SIMILAR PATTERNS OF AMINO ACIDS FOR 1K2U_B_H4BB2760_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae)
PF02840
(Prp18)
4 TRP A 242
PHE A 239
GLU A 241
ARG A 123
None
1.45A 1k2uA-1dvkA:
1.6
1k2uB-1dvkA:
1.4
1k2uA-1dvkA:
18.45
1k2uB-1dvkA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)


(Pseudomonas
aeruginosa)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 PHE A 501
GLU A 519
VAL A  41
TRP A 521
None
1.35A 1k2uA-1flgA:
0.0
1k2uB-1flgA:
0.0
1k2uA-1flgA:
21.00
1k2uB-1flgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 TRP A  97
PHE A 131
GLU A  95
ARG A 130
None
1.45A 1k2uA-1kexA:
undetectable
1k2uB-1kexA:
0.0
1k2uA-1kexA:
16.83
1k2uB-1kexA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
4 PHE A 220
GLU A 222
ARG A 282
VAL A 226
None
1.33A 1k2uA-1kh2A:
0.0
1k2uB-1kh2A:
0.0
1k2uA-1kh2A:
22.91
1k2uB-1kh2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knb ADENOVIRUS TYPE 5
FIBER PROTEIN


(Human
mastadenovirus
C)
PF00541
(Adeno_knob)
4 TRP A 558
PHE A 568
GLU A 566
VAL A 530
None
1.48A 1k2uA-1knbA:
0.0
1k2uB-1knbA:
0.0
1k2uA-1knbA:
18.98
1k2uB-1knbA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
4 PHE D  35
GLU D 132
VAL D  28
TRP D  31
None
1.32A 1k2uA-1mhzD:
0.0
1k2uB-1mhzD:
0.0
1k2uA-1mhzD:
20.89
1k2uB-1mhzD:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN


(Pseudomonas
aeruginosa)
PF01475
(FUR)
4 PHE A  79
GLU A  36
ARG A  69
VAL A  54
None
1.06A 1k2uA-1mzbA:
0.3
1k2uB-1mzbA:
0.6
1k2uA-1mzbA:
16.71
1k2uB-1mzbA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
4 TRP A 277
PHE A 254
GLU A 250
VAL A 122
None
1.48A 1k2uA-1tkiA:
0.0
1k2uB-1tkiA:
0.0
1k2uA-1tkiA:
20.37
1k2uB-1tkiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
4 TRP A 162
PHE A 265
GLU A 161
VAL A 221
None
1.45A 1k2uA-1vmkA:
0.0
1k2uB-1vmkA:
0.0
1k2uA-1vmkA:
21.53
1k2uB-1vmkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 PHE B 163
GLU B  26
ARG B 156
VAL B 128
None
1.16A 1k2uA-1wqlB:
undetectable
1k2uB-1wqlB:
undetectable
1k2uA-1wqlB:
19.79
1k2uB-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 PHE A 722
GLU A 693
ARG A 708
VAL A1424
None
1.06A 1k2uA-2b39A:
undetectable
1k2uB-2b39A:
undetectable
1k2uA-2b39A:
13.47
1k2uB-2b39A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Thermotoga
maritima)
PF02127
(Peptidase_M18)
4 PHE A  21
GLU A  17
ARG A 261
VAL A 443
None
1.24A 1k2uA-2glfA:
undetectable
1k2uB-2glfA:
undetectable
1k2uA-2glfA:
20.95
1k2uB-2glfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE


(Pyrococcus
furiosus)
PF00722
(Glyco_hydro_16)
4 TRP A 252
PHE A 254
GLU A 251
VAL A 245
None
None
MRD  A1301 (-4.3A)
None
1.41A 1k2uA-2vy0A:
undetectable
1k2uB-2vy0A:
undetectable
1k2uA-2vy0A:
19.68
1k2uB-2vy0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 TRP A 266
PHE A 261
ARG A 278
VAL A 269
None
1.41A 1k2uA-2w4oA:
undetectable
1k2uB-2w4oA:
undetectable
1k2uA-2w4oA:
20.91
1k2uB-2w4oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA


