SIMILAR PATTERNS OF AMINO ACIDS FOR 1KIA_C_SAMC2293_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		4 ASP A  20
SER A  99
ASN A 150
SER A 217
 None
 1.48A 1kiaC-1cq3A:
undetectable		 1kiaC-1cq3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ARG A 267
ASP A 312
SER A 316
SER A 303
 None
 1.33A 1kiaC-1fnnA:
undetectable		 1kiaC-1fnnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 ARG A  40
ASP A 529
SER A 526
SER A 547
 None
 1.39A 1kiaC-1gjuA:
undetectable		 1kiaC-1gjuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3d TYPE IV COLLAGEN
NONCOLLAGENOUS
DOMAIN- ALPHA2

(Bos taurus) 		PF01413
(C4) 		4 ASP C  45
SER C  51
ASN C  43
SER C 160
 None
 1.35A 1kiaC-1m3dC:
undetectable		 1kiaC-1m3dC:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 398
SER A 113
ASN A  95
SER A 167
 None
 1.25A 1kiaC-1r3nA:
undetectable		 1kiaC-1r3nA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		4 ASP A  85
SER A  87
ASN A 116
SER A 139
 None
 0.55A 1kiaC-1r8yA:
35.7		 1kiaC-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0d DNA FRAGMENTATION
FACTOR 40 KDA
SUBUNIT

(Mus musculus) 		PF09230
(DFF40) 		4 ARG A 151
SER A 257
ASN A 260
SER A 165
 None
None
MG  A 501 ( 4.9A)
None
 1.47A 1kiaC-1v0dA:
undetectable		 1kiaC-1v0dA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		4 ARG A  24
ASP A  67
SER A  69
SER A 112
 SAM  A 302 (-3.1A)
SAM  A 302 (-2.8A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
 0.79A 1kiaC-1ve3A:
19.1		 1kiaC-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 TRP A 178
ARG A 189
SER A 143
ASN A 294
 None
None
ACT  A 363 ( 4.3A)
None
 1.39A 1kiaC-1vquA:
2.5		 1kiaC-1vquA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 TRP A 265
ASP A 222
ASN A 194
SER A 226
 None
PLP  A 418 (-2.9A)
PLP  A 418 (-3.7A)
None
 1.08A 1kiaC-1wstA:
undetectable		 1kiaC-1wstA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		4 ARG A 228
ASP A 110
SER A  64
SER A 164
 GPP  A 401 (-4.2A)
MG  A 501 ( 4.5A)
GPP  A 401 ( 4.2A)
GPP  A 401 ( 4.1A)
 1.23A 1kiaC-1zcwA:
1.0		 1kiaC-1zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 TRP A 401
SER A 383
ASN A  13
SER A 390
 None
 1.15A 1kiaC-2g02A:
undetectable		 1kiaC-2g02A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		4 ARG A 168
ASP A 250
SER A 369
SER A 305
 None
 1.30A 1kiaC-2im5A:
undetectable		 1kiaC-2im5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 ARG A 147
ASP A  87
ASN A  57
SER A 108
 None
 1.18A 1kiaC-2ojhA:
undetectable		 1kiaC-2ojhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 ASP A 248
SER A 250
ASN A 273
SER A 281
 None
 1.42A 1kiaC-2wedA:
undetectable		 1kiaC-2wedA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 ARG A 309
ASP A 224
SER A 186
SER A 195
 None
 1.46A 1kiaC-3al0A:
undetectable		 1kiaC-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN

