SIMILAR PATTERNS OF AMINO ACIDS FOR 1KF6_B_ACTB704_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b88 T CELL RECEPTOR
V-ALPHA DOMAIN

(Mus musculus) 		PF07686
(V-set) 		3 ARG A  61
GLY A  83
ASP A  84
 None
 0.57A 1kf6A-1b88A:
undetectable
1kf6B-1b88A:
0.0		 1kf6A-1b88A:
11.77
1kf6B-1b88A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 ARG L  21
GLY L 483
ASP L 124
 None
 0.50A 1kf6A-1cc1L:
2.0
1kf6B-1cc1L:
0.0		 1kf6A-1cc1L:
22.45
1kf6B-1cc1L:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ARG A 530
GLY A 939
ASP A 948
 None
 0.58A 1kf6A-1h0hA:
0.0
1kf6B-1h0hA:
0.0		 1kf6A-1h0hA:
20.42
1kf6B-1h0hA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2s SENSORY RHODOPSIN II

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		3 ARG A  72
GLY A 181
ASP A 193
 None
 0.59A 1kf6A-1h2sA:
2.4
1kf6B-1h2sA:
0.0		 1kf6A-1h2sA:
19.11
1kf6B-1h2sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		3 ARG S 112
GLY L  37
ASP L  39
 None
SF4  L 422 (-3.5A)
None
 0.54A 1kf6A-1hfeS:
undetectable
1kf6B-1hfeS:
undetectable		 1kf6A-1hfeS:
11.64
1kf6B-1hfeS:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		3 ARG A 236
GLY A 214
ASP A 215
 None
 0.59A 1kf6A-1ii2A:
undetectable
1kf6B-1ii2A:
0.0		 1kf6A-1ii2A:
22.74
1kf6B-1ii2A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A   9
GLY A 101
ASP A 105
 PO4  A 422 (-3.9A)
PO4  A 422 ( 4.7A)
None
 0.44A 1kf6A-1iqrA:
undetectable
1kf6B-1iqrA:
0.0		 1kf6A-1iqrA:
21.51
1kf6B-1iqrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A 313
GLY A 342
ASP A 341
 FAD  A 421 (-3.9A)
FAD  A 421 (-3.5A)
FAD  A 421 (-3.6A)
 0.57A 1kf6A-1iqrA:
undetectable
1kf6B-1iqrA:
0.0		 1kf6A-1iqrA:
21.51
1kf6B-1iqrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itv MMP9

