SIMILAR PATTERNS OF AMINO ACIDS FOR 1KIA_B_SAMB1293_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cq3 VIRAL CHEMOKINE
INHIBITOR

(Cowpox virus) 		PF02250
(Orthopox_35kD) 		4 ASP A  20
SER A  99
ASN A 150
SER A 217
 None
 1.48A 1kiaB-1cq3A:
undetectable		 1kiaB-1cq3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ARG A 267
ASP A 312
SER A 316
SER A 303
 None
 1.33A 1kiaB-1fnnA:
undetectable		 1kiaB-1fnnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 ARG A  40
ASP A 529
SER A 526
SER A 547
 None
 1.38A 1kiaB-1gjuA:
2.6		 1kiaB-1gjuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  49
SER A 158
ASN A 155
SER A 375
 None
None
None
2PG  A 441 (-2.7A)
 1.38A 1kiaB-1p43A:
undetectable		 1kiaB-1p43A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 398
SER A 113
ASN A  95
SER A 167
 None
 1.27A 1kiaB-1r3nA:
undetectable		 1kiaB-1r3nA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		4 ASP A  85
SER A  87
ASN A 116
SER A 139
 None
 0.55A 1kiaB-1r8yA:
35.6		 1kiaB-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0d DNA FRAGMENTATION
FACTOR 40 KDA
SUBUNIT

(Mus musculus) 		PF09230
(DFF40) 		4 ARG A 151
SER A 257
ASN A 260
SER A 165
 None
None
MG  A 501 ( 4.9A)
None
 1.49A 1kiaB-1v0dA:
undetectable		 1kiaB-1v0dA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		4 ARG A  24
ASP A  67
SER A  69
SER A 112
 SAM  A 302 (-3.1A)
SAM  A 302 (-2.8A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
 0.81A 1kiaB-1ve3A:
17.7		 1kiaB-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgl TOLL-INTERACTING
PROTEIN

(Homo sapiens) 		PF02845
(CUE) 		4 ASP A  12
SER A   9
ASN A  38
SER A   2
 None
 1.34A 1kiaB-1wglA:
undetectable		 1kiaB-1wglA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		4 ARG A 228
ASP A 110
SER A  64
SER A 164
 GPP  A 401 (-4.2A)
MG  A 501 ( 4.5A)
GPP  A 401 ( 4.2A)
GPP  A 401 ( 4.1A)
 1.23A 1kiaB-1zcwA:
undetectable		 1kiaB-1zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		4 ARG A 168
ASP A 250
SER A 369
SER A 305
 None
 1.31A 1kiaB-2im5A:
undetectable		 1kiaB-2im5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgq TRIOSEPHOSPHATE
ISOMERASE

(Helicobacter
pylori) 		PF00121
(TIM) 		4 ASP A  42
SER A  11
ASN A   8
SER A  18
 None
 1.50A 1kiaB-2jgqA:
undetectable		 1kiaB-2jgqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 ARG A 147
ASP A  87
ASN A  57
SER A 108
 None
 1.17A 1kiaB-2ojhA:
undetectable		 1kiaB-2ojhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 ARG A 592
ASP A 402
SER A 497
ASN A 423
 None
 1.50A 1kiaB-2pggA:
undetectable		 1kiaB-2pggA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 ARG A 309
ASP A 224
SER A 186
SER A 195
 None
 1.48A 1kiaB-3al0A:
undetectable		 1kiaB-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN

(Solanum
tuberosum) 		PF00225
(Kinesin) 		4 ASP A1173
SER A1172
ASN A1212
SER A1113
 None
 1.46A 1kiaB-3cobA:
undetectable		 1kiaB-3cobA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 ARG A 191
SER A 377
ASN A 383
SER A 247
 None
 1.28A 1kiaB-3cqfA:
undetectable		 1kiaB-3cqfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 ASP A 189
SER A  59
ASN A  64
SER A 368
 None
None
GAL  A 701 (-3.9A)
None
 1.40A 1kiaB-3dh4A:
undetectable		 1kiaB-3dh4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASP A 326
SER A 325
ASN A 150
SER A 290
 None
 1.47A 1kiaB-3docA:
3.9		 1kiaB-3docA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis) 		PF13419
(HAD_2) 		4 ARG A 132
ASP A 181
SER A 182
ASN A 201
 None
 1.15A 1kiaB-3ed5A:
3.3		 1kiaB-3ed5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 ASP 2 135
SER 2 136
ASN 2 166
SER 2 144
 None
 1.49A 1kiaB-3epc2:
undetectable		 1kiaB-3epc2:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		4 ARG A 190
SER A 143
ASN A 172
SER A 150
 None
 1.46A 1kiaB-3eslA:
undetectable		 1kiaB-3eslA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 ARG A 316
ASP A 230
SER A 192
SER A 201
 None
 1.26A 1kiaB-3h0lA:
undetectable		 1kiaB-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 ARG A 261
ASP A 250
ASN A 248
SER A 337
 None
 1.14A 1kiaB-3ldoA:
undetectable		 1kiaB-3ldoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ARG A 191
ASP A 172
SER A 218
ASN A 170
 PEG  A 645 ( 3.5A)
None
None
None
 1.43A 1kiaB-3lk6A:
3.6		 1kiaB-3lk6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwx NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, C
SUBUNIT

(Parabacteroides
distasonis) 		PF04205
(FMN_bind) 		4 ASP A 176
SER A 177
ASN A 180
SER A 174
 None
None
GOL  A 272 (-3.5A)
None
 1.45A 1kiaB-3lwxA:
undetectable		 1kiaB-3lwxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		4 ASP A 346
SER A 345
ASN A  53
SER A 341
 None
 1.06A 1kiaB-3n8uA:
undetectable		 1kiaB-3n8uA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 ASP A 402
SER A 285
ASN A 260
SER A 447
 None
 1.24A 1kiaB-3nqhA:
undetectable		 1kiaB-3nqhA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ARG A 309
ASP A 392
ASN A 367
SER A 340
 None
 1.26A 1kiaB-3pmkA:
undetectable		 1kiaB-3pmkA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 127
SER A 128
ASN A 115
SER A 507
 None
 0.98A 1kiaB-4aipA:
undetectable		 1kiaB-4aipA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 ARG A 278
SER A 142
ASN A  91
SER A 314
 None
 1.34A 1kiaB-4be3A:
undetectable		 1kiaB-4be3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASP A 331
SER A 330
ASN A 335
SER A 372
 None
 1.31A 1kiaB-4c7vA:
2.8		 1kiaB-4c7vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 ARG A 214
ASP A 191
ASN A  80
SER A 194
 AIR  A 301 (-3.1A)
ADP  A 302 ( 3.9A)
None
None
 1.48A 1kiaB-4fe2A:
undetectable		 1kiaB-4fe2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 4 ASP D 261
SER D 260
ASN D 238
SER D 264
 None
 1.40A 1kiaB-4igbD:
undetectable		 1kiaB-4igbD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lur INTERPHOTORECEPTOR
RETINOID-BINDING
PROTEIN(IRBP)

