SIMILAR PATTERNS OF AMINO ACIDS FOR 1KB9_A_PCFA514_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 HIS A 646
ILE A 586
VAL A 123
SER A 535
 None
 1.06A 1kb9A-1b0kA:
0.0
1kb9C-1b0kA:
0.0
1kb9D-1b0kA:
0.0
1kb9E-1b0kA:
0.0		 1kb9A-1b0kA:
19.68
1kb9C-1b0kA:
19.68
1kb9D-1b0kA:
15.86
1kb9E-1b0kA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh9 TAFII28

(Homo sapiens) 		PF04719
(TAFII28) 		4 ILE B 141
VAL B 151
MET B 154
SER B 158
 None
 1.15A 1kb9A-1bh9B:
undetectable
1kb9C-1bh9B:
undetectable
1kb9D-1bh9B:
undetectable
1kb9E-1bh9B:
undetectable		 1kb9A-1bh9B:
11.59
1kb9C-1bh9B:
14.70
1kb9D-1bh9B:
15.04
1kb9E-1bh9B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 SER A 234
HIS A 381
ILE A 397
SER A 338
 None
 1.17A 1kb9A-1kv9A:
0.0
1kb9C-1kv9A:
0.0
1kb9D-1kv9A:
3.2
1kb9E-1kv9A:
0.0		 1kb9A-1kv9A:
22.67
1kb9C-1kv9A:
19.79
1kb9D-1kv9A:
15.55
1kb9E-1kv9A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		no annotation 4 ILE A 352
VAL A 411
MET A 391
SER A 377
 None
 0.88A 1kb9A-1lb4A:
0.3
1kb9C-1lb4A:
undetectable
1kb9D-1lb4A:
0.0
1kb9E-1lb4A:
undetectable		 1kb9A-1lb4A:
17.52
1kb9C-1lb4A:
18.49
1kb9D-1lb4A:
18.62
1kb9E-1lb4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 ILE A 185
VAL A 209
MET A 199
SER A 179
 None
 1.17A 1kb9A-1lnzA:
undetectable
1kb9C-1lnzA:
undetectable
1kb9D-1lnzA:
0.0
1kb9E-1lnzA:
0.0		 1kb9A-1lnzA:
21.57
1kb9C-1lnzA:
18.95
1kb9D-1lnzA:
22.91
1kb9E-1lnzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 SER A 475
ILE A 371
VAL A 340
MET A 344
 None
 1.13A 1kb9A-1np7A:
0.0
1kb9C-1np7A:
0.0
1kb9D-1np7A:
0.0
1kb9E-1np7A:
undetectable		 1kb9A-1np7A:
22.35
1kb9C-1np7A:
20.39
1kb9D-1np7A:
18.51
1kb9E-1np7A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q80 SARCOPLASMIC
CALCIUM-BINDING
PROTEIN

(Hediste
diversicolor) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 SER A 133
PHE A 150
VAL A 103
SER A  52
 None
 1.12A 1kb9A-1q80A:
0.0
1kb9C-1q80A:
0.4
1kb9D-1q80A:
0.0
1kb9E-1q80A:
undetectable		 1kb9A-1q80A:
19.15
1kb9C-1q80A:
18.68
1kb9D-1q80A:
20.31
1kb9E-1q80A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q98 THIOL PEROXIDASE

(Haemophilus
influenzae) 		PF08534
(Redoxin) 		4 SER A  62
ILE A  54
PHE A  51
VAL A 133
 None
 0.97A 1kb9A-1q98A:
undetectable
1kb9C-1q98A:
undetectable
1kb9D-1q98A:
undetectable
1kb9E-1q98A:
undetectable		 1kb9A-1q98A:
20.79
1kb9C-1q98A:
19.84
1kb9D-1q98A:
20.72
1kb9E-1q98A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		PF01582
(TIR) 		4 ILE A 489
PHE A 490
VAL A 507
SER A 470
 None
 1.14A 1kb9A-1t3gA:
undetectable
1kb9C-1t3gA:
undetectable
1kb9D-1t3gA:
undetectable
1kb9E-1t3gA:
0.0		 1kb9A-1t3gA:
17.36
1kb9C-1t3gA:
19.05
1kb9D-1t3gA:
21.09
1kb9E-1t3gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN

(Thermus
thermophilus) 		PF06778
(Chlor_dismutase) 		4 ILE A 187
VAL A 214
MET A 217
SER A 223
 None
 1.10A 1kb9A-1vdhA:
0.0
1kb9C-1vdhA:
0.0
1kb9D-1vdhA:
0.0
1kb9E-1vdhA:
0.0		 1kb9A-1vdhA:
20.50
1kb9C-1vdhA:
19.85
1kb9D-1vdhA:
23.05
1kb9E-1vdhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 SER A 105
HIS A 269
ILE A  87
VAL A 306
 None
 1.16A 1kb9A-1yaaA:
0.8
1kb9C-1yaaA:
0.0
1kb9D-1yaaA:
0.0
1kb9E-1yaaA:
0.0		 1kb9A-1yaaA:
22.25
1kb9C-1yaaA:
22.10
1kb9D-1yaaA:
21.53
1kb9E-1yaaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 SER A 239
HIS A 389
ILE A 405
SER A 343
 None
 1.08A 1kb9A-1yiqA:
undetectable
1kb9C-1yiqA:
undetectable
1kb9D-1yiqA:
4.6
1kb9E-1yiqA:
undetectable		 1kb9A-1yiqA:
20.40
1kb9C-1yiqA:
19.45
1kb9D-1yiqA:
16.98
1kb9E-1yiqA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 ILE A 214
VAL A 276
MET A 273
SER A 269
 None
 1.06A 1kb9A-1yyrA:
undetectable
1kb9C-1yyrA:
1.6
1kb9D-1yyrA:
undetectable
1kb9E-1yyrA:
undetectable		 1kb9A-1yyrA:
19.19
1kb9C-1yyrA:
20.90
1kb9D-1yyrA:
21.20
1kb9E-1yyrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhv HYPOTHETICAL PROTEIN
ATU0741

