifD-1cwuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 TYR A 470
TYR A 526
ILE A 175
GLY A 402
 None
 1.05A 1kifD-1e8tA:
undetectable		 1kifD-1e8tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 TYR A  53
TYR A  63
ILE A  75
GLY A 132
 None
 1.07A 1kifD-1h14A:
undetectable		 1kifD-1h14A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 473
ILE A 398
ARG A 391
GLY A 507
 None
 1.05A 1kifD-1jedA:
2.1		 1kifD-1jedA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.00A 1kifD-1nhwA:
2.8		 1kifD-1nhwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		4 TYR A 407
TYR A 333
ILE A 335
GLY A 388
 None
 0.93A 1kifD-1nw1A:
undetectable		 1kifD-1nw1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 TYR A 241
ILE A 214
ARG A 103
GLY A 375
 MTQ  A1394 (-4.3A)
MTQ  A1394 ( 4.5A)
None
None
 1.17A 1kifD-1ogpA:
undetectable		 1kifD-1ogpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 TYR A 298
ILE A 192
ARG A 232
GLY A 231
 None
 1.22A 1kifD-1p2zA:
undetectable		 1kifD-1p2zA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.05A 1kifD-1s4fA:
undetectable		 1kifD-1s4fA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdz MEXICAIN

(Jacaratia
mexicana) 		PF00112
(Peptidase_C1) 		4 TYR A 166
TYR A   1
ARG A 191
GLY A 167
 None
 1.31A 1kifD-2bdzA:
undetectable		 1kifD-2bdzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		4 TYR A 273
ILE A 250
ARG A 188
GLY A 189
 None
 1.32A 1kifD-2dulA:
3.2		 1kifD-2dulA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifD-2foiA:
2.8		 1kifD-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzv PUTATIVE ARSENICAL
RESISTANCE PROTEIN

(Shigella
flexneri) 		PF03358
(FMN_red) 		4 TYR A 195
ILE A 198
ARG A 188
GLY A 187
 None
 1.04A 1kifD-2fzvA:
3.9		 1kifD-2fzvA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mdi HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00397
(WW) 		4 TYR A  34
TYR A  32
ILE A  31
GLY A   1
 None
 1.15A 1kifD-2mdiA:
undetectable		 1kifD-2mdiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol3 ALLOGENEIC H-2KBM8
MHC CLASS I MOLECULE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR H  85
TYR H 118
ILE H  95
GLY H  83
 None
 1.22A 1kifD-2ol3H:
undetectable		 1kifD-2ol3H:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		4 TYR A 217
TYR A 174
ILE A 300
GLY A 245
 None
 1.11A 1kifD-2p5uA:
4.9		 1kifD-2p5uA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q03 UNCHARACTERIZED
PROTEIN

(Shewanella
denitrificans) 		PF11528
(DUF3224) 		4 TYR A  42
TYR A 130
ILE A 132
GLY A  48
 None
 1.03A 1kifD-2q03A:
undetectable		 1kifD-2q03A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.99A 1kifD-2r7eB:
undetectable		 1kifD-2r7eB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.13A 1kifD-2va8A:
undetectable		 1kifD-2va8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 TYR A 250
TYR A 193
ILE A 199
GLY A 249
 None
 1.21A 1kifD-2vy0A:
undetectable		 1kifD-2vy0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.14A 1kifD-2y3sA:
undetectable		 1kifD-2y3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.06A 1kifD-2y8vA:
undetectable		 1kifD-2y8vA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Methanocaldococcus
jannaschii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		4 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifD-2yzrA:
undetectable		 1kifD-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		4 TYR A 257
TYR A 260
ILE A 273
GLY A 253
 None
 1.24A 1kifD-2zbmA:
undetectable		 1kifD-2zbmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		4 TYR A 356
TYR A 357
ILE A 300
GLY A 230
 None
 1.19A 1kifD-3aarA:
undetectable		 1kifD-3aarA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifD-3am3A:
4.4		 1kifD-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ap1 PROTEIN-TYROSINE
SULFOTRANSFERASE 2

