SIMILAR PATTERNS OF AMINO ACIDS FOR 1KGL_A_RTLA175_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi) 		no annotation 5 PHE A 189
LEU A  77
GLY A  71
ILE A   2
LEU A  50
 None
 1.19A 1kglA-1am2A:
undetectable		 1kglA-1am2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 528
LEU A 587
ALA A 586
GLY A 566
ILE A 565
 None
 1.01A 1kglA-1bhyA:
0.0		 1kglA-1bhyA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 PHE A 568
LEU A 553
ALA A 555
ILE A 589
LEU A 598
 None
 1.17A 1kglA-1ex0A:
0.0		 1kglA-1ex0A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		5 PHE A 224
ALA A 210
TYR A 154
GLY A 187
ILE A 189
 None
None
None
TZP  A2005 ( 3.9A)
None
 1.19A 1kglA-1g67A:
undetectable		 1kglA-1g67A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ALA A  33
PRO A  38
LYS A  40
SER A  55
PHE A  57
LEU A 117
 None
 0.91A 1kglA-1gglA:
22.7		 1kglA-1gglA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PRO A  38
LYS A  40
SER A  55
PHE A  57
TYR A  60
LEU A 117
 None
 0.89A 1kglA-1gglA:
22.7		 1kglA-1gglA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 PHE A 142
SER A 158
PHE A  66
GLY A  56
LEU A 218
 None
None
GOL  A 531 (-2.8A)
GOL  A 531 ( 4.5A)
None
 1.13A 1kglA-1kfwA:
0.0		 1kglA-1kfwA:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
PRO A  38
SER A  55
LEU A 117
 None
 0.84A 1kglA-1lpjA:
23.2		 1kglA-1lpjA:
56.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 261
ALA A 164
PRO A  50
GLY A 183
ILE A 182
 None
None
None
None
NAD  A 460 (-3.6A)
 1.22A 1kglA-1lvlA:
0.2		 1kglA-1lvlA:
16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 LEU A  29
ALA A  33
PRO A  38
LYS A  40
SER A  55
ILE A  77
 RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-3.5A)
 1.13A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 LEU A  29
PRO A  38
LYS A  40
SER A  55
TYR A  60
GLY A  76
ILE A  77
 RTL  A 135 (-3.8A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.9A)
RTL  A 135 (-3.5A)
 1.08A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LYS A  40
SER A  55
PHE A  57
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
None
 1.27A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 PHE A  16
LEU A  29
ALA A  33
PRO A  38
LYS A  40
SER A  55
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
 1.05A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		5 PHE A  35
ALA A  44
ARG A 274
GLY A 289
LEU A   6
 None
 1.06A 1kglA-1n97A:
undetectable		 1kglA-1n97A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		5 LEU A 138
ALA A 168
SER A 218
PHE A 261
LEU A 158
 None
 1.06A 1kglA-1s8eA:
undetectable		 1kglA-1s8eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 PHE A  11
SER A 216
PHE A 438
TYR A 180
ILE A 176
 None
 1.17A 1kglA-1tdkA:
undetectable		 1kglA-1tdkA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 PHE A 204
ALA A 161
GLY A  48
ILE A  49
LEU A 186
 None
 1.26A 1kglA-1v5vA:
undetectable		 1kglA-1v5vA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkq GUANINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		5 ALA A  14
LYS A  61
PHE A  26
GLY A  23
ILE A  22
 None
None
IMD  A1301 (-3.3A)
None
None
 1.27A 1kglA-1wkqA:
undetectable		 1kglA-1wkqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 283
PHE A 279
TYR A 133
GLY A 130
ILE A 129
 None
 1.23A 1kglA-1yb5A:
undetectable		 1kglA-1yb5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A  62
PRO A 412
GLY A 581