(Agrobacterium
fabrum) 		PF13840
(ACT_7) 		4 HIS A 124
ILE A   5
PHE A  68
VAL A  96
 None
 1.13A 1kb9A-1zhvA:
undetectable
1kb9C-1zhvA:
undetectable
1kb9D-1zhvA:
undetectable
1kb9E-1zhvA:
undetectable		 1kb9A-1zhvA:
15.31
1kb9C-1zhvA:
17.10
1kb9D-1zhvA:
19.18
1kb9E-1zhvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 SER A 279
ILE A 300
VAL A 378
MET A 382
 None
 1.13A 1kb9A-2c3oA:
undetectable
1kb9C-2c3oA:
undetectable
1kb9D-2c3oA:
undetectable
1kb9E-2c3oA:
undetectable		 1kb9A-2c3oA:
16.79
1kb9C-2c3oA:
14.20
1kb9D-2c3oA:
11.72
1kb9E-2c3oA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		4 ILE A 176
PHE A 158
VAL A 181
SER A  70
 None
 0.96A 1kb9A-2c5uA:
undetectable
1kb9C-2c5uA:
1.8
1kb9D-2c5uA:
undetectable
1kb9E-2c5uA:
undetectable		 1kb9A-2c5uA:
22.65
1kb9C-2c5uA:
21.26
1kb9D-2c5uA:
20.57
1kb9E-2c5uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		4 ILE A 290
PHE A 250
VAL A 220
MET A 223
 None
 1.06A 1kb9A-2c6xA:
undetectable
1kb9C-2c6xA:
undetectable
1kb9D-2c6xA:
undetectable
1kb9E-2c6xA:
undetectable		 1kb9A-2c6xA:
22.72
1kb9C-2c6xA:
20.42
1kb9D-2c6xA:
20.11
1kb9E-2c6xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfa THYMIDYLATE SYNTHASE

(Paramecium
bursaria
Chlorella virus
1) 		PF02511
(Thy1) 		4 ILE B 209
PHE B 206
VAL B   8
MET B  62
 None
 1.15A 1kb9A-2cfaB:
undetectable
1kb9C-2cfaB:
undetectable
1kb9D-2cfaB:
undetectable
1kb9E-2cfaB:
undetectable		 1kb9A-2cfaB:
20.37
1kb9C-2cfaB:
17.66
1kb9D-2cfaB:
21.29
1kb9E-2cfaB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 SER A 211
ILE A 233
VAL A  91
SER A  87
 None
 0.96A 1kb9A-2cxiA:
3.2
1kb9C-2cxiA:
undetectable
1kb9D-2cxiA:
undetectable
1kb9E-2cxiA:
undetectable		 1kb9A-2cxiA:
21.94
1kb9C-2cxiA:
23.15
1kb9D-2cxiA:
20.05
1kb9E-2cxiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekd HYPOTHETICAL PROTEIN
PH0250

(Pyrococcus
horikoshii) 		PF03192
(DUF257) 		4 SER A 175
ILE A  33
PHE A   6
VAL A 199
 None
 1.09A 1kb9A-2ekdA:
undetectable
1kb9C-2ekdA:
undetectable
1kb9D-2ekdA:
undetectable
1kb9E-2ekdA:
undetectable		 1kb9A-2ekdA:
19.77
1kb9C-2ekdA:
18.91
1kb9D-2ekdA:
20.78
1kb9E-2ekdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE

(Pseudomonas
putida) 		PF04909
(Amidohydro_2) 		4 ILE A 201
PHE A 168
VAL A 196
SER A  17
 None
 1.08A 1kb9A-2ffiA:
undetectable
1kb9C-2ffiA:
undetectable
1kb9D-2ffiA:
undetectable
1kb9E-2ffiA:
undetectable		 1kb9A-2ffiA:
20.54
1kb9C-2ffiA:
21.75
1kb9D-2ffiA:
21.36
1kb9E-2ffiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhd DNA REPAIR PROTEIN
RHP9/CRB2

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 375
VAL A 408
MET A 395
SER A 393
 None
 1.15A 1kb9A-2fhdA:
undetectable
1kb9C-2fhdA:
undetectable
1kb9D-2fhdA:
undetectable
1kb9E-2fhdA:
undetectable		 1kb9A-2fhdA:
17.94
1kb9C-2fhdA:
16.81
1kb9D-2fhdA:
19.51
1kb9E-2fhdA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		4 SER A  66
HIS A 182
PHE A 101
VAL A  58
 None
 1.16A 1kb9A-2hpwA:
undetectable
1kb9C-2hpwA:
undetectable
1kb9D-2hpwA:
undetectable
1kb9E-2hpwA:
undetectable		 1kb9A-2hpwA:
19.11
1kb9C-2hpwA:
21.16
1kb9D-2hpwA:
22.22
1kb9E-2hpwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		4 ILE A  13
PHE A  59
VAL A  52
SER A  31
 None
 1.11A 1kb9A-2lkdA:
undetectable
1kb9C-2lkdA:
undetectable
1kb9D-2lkdA:
undetectable
1kb9E-2lkdA:
undetectable		 1kb9A-2lkdA:
16.40
1kb9C-2lkdA:
17.31
1kb9D-2lkdA:
20.08
1kb9E-2lkdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 HIS A  45
ILE A  48
VAL A  30
MET A  27
 None
 1.06A 1kb9A-2q6tA:
undetectable
1kb9C-2q6tA:
undetectable
1kb9D-2q6tA:
undetectable
1kb9E-2q6tA:
undetectable		 1kb9A-2q6tA:
22.65
1kb9C-2q6tA:
20.43
1kb9D-2q6tA:
21.62
1kb9E-2q6tA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 SER A  78
ILE A  11
VAL A  56
SER A  66
 None
 1.06A 1kb9A-2vk9A:
undetectable
1kb9C-2vk9A:
2.2
1kb9D-2vk9A:
undetectable
1kb9E-2vk9A:
undetectable		 1kb9A-2vk9A:
22.39
1kb9C-2vk9A:
20.46
1kb9D-2vk9A:
18.15
1kb9E-2vk9A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 ILE A 130
PHE A  67
VAL A  34
SER A  31
 None
 1.14A 1kb9A-2vreA:
undetectable
1kb9C-2vreA:
undetectable
1kb9D-2vreA:
undetectable
1kb9E-2vreA:
undetectable		 1kb9A-2vreA:
20.14
1kb9C-2vreA:
21.86
1kb9D-2vreA:
19.81
1kb9E-2vreA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vu5 NUCLEOSIDE
DIPHOSPHATE KINASE