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 TYR A 325
TYR A 334
ARG A 186
GLY A 185
 None
 1.09A 1kifD-3ap1A:
undetectable		 1kifD-3ap1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A 563
TYR A 549
ILE A 578
GLY A 559
 None
 1.30A 1kifD-3bgaA:
undetectable		 1kifD-3bgaA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 TYR A  93
TYR A  61
ILE A  65
ARG A  96
 None
 1.08A 1kifD-3chiA:
undetectable		 1kifD-3chiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A 539
TYR A 525
ILE A 554
GLY A 535
 None
 1.28A 1kifD-3decA:
undetectable		 1kifD-3decA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		4 TYR A 157
TYR A 186
ILE A 172
GLY A 146
 None
 1.28A 1kifD-3efvA:
3.4		 1kifD-3efvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 TYR A 277
TYR A 440
ILE A  62
GLY A 276
 None
 1.32A 1kifD-3ehmA:
undetectable		 1kifD-3ehmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		4 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.09A 1kifD-3f4bA:
4.4		 1kifD-3f4bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 TYR A  54
ILE A  69
ARG A  57
GLY A  30
 None
 1.16A 1kifD-3flbA:
undetectable		 1kifD-3flbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 TYR A 264
ILE A 258
ARG A 272
GLY A 271
 None
 1.00A 1kifD-3gecA:
undetectable		 1kifD-3gecA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 TYR A 165
TYR A 182
ILE A 176
GLY A 190
 None
 1.34A 1kifD-3icxA:
undetectable		 1kifD-3icxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id6 PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 TYR A 165
TYR A 182
ILE A 176
GLY A 190
 None
 1.32A 1kifD-3id6A:
undetectable		 1kifD-3id6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jts MHC CLASS I
MAMU-A*02

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TYR A  85
TYR A 118
ILE A  95
GLY A  83
 None
 1.27A 1kifD-3jtsA:
undetectable		 1kifD-3jtsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 TYR A 128
TYR A 127
ILE A 299
GLY A 246
 None
 1.04A 1kifD-3n5mA:
undetectable		 1kifD-3n5mA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 TYR A1361
ILE A1457
ARG A1461
GLY A1389
 None
 1.17A 1kifD-3opuA:
undetectable		 1kifD-3opuA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 4 TYR I 292
TYR I 332
ILE I 346
GLY I 326
 None
 1.33A 1kifD-3opyI:
2.2		 1kifD-3opyI:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TYR A 380
ILE A 291
ARG A 283
GLY A 248
 None
 1.13A 1kifD-3plrA:
4.4		 1kifD-3plrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TYR A 380
ILE A 364
ARG A 283
GLY A 248
 None
 1.30A 1kifD-3plrA:
4.4		 1kifD-3plrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 474
TYR A 470
ILE A 446
GLY A 497
 None
 1.23A 1kifD-3popA:
undetectable		 1kifD-3popA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4n UNCHARACTERIZED
PROTEIN MJ0754

(Methanocaldococcus
jannaschii) 		PF09968
(DUF2202) 		4 TYR A 161
TYR A 171
ILE A 166
GLY A 109
 None
 1.32A 1kifD-3q4nA:
undetectable		 1kifD-3q4nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4n UNCHARACTERIZED
PROTEIN MJ0754

(Methanocaldococcus
jannaschii) 		PF09968
(DUF2202) 		4 TYR A 161
TYR A 171
ILE A 174
GLY A 109
 None
 1.16A 1kifD-3q4nA:
undetectable		 1kifD-3q4nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4o UNCHARACTERIZED
PROTEIN MJ0754

(Methanocaldococcus
jannaschii) 		PF09968
(DUF2202) 		4 TYR A 161
TYR A 171
ILE A 166
GLY A 109
 None
 1.27A 1kifD-3q4oA:
undetectable		 1kifD-3q4oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4o UNCHARACTERIZED
PROTEIN MJ0754

