SIMILAR PATTERNS OF AMINO ACIDS FOR 1JLB_A_NVPA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by1 PROTEIN (PIX)

(Homo sapiens) 		PF00621
(RhoGEF) 		4 LEU A  40
CYH A  65
LEU A 141
TYR A  39
 None
 0.91A 1jlbA-1by1A:
undetectable		 1jlbA-1by1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e50 CORE-BINDING FACTOR
CBF-BETA

(Homo sapiens) 		PF02312
(CBF_beta) 		4 LEU B 125
CYH B  25
GLY B 112
LEU B  64
 None
 0.86A 1jlbA-1e50B:
undetectable		 1jlbA-1e50B:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2e GLUTATHIONE
S-TRANSFERASE

(Sphingomonas
paucimobilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 140
GLY A 148
LEU A 158
TYR A 181
 None
 0.95A 1jlbA-1f2eA:
undetectable		 1jlbA-1f2eA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 VAL A 331
TYR A 165
GLY A 330
TYR A 298
 None
None
None
FAD  A 579 (-4.4A)
 0.84A 1jlbA-1h81A:
0.0		 1jlbA-1h81A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		5 LEU A 193
TYR A 178
GLY A 149
TRP A 189
TYR A  25
 None
 1.42A 1jlbA-1mn6A:
undetectable		 1jlbA-1mn6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158

(Thermotoga
maritima) 		PF00117
(GATase) 		4 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 0.94A 1jlbA-1o1yA:
undetectable		 1jlbA-1o1yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 LEU A  82
TYR A 231
GLY A  77
LEU A  30
 None
 0.83A 1jlbA-1p88A:
undetectable		 1jlbA-1p88A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY

(Enterococcus
faecalis) 		PF02567
(PhzC-PhzF) 		4 VAL A 184
TYR A 226
GLY A 181
LEU A 235
 None
 0.91A 1jlbA-1s7jA:
undetectable		 1jlbA-1s7jA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shc SHC

(Homo sapiens) 		PF00640
(PID) 		4 VAL A 164
TYR A 166
GLY A 155
LEU A 124
 None
 0.83A 1jlbA-1shcA:
undetectable		 1jlbA-1shcA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 LEU A 539
VAL A 440
GLY A 439
LEU A 535
 None
 0.92A 1jlbA-1su7A:
undetectable		 1jlbA-1su7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA) 		4 LEU A 132
VAL A 157
LEU A 298
TYR A 166
 None
 0.91A 1jlbA-1t0pA:
undetectable		 1jlbA-1t0pA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux8 YJBI PROTEIN

(Bacillus
subtilis) 		PF01152
(Bac_globin) 		4 LEU A  17
TYR A  56
GLY A  59
LEU A 110
 None
 0.94A 1jlbA-1ux8A:
undetectable		 1jlbA-1ux8A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		4 LEU A1884
VAL A1891
GLY A1890
LEU A1860
 None
 0.85A 1jlbA-1uyvA:
undetectable		 1jlbA-1uyvA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 LEU A 645
VAL A 716
GLY A 638
LEU A 703
 None
 0.85A 1jlbA-1vrqA:
2.5		 1jlbA-1vrqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 LEU A 236
VAL A 330
GLY A 329
LEU A 353
 None
 0.82A 1jlbA-1wn1A:
undetectable		 1jlbA-1wn1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 155
VAL A  43
GLY A 148
LEU A 210
 None
 0.91A 1jlbA-1wopA:
2.5		 1jlbA-1wopA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL

(Bos taurus) 		PF00889
(EF_TS) 		4 VAL B 230
CYH B 328
GLY B 248
LEU B 244
 None
 0.91A 1jlbA-1xb2B:
undetectable		 1jlbA-1xb2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		4 LEU A 192
GLY A  23
LEU A  16
TYR A 196
 None
 0.82A 1jlbA-1xcrA:
undetectable		 1jlbA-1xcrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF16554
(OAM_dimer) 		4 LEU B 218
GLY B 125
LEU B 203
TYR B 235
 None
 0.96A 1jlbA-1xrsB:
undetectable		 1jlbA-1xrsB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  60
VAL A  87
GLY A  88
LEU A  12
TYR A  44
 GOL  A1272 (-4.0A)
None
GOL  A1271 (-3.8A)
None
None
 1.17A 1jlbA-1yq9A:
undetectable		 1jlbA-1yq9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A  77
GLY A 156
LEU A 135
TYR A 140
 None
 0.79A 1jlbA-2cmhA:
undetectable		 1jlbA-2cmhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpj NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN

(Mus musculus) 		PF00076
(RRM_1) 		4 LEU A 133
VAL A  77
GLY A  78
LEU A  92
 None
 0.72A 1jlbA-2cpjA:
2.8		 1jlbA-2cpjA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A 127
TYR A 123
GLY A 128
LEU A 193
 None
 0.92A 1jlbA-2d4wA:
2.9		 1jlbA-2d4wA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7z CONSERVED
HYPOTHETICAL PROTEIN
SPY1493

(Streptococcus
pyogenes) 		PF02645
(DegV) 		4 LEU A 213
VAL A 189
TYR A 158
GLY A 160
 None
 0.83A 1jlbA-2g7zA:
undetectable		 1jlbA-2g7zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 LEU A 646
VAL A 717
GLY A 639
LEU A 704
 None
 0.95A 1jlbA-2gahA:
undetectable		 1jlbA-2gahA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF04268
(SoxG) 		4 LEU C 135
VAL C  32
GLY C 128
LEU C 189
 None
 0.96A 1jlbA-2gahC:
undetectable		 1jlbA-2gahC:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  90
VAL A 116
GLY A 121
LEU A 147
 None
 0.95A 1jlbA-2hlwA:
undetectable		 1jlbA-2hlwA:
14.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LEU A 100
VAL A 106
TYR A 188
GLY A 190
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.52A 1jlbA-2hnzA:
35.1		 1jlbA-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 LEU A 552
VAL A 515
GLY A 599
LEU A 546
 None
 0.82A 1jlbA-2hruA:
undetectable		 1jlbA-2hruA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 149
VAL A 123
GLY A 122
TYR A 144
 None
 0.90A 1jlbA-2ipcA:
undetectable		 1jlbA-2ipcA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		4 LEU A 187
VAL A 200
GLY A 131
LEU A 214
 None
 0.85A 1jlbA-2jfnA:
undetectable		 1jlbA-2jfnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jr0 N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Aquifex
aeolicus) 		PF01029
(NusB) 		4 LEU A 110
VAL A 123
GLY A 120
LEU A  87
 None
 0.94A 1jlbA-2jr0A:
undetectable		 1jlbA-2jr0A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpt PUTATIVE SECRETED
PROTEIN

(Corynebacterium
glutamicum) 		PF04536
(TPM_phosphatase) 		4 LEU A 164
VAL A  79
GLY A 169
LEU A 117
 None
 0.94A 1jlbA-2kptA:
undetectable		 1jlbA-2kptA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx2 HYPOTHETICAL PROTEIN
YPSA

(Bacillus
subtilis) 		PF06908
(DUF1273) 		4 VAL A  54
TYR A   9
GLY A  53
LEU A 135
 None
 0.97A 1jlbA-2nx2A:
undetectable		 1jlbA-2nx2A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 149
VAL A 175
GLY A 176
LEU A   7
 None
 0.90A 1jlbA-2q5oA:
undetectable		 1jlbA-2q5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 254
GLY A 362
LEU A 357
TYR A 256
 None
 0.96A 1jlbA-2qpmA:
5.7		 1jlbA-2qpmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 0.96A 1jlbA-2qtvB:
undetectable		 1jlbA-2qtvB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		4 LEU A 357
TYR A 328
GLY A 333
LEU A 312
 None
 0.79A 1jlbA-2qz6A:
undetectable		 1jlbA-2qz6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		4 LEU A 279
GLY A 228
TRP A 119
LEU A 281
 None
 0.83A 1jlbA-2vk2A:
2.0		 1jlbA-2vk2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		4 LEU A  49
GLY A 196
LEU A 122
TYR A  48
 None
 0.82A 1jlbA-2w45A:
undetectable		 1jlbA-2w45A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w87 ESTERASE D

