SIMILAR PATTERNS OF AMINO ACIDS FOR 1JTX_A_CVIA200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE A 218
ILE A 216
ILE A 307
ALA A 285
THR A 325
 None
 1.19A 1jtxA-1a6dA:
0.8		 1jtxA-1a6dA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 ILE A 307
TYR A   9
ILE A  12
ALA A 317
THR A  92
 None
 1.19A 1jtxA-1al8A:
undetectable		 1jtxA-1al8A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 TYR A 160
ILE A  54
ILE A  52
GLU A 193
ALA A 115
 None
 1.25A 1jtxA-1avbA:
undetectable		 1jtxA-1avbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 THR A1016
ILE A1001
ILE A1005
ILE A 986
ALA A 961
 None
 1.15A 1jtxA-1c30A:
undetectable		 1jtxA-1c30A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 ILE A 189
ILE A 263
TYR A 192
ILE A  47
ALA A 178
 None
 1.09A 1jtxA-1kwmA:
undetectable		 1jtxA-1kwmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		5 THR A  69
ILE A  58
ILE A  19
ALA A  53
THR A   4
 None
 1.16A 1jtxA-1n47A:
undetectable		 1jtxA-1n47A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 456
ILE A  70
ILE A  71
ILE A  64
ALA A 428
 None
 1.28A 1jtxA-1pvdA:
0.0		 1jtxA-1pvdA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		5 THR 3 107
TYR 3 106
ILE 3 102
ILE 3  99
ILE 3 231
 None
 0.94A 1jtxA-1r1a3:
undetectable		 1jtxA-1r1a3:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		6 THR A 275
ILE A 344
ILE A 340
TYR A 341
ILE A 125
ALA A  85
 None
 1.32A 1jtxA-1rh9A:
1.8		 1jtxA-1rh9A:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		5 THR A  89
ILE A 124
ALA A 153
ASN A 154
THR A 161
 None
 0.39A 1jtxA-1rpwA:
24.2		 1jtxA-1rpwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rpw TRANSCRIPTIONAL
REGULATOR QACR

(Staphylococcus
aureus) 		PF00440
(TetR_N)
PF08360
(TetR_C_5) 		5 TRP A  61
THR A  89
ILE A 124
ALA A 153
ASN A 154
 None
 0.91A 1jtxA-1rpwA:
24.2		 1jtxA-1rpwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 ILE A 324
ILE A 240
GLU A 214
ALA A  66
THR A 318
 None
None
ZN  A 372 ( 3.9A)
None
None
 1.27A 1jtxA-1vheA:
undetectable		 1jtxA-1vheA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 THR A 319
TYR A 401
GLU A 233
ILE A 427
ALA A 428
 None
 1.30A 1jtxA-1wz2A:
2.2		 1jtxA-1wz2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 THR A 397
ILE A 354
ILE A 318
GLU A 380
ALA A 402
 None
None
None
None
NDG  A1404 ( 4.0A)
 1.30A 1jtxA-1xfdA:
undetectable		 1jtxA-1xfdA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		5 ILE A  72
ILE A  73
GLU A 253
TYR A 256
ILE A 257
 None
 1.23A 1jtxA-1zmbA:
undetectable		 1jtxA-1zmbA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 134
ILE A  71
ILE A 169
ALA A 324
ASN A 321
 None
 1.27A 1jtxA-2a9fA:
undetectable		 1jtxA-2a9fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 THR A 267
ILE A 125
ILE A 124
TYR A 202
ALA A 137
 None
 1.11A 1jtxA-2c9kA:
undetectable		 1jtxA-2c9kA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		5 TRP A  40
ILE A  48
ILE A  88
ALA A 118
THR A 272
 None
None
None
PLM  A 701 ( 4.0A)
None
 1.10A 1jtxA-2dt8A:
undetectable		 1jtxA-2dt8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ILE A  86
TYR A  89
ILE A 279
ALA A 338
ASN A 327
 None
 1.07A 1jtxA-2j1qA:
undetectable		 1jtxA-2j1qA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 THR A  59
ILE A  96
ILE A  95
GLU A  26
ASN A  48
 None
 1.09A 1jtxA-2kyrA:
undetectable		 1jtxA-2kyrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 TYR A  61
ILE A 105
ILE A  22
GLU A  98
THR A  15
 None
 1.30A 1jtxA-2nx4A:
14.9		 1jtxA-2nx4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 THR A 523
TYR A 520
ILE A 412
TYR A 494
THR A 541
 None
None
None
None
SO4  A1781 (-3.6A)
 1.10A 1jtxA-2vwkA:
undetectable		 1jtxA-2vwkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 ILE A3863
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.28A 1jtxA-2w5zA:
undetectable		 1jtxA-2w5zA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 ILE A3887
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.26A 1jtxA-2w5zA:
undetectable		 1jtxA-2w5zA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		5 THR A 783
ILE A 818
GLU A 855
TYR A 810
ASN A 746
 None
 1.18A 1jtxA-2ww8A:
undetectable		 1jtxA-2ww8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00578
(AhpC-TSA) 		5 THR A 129
ILE A 163
TYR A 112
ILE A  31
ALA A 103
 None
 1.22A 1jtxA-2ywiA:
undetectable		 1jtxA-2ywiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea) 		PF00182
(Glyco_hydro_19) 		5 ILE A 340
ILE A 344
GLU A 201
ILE A 150
THR A 209
 None
 1.22A 1jtxA-2z37A:
undetectable		 1jtxA-2z37A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		5 ILE A 191
ILE A 217
TYR A 224
ILE A  47
ALA A 266
 LLP  A 222 ( 4.4A)
None
None
None
None
 1.20A 1jtxA-2z61A:
undetectable		 1jtxA-2z61A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azc CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Thermosynechococcus
elongatus) 		PF00355
(Rieske) 		5 TYR A  69
ILE A  99
ILE A  84
ALA A  54
THR A 156
 None
 1.23A 1jtxA-3azcA:
undetectable		 1jtxA-3azcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 THR A 545
TYR A 558
ALA A 434
ASN A 439
THR A 390
 None
 1.06A 1jtxA-3b9eA:
2.2		 1jtxA-3b9eA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		5 THR A 217
TYR A 250
ILE A 246
ILE A 236
TYR A 235
 None
 1.12A 1jtxA-3btpA:
undetectable		 1jtxA-3btpA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		5 THR A   5
ILE A  17
ALA A 344
ASN A 342
THR A 308
 None
None
FMT  A2065 (-3.3A)
FMT  A2065 (-4.0A)
None
 1.10A 1jtxA-3c7oA:
undetectable		 1jtxA-3c7oA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cei SUPEROXIDE DISMUTASE