(Homo sapiens) 		PF00045
(Hemopexin) 		3 ARG A 119
GLY A  95
ASP A  97
 None
 0.36A 1kf6A-1itvA:
undetectable
1kf6B-1itvA:
0.0		 1kf6A-1itvA:
15.81
1kf6B-1itvA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		3 ARG A 998
GLY A 380
ASP A 385
 None
 0.59A 1kf6A-1k32A:
undetectable
1kf6B-1k32A:
0.0		 1kf6A-1k32A:
19.45
1kf6B-1k32A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		3 ARG A 285
GLY A 252
ASP A 251
 None
 0.59A 1kf6A-1kt8A:
undetectable
1kf6B-1kt8A:
undetectable		 1kf6A-1kt8A:
20.75
1kf6B-1kt8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		3 ARG A 235
GLY A  12
ASP A  16
 None
 0.31A 1kf6A-1lrzA:
4.5
1kf6B-1lrzA:
undetectable		 1kf6A-1lrzA:
21.41
1kf6B-1lrzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 ARG A 236
GLY A 268
ASP A 270
 None
 0.58A 1kf6A-1ofuA:
3.4
1kf6B-1ofuA:
undetectable		 1kf6A-1ofuA:
20.42
1kf6B-1ofuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A 431
GLY A 166
ASP A 396
 None
 0.50A 1kf6A-1rblA:
undetectable
1kf6B-1rblA:
undetectable		 1kf6A-1rblA:
22.37
1kf6B-1rblA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		3 ARG A 188
GLY A  98
ASP A  99
 None
 0.54A 1kf6A-1sk7A:
undetectable
1kf6B-1sk7A:
undetectable		 1kf6A-1sk7A:
16.52
1kf6B-1sk7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A 424
GLY A 159
ASP A 389
 None
 0.44A 1kf6A-1svdA:
undetectable
1kf6B-1svdA:
undetectable		 1kf6A-1svdA:
23.30
1kf6B-1svdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A  10
GLY A 106
ASP A 110
 HDF  A5486 (-4.9A)
HDF  A5486 (-3.1A)
None
 0.46A 1kf6A-1tezA:
undetectable
1kf6B-1tezA:
undetectable		 1kf6A-1tezA:
21.28
1kf6B-1tezA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 ARG A 392
GLY A 150
ASP A 154
 None
 0.57A 1kf6A-1uedA:
undetectable
1kf6B-1uedA:
undetectable		 1kf6A-1uedA:
21.60
1kf6B-1uedA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 ARG A  47
GLY A  88
ASP A  87
 NAG  A1403 (-3.6A)
NAG  A1404 ( 4.7A)
None
 0.43A 1kf6A-1uwyA:
undetectable
1kf6B-1uwyA:
undetectable		 1kf6A-1uwyA:
19.87
1kf6B-1uwyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01128
(IspD) 		3 ARG A 109
GLY A 195
ASP A 196
 None
 0.56A 1kf6A-1vpaA:
undetectable
1kf6B-1vpaA:
undetectable		 1kf6A-1vpaA:
17.59
1kf6B-1vpaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 ARG A 882
GLY A 746
ASP A 747
 None
 0.57A 1kf6A-1xf1A:
undetectable
1kf6B-1xf1A:
undetectable		 1kf6A-1xf1A:
21.19
1kf6B-1xf1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE

(Bacillus
halodurans) 		PF04616
(Glyco_hydro_43) 		3 ARG A1496
GLY A1433
ASP A1410
 None
 0.56A 1kf6A-1yrzA:
undetectable
1kf6B-1yrzA:
undetectable		 1kf6A-1yrzA:
22.64
1kf6B-1yrzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		3 ARG A 219
GLY A 153
ASP A 154
 None
 0.55A 1kf6A-2a7mA:
undetectable
1kf6B-2a7mA:
undetectable		 1kf6A-2a7mA:
18.21
1kf6B-2a7mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 309
GLY A 262
ASP A 243
 SRM  A 564 (-3.8A)
None
None
 0.46A 1kf6A-2akjA:
undetectable
1kf6B-2akjA:
undetectable		 1kf6A-2akjA:
22.42
1kf6B-2akjA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3d MODULATOR OF DRUG
ACTIVITY B

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		3 ARG A  54
GLY A  29
ASP A  33
 None
FAD  A1205 (-3.0A)
None
 0.56A 1kf6A-2b3dA:
2.1
1kf6B-2b3dA:
undetectable		 1kf6A-2b3dA:
15.33
1kf6B-2b3dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		3 ARG A 291
GLY A 319
ASP A 300
 None
 0.49A 1kf6A-2cxiA:
undetectable
1kf6B-2cxiA:
undetectable		 1kf6A-2cxiA:
20.85
1kf6B-2cxiA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 ARG A1086
GLY A 885
ASP A 881
 None
 0.54A 1kf6A-2ec5A:
4.0
1kf6B-2ec5A:
undetectable		 1kf6A-2ec5A:
20.05
1kf6B-2ec5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		3 ARG A 118
GLY A 186
ASP A 176
 BTX  A 501 (-3.1A)
BTX  A 501 (-3.3A)
BTX  A 501 (-3.5A)
 0.54A 1kf6A-2ewnA:
undetectable
1kf6B-2ewnA:
undetectable		 1kf6A-2ewnA:
20.00
1kf6B-2ewnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A 414
GLY A 444
ASP A 442
 None
 0.58A 1kf6A-2fknA:
3.2
1kf6B-2fknA:
undetectable		 1kf6A-2fknA:
24.26
1kf6B-2fknA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ici EXOTOXIN I