(Cellvibrio
japonicus) 		PF03422
(CBM_6) 		4 VAL A  91
TYR A  89
GLY A  77
LEU A  63
 None
 0.87A 1jlbA-2w87A:
undetectable		 1jlbA-2w87A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME

(Candida
albicans) 		PF09084
(NMT1) 		4 LEU A 124
VAL A 130
GLY A 129
LEU A 105
 None
 0.82A 1jlbA-2x7qA:
undetectable		 1jlbA-2x7qA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 LEU A 207
CYH A 214
GLY A 247
LEU A 239
 None
 0.94A 1jlbA-2ykyA:
undetectable		 1jlbA-2ykyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Aeropyrum
pernix) 		PF15985
(KH_6) 		4 LEU A 114
VAL A 138
GLY A 144
LEU A 100
 None
 0.95A 1jlbA-2z0sA:
4.2		 1jlbA-2z0sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		4 LEU A  90
VAL A 161
GLY A 158
LEU A  88
 None
 0.86A 1jlbA-2z9vA:
2.3		 1jlbA-2z9vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 LEU A 279
VAL A 499
GLY A 418
LEU A 522
 None
 0.95A 1jlbA-2zciA:
undetectable		 1jlbA-2zciA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 216
VAL A 127
GLY A 124
LEU A 138
 None
 0.96A 1jlbA-3a14A:
undetectable		 1jlbA-3a14A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 0.79A 1jlbA-3alxA:
undetectable		 1jlbA-3alxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU A 211
VAL B  42
LEU B  54
TYR A 207
 None
 0.85A 1jlbA-3ayxA:
2.7		 1jlbA-3ayxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 LEU A 127
VAL A 152
LEU A  98
TYR A 126
 None
 0.90A 1jlbA-3bhwA:
undetectable		 1jlbA-3bhwA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI

(Pseudomonas
putida) 		PF10778
(DehI) 		4 LEU A  42
GLY A 260
LEU A 124
TYR A  48
 None
 0.80A 1jlbA-3bjxA:
undetectable		 1jlbA-3bjxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 LEU A  75
VAL A 274
GLY A 275
TYR A 107
 None
 0.93A 1jlbA-3c9fA:
undetectable		 1jlbA-3c9fA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 LEU A 320
GLY A 277
TRP A  46
TYR A  36
 None
 0.92A 1jlbA-3cc1A:
undetectable		 1jlbA-3cc1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Enterococcus
faecalis) 		PF13377
(Peripla_BP_3) 		4 LEU A  77
VAL A  64
LEU A 115
TYR A  74
 None
 0.94A 1jlbA-3cs3A:
undetectable		 1jlbA-3cs3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  77
VAL A  57
GLY A 119
LEU A  72
 None
 0.96A 1jlbA-3ddmA:
undetectable		 1jlbA-3ddmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 196
VAL A  24
GLY A 189
LEU A  99
 None
 0.88A 1jlbA-3eoqA:
4.0		 1jlbA-3eoqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN

(Vibrio
parahaemolyticus) 		PF01965
(DJ-1_PfpI) 		4 LEU A  14
VAL A 120
GLY A 117
LEU A  97
 None
 0.75A 1jlbA-3er6A:
undetectable		 1jlbA-3er6A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et6 SOLUBLE GUANYLYL
CYCLASE BETA

