SIMILAR PATTERNS OF AMINO ACIDS FOR 1JS3_A_142A701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		7 TRP A  71
TYR A  79
PHE A  80
THR A  82
HIS A 192
THR A 246
HIS A 302
 None
None
PLP  A 601 (-4.7A)
None
PLP  A 601 (-3.4A)
PLP  A 601 (-4.3A)
PLP  A 601 (-4.2A)
 0.29A 1js3A-1js6A:
67.4
1js3B-1js6A:
67.4		 1js3A-1js6A:
100.00
1js3B-1js6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		7 TRP A  71
TYR A  79
PHE A  80
THR A  82
HIS A 192
THR A 246
LYS A 303
 None
None
PLP  A 601 (-4.7A)
None
PLP  A 601 (-3.4A)
PLP  A 601 (-4.3A)
PLP  A 601 (-1.2A)
 0.59A 1js3A-1js6A:
67.4
1js3B-1js6A:
67.4		 1js3A-1js6A:
100.00
1js3B-1js6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 PHE A  80
THR A  82
HIS A 192
THR A 245
HIS A 301
 LLP  A 302 ( 4.7A)
None
LLP  A 302 ( 3.6A)
LLP  A 302 ( 4.5A)
LLP  A 302 ( 4.3A)
 0.60A 1js3A-3k40A:
55.6
1js3B-3k40A:
55.6		 1js3A-3k40A:
58.64
1js3B-3k40A:
58.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 TRP A  72
TYR A  80
HIS A 194
THR A 248
LYS A 305
 None
PVH  A1001 (-4.9A)
PLP  A1000 ( 3.3A)
PLP  A1000 (-3.1A)
PLP  A1000 ( 3.1A)
 0.38A 1js3A-4e1oA:
61.3
1js3B-4e1oA:
61.3		 1js3A-4e1oA:
50.72
1js3B-4e1oA:
50.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 5 TRP A  41
TYR A  17
THR A  10
HIS A 155
THR A  80
 None
 1.47A 1js3A-6cipA:
1.3
1js3B-6cipA:
1.3		 1js3A-6cipA:
10.86
1js3B-6cipA:
10.86