ILE A 398
LEU A 105
 None
 1.11A 1kglA-1z8lA:
undetectable		 1kglA-1z8lA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 PHE A 263
LEU A 177
ALA A 267
TYR A 191
ILE A 189
 None
 1.20A 1kglA-2c4mA:
undetectable		 1kglA-2c4mA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		5 ALA A  56
PHE A  57
GLY A  98
ILE A  97
LEU A 178
 None
 1.21A 1kglA-2d2rA:
undetectable		 1kglA-2d2rA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e50 PROTEIN SET

(Homo sapiens) 		PF00956
(NAP) 		5 PHE A 189
SER A 155
GLY A 205
ILE A 208
LEU A 107
 None
 1.14A 1kglA-2e50A:
undetectable		 1kglA-2e50A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 247
LEU A 213
ALA A 209
SER A 183
LEU A 255
 None
 1.01A 1kglA-2f9qA:
undetectable		 1kglA-2f9qA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fls GLUTAREDOXIN-2

(Homo sapiens) 		PF00462
(Glutaredoxin) 		5 PHE A  47
ALA A  43
GLY A  92
ILE A  91
LEU A 107
 None
 1.27A 1kglA-2flsA:
undetectable		 1kglA-2flsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 PHE A  83
LEU A 284
ALA A 289
SER A 306
GLY A 105
 None
 1.14A 1kglA-2ghbA:
undetectable		 1kglA-2ghbA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 ALA A  36
ARG A 249
GLY A 256
ILE A 260
LEU A 172
 None
 1.21A 1kglA-2j7vA:
undetectable		 1kglA-2j7vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 PHE A 851
LEU A 860
PHE A 869
ILE A 845
LEU A 738
 None
 1.23A 1kglA-2jgdA:
undetectable		 1kglA-2jgdA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 PHE A 330
LEU A 285
ALA A 275
GLY A 288
LEU A 270
 None
 1.27A 1kglA-2okkA:
undetectable		 1kglA-2okkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 PHE A 207
LEU A 200
ALA A 203
SER A 196
GLY A 233
 None
 1.03A 1kglA-2p50A:
undetectable		 1kglA-2p50A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		5 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 1.06A 1kglA-2qvlA:
undetectable		 1kglA-2qvlA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LYS A  40
SER A  55
LEU A 117
 None
 0.92A 1kglA-2rcqA:
23.3		 1kglA-2rcqA:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
LYS A  40
SER A  55
ARG A  58
LEU A 117
 None
None
None
SO4  A 152 (-3.1A)
None
 1.17A 1kglA-2rcqA:
23.3		 1kglA-2rcqA:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
LYS A  40
SER A  55
PHE A  57
LEU A 117
 None
 0.87A 1kglA-2rcqA:
23.3		 1kglA-2rcqA:
54.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		5 PHE A  10
SER A  75
ARG A  77
ILE A 350
LEU A 439
 None
 1.26A 1kglA-3ahxA:
undetectable		 1kglA-3ahxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 PHE A  21
ALA A  48
GLY A  52
ILE A  53
LEU A  63
 FAD  A 380 (-4.7A)
None
None
FAD  A 380 (-4.5A)
None
 1.17A 1kglA-3allA:
undetectable		 1kglA-3allA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 PHE A 221
LEU A 229
SER A 160
GLY A 168
ILE A 169
 None
None
EDO  A 401 (-4.9A)
None
None
 1.24A 1kglA-3ce9A:
undetectable		 1kglA-3ce9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 168
ALA A 225
SER A 205
GLY A 164
ILE A 166
 None
 1.22A 1kglA-3cwcA:
undetectable		 1kglA-3cwcA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		5 ALA A 153
LYS A 194
PHE A 170
GLY A 164
ILE A 165
 None
 1.20A 1kglA-3efeA:
undetectable		 1kglA-3efeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 ALA A 226
PRO A 218
SER A 219
ARG A 224
LEU A 242
 None
 1.27A 1kglA-3emqA:
undetectable		 1kglA-3emqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 PRO A 218
SER A 219
ARG A 224
ILE A 227
LEU A 242
 None
 1.11A 1kglA-3emqA:
undetectable		 1kglA-3emqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Mus musculus) 		no annotation 5 LEU A  48
PHE A 156
ARG A 149
GLY A  44
ILE A 148
 None
 1.12A 1kglA-3ewiA:
undetectable		 1kglA-3ewiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h20 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		5 PHE A  22
LEU A  45
ALA A  41
GLY A  11
LEU A  73
 None
 0.98A 1kglA-3h20A:
undetectable		 1kglA-3h20A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h25 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		5 PHE A  22
LEU A  45
ALA A  41
GLY A  11
LEU A  73
 None
 1.01A 1kglA-3h25A:
undetectable		 1kglA-3h25A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  13
ALA A 339
SER A 164
GLY A  11
LEU A 404
 None
 1.28A 1kglA-3hhdA:
0.0		 1kglA-3hhdA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		5 PHE A1484
LEU A1516
ALA B1702
PHE B1694
GLY A1514
 None
 1.28A 1kglA-3i08A:
undetectable		 1kglA-3i08A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ALA E  92
SER E 186
PHE E 188
GLY F  46
ILE E 191
 None
 1.28A 1kglA-3kfuE:
undetectable		 1kglA-3kfuE:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		5 PHE A 273
LEU A 320
PRO A 264
GLY A 352
ILE A 353
 None
 1.23A 1kglA-3lcaA:
undetectable		 1kglA-3lcaA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 PRO A 218
SER A 219
ARG A 224
ILE A 227
LEU A 242
 None
 1.27A 1kglA-3msgA:
undetectable		 1kglA-3msgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwc SMC PROTEIN

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		5 PHE A 577
ALA A 560
GLY A 521
ILE A 522
LEU A 572
 None
 1.20A 1kglA-3nwcA:
undetectable		 1kglA-3nwcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A   9
SER A  48
PHE A  50
GLY A  39
ILE A  40
 None
 0.89A 1kglA-3oa2A:
undetectable		 1kglA-3oa2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pd7 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		5 ALA A 932
PRO A 904
GLY A 925
ILE A 926
LEU A 984
 None
 1.28A 1kglA-3pd7A:
undetectable		 1kglA-3pd7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 PHE A 449
LEU A 495
PRO A 737
GLY A 491
ILE A 490
 None
 1.15A 1kglA-3ppcA:
undetectable		 1kglA-3ppcA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Leptotrichia
buccalis) 		PF07883
(Cupin_2) 		5 ARG A  56
TYR A  57
GLY A 104
ILE A 103
LEU A 128
 None
 1.21A 1kglA-3rnsA:
undetectable		 1kglA-3rnsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 PHE A  70
ALA A  68
PRO A  62
GLY A 123
ILE A 124
 None
 1.22A 1kglA-3tz6A:
undetectable		 1kglA-3tz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 PHE A 919
LEU A 507
ALA A 508
SER A 926
PHE A 511
 None
 1.27A 1kglA-3u6nA:
undetectable		 1kglA-3u6nA:
10.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.70A 1kglA-3wbgA:
19.8		 1kglA-3wbgA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ALA A 384
PRO A 449
SER A 374
PHE A 365
GLY A 362
 None
None
None
None
MTT  A 803 ( 4.0A)
 1.04A 1kglA-3wdjA:
undetectable		 1kglA-3wdjA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze6 PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 SER A 223
PHE A 226
TYR A 234
GLY A 237
LEU A 214
 None
None
None
None
SF4  A 284 (-4.6A)
 1.21A 1kglA-3ze6A:
undetectable		 1kglA-3ze6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 LEU A 558