(Chlamydomonas
reinhardtii) 		PF00211
(Guanylate_cyc) 		4 LEU A 547
VAL A 572
GLY A 573
LEU A 551
 None
 0.84A 1jlbA-3et6A:
4.9		 1jlbA-3et6A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		4 LEU A 227
GLY A 217
LEU A 211
TYR A 232
 None
 0.78A 1jlbA-3futA:
undetectable		 1jlbA-3futA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 LEU A 141
VAL A 202
GLY A 146
LEU A 189
 None
 0.70A 1jlbA-3h8lA:
undetectable		 1jlbA-3h8lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 LEU A 305
TYR A 329
GLY A 331
LEU A 337
 None
 0.72A 1jlbA-3hbcA:
undetectable		 1jlbA-3hbcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		5 LEU B 245
VAL A 184
CYH B 268
GLY A 185
LEU B 260
 None
 1.24A 1jlbA-3it4B:
undetectable		 1jlbA-3it4B:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		4 LEU A 154
VAL A 131
GLY A 130
LEU A 196
 None
 0.94A 1jlbA-3k2dA:
undetectable		 1jlbA-3k2dA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		4 LEU A 353
VAL A 310
GLY A 309
LEU A 286
 None
 0.95A 1jlbA-3ka7A:
undetectable		 1jlbA-3ka7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		4 LEU A  81
VAL A 154
GLY A 155
LEU A 187
 None
 0.93A 1jlbA-3kcxA:
undetectable		 1jlbA-3kcxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU J 162
VAL J 173
GLY J 172
LEU J   4
 None
 0.80A 1jlbA-3mg6J:
undetectable		 1jlbA-3mg6J:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		4 LEU A 138
VAL A 188
GLY A 185
LEU A 155
 None
 0.97A 1jlbA-3qfwA:
2.3		 1jlbA-3qfwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv9 PYRUVATE KINASE 2

(Trypanosoma
cruzi) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 151
CYH A 178
GLY A 147
LEU A 102
 None
 0.97A 1jlbA-3qv9A:
undetectable		 1jlbA-3qv9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 LEU A 167
VAL A 155
TYR A 126
GLY A 128
 None
 0.83A 1jlbA-3rhyA:
undetectable		 1jlbA-3rhyA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnl SULFOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF13469
(Sulfotransfer_3) 		4 VAL A 161
TYR A 158
GLY A 162
LEU A 155
 None
None
None
GOL  A 313 (-3.9A)
 0.87A 1jlbA-3rnlA:
undetectable		 1jlbA-3rnlA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8m ENOYL-ACP REDUCTASE

(Xanthomonas
oryzae) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 LEU A 317
GLY A 264
LEU A 135
TYR A 318
 None
 0.96A 1jlbA-3s8mA:
undetectable		 1jlbA-3s8mA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sul CERATO-PLATANIN-LIKE
PROTEIN

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		4 VAL A 102
TYR A  58
GLY A  60
LEU A 110
 None
 0.68A 1jlbA-3sulA:
undetectable		 1jlbA-3sulA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t20 CIS-ACONITATE PORIN
OPDH