(Bacillus
anthracis) 		PF00334
(NDK) 		4 ILE A 129
PHE A 130
VAL A  70
MET A  38
 None
 0.96A 1kb9A-2vu5A:
undetectable
1kb9C-2vu5A:
undetectable
1kb9D-2vu5A:
undetectable
1kb9E-2vu5A:
undetectable		 1kb9A-2vu5A:
16.24
1kb9C-2vu5A:
15.83
1kb9D-2vu5A:
19.44
1kb9E-2vu5A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		4 SER A 105
ILE A  61
VAL A 126
MET A 129
 None
 1.06A 1kb9A-2wuqA:
undetectable
1kb9C-2wuqA:
undetectable
1kb9D-2wuqA:
0.0
1kb9E-2wuqA:
undetectable		 1kb9A-2wuqA:
21.44
1kb9C-2wuqA:
21.65
1kb9D-2wuqA:
20.38
1kb9E-2wuqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01128
(IspD) 		4 SER A 112
ILE A 177
VAL A 122
SER A 172
 None
30A  A1306 (-3.7A)
None
None
 1.12A 1kb9A-2ycmA:
undetectable
1kb9C-2ycmA:
undetectable
1kb9D-2ycmA:
undetectable
1kb9E-2ycmA:
undetectable		 1kb9A-2ycmA:
20.09
1kb9C-2ycmA:
20.10
1kb9D-2ycmA:
20.85
1kb9E-2ycmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 HIS A 245
ILE A 241
VAL A 419
SER A  28
 None
 0.97A 1kb9A-2yjgA:
undetectable
1kb9C-2yjgA:
undetectable
1kb9D-2yjgA:
undetectable
1kb9E-2yjgA:
undetectable		 1kb9A-2yjgA:
23.38
1kb9C-2yjgA:
21.87
1kb9D-2yjgA:
20.05
1kb9E-2yjgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylz PHENYLACETONE
MONOOXYGENASE

(Thermobifida
fusca) 		PF13738
(Pyr_redox_3) 		4 SER A 196
ILE A  67
VAL A  54
SER A  27
 SO4  A1543 (-4.6A)
FAD  A 700 (-3.8A)
FAD  A 700 (-3.6A)
FAD  A 700 (-2.7A)
 1.11A 1kb9A-2ylzA:
undetectable
1kb9C-2ylzA:
undetectable
1kb9D-2ylzA:
undetectable
1kb9E-2ylzA:
undetectable		 1kb9A-2ylzA:
20.74
1kb9C-2ylzA:
21.49
1kb9D-2ylzA:
19.92
1kb9E-2ylzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus;
Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 HIS A  30
ILE B  96
PHE B 101
VAL B 140
 None
 1.16A 1kb9A-3ayxA:
undetectable
1kb9C-3ayxA:
2.3
1kb9D-3ayxA:
undetectable
1kb9E-3ayxA:
undetectable		 1kb9A-3ayxA:
20.83
1kb9C-3ayxA:
19.45
1kb9D-3ayxA:
18.39
1kb9E-3ayxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 527
PHE A 528
VAL A 440
SER A 495
 None
 1.08A 1kb9A-3cmmA:
undetectable
1kb9C-3cmmA:
undetectable
1kb9D-3cmmA:
undetectable
1kb9E-3cmmA:
undetectable		 1kb9A-3cmmA:
18.39
1kb9C-3cmmA:
17.01
1kb9D-3cmmA:
12.62
1kb9E-3cmmA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 SER A 169
ILE A 152
VAL A 213
SER A 207
 None
None
None
GOL  A 267 (-4.9A)
 1.05A 1kb9A-3f3kA:
undetectable
1kb9C-3f3kA:
undetectable
1kb9D-3f3kA:
undetectable
1kb9E-3f3kA:
undetectable		 1kb9A-3f3kA:
20.23
1kb9C-3f3kA:
19.18
1kb9D-3f3kA:
21.40
1kb9E-3f3kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 HIS A  29
ILE A  78
VAL A 329
SER A 320
 None
 0.98A 1kb9A-3gdoA:
undetectable
1kb9C-3gdoA:
undetectable
1kb9D-3gdoA:
undetectable
1kb9E-3gdoA:
undetectable		 1kb9A-3gdoA:
20.39
1kb9C-3gdoA:
21.29
1kb9D-3gdoA:
20.81
1kb9E-3gdoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Staphylococcus
aureus) 		PF01470
(Peptidase_C15) 		4 ILE A  66
VAL A 116
MET A 119
SER A 122
 None
 1.14A 1kb9A-3giuA:
undetectable
1kb9C-3giuA:
undetectable
1kb9D-3giuA:
undetectable
1kb9E-3giuA:
undetectable		 1kb9A-3giuA:
19.06
1kb9C-3giuA:
20.05
1kb9D-3giuA:
21.37
1kb9E-3giuA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
CYTOCHROME B
MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN

(Gallus gallus;
Gallus gallus;
Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		4 SER A 439
HIS C 222
PHE C 227
LYS D 226
 PEE  A2008 ( 4.1A)
PEE  A2008 (-4.1A)
None
None
 0.65A 1kb9A-3h1lA:
45.4
1kb9C-3h1lA:
undetectable
1kb9D-3h1lA:
undetectable
1kb9E-3h1lA:
undetectable		 1kb9A-3h1lA:
33.12
1kb9C-3h1lA:
21.04
1kb9D-3h1lA:
20.27
1kb9E-3h1lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 ILE A 108
VAL A  24
MET A  27
SER A  31
 None
 0.92A 1kb9A-3hq2A:
undetectable
1kb9C-3hq2A:
1.0
1kb9D-3hq2A:
undetectable
1kb9E-3hq2A:
undetectable		 1kb9A-3hq2A:
22.41
1kb9C-3hq2A:
20.64
1kb9D-3hq2A:
17.93
1kb9E-3hq2A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvs THIOL PEROXIDASE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 SER A  64
ILE A  56
PHE A  53
VAL A 135
 CIT  A   1 (-2.8A)
None
None
None
 1.02A 1kb9A-3hvsA:
undetectable
1kb9C-3hvsA:
undetectable
1kb9D-3hvsA:
undetectable
1kb9E-3hvsA:
undetectable		 1kb9A-3hvsA:
19.80
1kb9C-3hvsA:
17.89
1kb9D-3hvsA:
21.60
1kb9E-3hvsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9y SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 4 ILE A 238
VAL A 147
MET A 150
SER A 154
 None
 0.92A 1kb9A-3i9yA:
undetectable
1kb9C-3i9yA:
4.4
1kb9D-3i9yA:
undetectable
1kb9E-3i9yA:
undetectable		 1kb9A-3i9yA:
21.36
1kb9C-3i9yA:
21.86
1kb9D-3i9yA:
19.64
1kb9E-3i9yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 4 SER K 722
HIS K 693
ILE K 534
VAL K 707
 None
SEP  K 533 ( 3.9A)
SEP  K 533 ( 4.0A)
None
 1.14A 1kb9A-3jblK:
undetectable
1kb9C-3jblK:
undetectable
1kb9D-3jblK:
undetectable
1kb9E-3jblK:
undetectable		 1kb9A-3jblK:
19.50
1kb9C-3jblK:
17.36
1kb9D-3jblK:
12.96
1kb9E-3jblK:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 SER A 548
ILE A 137
LYS A 143
VAL A 556
 None
 1.16A 1kb9A-3ksyA:
undetectable
1kb9C-3ksyA:
2.0
1kb9D-3ksyA:
undetectable
1kb9E-3ksyA:
undetectable		 1kb9A-3ksyA:
18.34
1kb9C-3ksyA:
15.71
1kb9D-3ksyA:
13.06
1kb9E-3ksyA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		4 ILE A 231
PHE A 232
VAL A  13
SER A 143
 None
 1.11A 1kb9A-3kvoA:
undetectable
1kb9C-3kvoA:
undetectable
1kb9D-3kvoA:
undetectable
1kb9E-3kvoA:
undetectable		 1kb9A-3kvoA:
23.06
1kb9C-3kvoA:
21.81
1kb9D-3kvoA:
22.38
1kb9E-3kvoA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 HIS C 379
VAL C 216
MET C 219
SER C 351
 PO4  C   1 (-4.2A)
None
None
None
 1.13A 1kb9A-3mc6C:
undetectable
1kb9C-3mc6C:
undetectable
1kb9D-3mc6C:
undetectable
1kb9E-3mc6C:
undetectable		 1kb9A-3mc6C:
22.26
1kb9C-3mc6C:
22.59
1kb9D-3mc6C:
17.40
1kb9E-3mc6C:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		4 SER A 277
ILE A 202
PHE A 203
VAL A 186
 None
 0.99A 1kb9A-3menA:
undetectable
1kb9C-3menA:
undetectable
1kb9D-3menA:
undetectable
1kb9E-3menA:
undetectable		 1kb9A-3menA:
21.14
1kb9C-3menA:
20.96
1kb9D-3menA:
22.05
1kb9E-3menA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owq LIN1025 PROTEIN

(Listeria
innocua) 		PF03816
(LytR_cpsA_psr) 		4 ILE A  95
VAL A 309
MET A 312
SER A 316
 None
 1.13A 1kb9A-3owqA:
undetectable
1kb9C-3owqA:
undetectable
1kb9D-3owqA:
undetectable
1kb9E-3owqA:
undetectable		 1kb9A-3owqA:
22.17
1kb9C-3owqA:
22.08
1kb9D-3owqA:
21.41
1kb9E-3owqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 HIS A 876
ILE A 877
VAL A 627
SER A 621
 None
None
None
PPV  A1001 (-2.9A)
 1.15A 1kb9A-3pihA:
undetectable
1kb9C-3pihA:
undetectable
1kb9D-3pihA:
undetectable
1kb9E-3pihA:
undetectable		 1kb9A-3pihA:
20.24
1kb9C-3pihA:
18.10
1kb9D-3pihA:
13.32
1kb9E-3pihA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		4 SER A 668
ILE A 541
VAL A 606
SER A 580
 None
 1.13A 1kb9A-3t0qA:
undetectable
1kb9C-3t0qA:
undetectable
1kb9D-3t0qA:
undetectable
1kb9E-3t0qA:
undetectable		 1kb9A-3t0qA:
22.39
1kb9C-3t0qA:
21.48
1kb9D-3t0qA:
19.89
1kb9E-3t0qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v68 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF10869
(DUF2666) 		4 SER A  42
ILE A 170
PHE A   8
VAL A  17
 None
 1.17A 1kb9A-3v68A:
undetectable
1kb9C-3v68A:
undetectable
1kb9D-3v68A:
undetectable
1kb9E-3v68A:
undetectable		 1kb9A-3v68A:
20.28
1kb9C-3v68A:
19.95
1kb9D-3v68A:
20.14
1kb9E-3v68A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 SER A 282
HIS A  61
ILE A 119
VAL A  85
 None
FE  A 429 (-3.2A)
None
None
 0.90A 1kb9A-3v7pA:
undetectable
1kb9C-3v7pA:
undetectable
1kb9D-3v7pA:
undetectable
1kb9E-3v7pA:
undetectable		 1kb9A-3v7pA:
23.78
1kb9C-3v7pA:
21.49
1kb9D-3v7pA:
19.36
1kb9E-3v7pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqq L2 PROTEIN III
(PENTON BASE)