(Methanocaldococcus
jannaschii) 		PF09968
(DUF2202) 		4 TYR A 161
TYR A 171
ILE A 174
GLY A 109
 None
 1.12A 1kifD-3q4oA:
undetectable		 1kifD-3q4oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 TYR A 240
ILE A 371
ARG A 323
GLY A 236
 None
 1.33A 1kifD-3u5uA:
undetectable		 1kifD-3u5uA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		4 TYR A 288
TYR A 297
ILE A 328
GLY A 281
 None
 1.31A 1kifD-3vsmA:
undetectable		 1kifD-3vsmA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 TYR A 224
TYR A 228
ARG A 283
GLY A 313
 3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
 0.80A 1kifD-3w4kA:
53.8		 1kifD-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 TYR A 228
ILE A 230
ARG A 283
GLY A 313
 3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
 0.33A 1kifD-3w4kA:
53.8		 1kifD-3w4kA:
84.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhc METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		4 TYR A  89
TYR A  57
ARG A 128
GLY A  90
 None
 1.14A 1kifD-4bhcA:
undetectable		 1kifD-4bhcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.25A 1kifD-4crmX:
undetectable		 1kifD-4crmX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 TYR A 136
TYR A 201
ILE A 204
GLY A 135
 None
 1.33A 1kifD-4dgkA:
10.4		 1kifD-4dgkA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Pyrococcus
horikoshii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		4 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 1kifD-4firA:
undetectable		 1kifD-4firA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.05A 1kifD-4fwtA:
undetectable		 1kifD-4fwtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzh HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 TYR A 470
TYR A 526
ILE A 175
GLY A 402
 None
 1.06A 1kifD-4fzhA:
undetectable		 1kifD-4fzhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifD-4gb7A:
undetectable		 1kifD-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		4 TYR A 518
TYR A 483
ILE A 492
GLY A 398
 None
 1.27A 1kifD-4gkpA:
undetectable		 1kifD-4gkpA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi0 UREASE ACCESSORY
PROTEIN UREH

(Helicobacter
pylori) 		PF01774
(UreD) 		4 TYR B 138
ILE B 128
ARG B  95
GLY B 124
 None
 1.30A 1kifD-4hi0B:
undetectable		 1kifD-4hi0B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 TYR A 639
TYR A 627
ILE A 186
GLY A 237
 GOL  A 709 (-3.5A)
GOL  A 709 (-4.7A)
None
GOL  A 709 (-3.8A)
 1.29A 1kifD-4jclA:
undetectable		 1kifD-4jclA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 4 TYR D 463
TYR D 523
ILE D 164
GLY D 391
 None
 0.99A 1kifD-4jf7D:
undetectable		 1kifD-4jf7D:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifD-4jx8A:
4.6		 1kifD-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 TYR A  46
TYR A  47
ILE A 296
GLY A 301
 None
 1.31A 1kifD-4lx4A:
undetectable		 1kifD-4lx4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		4 TYR A 161
TYR A 160
ILE A 137
GLY A 183
 None
 1.02A 1kifD-4m0vA:
2.1		 1kifD-4m0vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		4 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 301 ( 4.9A)
None
None
None
 1.13A 1kifD-4m87A:
4.1		 1kifD-4m87A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		4 TYR A 306
TYR A 322
ILE A 270
GLY A 307
 None
 1.18A 1kifD-4mmhA:
undetectable		 1kifD-4mmhA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk5 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Candidatus
Liberibacter
asiaticus) 		PF13561
(adh_short_C2) 		4 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 None
 1.13A 1kifD-4nk5A:
5.1		 1kifD-4nk5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic BET V I
ALLERGEN-LIKE

(Oryza sativa) 		PF10604
(Polyketide_cyc2) 		4 TYR A  73
ILE A  63
ARG A  94
GLY A  68
 None
 1.11A 1kifD-4oicA:
undetectable		 1kifD-4oicA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ose PUTATIVE HYDROLASE