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 ARG A  99
GLY A  25
ASP A  70
 None
 0.54A 1kf6A-2iciA:
undetectable
1kf6B-2iciA:
0.8		 1kf6A-2iciA:
17.58
1kf6B-2iciA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lta DE NOVO DESIGNED
PROTEIN

(synthetic
construct) 		PF01515
(PTA_PTB) 		3 ARG A  82
GLY A 101
ASP A  96
 None
 0.58A 1kf6A-2ltaA:
undetectable
1kf6B-2ltaA:
undetectable		 1kf6A-2ltaA:
12.34
1kf6B-2ltaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox7 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF09643
(YopX) 		3 ARG A   8
GLY A 135
ASP A  85
 None
 0.51A 1kf6A-2ox7A:
undetectable
1kf6B-2ox7A:
undetectable		 1kf6A-2ox7A:
15.47
1kf6B-2ox7A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p84 ORF041

(Staphylococcus
virus 37) 		PF09643
(YopX) 		3 ARG A   8
GLY A 120
ASP A  76
 None
 0.43A 1kf6A-2p84A:
undetectable
1kf6B-2p84A:
undetectable		 1kf6A-2p84A:
13.51
1kf6B-2p84A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF14597
(Lactamase_B_5) 		3 ARG A 166
GLY A 102
ASP A 101
 None
 0.52A 1kf6A-2p97A:
undetectable
1kf6B-2p97A:
undetectable		 1kf6A-2p97A:
17.05
1kf6B-2p97A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyz UNCHARACTERIZED
PROTEIN

(Clostridium
tetani) 		PF09643
(YopX) 		3 ARG A  10
GLY A 120
ASP A  70
 None
 0.56A 1kf6A-2qyzA:
undetectable
1kf6B-2qyzA:
undetectable		 1kf6A-2qyzA:
12.16
1kf6B-2qyzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 116
GLY B  91
ASP B  86
 None
 0.47A 1kf6A-2v4jA:
undetectable
1kf6B-2v4jA:
undetectable		 1kf6A-2v4jA:
21.39
1kf6B-2v4jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		3 ARG A 364
GLY A 189
ASP A 141
 None
 0.59A 1kf6A-2wn4A:
undetectable
1kf6B-2wn4A:
undetectable		 1kf6A-2wn4A:
19.90
1kf6B-2wn4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		3 ARG A 306
GLY A  48
ASP A  47
 SO4  A1401 (-4.0A)
None
None
 0.48A 1kf6A-2x5dA:
undetectable
1kf6B-2x5dA:
undetectable		 1kf6A-2x5dA:
22.95
1kf6B-2x5dA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 ARG A 167
GLY A 286
ASP A 287
 None
 0.54A 1kf6A-2y0kA:
undetectable
1kf6B-2y0kA:
undetectable		 1kf6A-2y0kA:
21.46
1kf6B-2y0kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		3 ARG A 220
GLY A 153
ASP A 152
 None
 0.59A 1kf6A-2zo4A:
undetectable
1kf6B-2zo4A:
undetectable		 1kf6A-2zo4A:
22.54
1kf6B-2zo4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aih PROTEIN OS-9

