SIMILAR PATTERNS OF AMINO ACIDS FOR 1JO3_B_DVAB6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwu PROTEIN (AGGLUTININ)

(Allium sativum) 		PF01453
(B_lectin) 		3 ALA Q  55
VAL Q  64
TRP Q  74
 None
 0.92A 1jo3B-1bwuQ:
undetectable		 1jo3B-1bwuQ:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		3 ALA A  54
VAL A 211
TRP A 210
 None
 0.88A 1jo3B-1dbnA:
undetectable		 1jo3B-1dbnA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		3 ALA A  41
VAL A  82
TRP A  99
 None
 0.91A 1jo3B-1edgA:
undetectable		 1jo3B-1edgA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		3 ALA A  54
VAL A 206
TRP A 205
 None
 0.92A 1jo3B-1fnzA:
undetectable		 1jo3B-1fnzA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fr0 ARCB

(Escherichia
coli) 		PF01627
(Hpt) 		3 ALA A 745
VAL A 750
TRP A 753
 None
 0.93A 1jo3B-1fr0A:
undetectable		 1jo3B-1fr0A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		3 ALA A 186
VAL A 191
TRP A 194
 None
 0.80A 1jo3B-1gomA:
undetectable		 1jo3B-1gomA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ALA A 284
VAL A 286
TRP A 248
 None
 0.84A 1jo3B-1hcyA:
undetectable		 1jo3B-1hcyA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 ALA A 349
VAL A 352
TRP A 489
 None
 0.83A 1jo3B-1j3bA:
undetectable		 1jo3B-1j3bA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 ALA A   6
VAL A   3
TRP A 116
 None
 0.91A 1jo3B-1kv9A:
undetectable		 1jo3B-1kv9A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.84A 1jo3B-1ot5A:
undetectable		 1jo3B-1ot5A:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		3 ALA A 218
VAL A 228
TRP A 156
 None
 0.68A 1jo3B-1r6vA:
undetectable		 1jo3B-1r6vA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A  15
VAL A  17
TRP A  66
 None
 0.91A 1jo3B-1rblA:
undetectable		 1jo3B-1rblA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfo WHISKER ANTIGEN
CONTROL PROTEIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 ALA A  12
VAL A  21
TRP A  20
 None
 0.83A 1jo3B-1rfoA:
undetectable		 1jo3B-1rfoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 ALA A 129
VAL A 123
TRP A  51
 None
 0.91A 1jo3B-1sfrA:
undetectable		 1jo3B-1sfrA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		3 ALA A 223
VAL A 232
TRP A 231
 None
 0.92A 1jo3B-1sq4A:
undetectable		 1jo3B-1sq4A:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 ALA B 183
VAL B 188
TRP B 191
 None
 0.77A 1jo3B-1ta3B:
undetectable		 1jo3B-1ta3B:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whg TUBULIN SPECIFIC
CHAPERONE B

(Mus musculus) 		PF01302
(CAP_GLY) 		3 ALA A  96
VAL A  67
TRP A  66
 None
 0.92A 1jo3B-1whgA:
undetectable		 1jo3B-1whgA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 ALA A  36
VAL A  33
TRP A  34
 PGO  A 604 ( 3.9A)
PGO  A 604 (-4.8A)
None
 0.91A 1jo3B-1womA:
undetectable		 1jo3B-1womA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA O  62
VAL O  57
TRP O  54
 None
 0.91A 1jo3B-1xupO:
undetectable		 1jo3B-1xupO:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 ALA A  10
VAL A   7
TRP A 120
 None
 0.93A 1jo3B-1yiqA:
undetectable		 1jo3B-1yiqA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		3 ALA A 224
VAL A 228
TRP A 231
 None
 0.91A 1jo3B-2cjeA:
undetectable		 1jo3B-2cjeA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  99
VAL A  87
TRP A  88
 None
 0.81A 1jo3B-2d4wA:
undetectable		 1jo3B-2d4wA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ALA A 484
VAL A 369
TRP A 375
 None
 0.93A 1jo3B-2fuvA:
undetectable		 1jo3B-2fuvA:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 ALA A 192
VAL A 190
TRP A 187
 None
 0.82A 1jo3B-2genA:
undetectable		 1jo3B-2genA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 ALA A  61
VAL A  54
TRP A  92
 None
 0.92A 1jo3B-2i44A:
undetectable		 1jo3B-2i44A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		3 ALA A  54
VAL A  90
TRP A 108
 None
 0.77A 1jo3B-2jepA:
undetectable		 1jo3B-2jepA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzk CYANOVIRIN-N HOMOLOG

