SIMILAR PATTERNS OF AMINO ACIDS FOR 1K74_A_9CRA463_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.96A 1k74A-1csjA:
undetectable		 1k74A-1csjA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		6 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
 None
 0.91A 1k74A-1e19A:
undetectable		 1k74A-1e19A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ALA A 303
ALA A 304
LEU A 260
LEU A 416
ALA A 417
 None
 0.93A 1k74A-1e1cA:
undetectable		 1k74A-1e1cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.88A 1k74A-1fc4A:
undetectable		 1k74A-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.96A 1k74A-1gxnA:
undetectable		 1k74A-1gxnA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 322
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.8A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.67A 1k74A-1hg4A:
24.2		 1k74A-1hg4A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 366
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.80A 1k74A-1hg4A:
24.2		 1k74A-1hg4A:
44.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		6 ILE A 132
ALA A 520
ALA A 519
LEU A 528
LEU A 136
ALA A 139
 None
 1.35A 1k74A-1iq0A:
undetectable		 1k74A-1iq0A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		6 ALA A 227
ALA A 226
LEU A 225
LEU A 124
ALA A 146
LEU A 212
 None
 1.24A 1k74A-1iqrA:
undetectable		 1k74A-1iqrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE A 428
ALA A 388
LEU A 441
LEU A 384
LEU A 486
 None
 0.80A 1k74A-1j0hA:
undetectable		 1k74A-1j0hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		6 ILE A 253
ALA A 298
LEU A 306
ALA A 299
VAL A 236
LEU A 282
 None
 1.40A 1k74A-1lv7A:
undetectable		 1k74A-1lv7A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
 None
 0.90A 1k74A-1n60A:
undetectable		 1k74A-1n60A:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 350
TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 EST  A   1 ( 3.7A)
None
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
 0.93A 1k74A-1pcgA:
25.3		 1k74A-1pcgA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
ARG A 297
LEU A 325
VAL A 341
LEU A 435
 None
None
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
 0.73A 1k74A-1r20A:
23.8		 1k74A-1r20A:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
LEU A 290
LEU A 325
VAL A 341
LEU A 435
 None
EPH  A4000 ( 4.8A)
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
 0.79A 1k74A-1r20A:
23.8		 1k74A-1r20A:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 342
ALA A 343
TRP A 376
LEU A 380
ARG A 387
ALA A 398
LEU A 526
 MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
None
 1.40A 1k74A-1uhlA:
34.1		 1k74A-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
ALA A 343
TRP A 376
LEU A 380
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.60A 1k74A-1uhlA:
34.1		 1k74A-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdl UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Mus musculus) 		PF14555
(UBA_4) 		5 ILE A  42
ALA A  46
LEU A  28
LEU A  61
ALA A  57
 None
 0.98A 1k74A-1vdlA:
undetectable		 1k74A-1vdlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		5 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.86A 1k74A-1wraA:
undetectable		 1k74A-1wraA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 ALA A 134
ALA A 135
LEU A 291
LEU A 165
ALA A 166
 None
 0.86A 1k74A-1xa0A:
undetectable		 1k74A-1xa0A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 ILE A 127
ALA A 135
LEU A 291
LEU A 165
ALA A 166
 None
 0.94A 1k74A-1xa0A:
undetectable		 1k74A-1xa0A:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 ILE A 242
ALA A 245
ALA A 246
TRP A 279
LEU A 283
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.31A 1k74A-1xiuA:
32.2		 1k74A-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.36A 1k74A-1xlsA:
37.4		 1k74A-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.89A 1k74A-1xv9B:
20.2		 1k74A-1xv9B:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
 None
 0.90A 1k74A-1z5xU:
21.4		 1k74A-1z5xU:
69.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 ILE A  22
ALA A  20
LEU A  62
VAL A  75
LEU A  97
 None
 0.88A 1k74A-2bibA:
undetectable		 1k74A-2bibA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		6 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.94A 1k74A-2dpnA:
undetectable		 1k74A-2dpnA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 TRP A  84
LEU A  88
PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
 None
 0.80A 1k74A-2gl8A:
27.0		 1k74A-2gl8A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.94A 1k74A-2hxoA:
undetectable		 1k74A-2hxoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ALA A 264
ALA A 263
LEU A 322
LEU A 250
ALA A 247
 None
 0.97A 1k74A-2iu3A:
undetectable		 1k74A-2iu3A:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.91A 1k74A-2nxxA:
25.3		 1k74A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.66A 1k74A-2nxxA:
25.3		 1k74A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 350
TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 EST  A 596 ( 3.9A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
CME  A 417 ( 3.2A)
EST  A 596 (-3.6A)
 0.93A 1k74A-2ocfA:
25.6		 1k74A-2ocfA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.95A 1k74A-2oi2A:
undetectable		 1k74A-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
VAL A 136
 None
 0.97A 1k74A-2p6wA:
undetectable		 1k74A-2p6wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.86A 1k74A-2ptzA:
undetectable		 1k74A-2ptzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.96A 1k74A-2pziA:
undetectable		 1k74A-2pziA:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		7 TRP A 180
LEU A 184
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
 None
 0.62A 1k74A-2q60A:
26.2		 1k74A-2q60A:
71.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.96A 1k74A-2vmlA:
undetectable		 1k74A-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150