(Solanum
tuberosum) 		PF00225
(Kinesin) 		4 ASP A1173
SER A1172
ASN A1212
SER A1113
 None
 1.44A 1kiaC-3cobA:
0.6		 1kiaC-3cobA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ARG A 191
SER A 377
ASN A 383
SER A 247
 None
 1.30A 1kiaC-3cqfA:
0.9		 1kiaC-3cqfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 ASP A 189
SER A  59
ASN A  64
SER A 368
 None
None
GAL  A 701 (-3.9A)
None
 1.40A 1kiaC-3dh4A:
undetectable		 1kiaC-3dh4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis) 		PF13419
(HAD_2) 		4 ARG A 132
ASP A 181
SER A 182
ASN A 201
 None
 1.15A 1kiaC-3ed5A:
3.4		 1kiaC-3ed5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 ASP 2 135
SER 2 136
ASN 2 166
SER 2 144
 None
 1.47A 1kiaC-3epc2:
undetectable		 1kiaC-3epc2:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		4 ARG A 190
SER A 143
ASN A 172
SER A 150
 None
 1.45A 1kiaC-3eslA:
undetectable		 1kiaC-3eslA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 ARG A 316
ASP A 230
SER A 192
SER A 201
 None
 1.24A 1kiaC-3h0lA:
undetectable		 1kiaC-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 ARG A 261
ASP A 250
ASN A 248
SER A 337
 None
 1.16A 1kiaC-3ldoA:
undetectable		 1kiaC-3ldoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ARG A 191
ASP A 172
SER A 218
ASN A 170
 PEG  A 645 ( 3.5A)
None
None
None
 1.44A 1kiaC-3lk6A:
3.4		 1kiaC-3lk6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT

(Parabacteroides
distasonis) 		PF04205
(FMN_bind) 		4 ASP A 176
SER A 177
ASN A 180
SER A 174
 None
None
GOL  A 272 (-3.5A)
None
 1.46A 1kiaC-3lwxA:
undetectable		 1kiaC-3lwxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 TRP A 410
SER A  32
ASN A  29
SER A  48
 None
 1.42A 1kiaC-3m8uA:
undetectable		 1kiaC-3m8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndh RESTRICTION
ENDONUCLEASE THAI

(Thermoplasma
acidophilum) 		PF15514
(ThaI) 		4 TRP A 107
ASP A  82
SER A  91
SER A  51
 None
NA  A 217 ( 2.7A)
NA  A 217 ( 4.6A)
None
 0.95A 1kiaC-3ndhA:
undetectable		 1kiaC-3ndhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 ASP A 402
SER A 285
ASN A 260
SER A 447
 None
 1.23A 1kiaC-3nqhA:
undetectable		 1kiaC-3nqhA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ARG A 309
ASP A 392
ASN A 367
SER A 340
 None
 1.25A 1kiaC-3pmkA:
undetectable		 1kiaC-3pmkA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 ASP A 233
SER A 235
ASN A 260
SER A  24
 None
 1.48A 1kiaC-3tr1A:
undetectable		 1kiaC-3tr1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 127
SER A 128
ASN A 115
SER A 507
 None
 1.00A 1kiaC-4aipA:
undetectable		 1kiaC-4aipA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 ARG A 278
SER A 142
ASN A  91
SER A 314
 None
 1.32A 1kiaC-4be3A:
undetectable		 1kiaC-4be3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 331
SER A 330
ASN A 335
SER A 372
 None
 1.32A 1kiaC-4c7vA:
2.7		 1kiaC-4c7vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 ARG A 214
ASP A 191
ASN A  80
SER A 194
 AIR  A 301 (-3.1A)
ADP  A 302 ( 3.9A)
None
None
 1.47A 1kiaC-4fe2A:
undetectable		 1kiaC-4fe2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 4 ASP D 261
SER D 260
ASN D 238
SER D 264
 None
 1.40A 1kiaC-4igbD:
undetectable		 1kiaC-4igbD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 ARG A 305
SER A 530
ASN A 546
SER A 537
 None
 1.40A 1kiaC-4iv9A:
undetectable		 1kiaC-4iv9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lur INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN(IRBP)

