SIMILAR PATTERNS OF AMINO ACIDS FOR 1K74_A_9CRA463

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.96A 1k74A-1csjA:
undetectable		 1k74A-1csjA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		6 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
 None
 0.91A 1k74A-1e19A:
undetectable		 1k74A-1e19A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ALA A 303
ALA A 304
LEU A 260
LEU A 416
ALA A 417
 None
 0.93A 1k74A-1e1cA:
undetectable		 1k74A-1e1cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.88A 1k74A-1fc4A:
undetectable		 1k74A-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.96A 1k74A-1gxnA:
undetectable		 1k74A-1gxnA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 322
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.8A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.67A 1k74A-1hg4A:
24.2		 1k74A-1hg4A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 366
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.80A 1k74A-1hg4A:
24.2		 1k74A-1hg4A:
44.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		6 ILE A 132
ALA A 520
ALA A 519
LEU A 528
LEU A 136
ALA A 139
 None
 1.35A 1k74A-1iq0A:
undetectable		 1k74A-1iq0A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		6 ALA A 227
ALA A 226
LEU A 225
LEU A 124
ALA A 146
LEU A 212
 None
 1.24A 1k74A-1iqrA:
undetectable		 1k74A-1iqrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE A 428
ALA A 388
LEU A 441
LEU A 384
LEU A 486
 None
 0.80A 1k74A-1j0hA:
undetectable		 1k74A-1j0hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		6 ILE A 253
ALA A 298
LEU A 306
ALA A 299
VAL A 236
LEU A 282
 None
 1.40A 1k74A-1lv7A:
undetectable		 1k74A-1lv7A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
 None
 0.90A 1k74A-1n60A:
undetectable		 1k74A-1n60A:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 350
TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 EST  A   1 ( 3.7A)
None
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
 0.93A 1k74A-1pcgA:
25.3		 1k74A-1pcgA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
ARG A 297
LEU A 325
VAL A 341
LEU A 435
 None
None
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
 0.73A 1k74A-1r20A:
23.8		 1k74A-1r20A:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
LEU A 290
LEU A 325
VAL A 341
LEU A 435
 None
EPH  A4000 ( 4.8A)
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
 0.79A 1k74A-1r20A:
23.8		 1k74A-1r20A:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 342
ALA A 343
TRP A 376
LEU A 380
ARG A 387
ALA A 398
LEU A 526
 MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
None
 1.40A 1k74A-1uhlA:
34.1		 1k74A-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
ALA A 343
TRP A 376
LEU A 380
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.60A 1k74A-1uhlA:
34.1		 1k74A-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdl UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Mus musculus) 		PF14555
(UBA_4) 		5 ILE A  42
ALA A  46
LEU A  28
LEU A  61
ALA A  57
 None
 0.98A 1k74A-1vdlA:
undetectable		 1k74A-1vdlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		5 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.86A 1k74A-1wraA:
undetectable		 1k74A-1wraA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 ALA A 134
ALA A 135
LEU A 291
LEU A 165
ALA A 166
 None
 0.86A 1k74A-1xa0A:
undetectable		 1k74A-1xa0A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 ILE A 127
ALA A 135
LEU A 291
LEU A 165
ALA A 166
 None
 0.94A 1k74A-1xa0A:
undetectable		 1k74A-1xa0A:
24.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 ILE A 242
ALA A 245
ALA A 246
TRP A 279
LEU A 283
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.31A 1k74A-1xiuA:
32.2		 1k74A-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.36A 1k74A-1xlsA:
37.4		 1k74A-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.89A 1k74A-1xv9B:
20.2		 1k74A-1xv9B:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
 None
 0.90A 1k74A-1z5xU:
21.4		 1k74A-1z5xU:
69.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 ILE A  22
ALA A  20
LEU A  62
VAL A  75
LEU A  97
 None
 0.88A 1k74A-2bibA:
undetectable		 1k74A-2bibA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		6 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 0.94A 1k74A-2dpnA:
undetectable		 1k74A-2dpnA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 TRP A  84
LEU A  88
PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
 None
 0.80A 1k74A-2gl8A:
27.0		 1k74A-2gl8A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.94A 1k74A-2hxoA:
undetectable		 1k74A-2hxoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ALA A 264
ALA A 263
LEU A 322
LEU A 250
ALA A 247
 None
 0.97A 1k74A-2iu3A:
undetectable		 1k74A-2iu3A:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.91A 1k74A-2nxxA:
25.3		 1k74A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.66A 1k74A-2nxxA:
25.3		 1k74A-2nxxA:
63.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 350
TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 EST  A 596 ( 3.9A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
CME  A 417 ( 3.2A)
EST  A 596 (-3.6A)
 0.93A 1k74A-2ocfA:
25.6		 1k74A-2ocfA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.95A 1k74A-2oi2A:
undetectable		 1k74A-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
VAL A 136
 None
 0.97A 1k74A-2p6wA:
undetectable		 1k74A-2p6wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.86A 1k74A-2ptzA:
undetectable		 1k74A-2ptzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 ILE A 661
ALA A 664
ALA A 665
LEU A 704
ALA A 644
 None
 0.96A 1k74A-2pziA:
undetectable		 1k74A-2pziA:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		7 TRP A 180
LEU A 184
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
 None
 0.62A 1k74A-2q60A:
26.2		 1k74A-2q60A:
71.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.96A 1k74A-2vmlA:
undetectable		 1k74A-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsx EUKARYOTIC
INITIATION FACTOR 4F
SUBUNIT P150

