SIMILAR PATTERNS OF AMINO ACIDS FOR 1JO4_A_DVAA8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hg4	6-DEOXYERYTHRONOLIDE B SYNTHASE (Saccharopolyspora erythraea)	PF00109 (ketoacyl-synt) PF00698 (Acyl_transf_1) PF02801 (Ketoacyl-synt_C) PF08990 (Docking) PF16197 (KAsynt_C_assoc)	4	GLY A 366 VAL A 331 TRP A 364 TRP A 425	None	1.35A	1jo4A-2hg4A: undetectable	1jo4A-2hg4A: 1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qo3	ERYAII ERYTHROMYCIN POLYKETIDE SYNTHASE MODULES 3 AND 4 (Saccharopolyspora erythraea)	PF00109 (ketoacyl-synt) PF00698 (Acyl_transf_1) PF02801 (Ketoacyl-synt_C) PF16197 (KAsynt_C_assoc)	4	GLY A 369 VAL A 334 TRP A 367 TRP A 428	None	1.34A	1jo4A-2qo3A: undetectable	1jo4A-2qo3A: 2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5f8u	BETA-1 ADRENERGIC RECEPTOR (Meleagris gallopavo)	no annotation	4	GLY B 105 VAL B 102 TRP B 109 TRP B 117	None None None P32 B 400 (-4.8A)	1.28A	1jo4A-5f8uB: undetectable	1jo4A-5f8uB: 5.30