SIMILAR PATTERNS OF AMINO ACIDS FOR 1KGL_A_RTLA175

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi) 		no annotation 5 PHE A 189
LEU A  77
GLY A  71
ILE A   2
LEU A  50
 None
 1.19A 1kglA-1am2A:
undetectable		 1kglA-1am2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 528
LEU A 587
ALA A 586
GLY A 566
ILE A 565
 None
 1.01A 1kglA-1bhyA:
0.0		 1kglA-1bhyA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 PHE A 568
LEU A 553
ALA A 555
ILE A 589
LEU A 598
 None
 1.17A 1kglA-1ex0A:
0.0		 1kglA-1ex0A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		5 PHE A 224
ALA A 210
TYR A 154
GLY A 187
ILE A 189
 None
None
None
TZP  A2005 ( 3.9A)
None
 1.19A 1kglA-1g67A:
undetectable		 1kglA-1g67A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 ALA A  33
PRO A  38
LYS A  40
SER A  55
PHE A  57
LEU A 117
 None
 0.91A 1kglA-1gglA:
22.7		 1kglA-1gglA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PRO A  38
LYS A  40
SER A  55
PHE A  57
TYR A  60
LEU A 117
 None
 0.89A 1kglA-1gglA:
22.7		 1kglA-1gglA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 PHE A 142
SER A 158
PHE A  66
GLY A  56
LEU A 218
 None
None
GOL  A 531 (-2.8A)
GOL  A 531 ( 4.5A)
None
 1.13A 1kglA-1kfwA:
0.0		 1kglA-1kfwA:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
PRO A  38
SER A  55
LEU A 117
 None
 0.84A 1kglA-1lpjA:
23.2		 1kglA-1lpjA:
56.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 261
ALA A 164
PRO A  50
GLY A 183
ILE A 182
 None
None
None
None
NAD  A 460 (-3.6A)
 1.22A 1kglA-1lvlA:
0.2		 1kglA-1lvlA:
16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 LEU A  29
ALA A  33
PRO A  38
LYS A  40
SER A  55
ILE A  77
 RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-3.5A)
 1.13A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 LEU A  29
PRO A  38
LYS A  40
SER A  55
TYR A  60
GLY A  76
ILE A  77
 RTL  A 135 (-3.8A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.9A)
RTL  A 135 (-3.5A)
 1.08A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LYS A  40
SER A  55
PHE A  57
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
None
 1.27A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 PHE A  16
LEU A  29
ALA A  33
PRO A  38
LYS A  40
SER A  55
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.4A)
 1.05A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		5 PHE A  35
ALA A  44
ARG A 274
GLY A 289
LEU A   6
 None
 1.06A 1kglA-1n97A:
undetectable		 1kglA-1n97A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		5 LEU A 138
ALA A 168
SER A 218
PHE A 261
LEU A 158
 None
 1.06A 1kglA-1s8eA:
undetectable		 1kglA-1s8eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 PHE A  11
SER A 216
PHE A 438
TYR A 180
ILE A 176
 None
 1.17A 1kglA-1tdkA:
undetectable		 1kglA-1tdkA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 PHE A 204
ALA A 161
GLY A  48
ILE A  49
LEU A 186
 None
 1.26A 1kglA-1v5vA:
undetectable		 1kglA-1v5vA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkq GUANINE DEAMINASE

(Bacillus
subtilis) 		PF00383
(dCMP_cyt_deam_1) 		5 ALA A  14
LYS A  61
PHE A  26
GLY A  23
ILE A  22
 None
None
IMD  A1301 (-3.3A)
None
None
 1.27A 1kglA-1wkqA:
undetectable		 1kglA-1wkqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 283
PHE A 279
TYR A 133
GLY A 130
ILE A 129
 None
 1.23A 1kglA-1yb5A:
undetectable		 1kglA-1yb5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A  62
PRO A 412
GLY A 581
ILE A 398
LEU A 105
 None
 1.11A 1kglA-1z8lA:
undetectable		 1kglA-1z8lA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 PHE A 263
LEU A 177
ALA A 267
TYR A 191
ILE A 189
 None
 1.20A 1kglA-2c4mA:
undetectable		 1kglA-2c4mA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		5 ALA A  56
PHE A  57
GLY A  98
ILE A  97
LEU A 178
 None
 1.21A 1kglA-2d2rA:
undetectable		 1kglA-2d2rA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e50 PROTEIN SET

(Homo sapiens) 		PF00956
(NAP) 		5 PHE A 189
SER A 155
GLY A 205
ILE A 208
LEU A 107
 None
 1.14A 1kglA-2e50A:
undetectable		 1kglA-2e50A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 247
LEU A 213
ALA A 209
SER A 183
LEU A 255
 None
 1.01A 1kglA-2f9qA:
undetectable		 1kglA-2f9qA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fls GLUTAREDOXIN-2