(Danio rerio) 		PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N) 		4 ARG A  64
ASP A 173
SER A 174
SER A 269
 None
 1.47A 1kiaC-4lurA:
undetectable		 1kiaC-4lurA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		4 ARG A 246
ASP A 321
SER A 320
SER A 238
 None
 1.45A 1kiaC-4pjuA:
undetectable		 1kiaC-4pjuA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 ARG A 353
ASP A 425
ASN A 118
SER A 191
 UGC  A 503 (-2.8A)
None
None
None
 1.41A 1kiaC-4pxbA:
undetectable		 1kiaC-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 ARG A 353
ASP A 425
SER A 137
ASN A 118
 UGC  A 503 (-2.8A)
None
None
None
 1.34A 1kiaC-4pxbA:
undetectable		 1kiaC-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 ASP A  72
SER A  71
ASN A  51
SER A 403
 None
 1.46A 1kiaC-4qjyA:
undetectable		 1kiaC-4qjyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 ARG A 313
SER A 268
ASN A 179
SER A 307
 None
CA  A1605 (-3.3A)
CA  A1604 ( 4.9A)
None
 1.41A 1kiaC-4ux8A:
undetectable		 1kiaC-4ux8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 ARG A 321
ASP A 235
SER A 197
SER A 206
 None
 1.37A 1kiaC-4wj3A:
undetectable		 1kiaC-4wj3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 ARG A 242
ASP A 219
SER A 179
SER A 210
 PO4  A 601 (-4.8A)
None
None
None
 1.44A 1kiaC-4y7iA:
undetectable		 1kiaC-4y7iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ARG A 111
SER A 381
ASN A 392
SER A 405
 None
 1.43A 1kiaC-4zr5A:
undetectable		 1kiaC-4zr5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		4 TRP A 195
ASP A 140
SER A 141
SER A 146
 None
 1.29A 1kiaC-4zxoA:
undetectable		 1kiaC-4zxoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		4 ARG A  64
ASP A 109
SER A 111
ASN A 130
 SAH  A 303 (-3.1A)
SAH  A 303 (-2.7A)
None
SAH  A 303 (-3.0A)
 0.58A 1kiaC-5bp9A:
13.1		 1kiaC-5bp9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ARG A 323
ASP A 503
SER A 502
ASN A 124
 None
 1.41A 1kiaC-5cslA:
2.4		 1kiaC-5cslA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grs STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN
STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
no annotation 		4 ARG A 841
SER I1004
ASN A 910
SER A 876
 None
 1.39A 1kiaC-5grsA:
undetectable		 1kiaC-5grsA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		4 ARG A  43
ASP A  88
SER A  90
SER A 135
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.8A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.1A)
 0.73A 1kiaC-5h02A:
21.2		 1kiaC-5h02A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 ASP A  81
SER A  82
ASN A  97
SER A 136
 None
 1.23A 1kiaC-5h6sA:
undetectable		 1kiaC-5h6sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		4 ASP A 288
SER A 289
ASN A 293
SER A 224
 None
 1.43A 1kiaC-5lt1A:
undetectable		 1kiaC-5lt1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 TRP A 595
ASP A 655
SER A 601
SER A 663
 None
 1.34A 1kiaC-5o0sA:
0.5		 1kiaC-5o0sA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.45A 1kiaC-5wtiZ:
undetectable		 1kiaC-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 129
ASP A  98
SER A 101
SER A   7
 None
 1.44A 1kiaC-5wz4A:
undetectable		 1kiaC-5wz4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 ARG A 185
ASP A1044
ASN A1070
SER A1076
 None
 1.26A 1kiaC-5xwyA:
undetectable		 1kiaC-5xwyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E
PHASE 2
FLAGELLIN,FLAGELLIN

(Mus musculus;
Salmonella
enterica) 		no annotation
no annotation 		4 ARG A1330
ASP A1215
SER A1189
SER C 452
 None
 0.97A 1kiaC-5yudA:
undetectable		 1kiaC-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 4 TRP A 163
ASP A 174
ASN A 491
SER A 320
 None
 1.42A 1kiaC-6c93A:
undetectable		 1kiaC-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ASP A 315
SER A 204
ASN A 176
SER A 389
 None
 1.47A 1kiaC-6cgmA:
undetectable		 1kiaC-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp7 ATP SYNTHASE SUBUNIT
A

(Saccharomyces
cerevisiae) 		no annotation 4 ASP X 244
SER X 240
ASN X 129
SER X 165
 None
 1.17A 1kiaC-6cp7X:
undetectable		 1kiaC-6cp7X:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 ARG A 261
ASP A 250
ASN A 248
SER A 337
 None
 1.31A 1kiaC-6eoeA:
undetectable		 1kiaC-6eoeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi NB696
SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Lama glama;
Pediculus
humanus) 		no annotation
no annotation 		4 ARG B  97
ASP C 338
SER C 337
ASN C 383
 None
GOL  C 602 (-4.2A)
GOL  C 602 (-2.9A)
None
 1.50A 1kiaC-6eqiB:
undetectable		 1kiaC-6eqiB:
17.95