TYR A 595
GLY A 594
ILE A 593
LEU A 662
 None
 1.27A 1kglA-3zgbA:
undetectable		 1kglA-3zgbA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		5 LEU A 270
ALA A 294
PRO A 216
GLY A 273
ILE A 274
 None
 1.17A 1kglA-4a0wA:
undetectable		 1kglA-4a0wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 PHE B 223
ALA B 257
PRO B 163
TYR A 313
GLY A 349
 None
 1.27A 1kglA-4cakB:
undetectable		 1kglA-4cakB:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF00004
(AAA) 		5 PHE J 246
LEU K 300
ARG K 330
GLY J 254
ILE J 253
 None
 1.21A 1kglA-4cr4J:
undetectable		 1kglA-4cr4J:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 ALA A 553
PHE A 555
GLY A 557
ILE A 539
LEU A 742
 None
 1.02A 1kglA-4cw5A:
undetectable		 1kglA-4cw5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 PHE A 438
ALA A 378
SER A 315
TYR A 373
GLY A 372
 None
 1.22A 1kglA-4cyjA:
undetectable		 1kglA-4cyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 PHE A 129
ARG A  80
GLY A 103
ILE A  99
LEU A  62
 None
 1.19A 1kglA-4df3A:
undetectable		 1kglA-4df3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4do7 AMIDOHYDROLASE 2

(Burkholderia
multivorans) 		PF04909
(Amidohydro_2) 		5 LEU A 189
ALA A 230
PHE A 234
GLY A 168
LEU A 260
 None
 1.20A 1kglA-4do7A:
undetectable		 1kglA-4do7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 LEU A 282
TYR A 105
GLY A  99
ILE A  98
LEU A  64
 None
 1.21A 1kglA-4hdtA:
undetectable		 1kglA-4hdtA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 268
ALA A 168
PRO A  52
GLY A 187
ILE A 186
 None
None
None
None
SO4  A 501 (-3.7A)
 1.26A 1kglA-4jq9A:
undetectable		 1kglA-4jq9A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 PHE A 453
LEU A 432
PRO A 397
SER A 400
PHE A 404
 None
 1.28A 1kglA-4mhcA:
undetectable		 1kglA-4mhcA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01425
(Amidase)
PF02934
(GatB_N) 		5 ALA A  78
SER A 175
PHE A 177
GLY B  73
ILE A 180
 None
 1.21A 1kglA-4n0iA:
undetectable		 1kglA-4n0iA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 ALA A 246
PHE A 351
GLY A 136
ILE A 137
LEU A 234
 None
 1.19A 1kglA-4npaA:
undetectable		 1kglA-4npaA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		5 PHE A  72
LEU A 167
ALA A 124
GLY A 169
LEU A  80
 None
 1.26A 1kglA-4p0dA:
undetectable		 1kglA-4p0dA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A 428
ALA A 431
TYR A 182
ILE A 181
LEU A   8
 None
 1.22A 1kglA-4p72A:
undetectable		 1kglA-4p72A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5t LIPOPROTEIN

(Streptococcus
mutans) 		PF03180
(Lipoprotein_9) 		5 LEU A 155
ALA A 158
SER A 220
TYR A 127
ILE A 133
 None
 1.25A 1kglA-4q5tA:
undetectable		 1kglA-4q5tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 PHE A 150
ARG A 115
TYR A 118
GLY A  64
ILE A  65
 None
SO4  A 404 (-2.9A)
None
None
None
 0.85A 1kglA-4xhlA:
undetectable		 1kglA-4xhlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A2618
SER A2589
GLY A2741
ILE A2756
LEU A2568
 None
 1.20A 1kglA-4z37A:
0.5		 1kglA-4z37A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		5 LEU A   7
ALA A   6
GLY A 245
ILE A 244
LEU A 337
 None
 1.17A 1kglA-4zadA:
undetectable		 1kglA-4zadA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxd BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD1

(Homo sapiens) 		PF02214
(BTB_2) 		5 PHE A 115
PHE A  76
TYR A  41
GLY A  38
LEU A  91
 None
