SIMILAR PATTERNS OF AMINO ACIDS FOR 1K74_A_9CRA463_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 GLN A  52
ILE A 246
HIS A  31
 None
 0.65A 1k74A-1amkA:
undetectable		 1k74A-1amkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 321
ILE A 352
HIS A 314
 None
 0.64A 1k74A-1bkhA:
undetectable		 1k74A-1bkhA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		3 GLN A  59
ILE A 114
HIS A 400
 None
 0.65A 1k74A-1by7A:
undetectable		 1k74A-1by7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 GLN A  33
ILE A 194
HIS A 168
 None
 0.60A 1k74A-1khdA:
undetectable		 1k74A-1khdA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 GLN A 366
ILE A 376
HIS A 251
 None
 0.70A 1k74A-1qrrA:
0.0		 1k74A-1qrrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		3 GLN A 246
ILE A 217
HIS A 183
 None
 0.68A 1k74A-1sddA:
undetectable		 1k74A-1sddA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 GLN A 474
ILE A 422
HIS A 364
 None
 0.59A 1k74A-1sxjA:
0.0		 1k74A-1sxjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 GLN A 249
ILE A 178
HIS A 223
 None
 0.70A 1k74A-1tv8A:
undetectable		 1k74A-1tv8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 GLN C 544
ILE C 473
HIS C 516
 None
 0.74A 1k74A-1u6gC:
0.0		 1k74A-1u6gC:
12.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 346
ILE A 416
HIS A 506
 None
 0.57A 1k74A-1uhlA:
34.1		 1k74A-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 GLN A  35
ILE A  81
HIS A  80
 None
 0.65A 1k74A-1vjzA:
undetectable		 1k74A-1vjzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		3 GLN A 150
ILE A 187
HIS A 185
 None
 0.60A 1k74A-1wnhA:
undetectable		 1k74A-1wnhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6d INTERLEUKIN-16

(Homo sapiens) 		PF00595
(PDZ) 		3 GLN A  89
ILE A  20
HIS A  22
 None
 0.71A 1k74A-1x6dA:
undetectable		 1k74A-1x6dA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		3 GLN A 249
ILE A 319
HIS A 409
 9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.8A)
 0.33A 1k74A-1xiuA:
32.2		 1k74A-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 801 (-4.7A)
9CR  A 801 ( 4.5A)
None
 0.34A 1k74A-1xlsA:
37.4		 1k74A-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		3 GLN A 239
ILE A 203
HIS A   7
 None
 0.74A 1k74A-1zswA:
undetectable		 1k74A-1zswA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 GLN A 172
ILE A  86
HIS A  97
 None
 0.73A 1k74A-2akjA:
undetectable		 1k74A-2akjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 GLN A 411
ILE A 228
HIS A 217
 None
 0.68A 1k74A-2dc0A:
undetectable		 1k74A-2dc0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 GLN A 324
ILE A 279
HIS A 261
 None
 0.69A 1k74A-2depA:
undetectable		 1k74A-2depA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlg FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		3 GLN A  86
ILE A  25
HIS A  57
 None
 0.71A 1k74A-2dlgA:
undetectable		 1k74A-2dlgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLN A  40
ILE A 104
HIS A  72
 None
CO  A5367 ( 4.7A)
CO  A5367 (-3.4A)
 0.56A 1k74A-2f7vA:
undetectable		 1k74A-2f7vA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcj SMALL TOPRIM DOMAIN
PROTEIN