(Helicobacter
pylori) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 THR A 115
GLU A 134
ILE A 133
ALA A 124
THR A 138
 None
 1.25A 1jtxA-3ceiA:
undetectable		 1jtxA-3ceiA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 THR A 416
TYR A 415
ILE A 442
ILE A 523
ALA A 216
 None
None
None
GOL  A3002 (-4.7A)
None
 1.14A 1jtxA-3cttA:
undetectable		 1jtxA-3cttA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 ILE A   8
ILE A   9
TYR A  32
GLU A  81
THR A 112
 None
FAD  A1001 (-4.7A)
None
None
None
 1.26A 1jtxA-3d8xA:
undetectable		 1jtxA-3d8xA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ILE A 173
ILE A 174
TYR A 193
ILE A 128
ALA A 221
 None
 1.15A 1jtxA-3djcA:
undetectable		 1jtxA-3djcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 ILE A  63
GLU A 114
TYR A  60
ILE A  58
THR A  72
 None
 1.07A 1jtxA-3e57A:
undetectable		 1jtxA-3e57A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		5 ILE D 150
ILE D 151
GLU D 100
TYR D 101
ASN D 213
 None
 1.26A 1jtxA-3fo8D:
undetectable		 1jtxA-3fo8D:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A 326
TYR A 502
ILE A 503
ALA A 498
ASN A 605
 None
 1.23A 1jtxA-3hkzA:
undetectable		 1jtxA-3hkzA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F

(Staphylococcus
epidermidis) 		PF04464
(Glyphos_transf) 		5 ILE A 541
ILE A 579
TYR A 543
TYR A 667
ILE A 666
 None
 1.26A 1jtxA-3l7iA:
undetectable		 1jtxA-3l7iA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg0 ORNITHINE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00202
(Aminotran_3) 		5 ILE A 198
ILE A 140
ILE A 209
ALA A 206
ASN A 145
 None
 1.25A 1jtxA-3lg0A:
undetectable		 1jtxA-3lg0A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 6 THR F 141
ILE F 212
ILE F 211
TYR F  46
ILE F  83
ALA F 127
 None
 1.30A 1jtxA-3n2nF:
undetectable		 1jtxA-3n2nF:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2q SEX PHEROMONE
STAPH-CAM373

