SIMILAR PATTERNS OF AMINO ACIDS FOR 1JTV_A_TESA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		7 LEU A 149
PRO A 187
TYR A 218
HIS A 221
SER A 222
VAL A 225
GLU A 282
 EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
None
None
EST  A 350 (-4.7A)
EST  A 350 ( 4.6A)
 0.78A 1jtvA-1a27A:
43.6		 1jtvA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A 143
LEU A 149
PRO A 187
HIS A 221
VAL A 225
 EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
EST  A 350 (-4.7A)
 0.65A 1jtvA-1a27A:
43.6		 1jtvA-1a27A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 235
HIS A 210
VAL A 204
GLU A 128
 None
 0.75A 1jtvA-1au8A:
undetectable		 1jtvA-1au8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnl COLLAGEN XVIII

(Homo sapiens) 		PF06482
(Endostatin) 		4 VAL A  13
LEU A  42
HIS A   3
VAL A   9
 None
None
ZN  A 179 (-3.2A)
None
 0.91A 1jtvA-1bnlA:
undetectable		 1jtvA-1bnlA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Toxoplasma
gondii) 		PF00156
(Pribosyltran) 		4 VAL A 142
LEU A 162
SER A 131
VAL A 113
 None
 0.99A 1jtvA-1dbrA:
2.0		 1jtvA-1dbrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		4 VAL A 285
LEU A 304
SER A 258
VAL A 259
 None
 1.11A 1jtvA-1dceA:
undetectable		 1jtvA-1dceA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 365
HIS A 357
VAL A 191
GLU A 384
 None
 1.05A 1jtvA-1dgsA:
undetectable		 1jtvA-1dgsA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1etz FAB NC10.14 - HEAVY
CHAIN

(Mus musculus) 		no annotation 4 VAL H 149
LEU H 151
PRO H 197
SER H 169
 None
 1.17A 1jtvA-1etzH:
undetectable		 1jtvA-1etzH:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A 143
LEU A 149
PRO A 187
TYR A 218
VAL A 225
 EST  A 350 (-4.8A)
EST  A 350 (-4.6A)
EST  A 350 (-4.3A)
None
None
 0.36A 1jtvA-1fdwA:
43.0		 1jtvA-1fdwA:
99.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 VAL A 143
LEU A 149
TYR A 218
SER A 222
VAL A 225
 EST  A 350 (-4.8A)
EST  A 350 (-4.6A)
None
EST  A 350 (-4.4A)
None
 0.53A 1jtvA-1fdwA:
43.0		 1jtvA-1fdwA:
99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj1 HYBRIDOMA ANTIBODY
LA2 (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 136
LEU B 138
PRO B 184
SER B 156
 None
 0.91A 1jtvA-1fj1B:
undetectable		 1jtvA-1fj1B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		4 VAL A 950
LEU A1069
PRO A 946
SER A1062
 None
 0.99A 1jtvA-1fx4A:
undetectable		 1jtvA-1fx4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A 394
SER A 424
VAL A 436
GLU A 336
 None
 0.95A 1jtvA-1g0dA:
undetectable		 1jtvA-1g0dA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5q EPIDERMIN MODIFYING
ENZYME EPID

(Staphylococcus
epidermidis) 		PF02441
(Flavoprotein) 		4 VAL A  79
LEU A  99
PRO A  81
SER A  40
 None
 0.98A 1jtvA-1g5qA:
6.1		 1jtvA-1g5qA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 202
LEU A 175
PRO A 228
VAL A 256
 None
 1.16A 1jtvA-1jvbA:
undetectable		 1jtvA-1jvbA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		4 VAL A 100
LEU A  27
HIS A  56
GLU A  52
 None
 1.03A 1jtvA-1n1qA:
undetectable		 1jtvA-1n1qA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		4 VAL A 243
LEU A 316
TYR A 233
VAL A 229
 None
 1.11A 1jtvA-1nijA:
3.3		 1jtvA-1nijA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocx MALTOSE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		4 LEU A 126
PRO A 129
TYR A  14
GLU A  12
 None
 1.15A 1jtvA-1ocxA:
undetectable		 1jtvA-1ocxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oow PLASTOCYANIN,
CHLOROPLAST

