SIMILAR PATTERNS OF AMINO ACIDS FOR 1KIA_D_SAMD3293_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 ILE A1372
ARG A1375
ASP A1278
ASN A1321
 None
 1.20A 1kiaD-2ix8A:
1.0		 1kiaD-2ix8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		4 TRP A 116
ILE A 261
ASP A 123
ASN A 157
 None
 1.48A 1kiaD-2radA:
1.3		 1kiaD-2radA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 4 ILE O 183
ARG O 236
ASP O 317
ASN O 324
 None
SO4  O6920 (-3.7A)
None
None
 1.43A 1kiaD-3e6aO:
3.7		 1kiaD-3e6aO:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 TRP A 232
ILE A  83
ASP A 192
ASN A 164
 None
None
LLP  A 221 ( 2.8A)
LLP  A 221 ( 3.9A)
 1.44A 1kiaD-3op7A:
2.3		 1kiaD-3op7A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 ILE A 191
ARG A  50
ASP A 229
ASN A 255
 None
DMA  A 500 (-3.1A)
None
None
 1.33A 1kiaD-3q1oA:
0.0		 1kiaD-3q1oA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgu LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF00155
(Aminotran_1_2) 		4 TRP A 293
ILE A 135
ASP A 248
ASN A 220
 GOL  A 452 (-4.4A)
None
None
None
 1.42A 1kiaD-3qguA:
0.2		 1kiaD-3qguA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1

(Mus musculus;
Homo sapiens) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		4 ILE A 224
ARG A 221
ASP B2005
ASN B2008
 None
 1.29A 1kiaD-3ro2A:
undetectable		 1kiaD-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		4 ILE A 420
ARG A 417
ASP A 360
ASN A 224
 None
 1.34A 1kiaD-3wvoA:
undetectable		 1kiaD-3wvoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar9 COLLAGENASE COLT

(Clostridium
tetani) 		PF01752
(Peptidase_M9) 		4 ILE A 614
ARG A 464
ASP A 556
ASN A 561
 None
 1.36A 1kiaD-4ar9A:
0.9		 1kiaD-4ar9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1t INVASIN

(Yersinia
pseudotuberculosis) 		PF11924
(IAT_beta) 		4 ILE A 385
ARG A 229
ASP A 170
ASN A 349
 None
 0.99A 1kiaD-4e1tA:
0.7		 1kiaD-4e1tA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		4 ILE A 547
ARG A 373
ASP A 351
ASN A 347
 None
 1.36A 1kiaD-5bq9A:
undetectable		 1kiaD-5bq9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		4 ILE A 547
ARG A 373
ASP A 351
ASN A 347
 None
 1.43A 1kiaD-5bu1A:
undetectable		 1kiaD-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F
ENTEROBACTIN
BIOSYNTHESIS PROTEIN
YBDZ

(Escherichia
coli;
Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
PF03621
(MbtH) 		4 ILE A 862
ARG A 903
ASP A 857
ASN B   5
 None
CL  A1302 (-3.7A)
None
None
 1.10A 1kiaD-5ja1A:
2.3		 1kiaD-5ja1A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 TRP A 162
ILE A 257
ASP A 135
ASN A 209
 None
 1.22A 1kiaD-5svcA:
undetectable		 1kiaD-5svcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 TRP A 339
ILE A 344
ASP A 210
ASN A 230
 None
None
GPE  A 402 (-3.7A)
None
 1.47A 1kiaD-5t1pA:
undetectable		 1kiaD-5t1pA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 ILE A 118
ARG A 332
ASP A  49
ASN A  51
 0V5  A 509 (-4.5A)
FMT  A 507 (-3.5A)
None
None
 1.32A 1kiaD-5u4hA:
undetectable		 1kiaD-5u4hA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6
CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
PF16679
(CDT1_C) 		4 ILE 6 368
ARG 6 277
ASP 8 544
ASN 8 547
 None
 1.48A 1kiaD-5udb6:
2.0		 1kiaD-5udb6:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.46A 1kiaD-5wtiZ:
undetectable		 1kiaD-5wtiZ:
13.74