(Bacillus cereus) 		PF07537
(CamS) 		5 ILE A 189
ILE A 204
ILE A  64
ALA A  67
ASN A  68
 None
 1.05A 1jtxA-3n2qA:
undetectable		 1jtxA-3n2qA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otx ADENOSINE KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00294
(PfkB) 		5 THR A 321
TYR A 324
ILE A 330
ILE A 108
ALA A  69
 None
None
AP5  A 346 (-4.9A)
None
None
 1.00A 1jtxA-3otxA:
undetectable		 1jtxA-3otxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		5 THR A 157
ILE A 133
ILE A 175
ALA A 142
THR A 163
 None
 1.19A 1jtxA-3pcoA:
undetectable		 1jtxA-3pcoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfd ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 234
ILE A 233
ALA A 187
ASN A 188
THR A 181
 None
None
None
None
IOD  A 410 (-4.4A)
 1.11A 1jtxA-3pfdA:
2.1		 1jtxA-3pfdA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 176
ILE A  65
ILE A  66
ALA A 144
THR A 233
 None
 1.27A 1jtxA-3ppsA:
undetectable		 1jtxA-3ppsA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 TYR A 311
GLU A  79
ILE A  77
ALA A  75
ASN A 415
 None
 1.15A 1jtxA-3u3iA:
undetectable		 1jtxA-3u3iA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 THR A 407
ILE A 495
ILE A 526
TYR A 447
ILE A 474
 None
 1.21A 1jtxA-3ua4A:
undetectable		 1jtxA-3ua4A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 TYR A 280
ILE A 243
ILE A 248
ILE A 200
ALA A 231
 None
 1.24A 1jtxA-3vpxA:
undetectable		 1jtxA-3vpxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgh REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Thermoanaerobacter
ethanolicus) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		5 THR A 137
ILE A 147
ILE A 171
ILE A 127
ALA A  92
 None
 1.14A 1jtxA-3wghA:
3.2		 1jtxA-3wghA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 ILE A 477
ILE A 476
GLU A 557
ALA A 559
ASN A 609
 None
 1.25A 1jtxA-4a2qA:
undetectable		 1jtxA-4a2qA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 ILE A 477
ILE A 476
GLU A 557
ALA A 559
ASN A 609
 None
 1.20A 1jtxA-4a2wA:
undetectable		 1jtxA-4a2wA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 THR A 372
ILE A 380
ILE A 365
ILE A 111
ALA A 108
 None
 1.24A 1jtxA-4a3rA:
undetectable		 1jtxA-4a3rA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4art STRUCTURAL PROTEIN
ORF273

(Acidianus
two-tailed
virus) 		no annotation 5 ILE A 162
ILE A 116
TYR A 140
TYR A  60
ALA A  70
 None
None
None
None
GOL  A1271 (-4.2A)
 1.09A 1jtxA-4artA:
undetectable		 1jtxA-4artA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blf SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
tumefaciens) 		PF07229
(VirE2) 		5 THR A 217
TYR A 250
ILE A 246
ILE A 236
TYR A 235
 None
 1.12A 1jtxA-4blfA:
undetectable		 1jtxA-4blfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		5 THR B 508
ILE B 479
ILE B 481
TYR B 404
TYR B 454
 None
 1.27A 1jtxA-4en8B:
undetectable		 1jtxA-4en8B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 THR A 135
ILE A 147
TYR A  47
GLU A 155
ALA A 159
 None
 1.29A 1jtxA-4fl3A:
undetectable		 1jtxA-4fl3A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		5 TYR A 271
ILE A 232
GLU A 300
ALA A 293
THR A 265
 None
 1.17A 1jtxA-4i1aA:
undetectable		 1jtxA-4i1aA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		5 ILE A 370
ILE A 366
GLU A 253
ILE A 640
ASN A 265
 None
 0.97A 1jtxA-4jc8A:
2.8		 1jtxA-4jc8A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jen CMP N-GLYCOSIDASE

(Clostridium
botulinum) 		no annotation 5 ILE A 130
ILE A 131
TYR A 132
ILE A  30
ALA A   9
 None
 1.17A 1jtxA-4jenA:
undetectable		 1jtxA-4jenA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1

