SIMILAR PATTERNS OF AMINO ACIDS FOR 1KF6_A_ACTA703_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2e11	HYDROLASE (Xanthomonas campestris)	PF00795 (CN_hydrolase)	4	PHE A 49 ASP A 207 ARG A 203 GLU A 43	CAC A1266 (-3.3A) None None CAC A1266 (-3.2A)	1.32A	1kf6A-2e11A: 0.6	1kf6A-2e11A: 19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qve	TYROSINE AMINOMUTASE (Streptomyces globisporus)	PF00221 (Lyase_aromatic)	4	PHE A 483 ASP A 478 ARG A 498 GLU A 495	None	1.11A	1kf6A-2qveA: 5.2	1kf6A-2qveA: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cih	PUTATIVE ALPHA-RHAMNOSIDASE (Bacteroides thetaiotaomicron)	PF17389 (Bac_rhamnosid6H) PF17390 (Bac_rhamnosid_C)	4	PHE A 46 ASP A 337 ARG A 336 GLU A 41	None TRS A 800 ( 4.3A) TRS A 800 (-4.1A) None	1.50A	1kf6A-3cihA: 0.0	1kf6A-3cihA: 20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3p4s	FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT (Escherichia coli)	PF00890 (FAD_binding_2) PF02910 (Succ_DH_flav_C)	4	PHE A 554 ASP A 556 ARG A 562 GLU A 564	None	0.50A	1kf6A-3p4sA: 68.6	1kf6A-3p4sA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xsv	ETHANOLAMINE-PHOSPHA TE CYTIDYLYLTRANSFERASE (Homo sapiens)	PF01467 (CTP_transf_like)	4	PHE A 71 ASP A 32 ARG A 76 GLU A 75	GOL A 403 (-4.0A) None None None	1.29A	1kf6A-4xsvA: 0.3	1kf6A-4xsvA: 21.86

[["1KF6_A_ACTA703_0","2e11","Xanthomonas campestris","HYDROLASE","PF00795(CN_hydrolase)",4,"PHE A  49;ASP A 207;ARG A 203;GLU A  43","CAC A1266 (-3.3A);None;None;CAC A1266 (-3.2A)","1.32A","1kf6A-2e11A:0.6","1kf6A-2e11A:19.01"],["1KF6_A_ACTA703_0","2qve","Streptomyces globisporus","TYROSINE AMINOMUTASE","PF00221(Lyase_aromatic)",4,"PHE A 483;ASP A 478;ARG A 498;GLU A 495","None","1.11A","1kf6A-2qveA:5.2","1kf6A-2qveA:22.26"],["1KF6_A_ACTA703_0","3cih","Bacteroides thetaiotaomicron","PUTATIVE ALPHA-RHAMNOSIDASE","PF17389(Bac_rhamnosid6H);PF17390(Bac_rhamnosid_C)",4,"PHE A  46;ASP A 337;ARG A 336;GLU A  41","None;TRS A 800 ( 4.3A);TRS A 800 (-4.1A);None","1.50A","1kf6A-3cihA:0.0","1kf6A-3cihA:20.87"],["1KF6_A_ACTA703_0","3p4s","Escherichia coli","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","PF00890(FAD_binding_2);PF02910(Succ_DH_flav_C)",4,"PHE A 554;ASP A 556;ARG A 562;GLU A 564","None","0.50A","1kf6A-3p4sA:68.6","1kf6A-3p4sA:100.00"],["1KF6_A_ACTA703_0","4xsv","Homo sapiens","ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE","PF01467(CTP_transf_like)",4,"PHE A  71;ASP A  32;ARG A  76;GLU A  75","GOL A 403 (-4.0A);None;None;None","1.29A","1kf6A-4xsvA:0.3","1kf6A-4xsvA:21.86"]]