(Human
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		4 SER A 378
ILE A 190
VAL A 257
SER A 262
 None
 1.05A 1kb9A-4aqqA:
undetectable
1kb9C-4aqqA:
undetectable
1kb9D-4aqqA:
undetectable
1kb9E-4aqqA:
undetectable		 1kb9A-4aqqA:
22.32
1kb9C-4aqqA:
22.53
1kb9D-4aqqA:
20.83
1kb9E-4aqqA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 SER P 309
ILE P 341
PHE P 264
VAL P 403
 None
 0.91A 1kb9A-4crnP:
undetectable
1kb9C-4crnP:
undetectable
1kb9D-4crnP:
undetectable
1kb9E-4crnP:
undetectable		 1kb9A-4crnP:
22.50
1kb9C-4crnP:
20.43
1kb9D-4crnP:
19.68
1kb9E-4crnP:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 SER A 150
ILE A 141
VAL A 166
SER A 172
 None
None
None
HEM  A1374 (-3.1A)
 1.07A 1kb9A-4czpA:
undetectable
1kb9C-4czpA:
undetectable
1kb9D-4czpA:
undetectable
1kb9E-4czpA:
undetectable		 1kb9A-4czpA:
20.94
1kb9C-4czpA:
21.88
1kb9D-4czpA:
21.77
1kb9E-4czpA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ILE B 538
VAL B 548
MET B 551
SER B 554
 None
 1.12A 1kb9A-4f92B:
undetectable
1kb9C-4f92B:
undetectable
1kb9D-4f92B:
undetectable
1kb9E-4f92B:
undetectable		 1kb9A-4f92B:
13.57
1kb9C-4f92B:
12.08
1kb9D-4f92B:
9.02
1kb9E-4f92B:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc1 10G3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  70
PHE H  79
VAL H  24
SER H   7
 None
 1.16A 1kb9A-4hc1H:
undetectable
1kb9C-4hc1H:
undetectable
1kb9D-4hc1H:
undetectable
1kb9E-4hc1H:
undetectable		 1kb9A-4hc1H:
19.12
1kb9C-4hc1H:
20.72
1kb9D-4hc1H:
21.45
1kb9E-4hc1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 846
ILE A 645
VAL A 401
SER A 550
 None
 1.14A 1kb9A-4iigA:
undetectable
1kb9C-4iigA:
undetectable
1kb9D-4iigA:
undetectable
1kb9E-4iigA:
undetectable		 1kb9A-4iigA:
20.39
1kb9C-4iigA:
19.37
1kb9D-4iigA:
14.01
1kb9E-4iigA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 248
PHE A  87
VAL A 211
SER A 124
 None
FAD  A 400 (-4.9A)
None
None
 1.17A 1kb9A-4irnA:
undetectable
1kb9C-4irnA:
undetectable
1kb9D-4irnA:
undetectable
1kb9E-4irnA:
undetectable		 1kb9A-4irnA:
22.86
1kb9C-4irnA:
22.54
1kb9D-4irnA:
19.09
1kb9E-4irnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
leprae) 		PF00885
(DMRL_synthase) 		4 SER A  25
HIS A  28
ILE A  83
VAL A  93
 None
 1.15A 1kb9A-4j07A:
undetectable
1kb9C-4j07A:
undetectable
1kb9D-4j07A:
undetectable
1kb9E-4j07A:
undetectable		 1kb9A-4j07A:
19.17
1kb9C-4j07A:
21.08
1kb9D-4j07A:
22.54
1kb9E-4j07A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A

(Legionella
drancourtii;
Homo sapiens) 		no annotation
PF00071
(Ras) 		4 ILE B  76
VAL A 438
MET A 445
SER B  42
 None
None
None
AF3  B 401 (-2.0A)
 1.10A 1kb9A-4jvsB:
undetectable
1kb9C-4jvsB:
undetectable
1kb9D-4jvsB:
undetectable
1kb9E-4jvsB:
undetectable		 1kb9A-4jvsB:
18.41
1kb9C-4jvsB:
17.16
1kb9D-4jvsB:
19.92
1kb9E-4jvsB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN

(Ketogulonicigenium
vulgare) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PHE A 167
VAL A 109
MET A 112
SER A 116
 None
 1.15A 1kb9A-4lswA:
undetectable
1kb9C-4lswA:
undetectable
1kb9D-4lswA:
undetectable
1kb9E-4lswA:
undetectable		 1kb9A-4lswA:
22.35
1kb9C-4lswA:
23.27
1kb9D-4lswA:
23.19
1kb9E-4lswA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mew SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 SER A 289
ILE A 266
PHE A 234
VAL A 218
 None
 1.17A 1kb9A-4mewA:
undetectable
1kb9C-4mewA:
undetectable
1kb9D-4mewA:
undetectable
1kb9E-4mewA:
undetectable		 1kb9A-4mewA:
21.90
1kb9C-4mewA:
21.80
1kb9D-4mewA:
20.99
1kb9E-4mewA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 ILE A 588
PHE A 595
VAL A 567
SER A 542
 None
 1.11A 1kb9A-4nfuA:
undetectable
1kb9C-4nfuA:
undetectable
1kb9D-4nfuA:
undetectable
1kb9E-4nfuA:
undetectable		 1kb9A-4nfuA:
22.36
1kb9C-4nfuA:
20.91
1kb9D-4nfuA:
15.52
1kb9E-4nfuA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 ILE A 815
PHE A 227
VAL A 462
SER A 234
 None
 1.04A 1kb9A-4q2cA:
undetectable
1kb9C-4q2cA:
undetectable
1kb9D-4q2cA:
undetectable
1kb9E-4q2cA:
undetectable		 1kb9A-4q2cA:
20.00
1kb9C-4q2cA:
17.18
1kb9D-4q2cA:
13.95
1kb9E-4q2cA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 ILE A 316
PHE A 313
VAL A 299
SER A 365
 None
 0.99A 1kb9A-4q65A:
undetectable
1kb9C-4q65A:
4.0
1kb9D-4q65A:
undetectable
1kb9E-4q65A:
undetectable		 1kb9A-4q65A:
21.81
1kb9C-4q65A:
21.40
1kb9D-4q65A:
18.14
1kb9E-4q65A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 SER A 265
ILE A 252
VAL A 245
SER A 109
 None
 1.17A 1kb9A-4qaxA:
undetectable
1kb9C-4qaxA:
undetectable
1kb9D-4qaxA:
undetectable
1kb9E-4qaxA:
undetectable		 1kb9A-4qaxA:
22.59
1kb9C-4qaxA:
21.48
1kb9D-4qaxA:
19.61
1kb9E-4qaxA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 SER A 168
ILE A 225
PHE A 221
VAL A 208
 None
 1.17A 1kb9A-4uulA:
undetectable
1kb9C-4uulA:
undetectable
1kb9D-4uulA:
undetectable
1kb9E-4uulA:
undetectable		 1kb9A-4uulA:
23.03
1kb9C-4uulA:
18.75
1kb9D-4uulA:
20.33
1kb9E-4uulA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 SER A  28
ILE A 155
VAL A  67
SER A 431
 None
 1.09A 1kb9A-4xniA:
undetectable
1kb9C-4xniA:
undetectable
1kb9D-4xniA:
undetectable
1kb9E-4xniA:
undetectable		 1kb9A-4xniA:
20.66
1kb9C-4xniA:
24.03
1kb9D-4xniA:
19.08
1kb9E-4xniA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2

(Homo sapiens;
Homo sapiens) 		PF00043
(GST_C)
PF00043
(GST_C) 		4 SER B 219
HIS A  75
ILE A  78
VAL B 237
 None
 1.10A 1kb9A-5a1nB:
undetectable
1kb9C-5a1nB:
undetectable
1kb9D-5a1nB:
undetectable
1kb9E-5a1nB:
undetectable		 1kb9A-5a1nB:
17.95
1kb9C-5a1nB:
19.74
1kb9D-5a1nB:
20.66
1kb9E-5a1nB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 SER A   0
ILE A 397
MET A 340
SER A 405
 None
 1.05A 1kb9A-5c70A:
undetectable
1kb9C-5c70A:
undetectable
1kb9D-5c70A:
undetectable
1kb9E-5c70A:
undetectable		 1kb9A-5c70A:
21.57
1kb9C-5c70A:
21.04
1kb9D-5c70A:
17.64
1kb9E-5c70A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 SER A 363
ILE A  15
PHE A  51
MET A 184
 None
UDP  A 501 (-3.7A)
None
None
 1.15A 1kb9A-5dldA:
undetectable
1kb9C-5dldA:
undetectable
1kb9D-5dldA:
undetectable
1kb9E-5dldA:
undetectable		 1kb9A-5dldA:
24.33
1kb9C-5dldA:
22.08
1kb9D-5dldA:
20.05
1kb9E-5dldA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 SER A 190
PHE A 244
VAL A 214
SER A 173
 None
 1.02A 1kb9A-5e3cA:
undetectable
1kb9C-5e3cA:
undetectable
1kb9D-5e3cA:
undetectable
1kb9E-5e3cA:
undetectable		 1kb9A-5e3cA:
20.73
1kb9C-5e3cA:
19.07
1kb9D-5e3cA:
16.09
1kb9E-5e3cA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 4 SER B 701
ILE B 622
PHE B 623
VAL B 606
 None
 0.91A 1kb9A-5efnB:
undetectable
1kb9C-5efnB:
undetectable
1kb9D-5efnB:
undetectable
1kb9E-5efnB:
undetectable		 1kb9A-5efnB:
23.44
1kb9C-5efnB:
20.78
1kb9D-5efnB:
21.54
1kb9E-5efnB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		4 HIS B 382
PHE B 365
LYS B 369
SER B 352
 None
 1.11A 1kb9A-5exrB:
undetectable
1kb9C-5exrB:
undetectable
1kb9D-5exrB:
undetectable
1kb9E-5exrB:
undetectable		 1kb9A-5exrB:
23.97
1kb9C-5exrB:
20.39
1kb9D-5exrB:
18.88
1kb9E-5exrB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 849
ILE A 646
VAL A 402
SER A 551
 None
 1.16A 1kb9A-5fjiA:
undetectable
1kb9C-5fjiA:
undetectable
1kb9D-5fjiA:
undetectable
1kb9E-5fjiA:
undetectable		 1kb9A-5fjiA:
20.17
1kb9C-5fjiA:
19.11
1kb9D-5fjiA:
14.56
1kb9E-5fjiA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 HEAVY CHAIN
(ANTI-LID)