(Danio rerio) 		PF03572
(Peptidase_S41)
PF11918
(Peptidase_S41_N) 		4 ARG A  64
ASP A 173
SER A 174
SER A 269
 None
 1.47A 1kiaB-4lurA:
undetectable		 1kiaB-4lurA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		4 ARG A 246
ASP A 321
SER A 320
SER A 238
 None
 1.45A 1kiaB-4pjuA:
undetectable		 1kiaB-4pjuA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 ARG A 353
ASP A 425
ASN A 118
SER A 191
 UGC  A 503 (-2.8A)
None
None
None
 1.42A 1kiaB-4pxbA:
undetectable		 1kiaB-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 ARG A 353
ASP A 425
SER A 137
ASN A 118
 UGC  A 503 (-2.8A)
None
None
None
 1.33A 1kiaB-4pxbA:
undetectable		 1kiaB-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 ASP A  72
SER A  71
ASN A  51
SER A 403
 None
 1.47A 1kiaB-4qjyA:
undetectable		 1kiaB-4qjyA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 ARG A 313
SER A 268
ASN A 179
SER A 307
 None
CA  A1605 (-3.3A)
CA  A1604 ( 4.9A)
None
 1.40A 1kiaB-4ux8A:
undetectable		 1kiaB-4ux8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		4 ARG A 321
ASP A 235
SER A 197
SER A 206
 None
 1.38A 1kiaB-4wj3A:
undetectable		 1kiaB-4wj3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 ARG A 242
ASP A 219
SER A 179
SER A 210
 PO4  A 601 (-4.8A)
None
None
None
 1.45A 1kiaB-4y7iA:
undetectable		 1kiaB-4y7iA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ARG A 111
SER A 381
ASN A 392
SER A 405
 None
 1.42A 1kiaB-4zr5A:
undetectable		 1kiaB-4zr5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		4 ARG A  64
ASP A 109
SER A 111
ASN A 130
 SAH  A 303 (-3.1A)
SAH  A 303 (-2.7A)
None
SAH  A 303 (-3.0A)
 0.60A 1kiaB-5bp9A:
12.6		 1kiaB-5bp9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ARG A 323
ASP A 503
SER A 502
ASN A 124
 None
 1.40A 1kiaB-5cslA:
2.7		 1kiaB-5cslA:
8.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		4 ARG A  43
ASP A  88
SER A  90
SER A 135
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.8A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.1A)
 0.74A 1kiaB-5h02A:
20.8		 1kiaB-5h02A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 ASP A  81
SER A  82
ASN A  97
SER A 136
 None
 1.23A 1kiaB-5h6sA:
undetectable		 1kiaB-5h6sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt1 KINESIN-LIKE PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		4 ASP A 288
SER A 289
ASN A 293
SER A 224
 None
 1.43A 1kiaB-5lt1A:
undetectable		 1kiaB-5lt1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 ARG A 301
ASP A 372
SER A  95
ASN A  76
 URP  A 503 (-2.9A)
None
ZN  A 501 ( 4.9A)
None
 1.24A 1kiaB-5thwA:
undetectable		 1kiaB-5thwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 129
ASP A  98
SER A 101
SER A   7
 None
 1.43A 1kiaB-5wz4A:
undetectable		 1kiaB-5wz4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 ARG A 185
ASP A1044
ASN A1070
SER A1076
 None
 1.24A 1kiaB-5xwyA:
undetectable		 1kiaB-5xwyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		4 ARG A 364
ASP A 213
SER A 199
SER A 368
 A9Y  A 602 (-3.5A)
None
None
None
 1.49A 1kiaB-5xzbA:
undetectable		 1kiaB-5xzbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E
PHASE 2
FLAGELLIN,FLAGELLIN

(Mus musculus;
Salmonella
enterica) 		no annotation
no annotation 		4 ARG A1330
ASP A1215
SER A1189
SER C 452
 None
 0.97A 1kiaB-5yudA:
undetectable		 1kiaB-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 ASP A 315
SER A 204
ASN A 176
SER A 389
 None
 1.47A 1kiaB-6cgmA:
2.2		 1kiaB-6cgmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp7 ATP SYNTHASE SUBUNIT
A

(Saccharomyces
cerevisiae) 		no annotation 4 ASP X 244
SER X 240
ASN X 129
SER X 165
 None
 1.18A 1kiaB-6cp7X:
undetectable		 1kiaB-6cp7X:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 ARG A 261
ASP A 250
ASN A 248
SER A 337
 None
 1.29A 1kiaB-6eoeA:
undetectable		 1kiaB-6eoeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi NB696
SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Lama glama;
Pediculus
humanus) 		no annotation
no annotation 		4 ARG B  97
ASP C 338
SER C 337
ASN C 383
 None
GOL  C 602 (-4.2A)
GOL  C 602 (-2.9A)
None
 1.50A 1kiaB-6eqiB:
undetectable		 1kiaB-6eqiB:
17.95