SIMILAR PATTERNS OF AMINO ACIDS FOR 1K2U_B_H4BB2760_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dvk | PRP18 (Saccharomycescerevisiae) |
PF02840(Prp18) | 4 | TRP A 242PHE A 239GLU A 241ARG A 123 | None | 1.45A | 1k2uA-1dvkA:1.61k2uB-1dvkA:1.4 | 1k2uA-1dvkA:18.451k2uB-1dvkA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1flg | PROTEIN(QUINOPROTEINETHANOLDEHYDROGENASE) (Pseudomonasaeruginosa) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | PHE A 501GLU A 519VAL A 41TRP A 521 | None | 1.35A | 1k2uA-1flgA:0.01k2uB-1flgA:0.0 | 1k2uA-1flgA:21.001k2uB-1flgA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kex | NEUROPILIN-1 (Homo sapiens) |
PF00754(F5_F8_type_C) | 4 | TRP A 97PHE A 131GLU A 95ARG A 130 | None | 1.45A | 1k2uA-1kexA:undetectable1k2uB-1kexA:0.0 | 1k2uA-1kexA:16.831k2uB-1kexA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kh2 | ARGININOSUCCINATESYNTHETASE (Thermusthermophilus) |
PF00764(Arginosuc_synth) | 4 | PHE A 220GLU A 222ARG A 282VAL A 226 | None | 1.33A | 1k2uA-1kh2A:0.01k2uB-1kh2A:0.0 | 1k2uA-1kh2A:22.911k2uB-1kh2A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1knb | ADENOVIRUS TYPE 5FIBER PROTEIN (HumanmastadenovirusC) |
PF00541(Adeno_knob) | 4 | TRP A 558PHE A 568GLU A 566VAL A 530 | None | 1.48A | 1k2uA-1knbA:0.01k2uB-1knbA:0.0 | 1k2uA-1knbA:18.981k2uB-1knbA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mhz | METHANEMONOOXYGENASEHYDROXYLASE (Methylosinustrichosporium) |
PF02332(Phenol_Hydrox) | 4 | PHE D 35GLU D 132VAL D 28TRP D 31 | None | 1.32A | 1k2uA-1mhzD:0.01k2uB-1mhzD:0.0 | 1k2uA-1mhzD:20.891k2uB-1mhzD:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzb | FERRIC UPTAKEREGULATION PROTEIN (Pseudomonasaeruginosa) |
PF01475(FUR) | 4 | PHE A 79GLU A 36ARG A 69VAL A 54 | None | 1.06A | 1k2uA-1mzbA:0.31k2uB-1mzbA:0.6 | 1k2uA-1mzbA:16.711k2uB-1mzbA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 4 | TRP A 277PHE A 254GLU A 250VAL A 122 | None | 1.48A | 1k2uA-1tkiA:0.01k2uB-1tkiA:0.0 | 1k2uA-1tkiA:20.371k2uB-1tkiA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmk | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermotogamaritima) |
PF01048(PNP_UDP_1) | 4 | TRP A 162PHE A 265GLU A 161VAL A 221 | None | 1.45A | 1k2uA-1vmkA:0.01k2uB-1vmkA:0.0 | 1k2uA-1vmkA:21.531k2uB-1vmkA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | ETHYLBENZENEDIOXYGENASE SMALLSUBUNIT (Pseudomonasfluorescens) |
PF00866(Ring_hydroxyl_B) | 4 | PHE B 163GLU B 26ARG B 156VAL B 128 | None | 1.16A | 1k2uA-1wqlB:undetectable1k2uB-1wqlB:undetectable | 1k2uA-1wqlB:19.791k2uB-1wqlB:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | PHE A 722GLU A 693ARG A 708VAL A1424 | None | 1.06A | 1k2uA-2b39A:undetectable1k2uB-2b39A:undetectable | 1k2uA-2b39A:13.471k2uB-2b39A:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glf | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Thermotogamaritima) |
PF02127(Peptidase_M18) | 4 | PHE A 21GLU A 17ARG A 261VAL A 443 | None | 1.24A | 1k2uA-2glfA:undetectable1k2uB-2glfA:undetectable | 1k2uA-2glfA:20.951k2uB-2glfA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vy0 | ENDO-BETA-1,3-GLUCANASE (Pyrococcusfuriosus) |
PF00722(Glyco_hydro_16) | 4 | TRP A 252PHE A 254GLU A 251VAL A 245 | NoneNoneMRD A1301 (-4.3A)None | 1.41A | 1k2uA-2vy0A:undetectable1k2uB-2vy0A:undetectable | 1k2uA-2vy0A:19.681k2uB-2vy0A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IV (Homo sapiens) |
PF00069(Pkinase) | 4 | TRP A 266PHE A 261ARG A 278VAL A 269 | None | 1.41A | 1k2uA-2w4oA:undetectable1k2uB-2w4oA:undetectable | 1k2uA-2w4oA:20.911k2uB-2w4oA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhy | 6-PHOSPHO-BETA-GLUCOSIDASE BGLA (Escherichiacoli) |