(Spinacia
oleracea) 		PF00127
(Copper-bind) 		4 VAL A  96
LEU A  74
SER A  56
VAL A  39
 None
 0.94A 1jtvA-1oowA:
undetectable		 1jtvA-1oowA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 VAL A 333
LEU A 374
PRO A 335
GLU A 366
 None
 1.03A 1jtvA-1r5mA:
undetectable		 1jtvA-1r5mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 PRO A 214
HIS A 313
SER A 310
GLU A 345
 None
 1.07A 1jtvA-1sh2A:
undetectable		 1jtvA-1sh2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuu ACETATE KINASE

(Methanosarcina
thermophila) 		PF00871
(Acetate_kinase) 		4 VAL A  67
LEU A  13
HIS A  90
VAL A  88
 None
 0.86A 1jtvA-1tuuA:
undetectable		 1jtvA-1tuuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 368
HIS A 360
VAL A 196
GLU A 387
 None
 1.00A 1jtvA-1v9pA:
undetectable		 1jtvA-1v9pA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt5 VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3

(Branchiostoma
floridae) 		PF07686
(V-set) 		4 VAL A  99
LEU A 129
PRO A 101
GLU A  15
 None
 1.22A 1jtvA-1xt5A:
undetectable		 1jtvA-1xt5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 VAL A 330
TYR A 127
SER A 226
GLU A 337
 None
 0.90A 1jtvA-1zbuA:
undetectable		 1jtvA-1zbuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs3 PROTEIN C14ORF4

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 VAL A  59
PRO A  62
VAL A  31
GLU A  82
 None
 0.93A 1jtvA-2cs3A:
undetectable		 1jtvA-2cs3A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwl MANGANESE-FREE
PSEUDOCATALASE

(Thermus
thermophilus) 		PF05067
(Mn_catalase) 		4 VAL A 262
HIS A 188
VAL A 187
GLU A  69
 None
 1.09A 1jtvA-2cwlA:
undetectable		 1jtvA-2cwlA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxa PROTEIN YBAK

(Escherichia
coli) 		PF04073
(tRNA_edit) 		4 VAL A  91
LEU A  59
PRO A  89
GLU A  85
 None
 1.21A 1jtvA-2dxaA:
undetectable		 1jtvA-2dxaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 132
PRO A 395
TYR A 422
GLU A 134
 None
 1.17A 1jtvA-2e6kA:
2.1		 1jtvA-2e6kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  86
LEU A 297
PRO A 136
VAL A 304
 None
 0.73A 1jtvA-2eihA:
undetectable		 1jtvA-2eihA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbo VARIABLE
REGION-CONTAINING
CHITIN-BINDING
PROTEIN 3

(Branchiostoma
floridae) 		PF07686
(V-set) 		4 VAL J  99
LEU J 129
PRO J 101
GLU J  15
 None
 1.07A 1jtvA-2fboJ:
undetectable		 1jtvA-2fboJ:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL A 586
LEU A 601
SER A 492
VAL A 493
 None
 0.92A 1jtvA-2gaiA:
3.0		 1jtvA-2gaiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 VAL A 344
LEU A 373
PRO A 347
HIS A  13
 None
 1.04A 1jtvA-2ip4A:
3.9		 1jtvA-2ip4A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 VAL A 340
LEU A 380
SER A 386
VAL A 363
 None
 1.13A 1jtvA-2pa6A:
undetectable		 1jtvA-2pa6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfr UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 VAL A  51
TYR A  27
HIS A  82
VAL A 104
 None
 1.19A 1jtvA-2rfrA:
undetectable		 1jtvA-2rfrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xet F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13953
(PapC_C) 		4 VAL A 789
LEU A 767
SER A 753
VAL A 744
 None
 0.89A 1jtvA-2xetA:
undetectable		 1jtvA-2xetA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 VAL A  32
TYR A 245
SER A 243
VAL A 211
 None
 1.09A 1jtvA-3a05A:
3.6		 1jtvA-3a05A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5x FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF08884
(Flagellin_D3) 		4 VAL A 418
LEU A 167
SER A 126
VAL A 125
 None
 0.99A 1jtvA-3a5xA:
undetectable		 1jtvA-3a5xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf4 ETHYL TERT-BUTYL
ETHER DEGRADATION
ETHD PROTEIN