(Mus musculus) 		no annotation 4 ILE X  70
PHE X  79
VAL X  24
SER X   7
 None
 1.17A 1kb9A-5gs0X:
undetectable
1kb9C-5gs0X:
undetectable
1kb9D-5gs0X:
undetectable
1kb9E-5gs0X:
undetectable		 1kb9A-5gs0X:
14.05
1kb9C-5gs0X:
13.95
1kb9D-5gs0X:
21.52
1kb9E-5gs0X:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5o DIGUANYLATE CYCLASE

(Xanthomonas
campestris) 		PF00027
(cNMP_binding) 		4 ILE A  63
PHE A  36
VAL A 131
MET A 130
 None
 1.04A 1kb9A-5h5oA:
undetectable
1kb9C-5h5oA:
undetectable
1kb9D-5h5oA:
undetectable
1kb9E-5h5oA:
undetectable		 1kb9A-5h5oA:
15.13
1kb9C-5h5oA:
15.82
1kb9D-5h5oA:
22.94
1kb9E-5h5oA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A 199
ILE A 273
PHE A 262
VAL A 231
 None
 0.93A 1kb9A-5hctA:
undetectable
1kb9C-5hctA:
undetectable
1kb9D-5hctA:
undetectable
1kb9E-5hctA:
undetectable		 1kb9A-5hctA:
22.46
1kb9C-5hctA:
22.37
1kb9D-5hctA:
20.76
1kb9E-5hctA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 PHE B 132
VAL B  69
MET B  80
SER B 142
 None
 1.12A 1kb9A-5hdfB:
undetectable
1kb9C-5hdfB:
undetectable
1kb9D-5hdfB:
undetectable
1kb9E-5hdfB:
undetectable		 1kb9A-5hdfB:
22.37
1kb9C-5hdfB:
20.37
1kb9D-5hdfB:
20.47
1kb9E-5hdfB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 SER A 144
ILE A 213
VAL A 178
SER A 360
 None
 1.16A 1kb9A-5hh9A:
undetectable
1kb9C-5hh9A:
undetectable
1kb9D-5hh9A:
undetectable
1kb9E-5hh9A:
undetectable		 1kb9A-5hh9A:
22.10
1kb9C-5hh9A:
21.69
1kb9D-5hh9A:
19.70
1kb9E-5hh9A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		4 SER A 299
ILE A 338
PHE A 190
SER A 279
 None
 1.07A 1kb9A-5hvnA:
undetectable
1kb9C-5hvnA:
undetectable
1kb9D-5hvnA:
undetectable
1kb9E-5hvnA:
undetectable		 1kb9A-5hvnA:
23.44
1kb9C-5hvnA:
22.09
1kb9D-5hvnA:
19.11
1kb9E-5hvnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 SER A1281
ILE A1274
PHE A1295
VAL A1255
 None
 1.11A 1kb9A-5i6gA:
undetectable
1kb9C-5i6gA:
undetectable
1kb9D-5i6gA:
undetectable
1kb9E-5i6gA:
undetectable		 1kb9A-5i6gA:
17.45
1kb9C-5i6gA:
14.99
1kb9D-5i6gA:
11.93
1kb9E-5i6gA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 SER A1281
ILE A1274
PHE A1295
VAL A1255
 None
 1.09A 1kb9A-5i6hA:
undetectable
1kb9C-5i6hA:
undetectable
1kb9D-5i6hA:
undetectable
1kb9E-5i6hA:
undetectable		 1kb9A-5i6hA:
15.17
1kb9C-5i6hA:
13.32
1kb9D-5i6hA:
10.22
1kb9E-5i6hA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 SER A 670
ILE A  97
PHE A 465
VAL A 562
 None
 1.08A 1kb9A-5lq3A:
2.5
1kb9C-5lq3A:
undetectable
1kb9D-5lq3A:
undetectable
1kb9E-5lq3A:
undetectable		 1kb9A-5lq3A:
19.55
1kb9C-5lq3A:
17.55
1kb9D-5lq3A:
12.08
1kb9E-5lq3A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		4 SER A 383
ILE A 270
VAL A 366
SER A 344
 None
 1.17A 1kb9A-5lqdA:
undetectable
1kb9C-5lqdA:
undetectable
1kb9D-5lqdA:
undetectable
1kb9E-5lqdA:
undetectable		 1kb9A-5lqdA:
25.24
1kb9C-5lqdA:
20.93
1kb9D-5lqdA:
19.55
1kb9E-5lqdA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 SER A 221
ILE A 375
PHE A 368
SER A 269
 None
 1.15A 1kb9A-5mktA:
undetectable
1kb9C-5mktA:
undetectable
1kb9D-5mktA:
undetectable
1kb9E-5mktA:
undetectable		 1kb9A-5mktA:
undetectable
1kb9C-5mktA:
undetectable
1kb9D-5mktA:
undetectable
1kb9E-5mktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A 199
ILE A 273
PHE A 262
VAL A 231
 None
 0.93A 1kb9A-5p60A:
undetectable
1kb9C-5p60A:
undetectable
1kb9D-5p60A:
undetectable
1kb9E-5p60A:
undetectable		 1kb9A-5p60A:
23.87
1kb9C-5p60A:
21.80
1kb9D-5p60A:
20.96
1kb9E-5p60A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE

(Pseudomonas
aeruginosa) 		PF03331
(LpxC) 		4 SER A  81
HIS A 237
VAL A 100
SER A  20
 None
ZN  A 501 ( 3.2A)
None
None
 1.12A 1kb9A-5u39A:
undetectable
1kb9C-5u39A:
undetectable
1kb9D-5u39A:
undetectable
1kb9E-5u39A:
undetectable		 1kb9A-5u39A:
20.19
1kb9C-5u39A:
22.08
1kb9D-5u39A:
22.29
1kb9E-5u39A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uto EDD DOMAIN PROTEIN,
DEGV FAMILY