(Homo sapiens) 		PF07915
(PRKCSH) 		3 ARG A 226
GLY A 204
ASP A 205
 None
 0.57A 1kf6A-3aihA:
undetectable
1kf6B-3aihA:
undetectable		 1kf6A-3aihA:
11.66
1kf6B-3aihA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		3 ARG A 387
GLY A 317
ASP A 318
 None
 0.59A 1kf6A-3au7A:
undetectable
1kf6B-3au7A:
undetectable		 1kf6A-3au7A:
21.32
1kf6B-3au7A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		3 ARG A  22
GLY A 360
ASP A 361
 None
 0.57A 1kf6A-3b98A:
undetectable
1kf6B-3b98A:
undetectable		 1kf6A-3b98A:
21.30
1kf6B-3b98A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		3 ARG A 222
GLY A 220
ASP A 157
 None
 0.59A 1kf6A-3bryA:
undetectable
1kf6B-3bryA:
undetectable		 1kf6A-3bryA:
21.42
1kf6B-3bryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwm CATECHOL
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		3 ARG A  78
GLY A  47
ASP A  51
 None
 0.37A 1kf6A-3bwmA:
4.0
1kf6B-3bwmA:
undetectable		 1kf6A-3bwmA:
16.97
1kf6B-3bwmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 ARG A 145
GLY A  71
ASP A  67
 None
 0.51A 1kf6A-3cghA:
2.2
1kf6B-3cghA:
1.1		 1kf6A-3cghA:
23.09
1kf6B-3cghA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ARG A 583
GLY A 666
ASP A 576
 None
 0.51A 1kf6A-3e9yA:
3.2
1kf6B-3e9yA:
undetectable		 1kf6A-3e9yA:
22.53
1kf6B-3e9yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN

(Shewanella
frigidimarina) 		PF01613
(Flavin_Reduct) 		3 ARG A 196
GLY A 170
ASP A 169
 None
 0.59A 1kf6A-3fgeA:
undetectable
1kf6B-3fgeA:
undetectable		 1kf6A-3fgeA:
15.36
1kf6B-3fgeA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzr UNCHARACTERIZED
PROTEIN WITH A
NTF2-LIKE FOLD

(Caulobacter
vibrioides) 		PF14534
(DUF4440) 		3 ARG A 144
GLY A  63
ASP A  62
 None
 0.52A 1kf6A-3gzrA:
undetectable
1kf6B-3gzrA:
undetectable		 1kf6A-3gzrA:
12.24
1kf6B-3gzrA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		3 ARG A 375
GLY A 313
ASP A 310
 None
 0.58A 1kf6A-3h5lA:
undetectable
1kf6B-3h5lA:
undetectable		 1kf6A-3h5lA:
22.24
1kf6B-3h5lA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9n RIBOSOME MATURATION
FACTOR RIMM

(Haemophilus
influenzae) 		PF01782
(RimM)
PF05239
(PRC) 		3 ARG A 150
GLY A 146
ASP A 143
 None
 0.54A 1kf6A-3h9nA:
undetectable
1kf6B-3h9nA:
undetectable		 1kf6A-3h9nA:
15.28
1kf6B-3h9nA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igs N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE 2

(Salmonella
enterica) 		PF04131
(NanE) 		3 ARG A  51
GLY A 151
ASP A 132
 CL  A 238 (-4.3A)
None
None
 0.38A 1kf6A-3igsA:
undetectable
1kf6B-3igsA:
undetectable		 1kf6A-3igsA:
16.97
1kf6B-3igsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 ARG A 374
GLY A 190
ASP A 189
 None
 0.53A 1kf6A-3ihjA:
undetectable
1kf6B-3ihjA:
undetectable		 1kf6A-3ihjA:
21.85
1kf6B-3ihjA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0x PROTEIN TEN1

(Schizosaccharomyces
pombe) 		PF12658
(Ten1) 		3 ARG A  92
GLY A  40
ASP A  39
 None
 0.44A 1kf6A-3k0xA:
undetectable
1kf6B-3k0xA:
undetectable		 1kf6A-3k0xA:
9.68
1kf6B-3k0xA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		3 ARG A 317
GLY A 202
ASP A 201
 None
 0.59A 1kf6A-3lunA:
undetectable
1kf6B-3lunA:
undetectable		 1kf6A-3lunA:
17.13
1kf6B-3lunA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mj9 JUNCTIONAL ADHESION
MOLECULE-LIKE