(Homo sapiens) 		PF00462
(Glutaredoxin) 		5 PHE A  47
ALA A  43
GLY A  92
ILE A  91
LEU A 107
 None
 1.27A 1kglA-2flsA:
undetectable		 1kglA-2flsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 PHE A  83
LEU A 284
ALA A 289
SER A 306
GLY A 105
 None
 1.14A 1kglA-2ghbA:
undetectable		 1kglA-2ghbA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		5 ALA A  36
ARG A 249
GLY A 256
ILE A 260
LEU A 172
 None
 1.21A 1kglA-2j7vA:
undetectable		 1kglA-2j7vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 PHE A 851
LEU A 860
PHE A 869
ILE A 845
LEU A 738
 None
 1.23A 1kglA-2jgdA:
undetectable		 1kglA-2jgdA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 PHE A 330
LEU A 285
ALA A 275
GLY A 288
LEU A 270
 None
 1.27A 1kglA-2okkA:
undetectable		 1kglA-2okkA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 PHE A 207
LEU A 200
ALA A 203
SER A 196
GLY A 233
 None
 1.03A 1kglA-2p50A:
undetectable		 1kglA-2p50A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		5 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 1.06A 1kglA-2qvlA:
undetectable		 1kglA-2qvlA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
LYS A  40
SER A  55
LEU A 117
 None
 0.92A 1kglA-2rcqA:
23.3		 1kglA-2rcqA:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
LYS A  40
SER A  55
ARG A  58
LEU A 117
 None
None
None
SO4  A 152 (-3.1A)
None
 1.17A 1kglA-2rcqA:
23.3		 1kglA-2rcqA:
54.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
LYS A  40
SER A  55
PHE A  57
LEU A 117
 None
 0.87A 1kglA-2rcqA:
23.3		 1kglA-2rcqA:
54.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		5 PHE A  10
SER A  75
ARG A  77
ILE A 350
LEU A 439
 None
 1.26A 1kglA-3ahxA:
undetectable		 1kglA-3ahxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 PHE A  21
ALA A  48
GLY A  52
ILE A  53
LEU A  63
 FAD  A 380 (-4.7A)
None
None
FAD  A 380 (-4.5A)
None
 1.17A 1kglA-3allA:
undetectable		 1kglA-3allA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 PHE A 221
LEU A 229
SER A 160
GLY A 168
ILE A 169
 None
None
EDO  A 401 (-4.9A)
None
None
 1.24A 1kglA-3ce9A:
undetectable		 1kglA-3ce9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 LEU A 168
ALA A 225
SER A 205
GLY A 164
ILE A 166
 None
 1.22A 1kglA-3cwcA:
undetectable		 1kglA-3cwcA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		5 ALA A 153
LYS A 194
PHE A 170
GLY A 164
ILE A 165
 None
 1.20A 1kglA-3efeA:
undetectable		 1kglA-3efeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 ALA A 226
PRO A 218
SER A 219
ARG A 224
LEU A 242
 None
 1.27A 1kglA-3emqA:
undetectable		 1kglA-3emqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emq ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		5 PRO A 218
SER A 219
ARG A 224
ILE A 227
LEU A 242
 None
 1.11A 1kglA-3emqA:
undetectable		 1kglA-3emqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Mus musculus) 		no annotation 5 LEU A  48
PHE A 156
ARG A 149
GLY A  44
ILE A 148
 None
 1.12A 1kglA-3ewiA:
undetectable		 1kglA-3ewiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h20 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		5 PHE A  22
LEU A  45
ALA A  41
GLY A  11
LEU A  73
 None
 0.98A 1kglA-3h20A:
undetectable		 1kglA-3h20A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h25 REPLICATION PROTEIN
B

(Plasmid RSF1010) 		PF16793
(RepB_primase) 		5 PHE A  22
LEU A  45
ALA A  41
GLY A  11
LEU A  73
 None
 1.01A 1kglA-3h25A:
undetectable		 1kglA-3h25A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  13
ALA A 339
SER A 164
GLY A  11
LEU A 404
 None
 1.28A 1kglA-3hhdA:
0.0		 1kglA-3hhdA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		5 PHE A1484
LEU A1516
ALA B1702
PHE B1694
GLY A1514
 None
 1.28A 1kglA-3i08A:
undetectable		 1kglA-3i08A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ALA E  92
SER E 186
PHE E 188
GLY F  46
ILE E 191
 None
 1.28A 1kglA-3kfuE:
undetectable		 1kglA-3kfuE:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		5 PHE A 273
LEU A 320
PRO A 264
GLY A 352
ILE A 353
 None
 1.23A 1kglA-3lcaA:
undetectable		 1kglA-3lcaA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 PRO A 218
SER A 219
ARG A 224
ILE A 227
LEU A 242
 None
 1.27A 1kglA-3msgA:
undetectable		 1kglA-3msgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwc SMC PROTEIN