(Staphylococcus
aureus) 		no annotation 4 SER A  97
ILE A  25
MET A 123
SER A 261
 None
 1.16A 1kb9A-5utoA:
undetectable
1kb9C-5utoA:
undetectable
1kb9D-5utoA:
undetectable
1kb9E-5utoA:
undetectable		 1kb9A-5utoA:
undetectable
1kb9C-5utoA:
undetectable
1kb9D-5utoA:
undetectable
1kb9E-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0r UBIQUITIN-CONJUGATIN
G ENZYME

(Naegleria
fowleri) 		PF00179
(UQ_con) 		4 SER A  57
ILE A  63
PHE A  64
VAL A 152
 None
 1.12A 1kb9A-5v0rA:
undetectable
1kb9C-5v0rA:
undetectable
1kb9D-5v0rA:
undetectable
1kb9E-5v0rA:
undetectable		 1kb9A-5v0rA:
20.65
1kb9C-5v0rA:
17.24
1kb9D-5v0rA:
19.28
1kb9E-5v0rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C 280
PHE C 281
VAL C 299
SER C 324
 None
 1.14A 1kb9A-5v8fC:
undetectable
1kb9C-5v8fC:
undetectable
1kb9D-5v8fC:
undetectable
1kb9E-5v8fC:
undetectable		 1kb9A-5v8fC:
22.01
1kb9C-5v8fC:
21.06
1kb9D-5v8fC:
17.52
1kb9E-5v8fC:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF13401
(AAA_22)
PF14630
(ORC5_C) 		4 SER E 137
VAL C 139
MET C 142
SER C 146
 None
 0.93A 1kb9A-5v8fE:
undetectable
1kb9C-5v8fE:
undetectable
1kb9D-5v8fE:
undetectable
1kb9E-5v8fE:
undetectable		 1kb9A-5v8fE:
22.10
1kb9C-5v8fE:
21.96
1kb9D-5v8fE:
19.33
1kb9E-5v8fE:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 ILE A 340
PHE A 334
VAL A 382
SER A 388
 None
 0.99A 1kb9A-5vf3A:
undetectable
1kb9C-5vf3A:
undetectable
1kb9D-5vf3A:
undetectable
1kb9E-5vf3A:
undetectable		 1kb9A-5vf3A:
22.13
1kb9C-5vf3A:
23.67
1kb9D-5vf3A:
19.60
1kb9E-5vf3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi4 DYNEIN LIGHT CHAIN
TCTEX-TYPE 1,RHO
GUANINE NUCLEOTIDE
EXCHANGE FACTOR 2

(Mus musculus) 		no annotation 4 ILE A  64
PHE A 109
VAL A 129
SER A  79
 None
 1.09A 1kb9A-5wi4A:
undetectable
1kb9C-5wi4A:
undetectable
1kb9D-5wi4A:
undetectable
1kb9E-5wi4A:
undetectable		 1kb9A-5wi4A:
16.32
1kb9C-5wi4A:
17.56
1kb9D-5wi4A:
22.32
1kb9E-5wi4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 SER A 321
HIS A 226
ILE A 227
SER A 236
 None
 1.11A 1kb9A-5x18A:
undetectable
1kb9C-5x18A:
1.9
1kb9D-5x18A:
undetectable
1kb9E-5x18A:
undetectable		 1kb9A-5x18A:
20.98
1kb9C-5x18A:
20.73
1kb9D-5x18A:
21.47
1kb9E-5x18A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 SER C 882
PHE C3887
VAL C3930
SER C3907
 None
 1.06A 1kb9A-5y3rC:
undetectable
1kb9C-5y3rC:
undetectable
1kb9D-5y3rC:
undetectable
1kb9E-5y3rC:
undetectable		 1kb9A-5y3rC:
7.69
1kb9C-5y3rC:
6.75
1kb9D-5y3rC:
5.19
1kb9E-5y3rC:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum) 		no annotation 4 SER A 257
HIS A  94
PHE A 112
VAL A  77
 None
 1.00A 1kb9A-5ybpA:
undetectable
1kb9C-5ybpA:
undetectable
1kb9D-5ybpA:
undetectable
1kb9E-5ybpA:
undetectable		 1kb9A-5ybpA:
undetectable
1kb9C-5ybpA:
undetectable
1kb9D-5ybpA:
undetectable
1kb9E-5ybpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywp JEV E PROTEIN
JEV M PROTEIN

(Japanese
encephalitis
virus;
Japanese
encephalitis
virus) 		no annotation
no annotation 		4 SER A 275
ILE A  48
VAL A 203
SER B  10
 None
 1.10A 1kb9A-5ywpA:
undetectable
1kb9C-5ywpA:
undetectable
1kb9D-5ywpA:
undetectable
1kb9E-5ywpA:
1.4		 1kb9A-5ywpA:
undetectable
1kb9C-5ywpA:
undetectable
1kb9D-5ywpA:
undetectable
1kb9E-5ywpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 4 SER A  77
ILE A  19
VAL A  36
SER A  50
 None
 1.14A 1kb9A-6b4pA:
undetectable
1kb9C-6b4pA:
undetectable
1kb9D-6b4pA:
undetectable
1kb9E-6b4pA:
undetectable		 1kb9A-6b4pA:
15.02
1kb9C-6b4pA:
15.80
1kb9D-6b4pA:
19.82
1kb9E-6b4pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 SER M 108
HIS M 104
ILE N 395
PHE M  88
 None
 0.86A 1kb9A-6eu2M:
undetectable
1kb9C-6eu2M:
undetectable
1kb9D-6eu2M:
undetectable
1kb9E-6eu2M:
undetectable		 1kb9A-6eu2M:
undetectable
1kb9C-6eu2M:
undetectable
1kb9D-6eu2M:
undetectable
1kb9E-6eu2M:
undetectable