(Tuber borchii) 		PF08881
(CVNH) 		3 ALA A  21
VAL A  31
TRP A  30
 None
 0.78A 1jo3B-2jzkA:
undetectable		 1jo3B-2jzkA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgy TRANSLOCATOR PROTEIN

(Mus musculus) 		PF03073
(TspO_MBR) 		3 ALA A 110
VAL A 115
TRP A 143
 PKA  A 201 (-2.9A)
None
None
 0.93A 1jo3B-2mgyA:
undetectable		 1jo3B-2mgyA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogj DIHYDROOROTASE

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		3 ALA A 389
VAL A 100
TRP A  73
 None
 0.86A 1jo3B-2ogjA:
undetectable		 1jo3B-2ogjA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v72 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 ALA A  64
VAL A 106
TRP A  97
 None
 0.87A 1jo3B-2v72A:
undetectable		 1jo3B-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v89 VDJ
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		PF13341
(RAG2_PHD) 		3 ALA A1442
VAL A1454
TRP A1453
 None
 0.86A 1jo3B-2v89A:
undetectable		 1jo3B-2v89A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbl RAC-LIKE GTP-BINDING
PROTEIN ARAC2

(Arabidopsis
thaliana) 		PF00071
(Ras) 		3 ALA C  62
VAL C  12
TRP C 100
 None
 0.89A 1jo3B-2wblC:
undetectable		 1jo3B-2wblC:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		3 ALA A  96
VAL A 106
TRP A  34
 None
 0.73A 1jo3B-2xrmA:
undetectable		 1jo3B-2xrmA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 ALA A 163
VAL A 173
TRP A  99
 None
 0.66A 1jo3B-2z2xA:
undetectable		 1jo3B-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 ALA A 163
VAL A 173
TRP A  99
 None
 0.65A 1jo3B-2z2zA:
undetectable		 1jo3B-2z2zA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ALA A 111
VAL A 116
TRP A 119
 None
 0.85A 1jo3B-3cinA:
undetectable		 1jo3B-3cinA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ALA A 651
VAL A 658
TRP A 659
 None
 0.72A 1jo3B-3cmgA:
undetectable		 1jo3B-3cmgA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxh CYTOCHROME B-C1
COMPLEX SUBUNIT 9

(Saccharomyces
cerevisiae) 		PF05365
(UCR_UQCRX_QCR9) 		3 ALA I  57
VAL I  52
TRP I  49
 None
 0.88A 1jo3B-3cxhI:
undetectable		 1jo3B-3cxhI:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		3 ALA A  81
VAL A  60
TRP A 157
 None
 0.92A 1jo3B-3fqdA:
undetectable		 1jo3B-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  99
VAL A  87
TRP A  88
 None
 0.82A 1jo3B-3g25A:
undetectable		 1jo3B-3g25A:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		3 ALA A 115
VAL A 126
TRP A  26
 None
 0.89A 1jo3B-3lpdA:
undetectable		 1jo3B-3lpdA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.85A 1jo3B-3m49A:
undetectable		 1jo3B-3m49A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbr GLUTAMINE
CYCLOTRANSFERASE

(Xanthomonas
campestris) 		PF05096
(Glu_cyclase_2) 		3 ALA X 216
VAL X 226
TRP X 246
 None
 0.87A 1jo3B-3mbrX:
undetectable		 1jo3B-3mbrX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D

(Clostridium
cellulovorans) 		PF00150
(Cellulase) 		3 ALA A  34
VAL A  66
TRP A  84
 None
 0.93A 1jo3B-3ndyA:
undetectable		 1jo3B-3ndyA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 353
VAL A 355
TRP A 358
 None
 0.89A 1jo3B-3qldA:
undetectable		 1jo3B-3qldA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo0 FAB FRAGMENT OF
IMMUNOGLOBULIN G1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ALA B  64
VAL B  48
TRP B  47
 None
 0.93A 1jo3B-3qo0B:
undetectable		 1jo3B-3qo0B:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		3 ALA A  69
VAL A  72
TRP A  28
 None
 0.82A 1jo3B-3sz3A:
undetectable		 1jo3B-3sz3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdp FORMATE/NITRITE
TRANSPORTER