(Saccharomyces
cerevisiae) 		PF02854
(MIF4G) 		5 ILE E 652
ALA E 656
LEU E 614
VAL E 673
LEU E 753
 None
 0.83A 1k74A-2vsxE:
undetectable		 1k74A-2vsxE:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.74A 1k74A-2w1zA:
undetectable		 1k74A-2w1zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c GENE 0.3 PROTEIN

(Escherichia
virus T7) 		PF08684
(ocr) 		5 ILE D  33
ALA D  36
ALA D  37
LEU D  85
LEU D  14
 None
 0.81A 1k74A-2y7cD:
undetectable		 1k74A-2y7cD:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		5 ILE C 247
ALA C 251
ALA C 250
LEU C 232
LEU C 166
 None
 0.93A 1k74A-2ynmC:
undetectable		 1k74A-2ynmC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
 None
 0.95A 1k74A-3afgA:
undetectable		 1k74A-3afgA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
 None
None
None
None
CLR  A 401 ( 4.6A)
 0.95A 1k74A-3am6A:
undetectable		 1k74A-3am6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		6 ILE A  42
ALA A 232
ALA A 231
LEU A 373
LEU A 239
LEU A  66
 ADP  A 411 (-4.9A)
ADP  A 411 (-3.6A)
None
None
ADP  A 411 (-4.4A)
None
 1.37A 1k74A-3c4nA:
undetectable		 1k74A-3c4nA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.95A 1k74A-3djcA:
undetectable		 1k74A-3djcA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.64A 1k74A-3dzuA:
32.8		 1k74A-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2) 		5 ILE K  86
ALA K  89
ALA K  90
LEU C 256
LEU K  49
 None
 0.91A 1k74A-3h0gK:
undetectable		 1k74A-3h0gK:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
 None
 0.66A 1k74A-3hveA:
undetectable		 1k74A-3hveA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.73A 1k74A-3hveA:
undetectable		 1k74A-3hveA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		6 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
LEU B  87
 None
 0.90A 1k74A-3hveB:
undetectable		 1k74A-3hveB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.79A 1k74A-3ic5A:
undetectable		 1k74A-3ic5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		5 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
 None
 0.80A 1k74A-3ipcA:
undetectable		 1k74A-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		6 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.16A 1k74A-3o0mA:
undetectable		 1k74A-3o0mA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o10 SACSIN

(Homo sapiens) 		PF05168
(HEPN) 		5 ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
 None
 0.95A 1k74A-3o10A:
undetectable		 1k74A-3o10A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.68A 1k74A-3q60A:
undetectable		 1k74A-3q60A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 0.88A 1k74A-3rkoN:
undetectable		 1k74A-3rkoN:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		6 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 1k74A-3rmjA:
undetectable		 1k74A-3rmjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.70A 1k74A-3wxwA:
undetectable		 1k74A-3wxwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
 None
 1.40A 1k74A-3zilA:
undetectable		 1k74A-3zilA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrg PEXRD2 FAMILY
SECRETED RXLR
EFFECTOR PEPTIDE,
PUTATIVE