(Pyrococcus
furiosus) 		PF06470
(SMC_hinge) 		5 PHE A 577
ALA A 560
GLY A 521
ILE A 522
LEU A 572
 None
 1.20A 1kglA-3nwcA:
undetectable		 1kglA-3nwcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A   9
SER A  48
PHE A  50
GLY A  39
ILE A  40
 None
 0.89A 1kglA-3oa2A:
undetectable		 1kglA-3oa2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pd7 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		5 ALA A 932
PRO A 904
GLY A 925
ILE A 926
LEU A 984
 None
 1.28A 1kglA-3pd7A:
undetectable		 1kglA-3pd7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 PHE A 449
LEU A 495
PRO A 737
GLY A 491
ILE A 490
 None
 1.15A 1kglA-3ppcA:
undetectable		 1kglA-3ppcA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Leptotrichia
buccalis) 		PF07883
(Cupin_2) 		5 ARG A  56
TYR A  57
GLY A 104
ILE A 103
LEU A 128
 None
 1.21A 1kglA-3rnsA:
undetectable		 1kglA-3rnsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 PHE A  70
ALA A  68
PRO A  62
GLY A 123
ILE A 124
 None
 1.22A 1kglA-3tz6A:
undetectable		 1kglA-3tz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 PHE A 919
LEU A 507
ALA A 508
SER A 926
PHE A 511
 None
 1.27A 1kglA-3u6nA:
undetectable		 1kglA-3u6nA:
10.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.70A 1kglA-3wbgA:
19.8		 1kglA-3wbgA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ALA A 384
PRO A 449
SER A 374
PHE A 365
GLY A 362
 None
None
None
None
MTT  A 803 ( 4.0A)
 1.04A 1kglA-3wdjA:
undetectable		 1kglA-3wdjA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze6 PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 SER A 223
PHE A 226
TYR A 234
GLY A 237
LEU A 214
 None
None
None
None
SF4  A 284 (-4.6A)
 1.21A 1kglA-3ze6A:
undetectable		 1kglA-3ze6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 LEU A 558
TYR A 595
GLY A 594
ILE A 593
LEU A 662
 None
 1.27A 1kglA-3zgbA:
undetectable		 1kglA-3zgbA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		5 LEU A 270
ALA A 294
PRO A 216
GLY A 273
ILE A 274
 None
 1.17A 1kglA-4a0wA:
undetectable		 1kglA-4a0wA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 PHE B 223
ALA B 257
PRO B 163
TYR A 313
GLY A 349
 None
 1.27A 1kglA-4cakB:
undetectable		 1kglA-4cakB:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF00004
(AAA) 		5 PHE J 246
LEU K 300
ARG K 330
GLY J 254
ILE J 253
 None
 1.21A 1kglA-4cr4J:
undetectable		 1kglA-4cr4J:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		5 ALA A 553
PHE A 555
GLY A 557
ILE A 539
LEU A 742
 None
 1.02A 1kglA-4cw5A:
undetectable		 1kglA-4cw5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 PHE A 438
ALA A 378
SER A 315
TYR A 373
GLY A 372
 None
 1.22A 1kglA-4cyjA:
undetectable		 1kglA-4cyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 PHE A 129
ARG A  80
GLY A 103
ILE A  99
LEU A  62
 None
 1.19A 1kglA-4df3A:
undetectable		 1kglA-4df3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4do7 AMIDOHYDROLASE 2

(Burkholderia
multivorans) 		PF04909
(Amidohydro_2) 		5 LEU A 189
ALA A 230
PHE A 234
GLY A 168
LEU A 260
 None
 1.20A 1kglA-4do7A:
undetectable		 1kglA-4do7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 LEU A 282
TYR A 105
GLY A  99
ILE A  98
LEU A  64
 None
 1.21A 1kglA-4hdtA:
undetectable		 1kglA-4hdtA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 268
ALA A 168
PRO A  52
GLY A 187
ILE A 186
 None
None
None
None
SO4  A 501 (-3.7A)
 1.26A 1kglA-4jq9A:
undetectable		 1kglA-4jq9A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 PHE A 453
LEU A 432
PRO A 397
SER A 400
PHE A 404
 None
 1.28A 1kglA-4mhcA:
undetectable		 1kglA-4mhcA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01425
(Amidase)
PF02934
(GatB_N) 		5 ALA A  78
SER A 175
PHE A 177
GLY B  73
ILE A 180
 None
 1.21A 1kglA-4n0iA:
undetectable		 1kglA-4n0iA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 ALA A 246
PHE A 351
GLY A 136
ILE A 137
LEU A 234
 None
 1.19A 1kglA-4npaA:
undetectable		 1kglA-4npaA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		5 PHE A  72
LEU A 167
ALA A 124
GLY A 169
LEU A  80
 None
 1.26A 1kglA-4p0dA:
undetectable		 1kglA-4p0dA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A 428
ALA A 431
TYR A 182
ILE A 181
LEU A   8
 None
 1.22A 1kglA-4p72A:
undetectable		 1kglA-4p72A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5t LIPOPROTEIN