 1.25A 1kglA-5bxdA:
undetectable		 1kglA-5bxdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 PHE A  93
ALA A  73
SER A 128
GLY A  67
LEU A  56
 None
 1.26A 1kglA-5fbzA:
undetectable		 1kglA-5fbzA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 0.95A 1kglA-5feiA:
undetectable		 1kglA-5feiA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		5 LEU E 117
ALA E 121
SER E  95
TYR E 105
GLY E 106
 None
 1.09A 1kglA-5ginE:
undetectable		 1kglA-5ginE:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 PRO B 231
SER B 233
GLY B 186
ILE B 185
LEU B 226
 None
 0.96A 1kglA-5hz1B:
undetectable		 1kglA-5hz1B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 PHE A 393
LEU A 426
ALA A 422
GLY A 410
ILE A 257
 None
 1.26A 1kglA-5j6bA:
undetectable		 1kglA-5j6bA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 SER A 223
PHE A 226
TYR A 234
GLY A 237
LEU A 214
 None
None
None
None
SF4  A 301 (-4.7A)
 1.19A 1kglA-5jsyA:
undetectable		 1kglA-5jsyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 PHE B 138
LEU B 179
ALA B 133
ILE B  74
LEU B 112
 None
 1.21A 1kglA-5lb3B:
undetectable		 1kglA-5lb3B:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 411
LEU A 489
ALA A 485
PRO A 466
LEU A 382
 None
 1.16A 1kglA-5lhkA:
undetectable		 1kglA-5lhkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 ALA A 607
TYR A 600
GLY A 599
ILE A 601
LEU A 532
 None
NDP  A 701 (-4.4A)
None
None
None
 1.14A 1kglA-5mq6A:
undetectable		 1kglA-5mq6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 PHE A 222
LEU A 239
TYR A  83
GLY A  81
ILE A  79
 None
None
None
SLB  A 503 (-3.7A)
None
 1.14A 1kglA-5nvaA:
undetectable		 1kglA-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 5 PHE C 150
ARG C 115
TYR C 118
GLY C  64
ILE C  65
 None
 0.97A 1kglA-5oktC:
undetectable		 1kglA-5oktC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		5 ALA A 141
PRO A 144
GLY A 174
ILE A 171
LEU A 196
 NHE  A 402 ( 4.0A)
None
None
None
None
 1.25A 1kglA-5trwA:
undetectable		 1kglA-5trwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A 285
PHE A 167
ARG A 163
GLY A 291
LEU A  32
 None
 1.23A 1kglA-5tukA:
undetectable		 1kglA-5tukA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A 285
PHE A 167
ARG A 163
GLY A 291
LEU A  32
 None
 1.24A 1kglA-5tulA:
undetectable		 1kglA-5tulA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 523
LEU A 582
ALA A 581
GLY A 561
ILE A 560
 None
 0.95A 1kglA-5u25A:
undetectable		 1kglA-5u25A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 PHE A  39
LEU A 248
ALA A  52
GLY A 244
LEU A  26
 None
 0.98A 1kglA-5u39A:
undetectable		 1kglA-5u39A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 PHE A  39
LEU A 248
ALA A  52
GLY A 244
LEU A  26
 None
 1.06A 1kglA-5vwmA:
undetectable		 1kglA-5vwmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		5 PHE A 183
LEU A  98
TYR A 169
GLY A 130
ILE A 134
 None
 1.12A 1kglA-5wggA:
undetectable		 1kglA-5wggA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 5 LEU A 123
ALA A 104
PHE A 101
GLY A 125
ILE A  92
 None
 1.15A 1kglA-5xr6A:
undetectable		 1kglA-5xr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 LEU A 139
ALA A 135
PHE A 120
TYR A  84
GLY A  87
 None
 1.20A 1kglA-5ygrA:
undetectable		 1kglA-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 SER A 502
PHE A 524
TYR A 478
GLY A 477
ILE A 497
 None
 1.28A 1kglA-6b6lA:
1.4		 1kglA-6b6lA:
9.97