(Phytophthora
infestans) 		no annotation 6 ILE A  86
ALA A  89
ALA A  90
LEU A  99
ALA A  95
VAL A  73
 None
None
None
BR  A1122 ( 4.5A)
None
None
 1.48A 1k74A-3zrgA:
undetectable		 1k74A-3zrgA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.88A 1k74A-4a7wA:
undetectable		 1k74A-4a7wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		6 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.12A 1k74A-4b8bA:
undetectable		 1k74A-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		5 ALA B 324
ALA B 325
LEU B 309
LEU B  27
LEU B 105
 None
 0.90A 1k74A-4g68B:
undetectable		 1k74A-4g68B:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.88A 1k74A-4g7fA:
undetectable		 1k74A-4g7fA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 7 ALA D 271
ALA D 272
TRP D 305
LEU D 309
ARG D 316
ALA D 327
LEU D 455
 None
 1.39A 1k74A-4j5xD:
32.8		 1k74A-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
ALA D 272
TRP D 305
LEU D 309
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
 None
 0.58A 1k74A-4j5xD:
32.8		 1k74A-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.83A 1k74A-4jz7A:
undetectable		 1k74A-4jz7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.94A 1k74A-4k70A:
undetectable		 1k74A-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
desulfuricans) 		PF03480
(DctP) 		5 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.85A 1k74A-4nhbA:
undetectable		 1k74A-4nhbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		6 ILE A 356
ALA A 542
ALA A 354
LEU A 350
LEU A  92
ALA A 539
 None
 1.46A 1k74A-4qfhA:
undetectable		 1k74A-4qfhA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE C  72
ALA C  69
ALA C  68
LEU C 307
LEU A 845
 None
 0.97A 1k74A-4qiwC:
undetectable		 1k74A-4qiwC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.91A 1k74A-4rrjA:
undetectable		 1k74A-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		6 ILE A 264
ALA A 261
ALA A 260
LEU A 134
ALA A 133
LEU A 286
 None
 1.33A 1k74A-4v1uA:
undetectable		 1k74A-4v1uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.13A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.41A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.38A 1k74A-4xboA:
undetectable		 1k74A-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
 None
 0.72A 1k74A-4xgjA:
undetectable		 1k74A-4xgjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		6 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.25A 1k74A-4ynvA:
undetectable		 1k74A-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
 None
 0.91A 1k74A-5gt5A:
undetectable		 1k74A-5gt5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM

(Pseudomonas
aeruginosa) 		PF01323
(DSBA) 		5 ALA A 149
ALA A 147
LEU A 134
LEU A 105
ALA A 101
 ALA  A 149 ( 0.0A)
ALA  A 147 ( 0.0A)
LEU  A 134 ( 0.6A)
LEU  A 105 ( 0.6A)
ALA  A 101 ( 0.0A)
 0.92A 1k74A-5hfiA:
undetectable		 1k74A-5hfiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.97A 1k74A-5hj5A:
undetectable		 1k74A-5hj5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A1072
ALA A1069
ALA A1068
LEU A1370
LEU A 841
 None
 0.93A 1k74A-5ip9A:
undetectable		 1k74A-5ip9A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		5 ALA A  62
ALA A  63
LEU A  68
VAL A  22
LEU A 109
 None
 0.97A 1k74A-5jr4A:
undetectable		 1k74A-5jr4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.50A 1k74A-5lpzA:
undetectable		 1k74A-5lpzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
 None
 0.98A 1k74A-5m49A:
undetectable		 1k74A-5m49A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 1k74A-5mzyA:
undetectable		 1k74A-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 6 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
VAL A  80
 None
 1.23A 1k74A-5n0gA:
undetectable		 1k74A-5n0gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.81A 1k74A-5ohsA:
undetectable		 1k74A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 302
TRP A 335
LEU A 339
ARG A 346
VAL A 370
LEU A 476
 EST  A 601 ( 3.9A)
None
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
None
EST  A 601 (-3.5A)
 1.07A 1k74A-5toaA:
23.2		 1k74A-5toaA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.56A 1k74A-5uanA:
33.2		 1k74A-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.93A 1k74A-5uvmA:
undetectable		 1k74A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.89A 1k74A-5uvmA:
undetectable		 1k74A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.93A 1k74A-5xnzA:
undetectable		 1k74A-5xnzA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A1074
ALA A1071
ALA A1070
LEU A1373
LEU A 842
 None
 0.97A 1k74A-5xogA:
undetectable		 1k74A-5xogA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 247
ALA B 229
LEU B 378
VAL B 277
LEU B 354
 None
 0.97A 1k74A-5xogB:
undetectable		 1k74A-5xogB:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
 None
 0.94A 1k74A-5xyiT:
undetectable		 1k74A-5xyiT:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 5 ALA A 256
ALA A 255
LEU A 251
PHE A 252
LEU A  28
 None
 0.90A 1k74A-5zmyA:
undetectable		 1k74A-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 138
LEU A 267
ALA A 266
 None
 0.92A 1k74A-6d95A:
undetectable		 1k74A-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 GLN A  52
ILE A 246
HIS A  31
 None
 0.65A 1k74A-1amkA:
undetectable		 1k74A-1amkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 321
ILE A 352
HIS A 314
 None
 0.64A 1k74A-1bkhA:
undetectable		 1k74A-1bkhA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		3 GLN A  59
ILE A 114
HIS A 400
 None
 0.65A 1k74A-1by7A:
undetectable		 1k74A-1by7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 GLN A  33
ILE A 194
HIS A 168
 None
 0.60A 1k74A-1khdA:
undetectable		 1k74A-1khdA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 GLN A 366
ILE A 376
HIS A 251
 None
 0.70A 1k74A-1qrrA:
0.0		 1k74A-1qrrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		3 GLN A 246
ILE A 217
HIS A 183
 None
 0.68A 1k74A-1sddA:
undetectable		 1k74A-1sddA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 GLN A 474
ILE A 422
HIS A 364
 None
 0.59A 1k74A-1sxjA:
0.0		 1k74A-1sxjA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 GLN A 249
ILE A 178
HIS A 223
 None
 0.70A 1k74A-1tv8A:
undetectable		 1k74A-1tv8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 GLN C 544
ILE C 473
HIS C 516
 None
 0.74A 1k74A-1u6gC:
0.0		 1k74A-1u6gC:
12.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 346
ILE A 416
HIS A 506
 None
 0.57A 1k74A-1uhlA:
34.1		 1k74A-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		3 GLN A  35
ILE A  81
HIS A  80
 None
 0.65A 1k74A-1vjzA:
undetectable		 1k74A-1vjzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		3 GLN A 150
ILE A 187
HIS A 185
 None
 0.60A 1k74A-1wnhA:
undetectable		 1k74A-1wnhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6d INTERLEUKIN-16

(Homo sapiens) 		PF00595
(PDZ) 		3 GLN A  89
ILE A  20
HIS A  22
 None
 0.71A 1k74A-1x6dA:
undetectable		 1k74A-1x6dA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		3 GLN A 249
ILE A 319
HIS A 409
 9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.8A)
 0.33A 1k74A-1xiuA:
32.2		 1k74A-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 801 (-4.7A)
9CR  A 801 ( 4.5A)
None
 0.34A 1k74A-1xlsA:
37.4		 1k74A-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		3 GLN A 239
ILE A 203
HIS A   7
 None
 0.74A 1k74A-1zswA:
undetectable		 1k74A-1zswA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 GLN A 172
ILE A  86
HIS A  97
 None
 0.73A 1k74A-2akjA:
undetectable		 1k74A-2akjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 GLN A 411
ILE A 228
HIS A 217
 None
 0.68A 1k74A-2dc0A:
undetectable		 1k74A-2dc0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 GLN A 324
ILE A 279
HIS A 261
 None
 0.69A 1k74A-2depA:
undetectable		 1k74A-2depA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlg FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		3 GLN A  86
ILE A  25
HIS A  57
 None
 0.71A 1k74A-2dlgA:
undetectable		 1k74A-2dlgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLN A  40
ILE A 104
HIS A  72
 None
CO  A5367 ( 4.7A)
CO  A5367 (-3.4A)
 0.56A 1k74A-2f7vA:
undetectable		 1k74A-2f7vA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcj SMALL TOPRIM DOMAIN
PROTEIN