(Streptococcus
mutans) 		PF03180
(Lipoprotein_9) 		5 LEU A 155
ALA A 158
SER A 220
TYR A 127
ILE A 133
 None
 1.25A 1kglA-4q5tA:
undetectable		 1kglA-4q5tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 PHE A 150
ARG A 115
TYR A 118
GLY A  64
ILE A  65
 None
SO4  A 404 (-2.9A)
None
None
None
 0.85A 1kglA-4xhlA:
undetectable		 1kglA-4xhlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A2618
SER A2589
GLY A2741
ILE A2756
LEU A2568
 None
 1.20A 1kglA-4z37A:
0.5		 1kglA-4z37A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		5 LEU A   7
ALA A   6
GLY A 245
ILE A 244
LEU A 337
 None
 1.17A 1kglA-4zadA:
undetectable		 1kglA-4zadA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxd BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD1

(Homo sapiens) 		PF02214
(BTB_2) 		5 PHE A 115
PHE A  76
TYR A  41
GLY A  38
LEU A  91
 None
 1.25A 1kglA-5bxdA:
undetectable		 1kglA-5bxdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbz ENZYME SUBTILASE
SUBHAL FROM BACILLUS
HALMAPALUS

(Bacillus
halmapalus) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 PHE A  93
ALA A  73
SER A 128
GLY A  67
LEU A  56
 None
 1.26A 1kglA-5fbzA:
undetectable		 1kglA-5fbzA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 0.95A 1kglA-5feiA:
undetectable		 1kglA-5feiA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		5 LEU E 117
ALA E 121
SER E  95
TYR E 105
GLY E 106
 None
 1.09A 1kglA-5ginE:
undetectable		 1kglA-5ginE:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 PRO B 231
SER B 233
GLY B 186
ILE B 185
LEU B 226
 None
 0.96A 1kglA-5hz1B:
undetectable		 1kglA-5hz1B:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 PHE A 393
LEU A 426
ALA A 422
GLY A 410
ILE A 257
 None
 1.26A 1kglA-5j6bA:
undetectable		 1kglA-5j6bA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 SER A 223
PHE A 226
TYR A 234
GLY A 237
LEU A 214
 None
None
None
None
SF4  A 301 (-4.7A)
 1.19A 1kglA-5jsyA:
undetectable		 1kglA-5jsyA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 PHE B 138
LEU B 179
ALA B 133
ILE B  74
LEU B 112
 None
 1.21A 1kglA-5lb3B:
undetectable		 1kglA-5lb3B:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PHE A 411
LEU A 489
ALA A 485
PRO A 466
LEU A 382
 None
 1.16A 1kglA-5lhkA:
undetectable		 1kglA-5lhkA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 ALA A 607
TYR A 600
GLY A 599
ILE A 601
LEU A 532
 None
NDP  A 701 (-4.4A)
None
None
None
 1.14A 1kglA-5mq6A:
undetectable		 1kglA-5mq6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 PHE A 222
LEU A 239
TYR A  83
GLY A  81
ILE A  79
 None
None
None
SLB  A 503 (-3.7A)
None
 1.14A 1kglA-5nvaA:
undetectable		 1kglA-5nvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 5 PHE C 150
ARG C 115
TYR C 118
GLY C  64
ILE C  65
 None
 0.97A 1kglA-5oktC:
undetectable		 1kglA-5oktC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		5 ALA A 141
PRO A 144
GLY A 174
ILE A 171
LEU A 196
 NHE  A 402 ( 4.0A)
None
None
None
None
 1.25A 1kglA-5trwA:
undetectable		 1kglA-5trwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A 285
PHE A 167
ARG A 163
GLY A 291
LEU A  32
 None
 1.23A 1kglA-5tukA:
undetectable		 1kglA-5tukA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A 285
PHE A 167
ARG A 163
GLY A 291
LEU A  32
 None
 1.24A 1kglA-5tulA:
undetectable		 1kglA-5tulA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)

(Neisseria
gonorrhoeae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 523
LEU A 582
ALA A 581
GLY A 561
ILE A 560
 None
 0.95A 1kglA-5u25A:
undetectable		 1kglA-5u25A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 PHE A  39
LEU A 248
ALA A  52
GLY A 244
LEU A  26
 None
 0.98A 1kglA-5u39A:
undetectable		 1kglA-5u39A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		5 PHE A  39
LEU A 248
ALA A  52
GLY A 244
LEU A  26
 None
 1.06A 1kglA-5vwmA:
undetectable		 1kglA-5vwmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN

(Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12) 		5 PHE A 183
LEU A  98
TYR A 169
GLY A 130
ILE A 134
 None
 1.12A 1kglA-5wggA:
undetectable		 1kglA-5wggA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 5 LEU A 123
ALA A 104
PHE A 101
GLY A 125
ILE A  92
 None
 1.15A 1kglA-5xr6A:
undetectable		 1kglA-5xr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 LEU A 139
ALA A 135
PHE A 120
TYR A  84
GLY A  87
 None
 1.20A 1kglA-5ygrA:
undetectable		 1kglA-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 SER A 502
PHE A 524
TYR A 478
GLY A 477
ILE A 497
 None
 1.28A 1kglA-6b6lA:
1.4		 1kglA-6b6lA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 LEU A  93
ILE A  86
THR A  90
GLN A  83
 None
None
SAH  A 287 (-3.5A)
None
 1.18A 1kglA-1bc5A:
0.0		 1kglA-1bc5A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzj EGI

(Thermoascus
aurantiacus) 		PF00150
(Cellulase) 		4 ILE A 150
THR A 130
GLN A 147
MET A 183
 None
 1.19A 1kglA-1gzjA:
0.0		 1kglA-1gzjA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LEU A  36
THR A  53
TRP A 106
GLN A 108
 None
 0.80A 1kglA-1kqxA:
24.3		 1kglA-1kqxA:
59.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  36
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 0.51A 1kglA-1lpjA:
23.2		 1kglA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  57
ILE A  51
THR A  53
TRP A 106
 None
 1.21A 1kglA-1lpjA:
23.2		 1kglA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 LEU A  36
ILE A  51
THR A  53
MET A  62
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.3A)
RTL  A 135 (-2.9A)
 0.73A 1kglA-1mx8A:
19.5		 1kglA-1mx8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		4 LEU A 175
ILE A 345
THR A 197
GLN A 300
 None
 1.24A 1kglA-1o9jA:
0.0		 1kglA-1o9jA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.20A 1kglA-1oh9A:
undetectable		 1kglA-1oh9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		4 LEU A 272
ILE A  58
THR A 277
MET A 279
 None
 1.28A 1kglA-1p0nA:
0.0		 1kglA-1p0nA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pov POLIOVIRUS NATIVE
EMPTY CAPSID (TYPE
1)

(Enterovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 LEU 0 320
ILE 0  73
THR 0 276
MET 0 325
 None
 1.30A 1kglA-1pov0:
0.0		 1kglA-1pov0:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		4 LEU A 170
THR A  74
GLN A  52
MET A  57
 None
 1.25A 1kglA-1rhcA:
undetectable		 1kglA-1rhcA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A 227
ILE A  74
THR A  15
MET A  71
 None
 1.26A 1kglA-1rxmA:
2.2		 1kglA-1rxmA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 104
ILE A  94
THR A  35
TRP A  69
 None
ADP  A 400 (-4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-4.2A)
 1.30A 1kglA-1s4eA:
undetectable		 1kglA-1s4eA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		4 LEU A 143
ILE B 282
THR B 316
MET A 154
 None
 1.29A 1kglA-1w2wA:
undetectable		 1kglA-1w2wA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)

(Caenorhabditis
elegans) 		PF13561
(adh_short_C2) 		4 LEU A 169
ILE A 113
THR A 117
GLN A 109
 None
 1.23A 1kglA-1xkqA:
undetectable		 1kglA-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 LEU A  78
ILE A 145
MET A 144
GLN A  90
 None
 1.10A 1kglA-1z0xA:
undetectable		 1kglA-1z0xA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		4 LEU A 562
ILE A 528
THR A 402
MET A 400
 None
 1.10A 1kglA-2b0tA:
undetectable		 1kglA-2b0tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		4 LEU A 279
ILE A 247
MET A 215
TRP A  59
 None
 1.26A 1kglA-2b81A:
undetectable		 1kglA-2b81A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A   5
ILE A  50
THR A  54
GLN A  80
 None
 1.16A 1kglA-2dpnA:
undetectable		 1kglA-2dpnA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyu FORMAMIDASE

(Helicobacter
pylori) 		PF00795
(CN_hydrolase) 		4 LEU A 134
ILE A 103
THR A 117
GLN A  64
 None
 1.22A 1kglA-2dyuA:
1.3		 1kglA-2dyuA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 108
ILE A 143
TRP A 148
GLN A 224
 None
 1.00A 1kglA-2h8hA:
undetectable		 1kglA-2h8hA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		4 LEU A 334
ILE A 218
THR A 220
MET A 316
 None
 1.27A 1kglA-2h9fA:
undetectable		 1kglA-2h9fA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 0.97A 1kglA-2j5tA:
undetectable		 1kglA-2j5tA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxd VIRAL PROTEIN
GENOME-LINKED