(Escherichia
coli)
PF00232
(Glyco_hydro_1)
4 PHE A  98
GLU A 108
ARG A 159
VAL A 164
None
1.43A 1k2uA-2xhyA:
undetectable
1k2uB-2xhyA:
undetectable
1k2uA-2xhyA:
20.36
1k2uB-2xhyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
4 PHE A 309
GLU A 305
ARG A 211
VAL A 239
None
1.21A 1k2uA-2ywbA:
undetectable
1k2uB-2ywbA:
undetectable
1k2uA-2ywbA:
21.89
1k2uB-2ywbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF13302
(Acetyltransf_3)
4 TRP A  66
PHE A   4
GLU A   6
VAL A  64
None
1.41A 1k2uA-2z11A:
undetectable
1k2uB-2z11A:
undetectable
1k2uA-2z11A:
17.59
1k2uB-2z11A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 TRP A 374
GLU A 372
VAL A 314
TRP A 293
None
EDO  A 404 ( 3.8A)
None
None
1.43A 1k2uA-3b7fA:
undetectable
1k2uB-3b7fA:
undetectable
1k2uA-3b7fA:
20.65
1k2uB-3b7fA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16


(Saccharomyces
cerevisiae)
PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob)
4 TRP A 147
PHE A 117
ARG A 105
VAL A  35
None
1.49A 1k2uA-3bitA:
undetectable
1k2uB-3bitA:
undetectable
1k2uA-3bitA:
23.65
1k2uB-3bitA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE


(Pseudomonas
aeruginosa)
PF14515
(HOASN)
PF14518
(Haem_oxygenas_2)
4 PHE A 152
GLU A 205
ARG A 153
VAL A 211
None
None
None
EDO  A 401 ( 4.2A)
1.48A 1k2uA-3bjdA:
undetectable
1k2uB-3bjdA:
undetectable
1k2uA-3bjdA:
21.70
1k2uB-3bjdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
4 TRP A 485
PHE A 489
GLU A 484
ARG A 437
None
1.03A 1k2uA-3ckbA:
undetectable
1k2uB-3ckbA:
undetectable
1k2uA-3ckbA:
19.68
1k2uB-3ckbA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 TRP A  70
PHE A  88
GLU A  71
VAL A  16
None
1.48A 1k2uA-3ddlA:
undetectable
1k2uB-3ddlA:
undetectable
1k2uA-3ddlA:
20.23
1k2uB-3ddlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri)
PF14496
(NEL)
4 TRP A 274
GLU A 314
VAL A 258
TRP A 261
None
1.28A 1k2uA-3l3pA:
undetectable
1k2uB-3l3pA:
undetectable
1k2uA-3l3pA:
20.70
1k2uB-3l3pA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
4 TRP A 257
PHE A 252
ARG A 269
VAL A 260
None
1.43A 1k2uA-3ma6A:
undetectable
1k2uB-3ma6A:
undetectable
1k2uA-3ma6A:
21.65
1k2uB-3ma6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Homo sapiens)
PF00443
(UCH)
4 TRP A1001
PHE A 946
GLU A 908
ARG A 944
None
1.43A 1k2uA-3n3kA:
undetectable
1k2uB-3n3kA:
undetectable
1k2uA-3n3kA:
19.74
1k2uB-3n3kA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens)
PF00173
(Cyt-b5)
4 PHE A  58
GLU A  56
ARG A  68
VAL A  61
HEM  A 201 (-4.7A)
None
None
HEM  A 201 (-4.5A)
1.49A 1k2uA-3nerA:
undetectable
1k2uB-3nerA:
undetectable
1k2uA-3nerA:
14.93
1k2uB-3nerA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 PHE A 121
GLU A 119
ARG A 175
VAL A  92
None
1.21A 1k2uA-3owcA:
undetectable
1k2uB-3owcA:
undetectable
1k2uA-3owcA:
16.39
1k2uB-3owcA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
4 TRP A 146
PHE A 162
GLU A 187
VAL A 149
None
1.30A 1k2uA-3rjyA:
undetectable
1k2uB-3rjyA:
undetectable
1k2uA-3rjyA:
20.18
1k2uB-3rjyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 PHE A 305
GLU A 265
VAL A 240
TRP A 239
None
1.44A 1k2uA-3ti8A:
undetectable
1k2uB-3ti8A:
undetectable
1k2uA-3ti8A:
22.15
1k2uB-3ti8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1