(Clostridioides
difficile) 		PF01226
(Form_Nir_trans) 		3 ALA A 226
VAL A 231
TRP A 112
 None
 0.92A 1jo3B-3tdpA:
undetectable		 1jo3B-3tdpA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		3 ALA A 115
VAL A 126
TRP A  26
 None
 0.83A 1jo3B-3ti7A:
undetectable		 1jo3B-3ti7A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvt DISKS LARGE 1 TUMOR
SUPPRESSOR PROTEIN

(Drosophila
melanogaster) 		PF00018
(SH3_1)
PF00625
(Guanylate_kin) 		3 ALA A 776
VAL A 969
TRP A 968
 None
 0.88A 1jo3B-3tvtA:
undetectable		 1jo3B-3tvtA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		3 ALA A 114
VAL A 125
TRP A  34
 None
 0.70A 1jo3B-3vv3A:
undetectable		 1jo3B-3vv3A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 ALA A 326
VAL A 331
TRP A 334
 None
 0.88A 1jo3B-3w6qA:
undetectable		 1jo3B-3w6qA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyf GSP1P

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.88A 1jo3B-3wyfA:
undetectable		 1jo3B-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		3 ALA A 169
VAL A 210
TRP A 228
 None
 0.71A 1jo3B-3zmrA:
undetectable		 1jo3B-3zmrA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg RHO-LIKE SMALL
GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		3 ALA A  76
VAL A  26
TRP A 114
 None
 0.90A 1jo3B-4dvgA:
undetectable		 1jo3B-4dvgA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 122
VAL A 110
TRP A 111
 None
 0.74A 1jo3B-4e1jA:
undetectable		 1jo3B-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		3 ALA B 193
VAL B 204
TRP B 110
 None
 0.81A 1jo3B-4i0wB:
undetectable		 1jo3B-4i0wB:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		3 ALA A  57
VAL A 276
TRP A 275
 None
 0.64A 1jo3B-4ly4A:
undetectable		 1jo3B-4ly4A:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c SEED LECTIN BETA
CHAIN

(Spatholobus
parviflorus) 		PF00139
(Lectin_legB) 		3 ALA F  55
VAL F 208
TRP F 207
 None
 0.91A 1jo3B-4m3cF:
undetectable		 1jo3B-4m3cF:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mit RHO FAMILY GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		3 ALA A  66
VAL A  16
TRP A 104
 None
 0.91A 1jo3B-4mitA:
undetectable		 1jo3B-4mitA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A  15
VAL A  17
TRP A  66
 None
 0.81A 1jo3B-4mkvA:
undetectable		 1jo3B-4mkvA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		3 ALA A 101
VAL A 128
TRP A   2
 None
 0.92A 1jo3B-4oecA:
undetectable		 1jo3B-4oecA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ALA A 367
VAL A  16
TRP A  15
 None
 0.91A 1jo3B-4qn3A:
undetectable		 1jo3B-4qn3A:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 ALA A1731
VAL A1742
TRP A1741
 None
 0.85A 1jo3B-4r7yA:
undetectable		 1jo3B-4r7yA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.75A 1jo3B-4rgqA:
undetectable		 1jo3B-4rgqA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 ALA A 115
VAL A 153
TRP A 171
 None
 0.83A 1jo3B-4w87A:
undetectable		 1jo3B-4w87A:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB

(Escherichia
coli) 		PF00814
(Peptidase_M22) 		3 ALA C 113
VAL C 161
TRP C 160
 None
 0.92A 1jo3B-4wq5C:
undetectable		 1jo3B-4wq5C:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxp PUTATIVE
UNCHARACTERIZED
PROTEIN (RV0315
ORTHOLOG)

(Mycobacterium
avium) 		PF00722
(Glyco_hydro_16) 		3 ALA A 174
VAL A 162
TRP A 200
 None
 0.87A 1jo3B-4xxpA:
undetectable		 1jo3B-4xxpA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 ALA A  40
VAL A  72
TRP A  90
 None
 0.84A 1jo3B-4yztA:
undetectable		 1jo3B-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ALA A 204
VAL A 215
TRP A 138
 None
 0.89A 1jo3B-4z2aA:
undetectable		 1jo3B-4z2aA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF12704
(MacB_PCD) 		3 ALA A  52
VAL A 180
TRP A  48
 None
 0.91A 1jo3B-5c59A:
undetectable		 1jo3B-5c59A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		3 ALA A  32
VAL A  73
TRP A  89
 None
 0.87A 1jo3B-5d9nA:
undetectable		 1jo3B-5d9nA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		3 ALA A 149
VAL A 154
TRP A 164
 None
 0.93A 1jo3B-5dacA:
undetectable		 1jo3B-5dacA:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.91A 1jo3B-5disB:
undetectable		 1jo3B-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7l CONTACTIN-2