(Sapporo virus) 		no annotation 4 LEU A1000
ILE A 963
MET A 970
GLN A 960
 None
 1.12A 1kglA-2mxdA:
undetectable		 1kglA-2mxdA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 963
THR A 950
TRP A 961
MET A 955
 None
 1.28A 1kglA-2np0A:
undetectable		 1kglA-2np0A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Escherichia
coli) 		PF04381
(RdgC) 		4 LEU A   7
ILE A 280
THR A 283
MET A   1
 None
 1.27A 1kglA-2owlA:
0.6		 1kglA-2owlA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU B  54
ILE B 221
THR B 197
MET B 217
 None
 1.18A 1kglA-2po2B:
undetectable		 1kglA-2po2B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		4 LEU A 338
ILE A 222
THR A 224
MET A 320
 None
 1.25A 1kglA-2pvzA:
0.1		 1kglA-2pvzA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 LEU A 328
ILE A 299
THR A 301
GLN A 446
 None
 1.29A 1kglA-2pyjA:
undetectable		 1kglA-2pyjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 308
ILE A 216
THR A 209
GLN A 257
 None
 1.25A 1kglA-2qytA:
undetectable		 1kglA-2qytA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT GAMMA

(Desulfovibrio
vulgaris) 		PF04358
(DsrC) 		4 LEU C  77
ILE C  50
MET C  95
GLN C  47
 None
 1.30A 1kglA-2v4jC:
undetectable		 1kglA-2v4jC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 1.00A 1kglA-2w21A:
undetectable		 1kglA-2w21A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		4 LEU B 495
ILE B 504
THR B 500
MET B 536
 None
 1.05A 1kglA-2wd5B:
undetectable		 1kglA-2wd5B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		4 LEU A  45
ILE A  14
TRP A  89
GLN A  54
 None
 1.00A 1kglA-2we5A:
undetectable		 1kglA-2we5A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 228
ILE A 178
THR A 196
MET A 219
 None
None
UAG  A1498 (-4.7A)
None
 1.16A 1kglA-2wtzA:
undetectable		 1kglA-2wtzA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 LEU A  20
ILE A 222
THR A 114
TRP A 198
 None
 1.29A 1kglA-2xmzA:
undetectable		 1kglA-2xmzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 610
ILE A 622
THR A 624
MET A 586
 None
 1.08A 1kglA-2ycbA:
undetectable		 1kglA-2ycbA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 ILE A 249
THR A 597
GLN A 658
MET A 655
 None
 1.26A 1kglA-2yfsA:
undetectable		 1kglA-2yfsA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 251
THR B 302
MET B 331
GLN B 271
 None
 1.26A 1kglA-3a79B:
undetectable		 1kglA-3a79B:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 625
ILE A 637
THR A 639
MET A 601
 None
 1.03A 1kglA-3af5A:
undetectable		 1kglA-3af5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn4 CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK HOMOLOG 1

(Synechocystis
sp.) 		PF00936
(BMC) 		4 LEU A  73
ILE A  77
GLN A  54
MET A  23
 None
 1.16A 1kglA-3bn4A:
undetectable		 1kglA-3bn4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtz PUTATIVE CHLORITE
DISMUTASE TA0507

(Thermoplasma
acidophilum) 		PF06778
(Chlor_dismutase) 		4 LEU A 133
ILE A 202
MET A 125
MET A 143
 None
 1.23A 1kglA-3dtzA:
undetectable		 1kglA-3dtzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		4 LEU A 475
ILE A 480
THR A 505
GLN A 424
 None
FMN  A 700 (-3.6A)
None
FMN  A 700 (-3.0A)
 1.13A 1kglA-3eo7A:
undetectable		 1kglA-3eo7A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 338
ILE A 310
THR A 341
MET A 315
 None
 1.24A 1kglA-3eoeA:
undetectable		 1kglA-3eoeA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF19

(Schizosaccharomyces
pombe) 		no annotation 4 LEU c 437
ILE c 470
MET c 474
TRP c 568
 None
 1.16A 1kglA-3jb9c:
undetectable		 1kglA-3jb9c:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k93 PHAGE RELATED
EXONUCLEASE

(Histophilus
somni) 		no annotation 4 LEU A  73
ILE A 192
THR A 190
GLN A 151
 None
 1.24A 1kglA-3k93A:
undetectable		 1kglA-3k93A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 LEU A 456
ILE A 446
THR A 449
GLN A 522
 None
 1.13A 1kglA-3kbhA:
undetectable		 1kglA-3kbhA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		4 LEU A  79
ILE A  36
THR A  38
GLN A  89
 MLY  A  76 ( 4.6A)
None
None
None
 1.22A 1kglA-3kv0A:
undetectable		 1kglA-3kv0A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 236
THR A 238
MET A 186
MET A 172
 None
 0.67A 1kglA-3lgxA:
undetectable		 1kglA-3lgxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT GAMA