(Saccharomyces
cerevisiae) 		PF02854
(MIF4G) 		5 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.83A 1k74A-2vsxE:
undetectable		 1k74A-2vsxE:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.74A 1k74A-2w1zA:
undetectable		 1k74A-2w1zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c GENE 0.3 PROTEIN

(Escherichia
virus T7) 		PF08684
(ocr) 		5 ILE D  33
ALA D  36
ALA D  37
LEU D  85
LEU D  14
 None
 0.81A 1k74A-2y7cD:
undetectable		 1k74A-2y7cD:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		5 ILE C 247
ALA C 251
ALA C 250
LEU C 232
LEU C 166
 None
 0.93A 1k74A-2ynmC:
undetectable		 1k74A-2ynmC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
 None
 0.95A 1k74A-3afgA:
undetectable		 1k74A-3afgA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
 None
None
None
None
CLR  A 401 ( 4.6A)
 0.95A 1k74A-3am6A:
undetectable		 1k74A-3am6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		6 ILE A  42
ALA A 232
ALA A 231
LEU A 373
LEU A 239
LEU A  66
 ADP  A 411 (-4.9A)
ADP  A 411 (-3.6A)
None
None
ADP  A 411 (-4.4A)
None
 1.37A 1k74A-3c4nA:
undetectable		 1k74A-3c4nA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.95A 1k74A-3djcA:
undetectable		 1k74A-3djcA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.64A 1k74A-3dzuA:
32.8		 1k74A-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2) 		5 ILE K  86
ALA K  89
ALA K  90
LEU C 256
LEU K  49
 None
 0.91A 1k74A-3h0gK:
undetectable		 1k74A-3h0gK:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
 None
 0.66A 1k74A-3hveA:
undetectable		 1k74A-3hveA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.73A 1k74A-3hveA:
undetectable		 1k74A-3hveA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		6 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
LEU B  87
 None
 0.90A 1k74A-3hveB:
undetectable		 1k74A-3hveB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.79A 1k74A-3ic5A:
undetectable		 1k74A-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
 None
 0.80A 1k74A-3ipcA:
undetectable		 1k74A-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		6 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.16A 1k74A-3o0mA:
undetectable		 1k74A-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o10 SACSIN

(Homo sapiens) 		PF05168
(HEPN) 		5 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.95A 1k74A-3o10A:
undetectable		 1k74A-3o10A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.68A 1k74A-3q60A:
undetectable		 1k74A-3q60A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 0.88A 1k74A-3rkoN:
undetectable		 1k74A-3rkoN:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		6 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 1k74A-3rmjA:
undetectable		 1k74A-3rmjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.70A 1k74A-3wxwA:
undetectable		 1k74A-3wxwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
 None
 1.40A 1k74A-3zilA:
undetectable		 1k74A-3zilA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrg PEXRD2 FAMILY
SECRETED RXLR
EFFECTOR PEPTIDE,
PUTATIVE