(Cupriavidus
pinatubonensis) 		PF07110
(EthD) 		4 VAL A   4
TYR A  21
HIS A  25
VAL A  29
 None
EDO  A 109 (-4.5A)
EDO  A 109 (-4.3A)
None
 0.93A 1jtvA-3bf4A:
undetectable		 1jtvA-3bf4A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 VAL A 225
HIS A 258
VAL A 269
GLU A 250
 None
 1.14A 1jtvA-3c8cA:
undetectable		 1jtvA-3c8cA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 4 VAL A 124
LEU A 150
SER A  41
VAL A  44
 None
None
None
EDO  A 214 ( 4.5A)
 1.15A 1jtvA-3cvoA:
7.0		 1jtvA-3cvoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 665
HIS A 560
SER A 561
VAL A 564
 None
ZN  A   1 (-3.4A)
None
None
 0.93A 1jtvA-3ecnA:
undetectable		 1jtvA-3ecnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 665
TYR A 549
SER A 561
VAL A 564
 None
 1.06A 1jtvA-3ecnA:
undetectable		 1jtvA-3ecnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 439
PRO A 417
HIS A 177
GLU A 316
 None
 1.04A 1jtvA-3ef1A:
3.3		 1jtvA-3ef1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PRO A  37
TYR A 141
SER A 142
VAL A 122
 None
 1.20A 1jtvA-3eh7A:
undetectable		 1jtvA-3eh7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk0 PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Burkholderia
pseudomallei) 		PF03740
(PdxJ) 		4 VAL A  82
LEU A 114
SER A 138
VAL A 137
 None
 1.03A 1jtvA-3gk0A:
undetectable		 1jtvA-3gk0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		4 VAL A 206
LEU A 156
HIS A 248
VAL A 250
 None
 0.93A 1jtvA-3hq0A:
undetectable		 1jtvA-3hq0A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		4 HIS A 632
SER A 631
VAL A 630
GLU A 707
 None
 1.01A 1jtvA-3hr0A:
undetectable		 1jtvA-3hr0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihu TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Cupriavidus
pinatubonensis) 		PF00392
(GntR)
PF07729
(FCD) 		4 VAL A 192
LEU A 147
SER A 120
VAL A 121
 None
 1.21A 1jtvA-3ihuA:
undetectable		 1jtvA-3ihuA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		4 VAL A 112
LEU A  91
SER A  69
VAL A  70
 None
 1.06A 1jtvA-3im8A:
undetectable		 1jtvA-3im8A:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11) 		4 LEU o 387
SER o 334
VAL o 427
GLU o 392
 None
 1.14A 1jtvA-3japo:
undetectable		 1jtvA-3japo:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js3 3-DEHYDROQUINATE
DEHYDRATASE

(Clostridioides
difficile) 		PF01487
(DHquinase_I) 		4 VAL A  50
LEU A 101
SER A 106
VAL A 111
 None
 1.11A 1jtvA-3js3A:
undetectable		 1jtvA-3js3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		4 VAL A 127
TYR A 169
HIS A 172
VAL A 176
 None
MES  A 492 (-3.9A)
None
None
 0.94A 1jtvA-3n71A:
undetectable		 1jtvA-3n71A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 VAL A 376
HIS A 341
SER A 342
VAL A 345
 None
 0.94A 1jtvA-3rcnA:
undetectable		 1jtvA-3rcnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666) 		PF04909
(Amidohydro_2) 		4 PRO A  62
TYR A 142
SER A 131
GLU A 192
 SO4  A 349 ( 4.3A)
None
None
None
 1.22A 1jtvA-3s4tA:
undetectable		 1jtvA-3s4tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6x ORF48

(Lactococcus
phage TP901-1) 		no annotation 4 VAL S 212
LEU S 282
PRO S 241
SER S 258
 None
 1.03A 1jtvA-3u6xS:
undetectable		 1jtvA-3u6xS:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3k PUTATIVE
UNCHARACTERIZED
PROTEIN ECS1815

(Escherichia
coli) 		PF16809
(NleF_casp_inhib) 		4 HIS B 118
SER B 119
VAL B 122
GLU B 162
 None
 0.83A 1jtvA-3v3kB:
undetectable		 1jtvA-3v3kB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 LEU B 291
PRO B 326
SER B 249
GLU B 254
 None
 0.81A 1jtvA-3wxmB:
undetectable		 1jtvA-3wxmB:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 VAL A 857
LEU A 825
SER A 893
VAL A 888
 None
 1.21A 1jtvA-4a5wA:
undetectable		 1jtvA-4a5wA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE

(Caenorhabditis
elegans) 		PF00583
(Acetyltransf_1) 		4 VAL A  24
LEU A  10
PRO A  15
SER A 127
 None
 0.87A 1jtvA-4ag9A:
undetectable		 1jtvA-4ag9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		4 HIS A 264
SER A 263
VAL A 262
GLU A 278
 None
 0.90A 1jtvA-4d48A:
undetectable		 1jtvA-4d48A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 456
TYR A 536
SER A 345
GLU A 505
 None
 1.21A 1jtvA-4d8mA:
undetectable		 1jtvA-4d8mA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq8 ACETATE KINASE

(Mycobacterium
marinum) 		PF00871
(Acetate_kinase) 		4 VAL A  58
LEU A  20
HIS A  79
VAL A  77
 None
 0.84A 1jtvA-4dq8A:
undetectable		 1jtvA-4dq8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		4 VAL A 537
LEU A 545
PRO A 535
VAL A 120
 None
 1.08A 1jtvA-4ep0A:
undetectable		 1jtvA-4ep0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 VAL A 193
LEU A 195
SER A 181
VAL A 180
 None
 1.06A 1jtvA-4ev0A:
undetectable		 1jtvA-4ev0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 VAL A 131
PRO A 212
TYR A 387
VAL A 369
 None
 1.07A 1jtvA-4g09A:
2.9		 1jtvA-4g09A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kto ISOVALERYL-COA
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A  92
HIS A  95
SER A  96
VAL A 100
 None
 0.75A 1jtvA-4ktoA:
undetectable		 1jtvA-4ktoA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 SILKWORM STORAGE
PROTEIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 VAL A 139
LEU A  23
PRO A 577
GLU A 145
 None
 1.01A 1jtvA-4l37A:
undetectable		 1jtvA-4l37A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 VAL A  10
TYR A  39
SER A  43
VAL A  46
 None
 1.17A 1jtvA-4npaA:
2.0		 1jtvA-4npaA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 PRO A 214
HIS A 313
SER A 310
GLU A 345
 None
 1.03A 1jtvA-4nruA:
undetectable		 1jtvA-4nruA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5m ISOVALERYL-COA
DEHYDROGENASE

(Brucella suis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A  87
HIS A  90
SER A  91
VAL A  95
 None
 0.92A 1jtvA-4o5mA:
undetectable		 1jtvA-4o5mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 VAL A 226
LEU A 259
SER A 237
VAL A 238
 None
 0.91A 1jtvA-4phcA:
undetectable		 1jtvA-4phcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0s L-RIBOSE ISOMERASE

(Acinetobacter
sp. DL-28) 		no annotation 4 VAL A 117
LEU A 200
SER A 196
GLU A 123
 None
 1.11A 1jtvA-4q0sA:
undetectable		 1jtvA-4q0sA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q48 DNA HELICASE RECQ