(Geobacillus
stearothermophilus) 		PF01751
(Toprim) 		3 GLN A  17
ILE A  82
HIS A  96
 None
 0.74A 1k74A-2fcjA:
undetectable		 1k74A-2fcjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		3 GLN A  43
ILE A  59
HIS A  65
 None
 0.66A 1k74A-2hb6A:
undetectable		 1k74A-2hb6A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 GLN A 152
ILE A 130
HIS A  89
 None
 0.69A 1k74A-2iirA:
undetectable		 1k74A-2iirA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 GLN A 634
ILE A 538
HIS A 646
 None
 0.75A 1k74A-2qtzA:
undetectable		 1k74A-2qtzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 GLN A 139
ILE A 202
HIS A 158
 None
 0.75A 1k74A-2ra1A:
undetectable		 1k74A-2ra1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		3 GLN A 106
ILE A  22
HIS A  84
 None
 0.75A 1k74A-2w1jA:
undetectable		 1k74A-2w1jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		3 GLN B 525
ILE B 511
HIS B 560
 None
 0.71A 1k74A-2wd5B:
undetectable		 1k74A-2wd5B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 GLN A  89
ILE A 265
HIS A 318
 None
 0.73A 1k74A-2xh1A:
undetectable		 1k74A-2xh1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 GLN A 569
ILE A 714
HIS A 716
 None
 0.73A 1k74A-3aflA:
undetectable		 1k74A-3aflA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 749
ILE A 639
HIS A 621
 None
 0.61A 1k74A-3c4fA:
undetectable		 1k74A-3c4fA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		3 GLN A  92
ILE A 144
HIS A 152
 None
 0.62A 1k74A-3colA:
undetectable		 1k74A-3colA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 285
ILE A 367
HIS A 324
 None
 0.69A 1k74A-3dfhA:
undetectable		 1k74A-3dfhA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		3 GLN A 122
ILE A  92
HIS A  53
 None
 0.76A 1k74A-3dkaA:
undetectable		 1k74A-3dkaA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A7223 (-4.6A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-4.3A)
 0.47A 1k74A-3dzuA:
32.8		 1k74A-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		3 GLN A 144
ILE A 246
HIS A 207
 None
 0.54A 1k74A-3eo7A:
undetectable		 1k74A-3eo7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 GLN A 652
ILE A 552
HIS A 543
 None
 0.73A 1k74A-3gwjA:
undetectable		 1k74A-3gwjA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M) 		3 GLN B 847
ILE B 813
HIS B 815
 None
 0.70A 1k74A-3hs0B:
undetectable		 1k74A-3hs0B:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		3 GLN A 189
ILE A 129
HIS A 133
 None
 0.75A 1k74A-3ij6A:
undetectable		 1k74A-3ij6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 GLN A 289
ILE A 192
HIS A 218
 None
 0.72A 1k74A-3ipoA:
undetectable		 1k74A-3ipoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		3 GLN A 158
ILE A 145
HIS A 108
 None
 0.67A 1k74A-3lmbA:
undetectable		 1k74A-3lmbA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Legionella
pneumophila) 		no annotation 3 GLN A 241
ILE A  19
HIS A 297
 None
 0.74A 1k74A-3ltoA:
undetectable		 1k74A-3ltoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.57A 1k74A-3m2tA:
undetectable		 1k74A-3m2tA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		3 GLN A 106
ILE A  96
HIS A 283
 None
 0.55A 1k74A-3mmkA:
undetectable		 1k74A-3mmkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A 341
ILE A 352
HIS A  90
 None
 0.74A 1k74A-3moiA:
undetectable		 1k74A-3moiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nby SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN B  15
ILE B 108
HIS B  24
 None
 0.62A 1k74A-3nbyB:
undetectable		 1k74A-3nbyB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 GLN A 378
ILE A 399
HIS A 326
 None
 0.72A 1k74A-3oflA:
undetectable		 1k74A-3oflA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		3 GLN A 130
ILE A  58
HIS A  68
 None
 0.73A 1k74A-3okfA:
undetectable		 1k74A-3okfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLN B 869
ILE B 835
HIS B 837
 None
 0.60A 1k74A-3prxB:
undetectable		 1k74A-3prxB:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 285
ILE A 367
HIS A 324
 None
 0.62A 1k74A-3s47A:
undetectable		 1k74A-3s47A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 GLN A 325
ILE A 272
HIS A 377
 None
 0.68A 1k74A-3s51A:
undetectable		 1k74A-3s51A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE

(Vibrio cholerae) 		PF00857
(Isochorismatase) 		3 GLN A  60
ILE A 152
HIS A  34
 None
 0.72A 1k74A-3tb4A:
undetectable		 1k74A-3tb4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 283
ILE A 365
HIS A 322
 None
 0.62A 1k74A-3tjiA:
undetectable		 1k74A-3tjiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.51A 1k74A-3tr1A:
undetectable		 1k74A-3tr1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 GLN A 175
ILE A  59
HIS A 157
 None
 0.58A 1k74A-3tr7A:
undetectable		 1k74A-3tr7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaf TTR-52

(Caenorhabditis
elegans) 		PF01060
(TTR-52) 		3 GLN A  73
ILE A 108
HIS A  95
 None
 0.68A 1k74A-3uafA:
undetectable		 1k74A-3uafA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiw GLUTAREDOXIN 2

(Danio rerio) 		PF00462
(Glutaredoxin) 		3 GLN A  89
ILE A  50
HIS A 101
 None
 0.66A 1k74A-3uiwA:
undetectable		 1k74A-3uiwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 GLN A 168
ILE A 156
HIS A 213
 None
 0.63A 1k74A-3zukA:
undetectable		 1k74A-3zukA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 GLN A 301
ILE A 166
HIS A 269
 None
 0.74A 1k74A-4arpA:
undetectable		 1k74A-4arpA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 GLN A 580
ILE A 475
HIS A 507
 None
 0.70A 1k74A-4b9yA:
undetectable		 1k74A-4b9yA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		3 GLN A 210
ILE A 145
HIS A  80
 None
 0.72A 1k74A-4dr0A:
3.3		 1k74A-4dr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		3 GLN A  52
ILE A  97
HIS A  89
 None
 0.66A 1k74A-4eeiA:
undetectable		 1k74A-4eeiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2)
PF12678
(zf-rbx1) 		3 GLN E 427
ILE B  37
HIS E 413
 None
 0.71A 1k74A-4f52E:
undetectable		 1k74A-4f52E:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		3 GLN A 148
ILE A 126
HIS A  85
 None
 0.74A 1k74A-4fwmA:
undetectable		 1k74A-4fwmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 259
ILE A 231
HIS A 246
 None
 0.56A 1k74A-4g56A:
undetectable		 1k74A-4g56A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 GLN A 102
ILE A 141
HIS A 111
 None
 0.53A 1k74A-4ggjA:
undetectable		 1k74A-4ggjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 283
ILE A 365
HIS A 322
 None
 0.61A 1k74A-4gisA:
undetectable		 1k74A-4gisA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		3 GLN A  53
ILE A 247
HIS A  32
 None
 0.60A 1k74A-4gnjA:
undetectable		 1k74A-4gnjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 263
ILE A 235
HIS A 250
 None
 0.55A 1k74A-4gqbA:
undetectable		 1k74A-4gqbA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 283
ILE A 365
HIS A 322
 None
 0.70A 1k74A-4hnlA:
undetectable		 1k74A-4hnlA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		3 GLN A 217
ILE A 138
HIS A 174
 None
 0.70A 1k74A-4i9cA:
undetectable		 1k74A-4i9cA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		3 GLN A 215
ILE A 127
HIS A 247
 None
 0.73A 1k74A-4ixuA:
undetectable		 1k74A-4ixuA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 3 GLN D 275
ILE D 345
HIS D 435
 None
 0.39A 1k74A-4j5xD:
32.8		 1k74A-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		3 GLN A 169
ILE A 235
HIS A 197
 None
 0.72A 1k74A-4j6cA:
undetectable		 1k74A-4j6cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 3 GLN A 257
ILE A 218
HIS A 217
 None
 0.73A 1k74A-4nkhA:
undetectable		 1k74A-4nkhA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 GLN A  40
ILE A 103
HIS A 237
 None
 0.75A 1k74A-4pu5A:
undetectable		 1k74A-4pu5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8g UNCONVENTIONAL
MYOSIN-IC