(Geobacillus
stearothermophilus) 		PF01751
(Toprim) 		3 GLN A  17
ILE A  82
HIS A  96
 None
 0.74A 1k74A-2fcjA:
undetectable		 1k74A-2fcjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		3 GLN A  43
ILE A  59
HIS A  65
 None
 0.66A 1k74A-2hb6A:
undetectable		 1k74A-2hb6A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 GLN A 152
ILE A 130
HIS A  89
 None
 0.69A 1k74A-2iirA:
undetectable		 1k74A-2iirA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 GLN A 634
ILE A 538
HIS A 646
 None
 0.75A 1k74A-2qtzA:
undetectable		 1k74A-2qtzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra1 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 GLN A 139
ILE A 202
HIS A 158
 None
 0.75A 1k74A-2ra1A:
undetectable		 1k74A-2ra1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		3 GLN A 106
ILE A  22
HIS A  84
 None
 0.75A 1k74A-2w1jA:
undetectable		 1k74A-2w1jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Mus musculus) 		PF06470
(SMC_hinge) 		3 GLN B 525
ILE B 511
HIS B 560
 None
 0.71A 1k74A-2wd5B:
undetectable		 1k74A-2wd5B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		3 GLN A  89
ILE A 265
HIS A 318
 None
 0.73A 1k74A-2xh1A:
undetectable		 1k74A-2xh1A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 GLN A 569
ILE A 714
HIS A 716
 None
 0.73A 1k74A-3aflA:
undetectable		 1k74A-3aflA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 749
ILE A 639
HIS A 621
 None
 0.61A 1k74A-3c4fA:
undetectable		 1k74A-3c4fA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		3 GLN A  92
ILE A 144
HIS A 152
 None
 0.62A 1k74A-3colA:
undetectable		 1k74A-3colA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 285
ILE A 367
HIS A 324
 None
 0.69A 1k74A-3dfhA:
undetectable		 1k74A-3dfhA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		3 GLN A 122
ILE A  92
HIS A  53
 None
 0.76A 1k74A-3dkaA:
undetectable		 1k74A-3dkaA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A7223 (-4.6A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-4.3A)
 0.47A 1k74A-3dzuA:
32.8		 1k74A-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		3 GLN A 144
ILE A 246
HIS A 207
 None
 0.54A 1k74A-3eo7A:
undetectable		 1k74A-3eo7A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 GLN A 652
ILE A 552
HIS A 543
 None
 0.73A 1k74A-3gwjA:
undetectable		 1k74A-3gwjA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M) 		3 GLN B 847
ILE B 813
HIS B 815
 None
 0.70A 1k74A-3hs0B:
undetectable		 1k74A-3hs0B:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		3 GLN A 189
ILE A 129
HIS A 133
 None
 0.75A 1k74A-3ij6A:
undetectable		 1k74A-3ij6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipo PUTATIVE THIOSULFATE
SULFURTRANSFERASE
YNJE

(Escherichia
coli) 		PF00581
(Rhodanese) 		3 GLN A 289
ILE A 192
HIS A 218
 None
 0.72A 1k74A-3ipoA:
undetectable		 1k74A-3ipoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmb UNCHARACTERIZED
PROTEIN

(Oleispira
antarctica) 		PF09500
(YiiD_C) 		3 GLN A 158
ILE A 145
HIS A 108
 None
 0.67A 1k74A-3lmbA:
undetectable		 1k74A-3lmbA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Legionella
pneumophila) 		no annotation 3 GLN A 241
ILE A  19
HIS A 297
 None
 0.74A 1k74A-3ltoA:
undetectable		 1k74A-3ltoA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.57A 1k74A-3m2tA:
undetectable		 1k74A-3m2tA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		3 GLN A 106
ILE A  96
HIS A 283
 None
 0.55A 1k74A-3mmkA:
undetectable		 1k74A-3mmkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A 341
ILE A 352
HIS A  90
 None
 0.74A 1k74A-3moiA:
undetectable		 1k74A-3moiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nby SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN B  15
ILE B 108
HIS B  24
 None
 0.62A 1k74A-3nbyB:
undetectable		 1k74A-3nbyB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 GLN A 378
ILE A 399
HIS A 326
 None
 0.72A 1k74A-3oflA:
undetectable		 1k74A-3oflA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		3 GLN A 130
ILE A  58
HIS A  68
 None
 0.73A 1k74A-3okfA:
undetectable		 1k74A-3okfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLN B 869
ILE B 835
HIS B 837
 None
 0.60A 1k74A-3prxB:
undetectable		 1k74A-3prxB:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 285
ILE A 367
HIS A 324
 None
 0.62A 1k74A-3s47A:
undetectable		 1k74A-3s47A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 GLN A 325
ILE A 272
HIS A 377
 None
 0.68A 1k74A-3s51A:
undetectable		 1k74A-3s51A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb4 VIBRIOBACTIN-SPECIFI
C ISOCHORISMATASE