PF00232(Glyco_hydro_1) | 4 | PHE A 98GLU A 108ARG A 159VAL A 164 | None | 1.43A | 1k2uA-2xhyA:undetectable1k2uB-2xhyA:undetectable | 1k2uA-2xhyA:20.361k2uB-2xhyA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 4 | PHE A 309GLU A 305ARG A 211VAL A 239 | None | 1.21A | 1k2uA-2ywbA:undetectable1k2uB-2ywbA:undetectable | 1k2uA-2ywbA:21.891k2uB-2ywbA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z11 | RIBOSOMAL-PROTEIN-ALANINEACETYLTRANSFERASE (Thermusthermophilus) |
PF13302(Acetyltransf_3) | 4 | TRP A 66PHE A 4GLU A 6VAL A 64 | None | 1.41A | 1k2uA-2z11A:undetectable1k2uB-2z11A:undetectable | 1k2uA-2z11A:17.591k2uB-2z11A:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 4 | TRP A 374GLU A 372VAL A 314TRP A 293 | NoneEDO A 404 ( 3.8A)NoneNone | 1.43A | 1k2uA-3b7fA:undetectable1k2uB-3b7fA:undetectable | 1k2uA-3b7fA:20.651k2uB-3b7fA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bit | FACT COMPLEX SUBUNITSPT16 (Saccharomycescerevisiae) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 4 | TRP A 147PHE A 117ARG A 105VAL A 35 | None | 1.49A | 1k2uA-3bitA:undetectable1k2uB-3bitA:undetectable | 1k2uA-3bitA:23.651k2uB-3bitA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjd | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE (Pseudomonasaeruginosa) |
PF14515(HOASN)PF14518(Haem_oxygenas_2) | 4 | PHE A 152GLU A 205ARG A 153VAL A 211 | NoneNoneNoneEDO A 401 ( 4.2A) | 1.48A | 1k2uA-3bjdA:undetectable1k2uB-3bjdA:undetectable | 1k2uA-3bjdA:21.701k2uB-3bjdA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckb | SUSD (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB) | 4 | TRP A 485PHE A 489GLU A 484ARG A 437 | None | 1.03A | 1k2uA-3ckbA:undetectable1k2uB-3ckbA:undetectable | 1k2uA-3ckbA:19.681k2uB-3ckbA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddl | XANTHORHODOPSIN (Salinibacterruber) |
PF01036(Bac_rhodopsin) | 4 | TRP A 70PHE A 88GLU A 71VAL A 16 | None | 1.48A | 1k2uA-3ddlA:undetectable1k2uB-3ddlA:undetectable | 1k2uA-3ddlA:20.231k2uB-3ddlA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3p | IPAH9.8 (Shigellaflexneri) |
PF14496(NEL) | 4 | TRP A 274GLU A 314VAL A 258TRP A 261 | None | 1.28A | 1k2uA-3l3pA:undetectable1k2uB-3l3pA:undetectable | 1k2uA-3l3pA:20.701k2uB-3l3pA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ma6 | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | TRP A 257PHE A 252ARG A 269VAL A 260 | None | 1.43A | 1k2uA-3ma6A:undetectable1k2uB-3ma6A:undetectable | 1k2uA-3ma6A:21.651k2uB-3ma6A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n3k | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Homo sapiens) |
PF00443(UCH) | 4 | TRP A1001PHE A 946GLU A 908ARG A 944 | None | 1.43A | 1k2uA-3n3kA:undetectable1k2uB-3n3kA:undetectable | 1k2uA-3n3kA:19.741k2uB-3n3kA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ner | CYTOCHROME B5 TYPE B (Homo sapiens) |
PF00173(Cyt-b5) | 4 | PHE A 58GLU A 56ARG A 68VAL A 61 | HEM A 201 (-4.7A)NoneNoneHEM A 201 (-4.5A) | 1.49A | 1k2uA-3nerA:undetectable1k2uB-3nerA:undetectable | 1k2uA-3nerA:14.931k2uB-3nerA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | PHE A 121GLU A 119ARG A 175VAL A 92 | None | 1.21A | 1k2uA-3owcA:undetectable1k2uB-3owcA:undetectable | 1k2uA-3owcA:16.391k2uB-3owcA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjy | ENDOGLUCANASEFNCEL5A (Fervidobacteriumnodosum) |