(Mycobacterium
tuberculosis) 		PF05108
(T7SS_ESX1_EccB) 		5 ILE A 178
ILE A 174
ILE A 335
ALA A 186
THR A 360
 None
 1.23A 1jtxA-4kk7A:
undetectable		 1jtxA-4kk7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 5 ILE A 194
ILE A  57
ALA A  24
ASN A 352
THR A 112
 None
 1.27A 1jtxA-4lypA:
0.5		 1jtxA-4lypA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mld RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 ILE A  31
ILE A  29
TYR A  55
ILE A  84
ALA A  82
 None
 1.23A 1jtxA-4mldA:
undetectable		 1jtxA-4mldA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 THR D   5
ILE D 225
ILE D 187
ILE D 132
ALA D 159
 None
 1.28A 1jtxA-4mwaD:
undetectable		 1jtxA-4mwaD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 THR E 248
ILE E 273
ILE E 300
ILE E 209
ALA E 196
 None
 1.15A 1jtxA-4obuE:
undetectable		 1jtxA-4obuE:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 475
ILE A 474
GLU A 556
ALA A 558
ASN A 608
 None
 1.20A 1jtxA-4on9A:
undetectable		 1jtxA-4on9A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1

(Escherichia
coli;
Homo sapiens) 		PF00003
(7tm_3)
PF07361
(Cytochrom_B562) 		5 TYR A 672
ILE A 634
ILE A 633
GLU A 783
THR A 677
 None
 1.19A 1jtxA-4or2A:
1.6		 1jtxA-4or2A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		5 THR A 379
TYR A 382
ILE A 328
GLU A 273
ALA A 286
 None
 1.26A 1jtxA-4qt9A:
undetectable		 1jtxA-4qt9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 THR A 662
TYR A 713
ILE A 739
ILE A 780
TYR A 779
 None
 1.06A 1jtxA-4r04A:
undetectable		 1jtxA-4r04A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4n HIV-1 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 THR A 373
ILE A 424
ILE A 423
GLU A 381
ALA A 329
 None
 1.22A 1jtxA-4r4nA:
undetectable		 1jtxA-4r4nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x27 FUSOLIN

(Entomopoxvirinae) 		PF03067
(LPMO_10) 		5 ILE A   4
ILE A   8
TYR A   3
ILE A 143
ASN A 192
 None
 1.29A 1jtxA-4x27A:
undetectable		 1jtxA-4x27A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 ILE A 541
ILE A 605
GLU A 534
TYR A 535
ILE A 531
 None
 1.11A 1jtxA-4xvmA:
undetectable		 1jtxA-4xvmA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amo NOELIN

(Mus musculus) 		PF02191
(OLF) 		5 ILE A 440
TYR A 397
ILE A 377
ALA A 402
THR A 422
 None
 1.11A 1jtxA-5amoA:
undetectable		 1jtxA-5amoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 5 THR A  89
TYR A  36
ILE A  41
ILE A  42
ALA A 164
 None
 1.20A 1jtxA-5bykA:
undetectable		 1jtxA-5bykA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 ILE A3863
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.23A 1jtxA-5f6lA:
undetectable		 1jtxA-5f6lA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 ILE A3887
GLU A3857
ILE A3856
ALA A3902
ASN A3900
 None
 1.23A 1jtxA-5f6lA:
undetectable		 1jtxA-5f6lA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 ILE A 389
ILE A 365
TYR A 356
ALA A 395
THR A 411
 None
 1.15A 1jtxA-5gjeA:
undetectable		 1jtxA-5gjeA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 TYR A 103
ILE A 177
ILE A 126
ALA A 334
ASN A 130
 None
 1.25A 1jtxA-5hc4A:
undetectable		 1jtxA-5hc4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		5 ILE A 140
ILE A 245
ILE A 181
ALA A 203
ASN A 204
 None
 1.14A 1jtxA-5hhlA:
1.0		 1jtxA-5hhlA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		5 THR A 105
ILE A 253
TYR A 141
ILE A 161
ALA A 182
 None
MPD  A 505 (-4.6A)
None
None
None
 1.25A 1jtxA-5hucA:
undetectable		 1jtxA-5hucA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hud CHORISMATE MUTASE