(Vibrio cholerae) 		PF00857
(Isochorismatase) 		3 GLN A  60
ILE A 152
HIS A  34
 None
 0.72A 1k74A-3tb4A:
undetectable		 1k74A-3tb4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 283
ILE A 365
HIS A 322
 None
 0.62A 1k74A-3tjiA:
undetectable		 1k74A-3tjiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.51A 1k74A-3tr1A:
undetectable		 1k74A-3tr1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 GLN A 175
ILE A  59
HIS A 157
 None
 0.58A 1k74A-3tr7A:
undetectable		 1k74A-3tr7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaf TTR-52

(Caenorhabditis
elegans) 		PF01060
(TTR-52) 		3 GLN A  73
ILE A 108
HIS A  95
 None
 0.68A 1k74A-3uafA:
undetectable		 1k74A-3uafA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiw GLUTAREDOXIN 2

(Danio rerio) 		PF00462
(Glutaredoxin) 		3 GLN A  89
ILE A  50
HIS A 101
 None
 0.66A 1k74A-3uiwA:
undetectable		 1k74A-3uiwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 GLN A 168
ILE A 156
HIS A 213
 None
 0.63A 1k74A-3zukA:
undetectable		 1k74A-3zukA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 GLN A 301
ILE A 166
HIS A 269
 None
 0.74A 1k74A-4arpA:
undetectable		 1k74A-4arpA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 GLN A 580
ILE A 475
HIS A 507
 None
 0.70A 1k74A-4b9yA:
undetectable		 1k74A-4b9yA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		3 GLN A 210
ILE A 145
HIS A  80
 None
 0.72A 1k74A-4dr0A:
3.3		 1k74A-4dr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		3 GLN A  52
ILE A  97
HIS A  89
 None
 0.66A 1k74A-4eeiA:
undetectable		 1k74A-4eeiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2)
PF12678
(zf-rbx1) 		3 GLN E 427
ILE B  37
HIS E 413
 None
 0.71A 1k74A-4f52E:
undetectable		 1k74A-4f52E:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwm PROPIONATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		3 GLN A 148
ILE A 126
HIS A  85
 None
 0.74A 1k74A-4fwmA:
undetectable		 1k74A-4fwmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 259
ILE A 231
HIS A 246
 None
 0.56A 1k74A-4g56A:
undetectable		 1k74A-4g56A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 GLN A 102
ILE A 141
HIS A 111
 None
 0.53A 1k74A-4ggjA:
undetectable		 1k74A-4ggjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 283
ILE A 365
HIS A 322
 None
 0.61A 1k74A-4gisA:
undetectable		 1k74A-4gisA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		3 GLN A  53
ILE A 247
HIS A  32
 None
 0.60A 1k74A-4gnjA:
undetectable		 1k74A-4gnjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 263
ILE A 235
HIS A 250
 None
 0.55A 1k74A-4gqbA:
undetectable		 1k74A-4gqbA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A 283
ILE A 365
HIS A 322
 None
 0.70A 1k74A-4hnlA:
undetectable		 1k74A-4hnlA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		3 GLN A 217
ILE A 138
HIS A 174
 None
 0.70A 1k74A-4i9cA:
undetectable		 1k74A-4i9cA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixu ARGINASE-2,
MITOCHONDRIAL

(Homo sapiens) 		PF00491
(Arginase) 		3 GLN A 215
ILE A 127
HIS A 247
 None
 0.73A 1k74A-4ixuA:
undetectable		 1k74A-4ixuA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 3 GLN D 275
ILE D 345
HIS D 435
 None
 0.39A 1k74A-4j5xD:
32.8		 1k74A-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		3 GLN A 169
ILE A 235
HIS A 197
 None
 0.72A 1k74A-4j6cA:
undetectable		 1k74A-4j6cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 3 GLN A 257
ILE A 218
HIS A 217
 None
 0.73A 1k74A-4nkhA:
undetectable		 1k74A-4nkhA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 GLN A  40
ILE A 103
HIS A 237
 None
 0.75A 1k74A-4pu5A:
undetectable		 1k74A-4pu5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8g UNCONVENTIONAL
MYOSIN-IC