(Mus musculus) 		PF07686
(V-set) 		3 ARG A 147
GLY A  82
ASP A  81
 None
 0.57A 1kf6A-3mj9A:
undetectable
1kf6B-3mj9A:
undetectable		 1kf6A-3mj9A:
15.89
1kf6B-3mj9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 113
GLY B  80
ASP B  75
 None
 0.44A 1kf6A-3mm5A:
undetectable
1kf6B-3mm5A:
undetectable		 1kf6A-3mm5A:
21.43
1kf6B-3mm5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ARG A 278
GLY A 178
ASP A 155
 None
 0.58A 1kf6A-3n05A:
3.4
1kf6B-3n05A:
undetectable		 1kf6A-3n05A:
23.25
1kf6B-3n05A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L24P

(Haloarcula
marismortui) 		PF00467
(KOW)
PF16906
(Ribosomal_L26) 		3 ARG S 108
GLY S  45
ASP S  46
 None
 0.58A 1kf6A-3ow2S:
undetectable
1kf6B-3ow2S:
undetectable		 1kf6A-3ow2S:
11.90
1kf6B-3ow2S:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		3 ARG A  30
GLY A  63
ASP A  62
 None
 0.59A 1kf6A-3ow2A:
undetectable
1kf6B-3ow2A:
undetectable		 1kf6A-3ow2A:
17.08
1kf6B-3ow2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		3 ARG A 368
GLY A 373
ASP A 374
 None
 0.59A 1kf6A-3pm0A:
undetectable
1kf6B-3pm0A:
undetectable		 1kf6A-3pm0A:
21.77
1kf6B-3pm0A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 ARG A 286
GLY A 298
ASP A 300
 None
 0.57A 1kf6A-3ps5A:
2.2
1kf6B-3ps5A:
undetectable		 1kf6A-3ps5A:
22.31
1kf6B-3ps5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ARG A 574
GLY A 396
ASP A 395
 None
 0.55A 1kf6A-3pstA:
2.2
1kf6B-3pstA:
undetectable		 1kf6A-3pstA:
21.38
1kf6B-3pstA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q58 N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Salmonella
enterica) 		PF04131
(NanE) 		3 ARG A  51
GLY A 151
ASP A 132
 None
 0.45A 1kf6A-3q58A:
undetectable
1kf6B-3q58A:
undetectable		 1kf6A-3q58A:
16.15
1kf6B-3q58A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 ARG A 430
GLY A 483
ASP A 485
 None
 0.53A 1kf6A-3q60A:
undetectable
1kf6B-3q60A:
undetectable		 1kf6A-3q60A:
19.41
1kf6B-3q60A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		3 ARG A 265
GLY A 238
ASP A 243
 None
 0.35A 1kf6A-3qanA:
3.4
1kf6B-3qanA:
undetectable		 1kf6A-3qanA:
20.94
1kf6B-3qanA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjh 5C.C7 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B  64
GLY B  85
ASP B  86
 None
 0.53A 1kf6A-3qjhB:
undetectable
1kf6B-3qjhB:
undetectable		 1kf6A-3qjhB:
16.94
1kf6B-3qjhB:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A 328
GLY A  14
ASP A  50
 None
 0.49A 1kf6A-3s2gA:
2.9
1kf6B-3s2gA:
undetectable		 1kf6A-3s2gA:
21.72
1kf6B-3s2gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		3 ARG A 340
GLY A 355
ASP A 302
 None
 0.41A 1kf6A-3w53A:
undetectable
1kf6B-3w53A:
undetectable		 1kf6A-3w53A:
22.22
1kf6B-3w53A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		3 ARG A 124
GLY A 217
ASP A 216
 None
 0.54A 1kf6A-4ag4A:
undetectable
1kf6B-4ag4A:
undetectable		 1kf6A-4ag4A:
22.11
1kf6B-4ag4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1721
GLY A1732
ASP A1734
 None
 0.58A 1kf6A-4bpcA:
undetectable
1kf6B-4bpcA:
undetectable		 1kf6A-4bpcA:
21.54
1kf6B-4bpcA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwy P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		3 ARG A 263
GLY A 104
ASP A 201
 None
 0.59A 1kf6A-4bwyA:
undetectable
1kf6B-4bwyA:
undetectable		 1kf6A-4bwyA:
18.62
1kf6B-4bwyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crh SH3KBP1-BINDING
PROTEIN 1