(Mus musculus) 		PF00612
(IQ)
PF06017
(Myosin_TH1) 		3 GLN E 960
ILE E 999
HIS E1017
 None
 0.74A 1k74A-4r8gE:
undetectable		 1k74A-4r8gE:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLN A 356
ILE A 321
HIS A 432
 None
 0.76A 1k74A-4w8jA:
undetectable		 1k74A-4w8jA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLN A 255
ILE A 344
HIS A 375
 None
 0.65A 1k74A-4yweA:
undetectable		 1k74A-4yweA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 GLN A 698
ILE A 710
HIS A 714
 None
 0.48A 1k74A-4z0cA:
undetectable		 1k74A-4z0cA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.67A 1k74A-5cioA:
undetectable		 1k74A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.57A 1k74A-5cioA:
undetectable		 1k74A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN C  16
ILE C 109
HIS C  25
 None
 0.55A 1k74A-5disC:
undetectable		 1k74A-5disC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 GLN B 446
ILE B 276
HIS B 292
 None
 0.75A 1k74A-5exrB:
undetectable		 1k74A-5exrB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		3 GLN A 144
ILE A 252
HIS A 248
 None
 0.70A 1k74A-5h42A:
undetectable		 1k74A-5h42A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 GLN A 355
ILE A 488
HIS A 568
 None
 0.65A 1k74A-5k3hA:
undetectable		 1k74A-5k3hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbc DSBA

(Chlamydia
trachomatis) 		PF13462
(Thioredoxin_4) 		3 GLN A 149
ILE A 137
HIS A  88
 None
 0.73A 1k74A-5kbcA:
undetectable		 1k74A-5kbcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpt AMYLOID-LIKE PROTEIN
2

(Homo sapiens) 		no annotation 3 GLN A 480
ILE A 557
HIS A 487
 None
 0.75A 1k74A-5tptA:
undetectable		 1k74A-5tptA:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.40A 1k74A-5uanA:
33.2		 1k74A-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 GLN A 148
ILE A 134
HIS A 143
 POP  A 401 ( 4.5A)
None
None
 0.73A 1k74A-5ub6A:
undetectable		 1k74A-5ub6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 GLN A 463
ILE A 490
HIS A 494
 None
 0.71A 1k74A-5ujuA:
undetectable		 1k74A-5ujuA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis) 		PF01245
(Ribosomal_L19) 		3 GLN P  40
ILE P  16
HIS P  76
 None
 0.73A 1k74A-5v7qP:
undetectable		 1k74A-5v7qP:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		3 GLN B 167
ILE B 432
HIS B 395
 None
 0.74A 1k74A-5x2oB:
undetectable		 1k74A-5x2oB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea) 		no annotation 3 GLN A  63
ILE A 151
HIS A 119
 None
 0.71A 1k74A-5x88A:
undetectable		 1k74A-5x88A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Saccharomyces
cerevisiae) 		no annotation 3 GLN C 108
ILE C 149
HIS D 111
 None
 0.68A 1k74A-5xynC:
undetectable		 1k74A-5xynC:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yep TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY

(Shewanella
oneidensis) 		no annotation 3 GLN B  44
ILE B   4
HIS B  56
 None
 0.72A 1k74A-5yepB:
undetectable		 1k74A-5yepB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E
PHASE 2
FLAGELLIN,FLAGELLIN

(Mus musculus;
Salmonella
enterica) 		no annotation 3 GLN C 485
ILE A 791
HIS A 835
 None
 0.74A 1k74A-5yudC:
undetectable		 1k74A-5yudC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.69A 1k74A-6cetN:
undetectable		 1k74A-6cetN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmn TAR-BINDING PROTEIN
6.7

(Oryctolagus
cuniculus) 		no annotation 3 GLN A  54
ILE A  40
HIS A  31
 A  D  35 ( 2.9A)
None
None
 0.57A 1k74A-6cmnA:
undetectable		 1k74A-6cmnA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 3 GLN A 481
ILE A 376
HIS A 464
 None
 0.63A 1k74A-6ercA:
undetectable		 1k74A-6ercA:
15.38