(Rickettsia
typhi) 		PF00561
(Abhydrolase_1) 		4 TYR A  85
ILE A  20
ARG A  73
GLY A  72
 None
 0.94A 1kifD-4oseA:
undetectable		 1kifD-4oseA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 287
TYR A 319
ILE A 305
GLY A 219
 None
 1.26A 1kifD-4rjkA:
undetectable		 1kifD-4rjkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		4 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.33A 1kifD-4rkkA:
undetectable		 1kifD-4rkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 589
TYR A 622
ILE A 555
GLY A 539
 None
 1.33A 1kifD-4xeuA:
undetectable		 1kifD-4xeuA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.91A 1kifD-4xhjA:
undetectable		 1kifD-4xhjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.23A 1kifD-4zwjA:
undetectable		 1kifD-4zwjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Pseudomonas sp.
WBC-3;
Pseudomonas sp.
WBC-3) 		no annotation
no annotation 		4 TYR A  31
ILE W 287
ARG W 284
GLY W 276
 None
 1.18A 1kifD-4zxcA:
undetectable		 1kifD-4zxcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 TYR A 367
TYR A 363
ILE A 416
GLY A 372
 EDO  A1579 (-4.9A)
None
None
None
 1.17A 1kifD-5a29A:
undetectable		 1kifD-5a29A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		4 TYR A 480
TYR A 540
ILE A 181
GLY A 408
 None
SLT  A 606 (-4.7A)
None
None
 0.93A 1kifD-5b2dA:
undetectable		 1kifD-5b2dA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		4 TYR A 321
TYR A 322
ILE A 405
GLY A 414
 None
 1.07A 1kifD-5bwiA:
undetectable		 1kifD-5bwiA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 TYR A 327
TYR A 332
ILE A 296
GLY A 324
 None
 1.22A 1kifD-5i2hA:
3.1		 1kifD-5i2hA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		4 TYR A 209
TYR A 293
ILE A 292
GLY A 214
 None
 1.32A 1kifD-5i6sA:
undetectable		 1kifD-5i6sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		4 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.03A 1kifD-5iuyA:
undetectable		 1kifD-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		4 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.34A 1kifD-5jsiA:
undetectable		 1kifD-5jsiA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifD-5koiA:
5.4		 1kifD-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 TYR A 370
TYR A 417
ILE A 416
GLY A 372
 None
None
None
ICS  A 502 (-3.5A)
 1.15A 1kifD-5kojA:
undetectable		 1kifD-5kojA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 TYR A 395
TYR A 403
ILE A 416
GLY A 372
 None
None
None
ICS  A 502 (-3.5A)
 1.29A 1kifD-5kojA:
undetectable		 1kifD-5kojA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 TYR A 286
ILE A 185
ARG A 221
GLY A 220
 None
 1.21A 1kifD-5ldnA:
undetectable		 1kifD-5ldnA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngh ODORANT BINDING
PROTEIN 3

(Ailuropoda
melanoleuca) 		no annotation 4 TYR A  19
ILE A  46
ARG A 163
GLY A 164
 None
 1.33A 1kifD-5nghA:
undetectable		 1kifD-5nghA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 TYR A 115
TYR A 106
ILE A 107
GLY A 113
 None
 1.16A 1kifD-5suoA:
undetectable		 1kifD-5suoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7a BH0236 PROTEIN

(Bacillus
halodurans) 		no annotation 4 TYR A1018
TYR A1000
ILE A 951
GLY A 929
 None
 1.29A 1kifD-5t7aA:
undetectable		 1kifD-5t7aA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		4 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.29A 1kifD-5ugzA:
undetectable		 1kifD-5ugzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlz DNA REPAIR PROTEIN
XRCC4,MYOSIN-7

(Homo sapiens) 		no annotation 4 TYR C  84
TYR C  94
ILE C  34
GLY C  77
 None
 1.14A 1kifD-5wlzC:
undetectable		 1kifD-5wlzC:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		4 TYR A 326
TYR A 335
ARG A 187
GLY A 186
 None
 1.07A 1kifD-5wrjA:
2.1		 1kifD-5wrjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  52
TYR A  50
ILE A 110
GLY A 301
 None
 1.07A 1kifD-5xd7A:
undetectable		 1kifD-5xd7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus) 		no annotation 4 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.19A 1kifD-5xsxA:
undetectable		 1kifD-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 1kifD-5yj6A:
undetectable		 1kifD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 TYR A 367
ILE A  56
ARG A  37
GLY A  42
 None
None
FAD  A 507 (-4.4A)
FAD  A 507 (-3.1A)
 1.22A 1kifD-6cr0A:
12.2		 1kifD-6cr0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 4 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 1kifD-6f74A:
undetectable		 1kifD-6f74A:
undetectable