(Homo sapiens) 		PF02214
(BTB_2) 		3 ARG A  29
GLY A  61
ASP A  58
 None
 0.53A 1kf6A-4crhA:
undetectable
1kf6B-4crhA:
undetectable		 1kf6A-4crhA:
13.65
1kf6B-4crhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvn HYPOTHETICAL PROTEIN

(Catenulispora
acidiphila) 		PF12680
(SnoaL_2) 		3 ARG A 103
GLY A  30
ASP A  29
 None
 0.44A 1kf6A-4hvnA:
undetectable
1kf6B-4hvnA:
undetectable		 1kf6A-4hvnA:
12.87
1kf6B-4hvnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isc METHYLTRANSFERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF05401
(NodS) 		3 ARG A  44
GLY A 138
ASP A 137
 None
 0.47A 1kf6A-4iscA:
3.7
1kf6B-4iscA:
undetectable		 1kf6A-4iscA:
14.74
1kf6B-4iscA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		3 ARG A 171
GLY A  42
ASP A 139
 None
 0.59A 1kf6A-4itmA:
undetectable
1kf6B-4itmA:
undetectable		 1kf6A-4itmA:
19.11
1kf6B-4itmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A  10
GLY A 106
ASP A 110
 None
 0.22A 1kf6A-4k0rA:
undetectable
1kf6B-4k0rA:
undetectable		 1kf6A-4k0rA:
22.00
1kf6B-4k0rA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ARG A 431
GLY A 166
ASP A 396
 None
 0.49A 1kf6A-4mkvA:
undetectable
1kf6B-4mkvA:
undetectable		 1kf6A-4mkvA:
21.19
1kf6B-4mkvA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzr PGT135 HEAVY CHAIN
PROTEIN M TD

(Homo sapiens;
Mycoplasma
genitalium) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 ARG M 457
GLY H  31
ASP H  31
 None
 0.57A 1kf6A-4nzrM:
undetectable
1kf6B-4nzrM:
undetectable		 1kf6A-4nzrM:
21.86
1kf6B-4nzrM:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 ARG A 106
GLY A 315
ASP A 294
 None
 0.57A 1kf6A-4om9A:
undetectable
1kf6B-4om9A:
undetectable		 1kf6A-4om9A:
21.29
1kf6B-4om9A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		3 ARG A 242
GLY A 273
ASP A 277
 None
 0.51A 1kf6A-4oqfA:
3.1
1kf6B-4oqfA:
undetectable		 1kf6A-4oqfA:
19.24
1kf6B-4oqfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		3 ARG A 121
GLY A  90
ASP A  94
 None
 0.33A 1kf6A-4p58A:
2.0
1kf6B-4p58A:
undetectable		 1kf6A-4p58A:
16.44
1kf6B-4p58A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		3 ARG A 147
GLY A  73
ASP A  69
 None
 0.51A 1kf6A-4pucA:
2.3
1kf6B-4pucA:
0.5		 1kf6A-4pucA:
21.34
1kf6B-4pucA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ARG A 207
GLY A 196
ASP A 449
 None
 0.50A 1kf6A-4q73A:
undetectable
1kf6B-4q73A:
undetectable		 1kf6A-4q73A:
20.75
1kf6B-4q73A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ARG A   2
GLY A 272
ASP A 275
 None
 0.59A 1kf6A-4qhrA:
undetectable
1kf6B-4qhrA:
undetectable		 1kf6A-4qhrA:
20.58
1kf6B-4qhrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ARG A   2
GLY A 274
ASP A 275
 None
 0.49A 1kf6A-4qhrA:
undetectable
1kf6B-4qhrA:
undetectable		 1kf6A-4qhrA:
20.58
1kf6B-4qhrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r38 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF13426
(PAS_9) 		3 ARG A  89
GLY A 122
ASP A 120
 None
 0.58A 1kf6A-4r38A:
undetectable
1kf6B-4r38A:
undetectable		 1kf6A-4r38A:
15.44
1kf6B-4r38A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rle UNCHARACTERIZED
PROTEIN YAAQ