PF00150(Cellulase) | 4 | TRP A 146PHE A 162GLU A 187VAL A 149 | None | 1.30A | 1k2uA-3rjyA:undetectable1k2uB-3rjyA:undetectable | 1k2uA-3rjyA:20.181k2uB-3rjyA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti8 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | PHE A 305GLU A 265VAL A 240TRP A 239 | None | 1.44A | 1k2uA-3ti8A:undetectable1k2uB-3ti8A:undetectable | 1k2uA-3ti8A:22.151k2uB-3ti8A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tix | CHROMODOMAIN-CONTAININGPROTEIN 1 (Schizosaccharomycespombe) |
no annotation | 4 | PHE B 953GLU B 951ARG B 924VAL B 944 | None | 1.22A | 1k2uA-3tixB:undetectable1k2uB-3tixB:undetectable | 1k2uA-3tixB:22.551k2uB-3tixB:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmv | GLUTATHIONETRANSFERASE (Phanerochaetechrysosporium) |
PF13417(GST_N_3) | 4 | PHE A 7GLU A 42ARG A 29VAL A 73 | NoneNoneNoneFLC A 300 (-4.1A) | 1.07A | 1k2uA-4lmvA:undetectable1k2uB-4lmvA:undetectable | 1k2uA-4lmvA:21.101k2uB-4lmvA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh1 | SORBOSEDEHYDROGENASE (Ketogulonicigeniumvulgare) |
PF13360(PQQ_2) | 4 | TRP A 218PHE A 286ARG A 385TRP A 387 | None | 1.41A | 1k2uA-4mh1A:undetectable1k2uB-4mh1A:undetectable | 1k2uA-4mh1A:21.281k2uB-4mh1A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | PHE A 264GLU A 266ARG A 276VAL A 305 | None | 1.22A | 1k2uA-4xj6A:undetectable1k2uB-4xj6A:undetectable | 1k2uA-4xj6A:21.031k2uB-4xj6A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | TRP A 263PHE A 264GLU A 266VAL A 305 | None | 1.07A | 1k2uA-4xj6A:undetectable1k2uB-4xj6A:undetectable | 1k2uA-4xj6A:21.031k2uB-4xj6A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylr | TUBULINPOLYGLUTAMYLASETTLL7 (Homo sapiens) |
PF03133(TTL) | 4 | PHE A 277GLU A 279VAL A 288TRP A 292 | None | 1.39A | 1k2uA-4ylrA:undetectable1k2uB-4ylrA:undetectable | 1k2uA-4ylrA:22.901k2uB-4ylrA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 4 | TRP A 732GLU A 731ARG A 505VAL A 736 | None | 1.39A | 1k2uA-5by3A:undetectable1k2uB-5by3A:undetectable | 1k2uA-5by3A:19.871k2uB-5by3A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6g | AGR133CPSISTER CHROMATIDCOHESION PROTEIN 2 (Eremotheciumgossypii) |
PF10345(Cohesin_load)no annotation | 4 | TRP A 401PHE A 397GLU A 402VAL B 28 | None | 1.48A | 1k2uA-5c6gA:3.61k2uB-5c6gA:undetectable | 1k2uA-5c6gA:22.191k2uB-5c6gA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjn | L-AMINO ACIDDEAMINASE (Cosenzaeamyxofaciens) |
PF01266(DAO) | 4 | GLU A 418ARG A 316VAL A 438TRP A 439 | NoneBE2 A1476 (-4.0A)BE2 A1476 ( 4.3A)BE2 A1476 ( 3.7A) | 1.35A | 1k2uA-5fjnA:undetectable1k2uB-5fjnA:undetectable | 1k2uA-5fjnA:24.551k2uB-5fjnA:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kqi | CATALASE-PEROXIDASE (Burkholderiapseudomallei) |
PF00141(peroxidase) | 4 | TRP A 736PHE A 732GLU A 560VAL A 481 | None | 1.48A | 1k2uA-5kqiA:undetectable1k2uB-5kqiA:undetectable | 1k2uA-5kqiA:19.971k2uB-5kqiA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | TRP A 414PHE A 411GLU A 413ARG A 225 | None | 1.03A | 1k2uA-5m8tA:undetectable1k2uB-5m8tA:undetectable | 1k2uA-5m8tA:19.871k2uB-5m8tA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xf7 | PROTEINDISULFIDE-ISOMERASE-LIKE PROTEIN OF THETESTIS (Homo sapiens) |
no annotation | 4 | PHE A 113GLU A 106ARG A 129VAL A 65 | None | 1.20A | 1k2uA-5xf7A:undetectable1k2uB-5xf7A:undetectable | 1k2uA-5xf7A:13.091k2uB-5xf7A:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgp | SECRETED XWNT8INHIBITOR SIZZLED (Xenopus laevis) |
PF01392(Fz) | 4 | PHE A 180GLU A 222VAL A 254TRP A 224 | None | 0.91A | 1k2uA-5xgpA:undetectable1k2uB-5xgpA:undetectable | 1k2uA-5xgpA:19.811k2uB-5xgpA:19.81 |