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A 202
GLY A 174
LEU A 278
TYR A 206
 None
 0.81A 1jlbA-3t20A:
undetectable		 1jlbA-3t20A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		4 LEU A 100
VAL A  32
GLY A  37
LEU A  52
 None
 0.81A 1jlbA-3u37A:
undetectable		 1jlbA-3u37A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u92 GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A  39
GLY A 216
LEU A 242
TYR A  35
 None
 0.86A 1jlbA-3u92A:
undetectable		 1jlbA-3u92A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 LEU A 143
VAL A 127
GLY A 184
LEU A 199
 None
 0.78A 1jlbA-3uaiA:
1.9		 1jlbA-3uaiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 124
VAL A 316
GLY A 130
TRP A 113
 None
 0.93A 1jlbA-3ugvA:
undetectable		 1jlbA-3ugvA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 LEU A  94
VAL A 146
GLY A 147
LEU A 185
 None
 0.97A 1jlbA-3wmtA:
undetectable		 1jlbA-3wmtA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 LEU K 167
VAL K 178
GLY K 177
LEU K   4
 None
 0.85A 1jlbA-3wxrK:
undetectable		 1jlbA-3wxrK:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 LEU A 149
VAL A  83
GLY A 129
LEU A  78
 None
None
NA  A 502 ( 4.3A)
None
 0.92A 1jlbA-4ayrA:
undetectable		 1jlbA-4ayrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 LEU A 371
GLY A 316
LEU A 449
TYR A 431
 None
 0.93A 1jlbA-4ayrA:
undetectable		 1jlbA-4ayrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LEU A 333
TYR A 136
GLY A 145
TYR A 152
 None
 0.87A 1jlbA-4bgbA:
3.4		 1jlbA-4bgbA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 LEU A1040
TYR A 956
GLY A 958
LEU A 928
 None
 0.73A 1jlbA-4bocA:
2.3		 1jlbA-4bocA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 LEU B 151
VAL B  98
GLY B 131
LEU B 113
 None
 0.96A 1jlbA-4bziB:
undetectable		 1jlbA-4bziB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 LEU A 234
VAL A  81
TYR A  67
GLY A  69
 None
 0.91A 1jlbA-4c1oA:
undetectable		 1jlbA-4c1oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		4 LEU A  36
VAL A  46
GLY A  45
LEU A 285
 PEG  A 297 ( 4.8A)
None
None
None
 0.96A 1jlbA-4c6yA:
2.1		 1jlbA-4c6yA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 LEU A 276
TYR A   4
LEU A 327
TYR A 331
 None
 0.96A 1jlbA-4d47A:
undetectable		 1jlbA-4d47A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 228
VAL A 234
GLY A 233
LEU A 276
 None
 0.92A 1jlbA-4d5gA:
undetectable		 1jlbA-4d5gA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 LEU A 263
TYR A 275
GLY A   6
LEU A 302
TYR A 306
 None
 1.35A 1jlbA-4ee9A:
undetectable		 1jlbA-4ee9A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		4 LEU A  43
VAL A  60
GLY A   5
TYR A  47
 None
 0.96A 1jlbA-4ehtA:
2.9		 1jlbA-4ehtA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 405
GLY A 397
LEU A 460
TYR A 480
 None
 0.90A 1jlbA-4eqvA:
undetectable		 1jlbA-4eqvA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esr JOUBERIN

(Homo sapiens) 		PF00018
(SH3_1) 		4 LEU A1115
VAL A1057
GLY A1075
LEU A1111
 None
 0.93A 1jlbA-4esrA:
undetectable		 1jlbA-4esrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx7 CYTOLYSIN AND
HEMOLYSIN HLYA
PORE-FORMING TOXIN

(Vibrio cholerae) 		PF16458
(Beta-prism_lec) 		4 LEU A 619
VAL A 674
GLY A 675
LEU A 608
 None
 0.94A 1jlbA-4gx7A:
undetectable		 1jlbA-4gx7A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 LEU A 317
TYR A 308
GLY A 310
LEU A 303
 None
 0.95A 1jlbA-4gyoA:
2.2		 1jlbA-4gyoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS) 		4 LEU S 110
VAL S 144
GLY S 145
LEU S 114
 None
 0.84A 1jlbA-4hzuS:
undetectable		 1jlbA-4hzuS:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io6 AVGLUR1 LIGAND
BINDING DOMAIN

(Adineta vaga) 		PF00497
(SBP_bac_3) 		4 LEU A  44
GLY A 208
LEU A 234
TYR A  40
 None
 0.93A 1jlbA-4io6A:
undetectable		 1jlbA-4io6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		4 LEU A  69
VAL A 138
TYR A 135
GLY A 139
 GOL  A 301 ( 4.5A)
None
None
None
 0.93A 1jlbA-4jfcA:
undetectable		 1jlbA-4jfcA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 212
CYH A 186
GLY A 129
LEU A 179
 None
 0.95A 1jlbA-4jr7A:
undetectable		 1jlbA-4jr7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		4 LEU A 221
VAL A 258
TYR A 256
GLY A 265
 None
None
ACT  A 404 ( 4.6A)
None
 0.92A 1jlbA-4krtA:
undetectable		 1jlbA-4krtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN

(Pseudomonas
aeruginosa;
Vibrio cholerae) 		PF00437
(T2SSE)
PF05638
(T6SS_HCP) 		4 LEU A 370
VAL A 387
GLY A 386
LEU A 358
 None
 0.88A 1jlbA-4kssA:
undetectable		 1jlbA-4kssA:
22.43