(Desulfovibrio
gigas) 		PF04358
(DsrC) 		4 LEU C  77
ILE C  50
MET C  95
GLN C  47
 None
 1.26A 1kglA-3or2C:
undetectable		 1kglA-3or2C:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 4 LEU A 641
ILE A 691
THR A 713
TRP A 739
 GOL  A 102 ( 4.5A)
None
None
None
 1.23A 1kglA-3p06A:
undetectable		 1kglA-3p06A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 LEU X 373
THR X 382
GLN X 288
MET X 263
 None
 1.08A 1kglA-3qc5X:
2.1		 1kglA-3qc5X:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3raz THIOREDOXIN-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF08534
(Redoxin) 		4 ILE A  45
THR A 126
MET A  77
TRP A  66
 None
 1.21A 1kglA-3razA:
undetectable		 1kglA-3razA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 LEU B 133
THR B 102
GLN B 157
MET B 170
 None
 1.11A 1kglA-3s4wB:
undetectable		 1kglA-3s4wB:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		4 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.27A 1kglA-3t7bA:
undetectable		 1kglA-3t7bA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 LEU A 666
ILE A 399
THR A 690
GLN A 397
 None
 1.23A 1kglA-3ue1A:
undetectable		 1kglA-3ue1A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 257
ILE A 270
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.19A 1kglA-3vlaA:
undetectable		 1kglA-3vlaA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF03167
(UDG)
PF06106
(SAUGI) 		4 LEU B  77
ILE B  28
THR B  53
GLN A  58
 None
 1.29A 1kglA-3wdgB:
undetectable		 1kglA-3wdgB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 LEU A 209
ILE A 222
THR A 218
GLN A  26
 None
EDO  A1417 (-4.7A)
EDO  A1417 (-4.2A)
None
 1.15A 1kglA-4arvA:
undetectable		 1kglA-4arvA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A1622
THR A1617
GLN A1601
MET A1603
 None
 1.26A 1kglA-4c3hA:
undetectable		 1kglA-4c3hA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 178
ILE A 216
THR A 242
GLN A 233
 None
 1.10A 1kglA-4c7vA:
undetectable		 1kglA-4c7vA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		4 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
None
None
PGE  A 502 (-4.4A)
 1.18A 1kglA-4exkA:
undetectable		 1kglA-4exkA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 LEU A 305
ILE A 330
THR A  94
MET A 322
 TYI  A 308 ( 4.6A)
EDO  A 505 ( 4.9A)
None
None
 1.25A 1kglA-4ikmA:
undetectable		 1kglA-4ikmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 LEU A 287
ILE A 219
THR A 238
MET A 193
 None
 1.14A 1kglA-4imdA:
undetectable		 1kglA-4imdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 LEU A 351
ILE A 109
THR A 114
GLN A 105
 None
 1.20A 1kglA-4j3qA:
undetectable		 1kglA-4j3qA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 287
ILE A 313
THR A 309
TRP A 141
 None
 1.16A 1kglA-4jzyA:
undetectable		 1kglA-4jzyA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 278
ILE A   5
MET A   8
MET A  93
 None
 1.18A 1kglA-4m0xA:
undetectable		 1kglA-4m0xA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 LEU A  55
ILE A  92
MET A  67
MET A  86
 None
 1.21A 1kglA-4mo9A:
undetectable		 1kglA-4mo9A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 306
ILE A 347
THR A 303
GLN A 246
 None
 1.30A 1kglA-4rcnA:
undetectable		 1kglA-4rcnA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 ILE A  37
THR A 274
TRP A  45
MET A 256
 None
 1.22A 1kglA-4ryeA:
0.8		 1kglA-4ryeA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		4 LEU H 126
ILE H 120
MET H 175
MET H 154
 None
None
None
MLI  H 301 ( 4.6A)
 0.86A 1kglA-4ryfH:
undetectable		 1kglA-4ryfH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A 356
ILE A  62
THR A  60
MET A  65
 None
 0.99A 1kglA-4yu9A:
undetectable		 1kglA-4yu9A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00043
(GST_C) 		4 ILE A  99
THR A  98
TRP A 134
GLN A 137
 None
 1.28A 1kglA-5a1nA:
undetectable		 1kglA-5a1nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 LEU A 665
ILE A 719
THR A 717
GLN A 699
 None
U  C   7 ( 3.9A)
U  C   7 ( 2.9A)
None
 1.04A 1kglA-5aorA:
undetectable		 1kglA-5aorA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A 816
ILE A 768
MET A 789
TRP A 458
 None
 1.13A 1kglA-5azaA:
undetectable		 1kglA-5azaA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF12704
(MacB_PCD) 		4 LEU A 173
THR A 177
MET A 211
GLN A  96
 None
 1.25A 1kglA-5c59A:
undetectable		 1kglA-5c59A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 207
ILE A 135
MET A 132
MET A 215
 None
NAD  A 300 (-3.8A)
None
NAD  A 300 (-3.6A)
 1.14A 1kglA-5ej2A:
undetectable		 1kglA-5ej2A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A 187
ILE A 357
THR A 209
GLN A 312
 None
 1.29A 1kglA-5fhzA:
undetectable		 1kglA-5fhzA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3p FORMAMIDASE