(Mus musculus) 		PF00041
(fn3) 		3 ALA A 819
VAL A 821
TRP A 822
 None
 0.77A 1jo3B-5e7lA:
undetectable		 1jo3B-5e7lA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		3 ALA A  59
VAL A 101
TRP A 118
 None
 0.89A 1jo3B-5h4rA:
undetectable		 1jo3B-5h4rA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h98 GEOBACTER
METALLIREDUCENS
SMUG1

(Geobacter
metallireducens) 		no annotation 3 ALA A 135
VAL A  69
TRP A 115
 None
 0.81A 1jo3B-5h98A:
undetectable		 1jo3B-5h98A:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		3 ALA A 208
VAL A   9
TRP A 246
 None
 0.92A 1jo3B-5hzhA:
undetectable		 1jo3B-5hzhA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		3 ALA A 670
VAL A 666
TRP A 685
 None
 0.88A 1jo3B-5kdxA:
undetectable		 1jo3B-5kdxA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 ALA B  91
VAL B  82
TRP B  83
 None
 0.91A 1jo3B-5ldrB:
undetectable		 1jo3B-5ldrB:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj8 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 3 ALA A 348
VAL A 476
TRP A 344
 None
 0.92A 1jo3B-5lj8A:
undetectable		 1jo3B-5lj8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 3 ALA A 528
VAL A 533
TRP A 536
 NAG  A1141 ( 3.8A)
None
None
 0.81A 1jo3B-5nbsA:
undetectable		 1jo3B-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf4 MINOR FIMBRIUM TIP
SUBUNIT MFA3

(Porphyromonas
gingivalis) 		no annotation 3 ALA A 240
VAL A 238
TRP A 244
 None
 0.90A 1jo3B-5nf4A:
undetectable		 1jo3B-5nf4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A  16
VAL A  18
TRP A  68
 None
 0.91A 1jo3B-5nv3A:
undetectable		 1jo3B-5nv3A:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 3 ALA A 136
VAL A 168
TRP A 185
 None
 0.66A 1jo3B-5oydA:
undetectable		 1jo3B-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		3 ALA A 529
VAL A 538
TRP A 537
 None
 0.85A 1jo3B-5tdgA:
undetectable		 1jo3B-5tdgA:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkf LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		3 ALA A 101
VAL A 104
TRP A 108
 None
 0.87A 1jo3B-5tkfA:
undetectable		 1jo3B-5tkfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3l DH511.2 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ALA H  61
VAL H  48
TRP H  47
 None
 0.92A 1jo3B-5u3lH:
undetectable		 1jo3B-5u3lH:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.76A 1jo3B-5v2mA:
undetectable		 1jo3B-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		3 ALA A 238
VAL A 243
TRP A 201
 None
 0.90A 1jo3B-5xd0A:
undetectable		 1jo3B-5xd0A:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7l -

(-) 		no annotation 3 ALA A  98
VAL A  87
TRP A 133
 None
 0.84A 1jo3B-5y7lA:
undetectable		 1jo3B-5y7lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 3 ALA A 254
VAL A 265
TRP A 171
 None
 0.87A 1jo3B-5yl7A:
undetectable		 1jo3B-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.81A 1jo3B-5zvs4:
undetectable		 1jo3B-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 3 ALA A  80
VAL A  71
TRP A  82
 None
 0.93A 1jo3B-6c7sA:
undetectable		 1jo3B-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A  82
VAL A  68
TRP A  69
 None
 0.91A 1jo3B-6f0qA:
undetectable		 1jo3B-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A 125
VAL A 110
TRP A 111
 None
 0.83A 1jo3B-6f0qA:
undetectable		 1jo3B-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 3 ALA A  96
VAL A 107
TRP A  34
 NA  A 402 ( 4.7A)
None
None
 0.69A 1jo3B-6f9mA:
undetectable		 1jo3B-6f9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 3 ALA A 188
VAL A 155
TRP A 153
 None
 0.93A 1jo3B-6fbtA:
undetectable		 1jo3B-6fbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdr -

(-) 		no annotation 3 ALA A 216
VAL A 268
TRP A 267
 None
 0.88A 1jo3B-6gdrA:
undetectable		 1jo3B-6gdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 ALA B 538
VAL B 534
TRP B 535
 None
 0.86A 1jo3B-6reqB:
undetectable		 1jo3B-6reqB:
4.18