SIMILAR PATTERNS OF AMINO ACIDS FOR 1JWJ_B_H4BB902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9u HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		4 MET A  34
ARG A 136
ILE A 211
PHE A 214
 HEM  A 300 (-3.8A)
DTU  A2001 (-3.1A)
None
HEM  A 300 (-4.5A)
 1.32A 1jwjB-3i9uA:
0.0		 1jwjB-3i9uA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 MET A  34
ARG A 136
ILE A 211
PHE A 214
 HEM  A 300 (-3.4A)
HEM  A 300 ( 4.0A)
None
None
 1.37A 1jwjB-4wd4A:
0.0		 1jwjB-4wd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		4 MET A 128
ARG A 262
ILE A 163
PHE A 159
 None
 1.45A 1jwjB-5butA:
0.0		 1jwjB-5butA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		4 MET A 270
ARG A 120
ILE A  21
PHE A  17
 None
 1.46A 1jwjB-5butA:
0.0		 1jwjB-5butA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 4 MET A 275
ARG A 265
ILE A 360
PHE A 361
 None
 1.24A 1jwjB-5xxgA:
0.0		 1jwjB-5xxgA:
undetectable