(Mus musculus) 		PF00612
(IQ)
PF06017
(Myosin_TH1) 		3 GLN E 960
ILE E 999
HIS E1017
 None
 0.74A 1k74A-4r8gE:
undetectable		 1k74A-4r8gE:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLN A 356
ILE A 321
HIS A 432
 None
 0.76A 1k74A-4w8jA:
undetectable		 1k74A-4w8jA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLN A 255
ILE A 344
HIS A 375
 None
 0.65A 1k74A-4yweA:
undetectable		 1k74A-4yweA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 GLN A 698
ILE A 710
HIS A 714
 None
 0.48A 1k74A-4z0cA:
undetectable		 1k74A-4z0cA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.67A 1k74A-5cioA:
undetectable		 1k74A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.57A 1k74A-5cioA:
undetectable		 1k74A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN C  16
ILE C 109
HIS C  25
 None
 0.55A 1k74A-5disC:
undetectable		 1k74A-5disC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 GLN B 446
ILE B 276
HIS B 292
 None
 0.75A 1k74A-5exrB:
undetectable		 1k74A-5exrB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		3 GLN A 144
ILE A 252
HIS A 248
 None
 0.70A 1k74A-5h42A:
undetectable		 1k74A-5h42A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 GLN A 355
ILE A 488
HIS A 568
 None
 0.65A 1k74A-5k3hA:
undetectable		 1k74A-5k3hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbc DSBA

(Chlamydia
trachomatis) 		PF13462
(Thioredoxin_4) 		3 GLN A 149
ILE A 137
HIS A  88
 None
 0.73A 1k74A-5kbcA:
undetectable		 1k74A-5kbcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpt AMYLOID-LIKE PROTEIN
2

(Homo sapiens) 		no annotation 3 GLN A 480
ILE A 557
HIS A 487
 None
 0.75A 1k74A-5tptA:
undetectable		 1k74A-5tptA:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.40A 1k74A-5uanA:
33.2		 1k74A-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 GLN A 148
ILE A 134
HIS A 143
 POP  A 401 ( 4.5A)
None
None
 0.73A 1k74A-5ub6A:
undetectable		 1k74A-5ub6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 GLN A 463
ILE A 490
HIS A 494
 None
 0.71A 1k74A-5ujuA:
undetectable		 1k74A-5ujuA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis) 		PF01245
(Ribosomal_L19) 		3 GLN P  40
ILE P  16
HIS P  76
 None
 0.73A 1k74A-5v7qP:
undetectable		 1k74A-5v7qP:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		3 GLN B 167
ILE B 432
HIS B 395
 None
 0.74A 1k74A-5x2oB:
undetectable		 1k74A-5x2oB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea) 		no annotation 3 GLN A  63
ILE A 151
HIS A 119
 None
 0.71A 1k74A-5x88A:
undetectable		 1k74A-5x88A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Saccharomyces
cerevisiae) 		no annotation 3 GLN C 108
ILE C 149
HIS D 111
 None
 0.68A 1k74A-5xynC:
undetectable		 1k74A-5xynC:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yep TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY

(Shewanella
oneidensis) 		no annotation 3 GLN B  44
ILE B   4
HIS B  56
 None
 0.72A 1k74A-5yepB:
undetectable		 1k74A-5yepB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E
PHASE 2
FLAGELLIN,FLAGELLIN

(Mus musculus;
Salmonella
enterica) 		no annotation 3 GLN C 485
ILE A 791
HIS A 835
 None
 0.74A 1k74A-5yudC:
undetectable		 1k74A-5yudC:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.69A 1k74A-6cetN:
undetectable		 1k74A-6cetN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmn TAR-BINDING PROTEIN
6.7

(Oryctolagus
cuniculus) 		no annotation 3 GLN A  54
ILE A  40
HIS A  31
 A  D  35 ( 2.9A)
None
None
 0.57A 1k74A-6cmnA:
undetectable		 1k74A-6cmnA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 3 GLN A 481
ILE A 376
HIS A 464
 None
 0.63A 1k74A-6ercA:
undetectable		 1k74A-6ercA:
15.38