(Deinococcus
radiodurans) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 VAL A  89
LEU A 117
TYR A  56
SER A  53
 None
 1.19A 1jtvA-4q48A:
2.4		 1jtvA-4q48A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 VAL A  90
LEU A 118
TYR A  57
SER A  54
 None
 1.15A 1jtvA-4tmuA:
2.3		 1jtvA-4tmuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 LEU A 377
PRO A 355
HIS A 177
GLU A 316
 None
PG4  A 603 (-4.5A)
None
None
 1.01A 1jtvA-4xpzA:
3.0		 1jtvA-4xpzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 4 VAL A 613
LEU A 642
SER A 655
VAL A 654
 None
 1.16A 1jtvA-4yhcA:
undetectable		 1jtvA-4yhcA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 VAL A 349
LEU A 440
HIS A 396
VAL A 368
 None
 1.12A 1jtvA-4zm4A:
3.5		 1jtvA-4zm4A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 VAL A 431
LEU A 201
PRO A  23
VAL A 398
 None
 1.07A 1jtvA-5a0tA:
undetectable		 1jtvA-5a0tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF03740
(PdxJ) 		4 VAL A  86
LEU A 118
SER A 155
VAL A 158
 None
 0.98A 1jtvA-5dlcA:
undetectable		 1jtvA-5dlcA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3q 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Corynebacterium
glutamicum) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		4 VAL A 188
LEU A 216
SER A 178
VAL A 180
 None
 1.22A 1jtvA-5e3qA:
undetectable		 1jtvA-5e3qA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF02775
(TPP_enzyme_C) 		4 VAL C 114
PRO C 179
HIS C 222
GLU C 139
 None
 0.94A 1jtvA-5exeC:
2.2		 1jtvA-5exeC:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		4 LEU A 109
PRO A  93
HIS A 231
VAL A 228
 FIJ  A 602 (-4.7A)
FIJ  A 602 (-4.5A)
FIJ  A 602 (-4.0A)
AKG  A 603 ( 4.7A)
 1.12A 1jtvA-5f8pA:
undetectable		 1jtvA-5f8pA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 VAL A 624
LEU A 241
TYR A 437
GLU A 448
 None
 0.98A 1jtvA-5hmpA:
undetectable		 1jtvA-5hmpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A  59
TYR A 200
HIS A 186
SER A 134
 FAD  A 601 (-4.5A)
None
None
None
 1.01A 1jtvA-5i1wA:
undetectable		 1jtvA-5i1wA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 VAL A 990
LEU A1053
TYR A1034
SER A1078
 None
 1.12A 1jtvA-5ikzA:
undetectable		 1jtvA-5ikzA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 VAL A 139
LEU A 176
PRO A 147
SER A 225
 None
 0.98A 1jtvA-5jrlA:
4.7		 1jtvA-5jrlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 VAL A  47
LEU A  27
PRO A  53
SER A  56
 None
None
MG  A1004 (-4.0A)
None
 0.94A 1jtvA-5nlmA:
6.7		 1jtvA-5nlmA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 VAL A 299
LEU A 278
SER A 306
VAL A 310
 None
 1.17A 1jtvA-5u70A:
7.2		 1jtvA-5u70A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 VAL A 909
LEU A 897
PRO A 855
HIS A 836
 None
 1.03A 1jtvA-5ue8A:
undetectable		 1jtvA-5ue8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vms POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 1

(Xenopus laevis) 		PF00520
(Ion_trans)
PF03520
(KCNQ_channel) 		4 VAL A 123
LEU A 153
SER A 199
VAL A 195
 None
 1.07A 1jtvA-5vmsA:
undetectable		 1jtvA-5vmsA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 VAL A   6
PRO A  80
HIS A 295
VAL A 291
 None
 1.20A 1jtvA-5vywA:
3.8		 1jtvA-5vywA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wru PROBABLE INORGANIC
PYROPHOSPHATASE

(Plasmodium
falciparum) 		no annotation 4 VAL A 217
PRO A 172
SER A 109
GLU A  99
 None
 1.18A 1jtvA-5wruA:
undetectable		 1jtvA-5wruA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 VAL A 614
LEU A 664
SER A 741
VAL A 745
 None
 1.12A 1jtvA-5xapA:
undetectable		 1jtvA-5xapA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xly CHEMOTAXIS PROTEIN
METHYLTRANSFERASE 1

(Pseudomonas
aeruginosa) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 VAL A 219
LEU A 201
TYR A 205
VAL A 214
 None
 0.95A 1jtvA-5xlyA:
undetectable		 1jtvA-5xlyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 4 VAL i 118
LEU i 130
PRO i 116
SER i 183
 None
 1.14A 1jtvA-5xtci:
undetectable		 1jtvA-5xtci:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 4 VAL A 313
LEU A 297
SER A 258
VAL A 257
 None
 1.04A 1jtvA-6b5dA:
undetectable		 1jtvA-6b5dA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 VAL M 378
LEU M 420
SER M 281
VAL M 295
 None
 1.18A 1jtvA-6criM:
undetectable		 1jtvA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Mus musculus) 		no annotation 4 LEU J  19
PRO J  25
VAL J  66
GLU K  34
 None
 1.11A 1jtvA-6g2jJ:
undetectable		 1jtvA-6g2jJ:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 VAL A  76
LEU A 125
SER A 283
VAL A 284
 None
 1.19A 1jtvA-6gh2A:
undetectable		 1jtvA-6gh2A:
15.52