(Phytophthora
infestans) 		no annotation 6 ILE A  86
ALA A  89
ALA A  90
LEU A  99
ALA A  95
VAL A  73
 None
None
None
BR  A1122 ( 4.5A)
None
None
 1.48A 1k74A-3zrgA:
undetectable		 1k74A-3zrgA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.88A 1k74A-4a7wA:
undetectable		 1k74A-4a7wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		6 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.12A 1k74A-4b8bA:
undetectable		 1k74A-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		5 ALA B 324
ALA B 325
LEU B 309
LEU B  27
LEU B 105
 None
 0.90A 1k74A-4g68B:
undetectable		 1k74A-4g68B:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.88A 1k74A-4g7fA:
undetectable		 1k74A-4g7fA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 7 ALA D 271
ALA D 272
TRP D 305
LEU D 309
ARG D 316
ALA D 327
LEU D 455
 None
 1.39A 1k74A-4j5xD:
32.8		 1k74A-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
ALA D 272
TRP D 305
LEU D 309
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
 None
 0.58A 1k74A-4j5xD:
32.8		 1k74A-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.83A 1k74A-4jz7A:
undetectable		 1k74A-4jz7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.94A 1k74A-4k70A:
undetectable		 1k74A-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
desulfuricans) 		PF03480
(DctP) 		5 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.85A 1k74A-4nhbA:
undetectable		 1k74A-4nhbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		6 ILE A 356
ALA A 542
ALA A 354
LEU A 350
LEU A  92
ALA A 539
 None
 1.46A 1k74A-4qfhA:
undetectable		 1k74A-4qfhA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE C  72
ALA C  69
ALA C  68
LEU C 307
LEU A 845
 None
 0.97A 1k74A-4qiwC:
undetectable		 1k74A-4qiwC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.91A 1k74A-4rrjA:
undetectable		 1k74A-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		6 ILE A 264
ALA A 261
ALA A 260
LEU A 134
ALA A 133
LEU A 286
 None
 1.33A 1k74A-4v1uA:
undetectable		 1k74A-4v1uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.13A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.41A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.38A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
 None
 0.72A 1k74A-4xgjA:
undetectable		 1k74A-4xgjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		6 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.25A 1k74A-4ynvA:
undetectable		 1k74A-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
 None
 0.91A 1k74A-5gt5A:
undetectable		 1k74A-5gt5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM

(Pseudomonas
aeruginosa) 		PF01323
(DSBA) 		5 ALA A 149
ALA A 147
LEU A 134
LEU A 105
ALA A 101
 ALA  A 149 ( 0.0A)
ALA  A 147 ( 0.0A)
LEU  A 134 ( 0.6A)
LEU  A 105 ( 0.6A)
ALA  A 101 ( 0.0A)
 0.92A 1k74A-5hfiA:
undetectable		 1k74A-5hfiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.97A 1k74A-5hj5A:
undetectable		 1k74A-5hj5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A1072
ALA A1069
ALA A1068
LEU A1370
LEU A 841
 None
 0.93A 1k74A-5ip9A:
undetectable		 1k74A-5ip9A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		5 ALA A  62
ALA A  63
LEU A  68
VAL A  22
LEU A 109
 None
 0.97A 1k74A-5jr4A:
undetectable		 1k74A-5jr4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.50A 1k74A-5lpzA:
undetectable		 1k74A-5lpzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
 None
 0.98A 1k74A-5m49A:
undetectable		 1k74A-5m49A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 1k74A-5mzyA:
undetectable		 1k74A-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 6 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
VAL A  80
 None
 1.23A 1k74A-5n0gA:
undetectable		 1k74A-5n0gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.81A 1k74A-5ohsA:
undetectable		 1k74A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 302
TRP A 335
LEU A 339
ARG A 346
VAL A 370
LEU A 476
 EST  A 601 ( 3.9A)
None
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
None
EST  A 601 (-3.5A)
 1.07A 1k74A-5toaA:
23.2		 1k74A-5toaA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.56A 1k74A-5uanA:
33.2		 1k74A-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.93A 1k74A-5uvmA:
undetectable		 1k74A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.89A 1k74A-5uvmA:
undetectable		 1k74A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.93A 1k74A-5xnzA:
undetectable		 1k74A-5xnzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.97A 1k74A-5xogA:
undetectable		 1k74A-5xogA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 0.97A 1k74A-5xogB:
undetectable		 1k74A-5xogB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
 None
 0.94A 1k74A-5xyiT:
undetectable		 1k74A-5xyiT:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 5 ALA A 256
ALA A 255
LEU A 251
PHE A 252
LEU A  28
 None
 0.90A 1k74A-5zmyA:
undetectable		 1k74A-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 138
LEU A 267
ALA A 266
 None
 0.92A 1k74A-6d95A:
undetectable		 1k74A-6d95A:
undetectable