(Bacillus cereus) 		PF00795
(CN_hydrolase) 		4 LEU A 133
ILE A 103
THR A 116
GLN A  64
 None
 1.17A 1kglA-5g3pA:
undetectable		 1kglA-5g3pA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		4 LEU A 266
THR A 120
MET A 123
TRP A 126
 None
GOL  A1374 (-3.1A)
GOL  A1374 ( 4.9A)
MMC  A1379 ( 3.4A)
 1.24A 1kglA-5g5nA:
undetectable		 1kglA-5g5nA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 LEU A 305
ILE A 330
THR A  94
MET A 322
 None
 1.22A 1kglA-5h7nA:
undetectable		 1kglA-5h7nA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 LEU A 195
ILE A 206
THR A 202
MET A 323
 None
 1.07A 1kglA-5hyhA:
undetectable		 1kglA-5hyhA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 671
ILE A 696
THR A 460
MET A 688
 None
 1.28A 1kglA-5hzvA:
undetectable		 1kglA-5hzvA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		4 ILE A 159
THR A 139
GLN A 156
MET A 192
 None
 1.13A 1kglA-5i6sA:
undetectable		 1kglA-5i6sA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 480
ILE A 293
THR A 296
GLN A 376
 None
 1.30A 1kglA-5jbgA:
undetectable		 1kglA-5jbgA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 117
ILE A  69
GLN A  -2
MET A   1
 None
 1.05A 1kglA-5k1sA:
undetectable		 1kglA-5k1sA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 LEU M 216
ILE M 270
THR M 272
TRP M 267
 None
 1.27A 1kglA-5lc5M:
undetectable		 1kglA-5lc5M:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 LEU B 342
ILE B 409
THR B 395
MET B 384
 None
 1.30A 1kglA-5lxzB:
undetectable		 1kglA-5lxzB:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1947
ILE A1901
THR A1903
MET A1997
 None
 1.12A 1kglA-5m59A:
undetectable		 1kglA-5m59A:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 LEU A  41
ILE A  52
GLN A  65
MET A  69
 None
 0.76A 1kglA-5nn7A:
undetectable		 1kglA-5nn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 LEU A 351
ILE A 109
THR A 114
GLN A 105
 None
 1.13A 1kglA-5or4A:
undetectable		 1kglA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 4 LEU A 341
ILE A 407
THR A 403
TRP A 287
 None
 1.21A 1kglA-5ukhA:
undetectable		 1kglA-5ukhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 LEU A 384
ILE A 409
THR A 173
MET A 401
 None
 1.16A 1kglA-6anvA:
undetectable		 1kglA-6anvA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 4 LEU A 181
ILE A 407
THR A 344
MET A 220
 None
 1.28A 1kglA-6b4oA:
undetectable		 1kglA-6b4oA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 LEU A   8
ILE A 119
THR A 121
TRP A  42
 None
 1.21A 1kglA-6c29A:
undetectable		 1kglA-6c29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz ASK1
DAD2
HSK3

(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation
no annotation 		4 LEU A  50
ILE C  73
THR C  70
MET G  59
 None
 1.19A 1kglA-6cfzA:
undetectable		 1kglA-6cfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cl5 TAIL FIBER PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 393
THR A 379
TRP A 436
GLN A 407
 None
 1.08A 1kglA-6cl5A:
undetectable		 1kglA-6cl5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cl6 TAIL FIBER PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 393
THR A 379
TRP A 436
GLN A 407
 None
 1.05A 1kglA-6cl6A:
undetectable		 1kglA-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 LEU R  65
ILE R  95
THR R  91
MET R 180
 None
None
ADN  R 400 (-3.6A)
ADN  R 400 (-4.6A)
 1.24A 1kglA-6d9hR:
undetectable		 1kglA-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emg G0S4M2

(Chaetomium
thermophilum) 		no annotation 4 LEU A  58
MET A 193
TRP A 165
GLN A 187
 None
 1.26A 1kglA-6emgA:
undetectable		 1kglA-6emgA:
undetectable