(Schizosaccharomyces
pombe)
no annotation 4 PHE B 953
GLU B 951
ARG B 924
VAL B 944
None
1.22A 1k2uA-3tixB:
undetectable
1k2uB-3tixB:
undetectable
1k2uA-3tixB:
22.55
1k2uB-3tixB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE


(Phanerochaete
chrysosporium)
PF13417
(GST_N_3)
4 PHE A   7
GLU A  42
ARG A  29
VAL A  73
None
None
None
FLC  A 300 (-4.1A)
1.07A 1k2uA-4lmvA:
undetectable
1k2uB-4lmvA:
undetectable
1k2uA-4lmvA:
21.10
1k2uB-4lmvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE


(Ketogulonicigenium
vulgare)
PF13360
(PQQ_2)
4 TRP A 218
PHE A 286
ARG A 385
TRP A 387
None
1.41A 1k2uA-4mh1A:
undetectable
1k2uB-4mh1A:
undetectable
1k2uA-4mh1A:
21.28
1k2uB-4mh1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 PHE A 264
GLU A 266
ARG A 276
VAL A 305
None
1.22A 1k2uA-4xj6A:
undetectable
1k2uB-4xj6A:
undetectable
1k2uA-4xj6A:
21.03
1k2uB-4xj6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 TRP A 263
PHE A 264
GLU A 266
VAL A 305
None
1.07A 1k2uA-4xj6A:
undetectable
1k2uB-4xj6A:
undetectable
1k2uA-4xj6A:
21.03
1k2uB-4xj6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
4 PHE A 277
GLU A 279
VAL A 288
TRP A 292
None
1.39A 1k2uA-4ylrA:
undetectable
1k2uB-4ylrA:
undetectable
1k2uA-4ylrA:
22.90
1k2uB-4ylrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron)
PF15979
(Glyco_hydro_115)
4 TRP A 732
GLU A 731
ARG A 505
VAL A 736
None
1.39A 1k2uA-5by3A:
undetectable
1k2uB-5by3A:
undetectable
1k2uA-5by3A:
19.87
1k2uB-5by3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
4 TRP A 401
PHE A 397
GLU A 402
VAL B  28
None
1.48A 1k2uA-5c6gA:
3.6
1k2uB-5c6gA:
undetectable
1k2uA-5c6gA:
22.19
1k2uB-5c6gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE


(Cosenzaea
myxofaciens)
PF01266
(DAO)
4 GLU A 418
ARG A 316
VAL A 438
TRP A 439
None
BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
1.35A 1k2uA-5fjnA:
undetectable
1k2uB-5fjnA:
undetectable
1k2uA-5fjnA:
24.55
1k2uB-5fjnA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
4 TRP A 736
PHE A 732
GLU A 560
VAL A 481
None
1.48A 1k2uA-5kqiA:
undetectable
1k2uB-5kqiA:
undetectable
1k2uA-5kqiA:
19.97
1k2uB-5kqiA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 TRP A 414
PHE A 411
GLU A 413
ARG A 225
None
1.03A 1k2uA-5m8tA:
undetectable
1k2uB-5m8tA:
undetectable
1k2uA-5m8tA:
19.87
1k2uB-5m8tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS


(Homo sapiens)
no annotation 4 PHE A 113
GLU A 106
ARG A 129
VAL A  65
None
1.20A 1k2uA-5xf7A:
undetectable
1k2uB-5xf7A:
undetectable
1k2uA-5xf7A:
13.09
1k2uB-5xf7A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgp SECRETED XWNT8
INHIBITOR SIZZLED


(Xenopus laevis)
PF01392
(Fz)
4 PHE A 180
GLU A 222
VAL A 254
TRP A 224
None
0.91A 1k2uA-5xgpA:
undetectable
1k2uB-5xgpA:
undetectable
1k2uA-5xgpA:
19.81
1k2uB-5xgpA:
19.81