(Corynebacterium
glutamicum) 		PF01817
(CM_2) 		5 ILE E  42
GLU E  59
ILE E  63
ALA E  78
THR E  36
 TSA  E 108 (-3.6A)
TSA  E 108 (-3.7A)
None
None
None
 0.75A 1jtxA-5hudE:
undetectable		 1jtxA-5hudE:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 122
ILE A 152
ILE A 252
ALA A 223
ASN A 224
 None
 1.20A 1jtxA-5hx6A:
undetectable		 1jtxA-5hx6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		5 TYR A 199
ILE A 197
ILE A 171
TYR A 155
ALA A 119
 None
 1.29A 1jtxA-5i2uA:
undetectable		 1jtxA-5i2uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		5 THR A 193
TYR A 192
ILE A 109
TYR A 113
TYR A  64
 None
None
LYR  A 200 ( 4.8A)
OLC  A 322 ( 3.7A)
None
 1.20A 1jtxA-5jsiA:
2.0		 1jtxA-5jsiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlp UNCHARACTERIZED
PROTEIN

(Rickettsiella
grylli) 		no annotation 5 TYR A 212
ILE A 213
GLU A 135
TYR A 138
ASN A 180
 None
 1.15A 1jtxA-5mlpA:
undetectable		 1jtxA-5mlpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n81 TYROCIDINE SYNTHASE
1

(Brevibacillus
parabrevis) 		no annotation 5 THR A 188
TYR A 187
ILE A 117
ILE A 126
ALA A 228
 8Q2  A 501 ( 4.8A)
None
None
None
None
 1.30A 1jtxA-5n81A:
undetectable		 1jtxA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		5 THR A 183
ILE A 170
ILE A 100
ILE A  87
ALA A 319
 None
 1.15A 1jtxA-5tevA:
undetectable		 1jtxA-5tevA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 5 THR A  98
TYR A  51
ILE A  56
ILE A  57
ALA A 173
 None
None
None
OAQ  A 302 ( 4.9A)
None
 1.15A 1jtxA-5tiwA:
undetectable		 1jtxA-5tiwA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 ILE A 353
ILE A 354
TYR A 294
ILE A 297
ALA A 342
 None
 1.13A 1jtxA-5u09A:
1.7		 1jtxA-5u09A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u56 STRINGENT STARVATION
PROTEIN A

(Francisella
tularensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 ILE C  45
ILE C  42
ILE C  71
ALA C  18
THR C   9
 None
 1.18A 1jtxA-5u56C:
undetectable		 1jtxA-5u56C:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ILE A  86
TYR A  89
ILE A 279
ALA A 338
ASN A 327
 None
 1.08A 1jtxA-5u8eA:
undetectable		 1jtxA-5u8eA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn3 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 THR G 373
ILE G 424
ILE G 423
GLU G 381
ALA G 329
 None
 1.29A 1jtxA-5vn3G:
undetectable		 1jtxA-5vn3G:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wua ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL
11,SUPERFOLDER GFP

(Mus musculus;
synthetic
construct) 		PF01007
(IRK) 		5 ILE A 215
ILE A 249
TYR A 304
ILE A 309
ALA A 187
 None
 0.89A 1jtxA-5wuaA:
undetectable		 1jtxA-5wuaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9a CHORISMATE SYNTHASE

(Pseudomonas
aeruginosa) 		no annotation 5 TYR A   6
ILE A 337
GLU A 332
ILE A 206
ALA A 327
 None
 1.16A 1jtxA-5z9aA:
undetectable		 1jtxA-5z9aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		5 TYR B  64
ILE B  41
GLU D  56
ILE G  45
ALA D  62
 None
 1.05A 1jtxA-6cfwB:
undetectable		 1jtxA-6cfwB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		5 TYR B  64
ILE B  41
ILE B  44
ILE G  45
ALA D  62
 None
 1.28A 1jtxA-6cfwB:
undetectable		 1jtxA-6cfwB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ILE A 144
ILE A 148
ILE A  23
ALA A 225
THR A 240
 None
 1.16A 1jtxA-6ci9A:
undetectable		 1jtxA-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cu5 PROTEIN ARGININE
N-METHYLTRANSFERASE

(Naegleria
fowleri) 		no annotation 5 THR A  28
TYR A  31
ILE A 118
ILE A  78
ALA A  81
 None
 1.18A 1jtxA-6cu5A:
undetectable		 1jtxA-6cu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 272
ILE A 280
TYR A 192
ALA A 236
THR A 188
 None
 1.28A 1jtxA-6fnuA:
undetectable		 1jtxA-6fnuA:
undetectable