(Bacillus
subtilis) 		PF06153
(CdAMP_rec) 		3 ARG A  67
GLY A  64
ASP A  12
 None
 0.59A 1kf6A-4rleA:
undetectable
1kf6B-4rleA:
undetectable		 1kf6A-4rleA:
10.95
1kf6B-4rleA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u63 DNA PHOTOLYASE

(Agrobacterium
fabrum) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A  13
GLY A 106
ASP A 110
 None
 0.26A 1kf6A-4u63A:
undetectable
1kf6B-4u63A:
undetectable		 1kf6A-4u63A:
21.27
1kf6B-4u63A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A  28
GLY A 124
ASP A 128
 None
 0.35A 1kf6A-4u8hA:
undetectable
1kf6B-4u8hA:
undetectable		 1kf6A-4u8hA:
21.95
1kf6B-4u8hA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		3 ARG A 271
GLY A 212
ASP A 280
 None
 0.57A 1kf6A-4uhiA:
undetectable
1kf6B-4uhiA:
undetectable		 1kf6A-4uhiA:
19.55
1kf6B-4uhiA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqz HSIE1

(Pseudomonas
aeruginosa) 		PF07024
(ImpE) 		3 ARG A 150
GLY A 143
ASP A 138
 None
ACT  A 301 (-4.2A)
None
 0.58A 1kf6A-4uqzA:
2.8
1kf6B-4uqzA:
undetectable		 1kf6A-4uqzA:
19.64
1kf6B-4uqzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		3 ARG A  65
GLY A 216
ASP A 220
 None
 0.35A 1kf6A-4y7dA:
undetectable
1kf6B-4y7dA:
undetectable		 1kf6A-4y7dA:
21.58
1kf6B-4y7dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		3 ARG A 127
GLY A  55
ASP A  56
 None
 0.56A 1kf6A-4zdaA:
2.2
1kf6B-4zdaA:
undetectable		 1kf6A-4zdaA:
22.93
1kf6B-4zdaA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		3 ARG B  21
GLY B  93
ASP B  92
 None
 0.58A 1kf6A-5aoxB:
2.0
1kf6B-5aoxB:
undetectable		 1kf6A-5aoxB:
10.24
1kf6B-5aoxB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awn HEAVY CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG H  66
GLY H  85
ASP H  86
 None
 0.57A 1kf6A-5awnH:
undetectable
1kf6B-5awnH:
undetectable		 1kf6A-5awnH:
16.36
1kf6B-5awnH:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 ARG A1040
GLY A1270
ASP A1084
 None
 0.57A 1kf6A-5cs4A:
2.4
1kf6B-5cs4A:
undetectable		 1kf6A-5cs4A:
20.59
1kf6B-5cs4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		3 ARG A 316
GLY A 384
ASP A 386
 None
 0.54A 1kf6A-5e9gA:
undetectable
1kf6B-5e9gA:
undetectable		 1kf6A-5e9gA:
21.07
1kf6B-5e9gA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 ARG A 173
GLY A 401
ASP A 402
 None
 0.56A 1kf6A-5ek8A:
undetectable
1kf6B-5ek8A:
undetectable		 1kf6A-5ek8A:
21.19
1kf6B-5ek8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A  73
GLY A 643
ASP A 667
 None
 0.59A 1kf6A-5fokA:
undetectable
1kf6B-5fokA:
undetectable		 1kf6A-5fokA:
22.28
1kf6B-5fokA:
15.10